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Traditional Serrated Adenoma

MedGen UID:
226832
Concept ID:
C1266025
Neoplastic Process
Synonyms: Mixed adenomatous and hyperplastic polyp; Serrated Adenoma; Serrated adenoma; Serrated Adenoma Type II; Traditional serrated adenoma
SNOMED CT: Mixed adenomatous and hyperplastic polyp (128653004); Serrated adenoma (128653004); Traditional serrated adenoma (443734007)

Definition

An adenoma that arises from the large intestine and the appendix. It is characterized by prominent serration of the glands. [from NCI]

Professional guidelines

PubMed

van Toledo DEFWM, Breekveldt ECH, IJspeert JEG, van Vuuren AJ, van Kemenade FJ, Ramakers C, Nagtegaal ID, van Leerdam ME, Spaander MCW, Lansdorp-Vogelaar I, Toes-Zoutendijk E, Dekker E
Endoscopy 2023 Jun;55(6):526-534. Epub 2022 Nov 2 doi: 10.1055/a-1971-3488. PMID: 36323332
Cansiz Ersöz C, Kiremitci S, Savas B, Ensari A
Acta Gastroenterol Belg 2020 Oct-Dec;83(4):549-556. PMID: 33321010
Bateman AC, Shepherd NA
J Clin Pathol 2015 Aug;68(8):585-91. Epub 2015 Apr 30 doi: 10.1136/jclinpath-2015-203016. PMID: 25934843

Recent clinical studies

Etiology

Mizuguchi Y, Tanaka Y, Cho H, Sekiguchi M, Takamaru H, Yamada M, Sakamoto T, Matsuda T, Hashimoto T, Sekine S, Saito Y
Dig Endosc 2022 Jan;34(1):153-162. Epub 2021 May 24 doi: 10.1111/den.13992. PMID: 33871900
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Geramizadeh B, Robertson S
J Gastrointest Cancer 2017 Dec;48(4):291-298. doi: 10.1007/s12029-017-9977-y. PMID: 28639142
Rashtak S, Rego R, Sweetser SR, Sinicrope FA
Cancer Prev Res (Phila) 2017 May;10(5):270-278. Epub 2017 Mar 21 doi: 10.1158/1940-6207.CAPR-16-0264. PMID: 28325827
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333

Diagnosis

Sano W, Hirata D, Teramoto A, Iwatate M, Hattori S, Fujita M, Sano Y
World J Gastroenterol 2020 May 21;26(19):2276-2285. doi: 10.3748/wjg.v26.i19.2276. PMID: 32476792Free PMC Article
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Geramizadeh B, Robertson S
J Gastrointest Cancer 2017 Dec;48(4):291-298. doi: 10.1007/s12029-017-9977-y. PMID: 28639142
Chetty R
J Clin Pathol 2016 Jan;69(1):6-11. Epub 2015 Nov 9 doi: 10.1136/jclinpath-2015-203452. PMID: 26553935
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333

Therapy

Harpaz N, Goldblum JR, Shepherd NA, Riddell RH, Rubio CA, Vieth M, Wang HH, Odze RD
Hum Pathol 2023 Aug;138:49-61. Epub 2023 May 27 doi: 10.1016/j.humpath.2023.05.008. PMID: 37247824
Bozorg SR, Song M, Emilsson L, Ludvigsson JF
BMC Gastroenterol 2019 Dec 31;20(1):3. doi: 10.1186/s12876-019-1134-6. PMID: 31892305Free PMC Article
Aziz M, Desai M, Hassan S, Fatima R, Dasari CS, Chandrasekar VT, Jegadeesan R, Duvvuri A, Patel H, Rai T, Sathyamurthy A, Kohli DR, Vennalaganti P, Nawras A, Wallace M, Sharma P
Gastrointest Endosc 2019 Nov;90(5):721-731.e1. Epub 2019 Jul 6 doi: 10.1016/j.gie.2019.06.041. PMID: 31288029
Tsai JH, Jeng YM, Yuan CT, Lin YL, Cheng ML, Liau JY
Am J Surg Pathol 2019 Aug;43(8):1042-1051. doi: 10.1097/PAS.0000000000001274. PMID: 31094930
Hafezi-Bakhtiari S, Wang LM, Colling R, Serra S, Chetty R
Histopathology 2015 Jan;66(2):308-13. Epub 2014 Nov 13 doi: 10.1111/his.12555. PMID: 25257227

Prognosis

He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Chetty R
J Clin Pathol 2016 Jan;69(1):6-11. Epub 2015 Nov 9 doi: 10.1136/jclinpath-2015-203452. PMID: 26553935
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333
Moussata D, Boschetti G, Chauvenet M, Stroeymeyt K, Nancey S, Berger F, Lecomte T, Flourié B
World J Gastroenterol 2015 Mar 14;21(10):2896-904. doi: 10.3748/wjg.v21.i10.2896. PMID: 25780286Free PMC Article
Yamane L, Scapulatempo-Neto C, Reis RM, Guimarães DP
World J Gastroenterol 2014 Mar 14;20(10):2634-40. doi: 10.3748/wjg.v20.i10.2634. PMID: 24627599Free PMC Article

Clinical prediction guides

Zhou YJ, Lu XF, Chen H, Wang XY, Cheng W, Zhang QW, Chen JN, Wang XY, Jin JZ, Yan FR, Chen H, Li XB
Cell Mol Gastroenterol Hepatol 2023;15(2):393-424. Epub 2022 Oct 8 doi: 10.1016/j.jcmgh.2022.10.001. PMID: 36216310Free PMC Article
Sekine S, Yamashita S, Yamada M, Hashimoto T, Ogawa R, Yoshida H, Taniguchi H, Kojima M, Ushijima T, Saito Y
J Gastroenterol 2020 Apr;55(4):418-427. Epub 2020 Feb 12 doi: 10.1007/s00535-020-01673-z. PMID: 32052185
Rashtak S, Rego R, Sweetser SR, Sinicrope FA
Cancer Prev Res (Phila) 2017 May;10(5):270-278. Epub 2017 Mar 21 doi: 10.1158/1940-6207.CAPR-16-0264. PMID: 28325827
Chetty R
J Clin Pathol 2016 Jan;69(1):6-11. Epub 2015 Nov 9 doi: 10.1136/jclinpath-2015-203452. PMID: 26553935
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333

Recent systematic reviews

Aziz M, Desai M, Hassan S, Fatima R, Dasari CS, Chandrasekar VT, Jegadeesan R, Duvvuri A, Patel H, Rai T, Sathyamurthy A, Kohli DR, Vennalaganti P, Nawras A, Wallace M, Sharma P
Gastrointest Endosc 2019 Nov;90(5):721-731.e1. Epub 2019 Jul 6 doi: 10.1016/j.gie.2019.06.041. PMID: 31288029
Travaglino A, D'Armiento FP, Cassese G, Campanino MR, Borrelli G, Pignatiello S, Luglio G, Maione F, De Palma GD, D'Armiento M
Histopathology 2019 Aug;75(2):160-173. Epub 2019 May 16 doi: 10.1111/his.13846. PMID: 30815911

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