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Traditional Serrated Adenoma

MedGen UID:
226832
•Concept ID:
C1266025
•
Neoplastic Process
Synonyms: Mixed adenomatous and hyperplastic polyp; Serrated Adenoma; Serrated adenoma; Serrated Adenoma Type II; Traditional serrated adenoma
SNOMED CT: Mixed adenomatous and hyperplastic polyp (128653004); Serrated adenoma (128653004); Traditional serrated adenoma (443734007)

Definition

An adenoma that arises from the large intestine and the appendix. It is characterized by prominent serration of the glands. [from NCI]

Professional guidelines

PubMed

Differential diagnosis of traditional serrated adenomas and tubulovillous adenomas: a compartmental morphologic and immunohistochemical analysis.
Cansiz Ersöz C, Kiremitci S, Savas B, Ensari A
Acta Gastroenterol Belg 2020 Oct-Dec;83(4):549-556. PMID: 33321010
UK guidance for the pathological reporting of serrated lesions of the colorectum.
Bateman AC, Shepherd NA
J Clin Pathol 2015 Aug;68(8):585-91. Epub 2015 Apr 30 doi: 10.1136/jclinpath-2015-203016. PMID: 25934843
Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management.
Rosty C, Hewett DG, Brown IS, Leggett BA, Whitehall VL
J Gastroenterol 2013 Mar;48(3):287-302. Epub 2012 Dec 4 doi: 10.1007/s00535-012-0720-y. PMID: 23208018Free PMC Article

Recent clinical studies

Etiology

Traditional serrated adenoma-like lesions in patients with inflammatory bowel disease.
Miller GC, Liu C, Bettington ML, Leggett B, Whitehall VLJ, Rosty C
Hum Pathol 2020 Mar;97:19-28. Epub 2020 Jan 7 doi: 10.1016/j.humpath.2019.12.005. PMID: 31917154
Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Sessile Serrated Polyps and Colon Cancer Prevention.
Rashtak S, Rego R, Sweetser SR, Sinicrope FA
Cancer Prev Res (Phila) 2017 May;10(5):270-278. Epub 2017 Mar 21 doi: 10.1158/1940-6207.CAPR-16-0264. PMID: 28325827
Traditional serrated adenoma: an update.
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333
Serrated pathway in colorectal carcinogenesis.
Yamane L, Scapulatempo-Neto C, Reis RM, Guimarães DP
World J Gastroenterol 2014 Mar 14;20(10):2634-40. doi: 10.3748/wjg.v20.i10.2634. PMID: 24627599Free PMC Article

Diagnosis

Serrated polyps of the colon and rectum: Remove or not?
Sano W, Hirata D, Teramoto A, Iwatate M, Hattori S, Fujita M, Sano Y
World J Gastroenterol 2020 May 21;26(19):2276-2285. doi: 10.3748/wjg.v26.i19.2276. PMID: 32476792Free PMC Article
Traditional serrated adenoma-like lesions in patients with inflammatory bowel disease.
Miller GC, Liu C, Bettington ML, Leggett B, Whitehall VLJ, Rosty C
Hum Pathol 2020 Mar;97:19-28. Epub 2020 Jan 7 doi: 10.1016/j.humpath.2019.12.005. PMID: 31917154
Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Traditional serrated adenoma (TSA): morphological questions, queries and quandaries.
Chetty R
J Clin Pathol 2016 Jan;69(1):6-11. Epub 2015 Nov 9 doi: 10.1136/jclinpath-2015-203452. PMID: 26553935
Traditional serrated adenoma: an update.
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333

Therapy

Colorectal dysplasia in chronic inflammatory bowel disease: a contemporary consensus classification and interobserver study.
Harpaz N, Goldblum JR, Shepherd NA, Riddell RH, Rubio CA, Vieth M, Wang HH, Odze RD
Hum Pathol 2023 Aug;138:49-61. Epub 2023 May 27 doi: 10.1016/j.humpath.2023.05.008. PMID: 37247824
Improving serrated adenoma detection rate in the colon by electronic chromoendoscopy and distal attachment: systematic review and meta-analysis.
Aziz M, Desai M, Hassan S, Fatima R, Dasari CS, Chandrasekar VT, Jegadeesan R, Duvvuri A, Patel H, Rai T, Sathyamurthy A, Kohli DR, Vennalaganti P, Nawras A, Wallace M, Sharma P
Gastrointest Endosc 2019 Nov;90(5):721-731.e1. Epub 2019 Jul 6 doi: 10.1016/j.gie.2019.06.041. PMID: 31288029
Traditional Serrated Pathway-associated Colorectal Carcinoma: Morphologic Reappraisal of Serrated Morphology, Tumor Budding, and Identification of Frequent PTEN Alterations.
Tsai JH, Jeng YM, Yuan CT, Lin YL, Cheng ML, Liau JY
Am J Surg Pathol 2019 Aug;43(8):1042-1051. doi: 10.1097/PAS.0000000000001274. PMID: 31094930
Histological overlap between colorectal villous/tubulovillous and traditional serrated adenomas.
Hafezi-Bakhtiari S, Wang LM, Colling R, Serra S, Chetty R
Histopathology 2015 Jan;66(2):308-13. Epub 2014 Nov 13 doi: 10.1111/his.12555. PMID: 25257227
Differential expression of p53 and p504s in hyperplastic polyp, sessile serrated adenoma and traditional serrated adenoma.
Ngo NT, Tan E, Tekkis P, Peston D, Cohen P
Int J Colorectal Dis 2010 Oct;25(10):1193-200. Epub 2010 Jul 17 doi: 10.1007/s00384-010-1007-5. PMID: 20640432

Prognosis

Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Traditional serrated adenoma (TSA): morphological questions, queries and quandaries.
Chetty R
J Clin Pathol 2016 Jan;69(1):6-11. Epub 2015 Nov 9 doi: 10.1136/jclinpath-2015-203452. PMID: 26553935
Traditional serrated adenoma: an update.
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333
Endoscopic and histologic characteristics of serrated lesions.
Moussata D, Boschetti G, Chauvenet M, Stroeymeyt K, Nancey S, Berger F, Lecomte T, Flourié B
World J Gastroenterol 2015 Mar 14;21(10):2896-904. doi: 10.3748/wjg.v21.i10.2896. PMID: 25780286Free PMC Article
Serrated pathway in colorectal carcinogenesis.
Yamane L, Scapulatempo-Neto C, Reis RM, Guimarães DP
World J Gastroenterol 2014 Mar 14;20(10):2634-40. doi: 10.3748/wjg.v20.i10.2634. PMID: 24627599Free PMC Article

Clinical prediction guides

Single-cell Transcriptomics Reveals Early Molecular and Immune Alterations Underlying the Serrated Neoplasia Pathway Toward Colorectal Cancer.
Zhou YJ, Lu XF, Chen H, Wang XY, Cheng W, Zhang QW, Chen JN, Wang XY, Jin JZ, Yan FR, Chen H, Li XB
Cell Mol Gastroenterol Hepatol 2023;15(2):393-424. Epub 2022 Oct 8 doi: 10.1016/j.jcmgh.2022.10.001. PMID: 36216310Free PMC Article
Clinicopathological and molecular correlations in traditional serrated adenoma.
Sekine S, Yamashita S, Yamada M, Hashimoto T, Ogawa R, Yoshida H, Taniguchi H, Kojima M, Ushijima T, Saito Y
J Gastroenterol 2020 Apr;55(4):418-427. Epub 2020 Feb 12 doi: 10.1007/s00535-020-01673-z. PMID: 32052185
Traditional serrated adenoma (TSA): morphological questions, queries and quandaries.
Chetty R
J Clin Pathol 2016 Jan;69(1):6-11. Epub 2015 Nov 9 doi: 10.1136/jclinpath-2015-203452. PMID: 26553935
Traditional serrated adenoma: an update.
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333
Endoscopic and histologic characteristics of serrated lesions.
Moussata D, Boschetti G, Chauvenet M, Stroeymeyt K, Nancey S, Berger F, Lecomte T, Flourié B
World J Gastroenterol 2015 Mar 14;21(10):2896-904. doi: 10.3748/wjg.v21.i10.2896. PMID: 25780286Free PMC Article

Recent systematic reviews

Improving serrated adenoma detection rate in the colon by electronic chromoendoscopy and distal attachment: systematic review and meta-analysis.
Aziz M, Desai M, Hassan S, Fatima R, Dasari CS, Chandrasekar VT, Jegadeesan R, Duvvuri A, Patel H, Rai T, Sathyamurthy A, Kohli DR, Vennalaganti P, Nawras A, Wallace M, Sharma P
Gastrointest Endosc 2019 Nov;90(5):721-731.e1. Epub 2019 Jul 6 doi: 10.1016/j.gie.2019.06.041. PMID: 31288029
Clinicopathological factors associated with BRAF-V600E mutation in colorectal serrated adenomas.
Travaglino A, D'Armiento FP, Cassese G, Campanino MR, Borrelli G, Pignatiello S, Luglio G, Maione F, De Palma GD, D'Armiento M
Histopathology 2019 Aug;75(2):160-173. Epub 2019 May 16 doi: 10.1111/his.13846. PMID: 30815911

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