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HHV8-Related Malignant Neoplasm

MedGen UID:
232293
•Concept ID:
C1334047
•
Neoplastic Process
Synonyms: HHV-8 Related Malignancy; HHV-8-Related Malignancy; Human Herpes Virus 8 Related Malignancy; Human Herpes Virus 8-Related Malignancy; Human Herpes Virus 8-Related Malignant Neoplasm

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHHV8-Related Malignant Neoplasm

Recent clinical studies

Etiology

Iatrogenic solid tumors following immunosuppressive therapy.
Dantey K, Pantanowitz L
Semin Diagn Pathol 2018 Jul;35(4):272-278. Epub 2017 Sep 20 doi: 10.1053/j.semdp.2017.09.002. PMID: 29066044
Comparison of human herpes virus 8 related primary effusion lymphoma with human herpes virus 8 unrelated primary effusion lymphoma-like lymphoma on the basis of HIV: report of 2 cases and review of 212 cases in the literature.
Kobayashi Y, Kamitsuji Y, Kuroda J, Tsunoda S, Uoshima N, Kimura S, Wada K, Matsumoto Y, Nomura K, Horiike S, Shimazaki C, Yoshikawa T, Taniwaki M
Acta Haematol 2007;117(3):132-44. Epub 2006 Nov 29 doi: 10.1159/000097460. PMID: 17135726
Reduced seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV), human herpesvirus 8 (HHV8), related to suppression of Anopheles density in Italy.
Coluzzi M, Calabrò ML, Manno D, Chieco-Bianchi L, Schulz TF, Ascoli V
Med Vet Entomol 2003 Dec;17(4):461-4. doi: 10.1111/j.1365-2915.2003.00465.x. PMID: 14651663
Human herpesvirus-8 infection among heterosexual partners of patients with classical Kaposi's sarcoma.
Brambilla L, Boneschi V, Ferrucci S, Taglioni M, Berti E
Br J Dermatol 2000 Nov;143(5):1021-5. doi: 10.1046/j.1365-2133.2000.03837.x. PMID: 11069513

Diagnosis

Human Herpes-8 virus copy to cell ratio: A diagnostic tool in primary effusion lymphoma.
Carne S, Smit E, Price N, Paul J, Guiver M, Tedder R
J Clin Virol 2019 Jul;116:7-10. Epub 2019 Mar 22 doi: 10.1016/j.jcv.2019.03.013. PMID: 30991238
Iatrogenic solid tumors following immunosuppressive therapy.
Dantey K, Pantanowitz L
Semin Diagn Pathol 2018 Jul;35(4):272-278. Epub 2017 Sep 20 doi: 10.1053/j.semdp.2017.09.002. PMID: 29066044
HHV8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma.
Gonzalez-Farre B, Martinez D, Lopez-Guerra M, Xipell M, Monclus E, Rovira J, Garcia F, Lopez-Guillermo A, Colomo L, Campo E, Martinez A
Mod Pathol 2017 May;30(5):745-760. Epub 2017 Jan 13 doi: 10.1038/modpathol.2016.233. PMID: 28084335
Review of latent and lytic phase biomarkers in Kaposi's sarcoma.
Amin M, Pantanowitz L
Expert Opin Med Diagn 2013 Nov;7(6):531-42. Epub 2013 Sep 26 doi: 10.1517/17530059.2013.842227. PMID: 24070121
How I treat HHV8/KSHV-related diseases in posttransplant patients.
Riva G, Luppi M, Barozzi P, Forghieri F, Potenza L
Blood 2012 Nov 15;120(20):4150-9. Epub 2012 Sep 11 doi: 10.1182/blood-2012-04-421412. PMID: 22968461

Therapy

Concurrent development of HIV-negative Kaposi's sarcoma and mycosis fungoides in an elderly Inuit from Canada.
Bedier H, Lin J, Julien LA, Routy JP
BMJ Case Rep 2021 Jan 28;14(1) doi: 10.1136/bcr-2020-238644. PMID: 33509877Free PMC Article
Remission of an HHV8-related extracavitary primary effusion lymphoma in an HIV-positive patient during antiretroviral treatment containing dolutegravir.
Campogiani L, Cerva C, Maffongelli G, Teti E, Pupo L, Vaccarini S, Cantonetti M, Pennica A, Andreoni M, Sarmati L
AIDS Res Ther 2019 Jul 27;16(1):15. doi: 10.1186/s12981-019-0230-6. PMID: 31351487Free PMC Article
Iatrogenic solid tumors following immunosuppressive therapy.
Dantey K, Pantanowitz L
Semin Diagn Pathol 2018 Jul;35(4):272-278. Epub 2017 Sep 20 doi: 10.1053/j.semdp.2017.09.002. PMID: 29066044
How I treat HHV8/KSHV-related diseases in posttransplant patients.
Riva G, Luppi M, Barozzi P, Forghieri F, Potenza L
Blood 2012 Nov 15;120(20):4150-9. Epub 2012 Sep 11 doi: 10.1182/blood-2012-04-421412. PMID: 22968461
Update on Kaposi's sarcoma and other HHV8 associated diseases. Part 1: epidemiology, environmental predispositions, clinical manifestations, and therapy.
Hengge UR, Ruzicka T, Tyring SK, Stuschke M, Roggendorf M, Schwartz RA, Seeber S
Lancet Infect Dis 2002 May;2(5):281-92. doi: 10.1016/s1473-3099(02)00263-3. PMID: 12062994

Prognosis

Remission of an HHV8-related extracavitary primary effusion lymphoma in an HIV-positive patient during antiretroviral treatment containing dolutegravir.
Campogiani L, Cerva C, Maffongelli G, Teti E, Pupo L, Vaccarini S, Cantonetti M, Pennica A, Andreoni M, Sarmati L
AIDS Res Ther 2019 Jul 27;16(1):15. doi: 10.1186/s12981-019-0230-6. PMID: 31351487Free PMC Article
Multiple remissions of extracavitary primary effusion lymphoma treated with a single cycle of liposomal doxorubicin in a patient infected with HIV.
Chen J, Mehraj V, Szabo J, Routy B, Michel RP, Routy JP
Curr Oncol 2018 Dec;25(6):e592-e596. Epub 2018 Dec 1 doi: 10.3747/co.25.4119. PMID: 30607128Free PMC Article
HHV8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma.
Gonzalez-Farre B, Martinez D, Lopez-Guerra M, Xipell M, Monclus E, Rovira J, Garcia F, Lopez-Guillermo A, Colomo L, Campo E, Martinez A
Mod Pathol 2017 May;30(5):745-760. Epub 2017 Jan 13 doi: 10.1038/modpathol.2016.233. PMID: 28084335
Human herpesvirus 8 DNA quantification in matched plasma and PBMCs samples of patients with HHV8-related lymphoproliferative diseases.
Tedeschi R, Marus A, Bidoli E, Simonelli C, De Paoli P
J Clin Virol 2008 Nov;43(3):255-9. Epub 2008 Aug 23 doi: 10.1016/j.jcv.2008.07.005. PMID: 18723390
Comparison of human herpes virus 8 related primary effusion lymphoma with human herpes virus 8 unrelated primary effusion lymphoma-like lymphoma on the basis of HIV: report of 2 cases and review of 212 cases in the literature.
Kobayashi Y, Kamitsuji Y, Kuroda J, Tsunoda S, Uoshima N, Kimura S, Wada K, Matsumoto Y, Nomura K, Horiike S, Shimazaki C, Yoshikawa T, Taniwaki M
Acta Haematol 2007;117(3):132-44. Epub 2006 Nov 29 doi: 10.1159/000097460. PMID: 17135726

Clinical prediction guides

HHV8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma.
Gonzalez-Farre B, Martinez D, Lopez-Guerra M, Xipell M, Monclus E, Rovira J, Garcia F, Lopez-Guillermo A, Colomo L, Campo E, Martinez A
Mod Pathol 2017 May;30(5):745-760. Epub 2017 Jan 13 doi: 10.1038/modpathol.2016.233. PMID: 28084335

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