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Hypopharyngeal carcinoma

MedGen UID:
237150
•Concept ID:
C1368404
•
Neoplastic Process
Synonyms: Cancer of Hypopharynx; Cancer of the Hypopharynx; Carcinoma of Hypopharynx; carcinoma of hypopharynx; Carcinoma of the Hypopharynx; carcinoma of the hypopharynx; Hypopharyngeal Cancer; Hypopharyngeal Carcinoma; hypopharyngeal carcinoma; hypopharynx carcinoma
 
Monarch Initiative: MONDO:0005216

Definition

Carcinoma, predominantly squamous cell, arising from the epithelial cells of the hypopharynx. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypopharyngeal carcinoma

Professional guidelines

PubMed

Integrated transcriptome study of the tumor microenvironment for treatment response prediction in male predominant hypopharyngeal carcinoma.
Zhang Y, Liu G, Tao M, Ning H, Guo W, Yin G, Gao W, Feng L, Gu J, Xie Z, Huang Z
Nat Commun 2023 Mar 16;14(1):1466. doi: 10.1038/s41467-023-37159-8. PMID: 36928331Free PMC Article
Management of advanced hypopharyngeal carcinoma: systematic review of survival following surgical and non-surgical treatments.
Habib A
J Laryngol Otol 2018 May;132(5):385-400. doi: 10.1017/S0022215118000555. PMID: 29891019
Current management strategy of hypopharyngeal carcinoma.
Chan JY, Wei WI
Auris Nasus Larynx 2013 Feb;40(1):2-6. Epub 2012 Jun 17 doi: 10.1016/j.anl.2011.11.009. PMID: 22709574

Recent clinical studies

Etiology

Integrated transcriptome study of the tumor microenvironment for treatment response prediction in male predominant hypopharyngeal carcinoma.
Zhang Y, Liu G, Tao M, Ning H, Guo W, Yin G, Gao W, Feng L, Gu J, Xie Z, Huang Z
Nat Commun 2023 Mar 16;14(1):1466. doi: 10.1038/s41467-023-37159-8. PMID: 36928331Free PMC Article
Hypopharyngeal Reconstruction: Possibilities, Outcomes, and Updates for Improving the Human Health for Quality of Life.
Marzouki H, Addas MA, Nujoom M, Zawawi F, Almarzouki HZ, Merdad M
Comput Intell Neurosci 2022;2022:6132481. Epub 2022 Feb 8 doi: 10.1155/2022/6132481. PMID: 35178078Free PMC Article
Apatinib and Ginsenoside-Rb1 Synergetically Control the Growth of Hypopharyngeal Carcinoma Cells.
Li Y, He F, Zhang Y, Pan Z
Dis Markers 2022;2022:3833489. Epub 2022 Jan 13 doi: 10.1155/2022/3833489. PMID: 35069931Free PMC Article
Hypopharyngeal carcinoma: Do you know your guidelines?
Kwon DI, Miles BA; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2019 Mar;41(3):569-576. Epub 2018 Dec 20 doi: 10.1002/hed.24752. PMID: 30570183
Salvage surgery in post-chemoradiation laryngeal and hypopharyngeal carcinoma: outcome and review.
Putten L, Bree R, Doornaert PA, Buter J, Eerenstein SE, Rietveld DH, Kuik DJ, Leemans CR
Acta Otorhinolaryngol Ital 2015 Jun;35(3):162-72. PMID: 26246660Free PMC Article

Diagnosis

Hypopharyngeal Reconstruction: Possibilities, Outcomes, and Updates for Improving the Human Health for Quality of Life.
Marzouki H, Addas MA, Nujoom M, Zawawi F, Almarzouki HZ, Merdad M
Comput Intell Neurosci 2022;2022:6132481. Epub 2022 Feb 8 doi: 10.1155/2022/6132481. PMID: 35178078Free PMC Article
Clinical and Radiological Evaluation of Hypopharyngeal Carcinoma.
Piazza C, Paderno A, Ravanelli M, Pessina C
Adv Otorhinolaryngol 2019;83:35-46. Epub 2019 Feb 12 doi: 10.1159/000492306. PMID: 30943514
Hypopharyngeal carcinoma: Do you know your guidelines?
Kwon DI, Miles BA; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2019 Mar;41(3):569-576. Epub 2018 Dec 20 doi: 10.1002/hed.24752. PMID: 30570183
Salvage surgery in post-chemoradiation laryngeal and hypopharyngeal carcinoma: outcome and review.
Putten L, Bree R, Doornaert PA, Buter J, Eerenstein SE, Rietveld DH, Kuik DJ, Leemans CR
Acta Otorhinolaryngol Ital 2015 Jun;35(3):162-72. PMID: 26246660Free PMC Article
Cancer of the pharynx and larynx.
Sasaki CT, Jassin B
Am J Med 2001 Dec 3;111 Suppl 8A:118S-123S. doi: 10.1016/s0002-9343(01)00850-6. PMID: 11749936

Therapy

Chemical modification of curcumin increases its potency against hypopharyngeal carcinoma.
Zhang L, Cheng L, Chen Z, Fang Y, Li C, Chen M, He P, Wu H, Wu J, Chen J
J Drug Target 2023 Sep;31(8):867-877. Epub 2023 Aug 23 doi: 10.1080/1061186X.2023.2247581. PMID: 37577780
Apatinib and Ginsenoside-Rb1 Synergetically Control the Growth of Hypopharyngeal Carcinoma Cells.
Li Y, He F, Zhang Y, Pan Z
Dis Markers 2022;2022:3833489. Epub 2022 Jan 13 doi: 10.1155/2022/3833489. PMID: 35069931Free PMC Article
Longitudinal atherosclerotic changes after radio(chemo)therapy of hypopharyngeal carcinoma.
Simonetto C, Mayinger M, Ahmed T, Borm K, Kundrát P, Pigorsch S, Kaiser JC, Combs SE
Radiat Oncol 2020 May 7;15(1):102. doi: 10.1186/s13014-020-01541-3. PMID: 32381045Free PMC Article
Quality of Life Outcomes following Treatment of Hypopharyngeal Cancer.
Mahalingam S, Spielmann P
Adv Otorhinolaryngol 2019;83:126-134. Epub 2019 Feb 12 doi: 10.1159/000492356. PMID: 30943471
Hypopharyngeal carcinoma.
Hinerman RW, Amdur RJ, Mendenhall WM, Villaret DB, Robbins KT
Curr Treat Options Oncol 2002 Feb;3(1):41-9. doi: 10.1007/s11864-002-0040-1. PMID: 12057086

Prognosis

Integrated transcriptome study of the tumor microenvironment for treatment response prediction in male predominant hypopharyngeal carcinoma.
Zhang Y, Liu G, Tao M, Ning H, Guo W, Yin G, Gao W, Feng L, Gu J, Xie Z, Huang Z
Nat Commun 2023 Mar 16;14(1):1466. doi: 10.1038/s41467-023-37159-8. PMID: 36928331Free PMC Article
Hypopharyngeal Reconstruction: Possibilities, Outcomes, and Updates for Improving the Human Health for Quality of Life.
Marzouki H, Addas MA, Nujoom M, Zawawi F, Almarzouki HZ, Merdad M
Comput Intell Neurosci 2022;2022:6132481. Epub 2022 Feb 8 doi: 10.1155/2022/6132481. PMID: 35178078Free PMC Article
Quality of Life Outcomes following Treatment of Hypopharyngeal Cancer.
Mahalingam S, Spielmann P
Adv Otorhinolaryngol 2019;83:126-134. Epub 2019 Feb 12 doi: 10.1159/000492356. PMID: 30943471
Hypopharyngeal carcinoma: Do you know your guidelines?
Kwon DI, Miles BA; Education Committee of the American Head and Neck Society (AHNS)
Head Neck 2019 Mar;41(3):569-576. Epub 2018 Dec 20 doi: 10.1002/hed.24752. PMID: 30570183
Salvage surgery in post-chemoradiation laryngeal and hypopharyngeal carcinoma: outcome and review.
Putten L, Bree R, Doornaert PA, Buter J, Eerenstein SE, Rietveld DH, Kuik DJ, Leemans CR
Acta Otorhinolaryngol Ital 2015 Jun;35(3):162-72. PMID: 26246660Free PMC Article

Clinical prediction guides

Integrated transcriptome study of the tumor microenvironment for treatment response prediction in male predominant hypopharyngeal carcinoma.
Zhang Y, Liu G, Tao M, Ning H, Guo W, Yin G, Gao W, Feng L, Gu J, Xie Z, Huang Z
Nat Commun 2023 Mar 16;14(1):1466. doi: 10.1038/s41467-023-37159-8. PMID: 36928331Free PMC Article
Hypopharyngeal Reconstruction: Possibilities, Outcomes, and Updates for Improving the Human Health for Quality of Life.
Marzouki H, Addas MA, Nujoom M, Zawawi F, Almarzouki HZ, Merdad M
Comput Intell Neurosci 2022;2022:6132481. Epub 2022 Feb 8 doi: 10.1155/2022/6132481. PMID: 35178078Free PMC Article
The role of MMP-2 and MMP-9 in the metastasis and development of hypopharyngeal carcinoma.
Song Z, Wang J, Su Q, Luan M, Chen X, Xu X
Braz J Otorhinolaryngol 2021 Sep-Oct;87(5):521-528. Epub 2019 Dec 10 doi: 10.1016/j.bjorl.2019.10.009. PMID: 31882379Free PMC Article
Salvage surgery in post-chemoradiation laryngeal and hypopharyngeal carcinoma: outcome and review.
Putten L, Bree R, Doornaert PA, Buter J, Eerenstein SE, Rietveld DH, Kuik DJ, Leemans CR
Acta Otorhinolaryngol Ital 2015 Jun;35(3):162-72. PMID: 26246660Free PMC Article
Cancer of the pharynx and larynx.
Sasaki CT, Jassin B
Am J Med 2001 Dec 3;111 Suppl 8A:118S-123S. doi: 10.1016/s0002-9343(01)00850-6. PMID: 11749936

Recent systematic reviews

Prognostic imaging variables for recurrent laryngeal and hypopharyngeal carcinoma treated with primary chemoradiotherapy: A systematic review and meta-analysis.
Smits HJG, Assili S, Kauw F, Philippens MEP, de Bree R, Dankbaar JW
Head Neck 2021 Jul;43(7):2202-2215. Epub 2021 Apr 2 doi: 10.1002/hed.26698. PMID: 33797818Free PMC Article
Management of advanced hypopharyngeal carcinoma: systematic review of survival following surgical and non-surgical treatments.
Habib A
J Laryngol Otol 2018 May;132(5):385-400. doi: 10.1017/S0022215118000555. PMID: 29891019
Selective neck dissection in surgically treated head and neck squamous cell carcinoma patients with a clinically positive neck: Systematic review.
Rodrigo JP, Grilli G, Shah JP, Medina JE, Robbins KT, Takes RP, Hamoir M, Kowalski LP, Suárez C, López F, Quer M, Boedeker CC, de Bree R, Coskun H, Rinaldo A, Silver CE, Ferlito A
Eur J Surg Oncol 2018 Apr;44(4):395-403. Epub 2018 Jan 11 doi: 10.1016/j.ejso.2018.01.003. PMID: 29395434
Risk factors for late dysphagia after (chemo)radiotherapy for head and neck cancer: A systematic methodological review.
Jiang N, Zhang LJ, Li LY, Zhao Y, Eisele DW
Head Neck 2016 May;38(5):792-800. Epub 2015 Jun 18 doi: 10.1002/hed.23963. PMID: 25532723
Thyroid gland invasion in total laryngectomy and total laryngopharyngectomy: a systematic review and meta-analysis of the English literature.
Kumar R, Drinnan M, Robinson M, Meikle D, Stafford F, Welch A, Zammit-Maempel I, Paleri V
Clin Otolaryngol 2013 Oct;38(5):372-8. doi: 10.1111/coa.12165. PMID: 23998197

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