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Neoplasm of hypopharynx

MedGen UID:
43797
•Concept ID:
C0020627
•
Neoplastic Process
Synonyms: Hypopharyngeal Neoplasm; Hypopharyngeal Neoplasms; Neoplasm, Hypopharyngeal; Neoplasms, Hypopharyngeal
SNOMED CT: Neoplasm of hypopharynx (126686005); Tumor of hypopharynx (126686005); Tumor of laryngopharynx (126686005)
 
Monarch Initiative: MONDO:0021358

Definition

A benign or malignant neoplasm that affects the hypopharynx. [from NCI]

Professional guidelines

PubMed

Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Target volume selection and delineation (T and N) for primary radiation treatment of oral cavity, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma.
Grégoire V, Grau C, Lapeyre M, Maingon P
Oral Oncol 2018 Dec;87:131-137. Epub 2018 Nov 3 doi: 10.1016/j.oraloncology.2018.10.034. PMID: 30527228
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Recent clinical studies

Etiology

Integrated transcriptome study of the tumor microenvironment for treatment response prediction in male predominant hypopharyngeal carcinoma.
Zhang Y, Liu G, Tao M, Ning H, Guo W, Yin G, Gao W, Feng L, Gu J, Xie Z, Huang Z
Nat Commun 2023 Mar 16;14(1):1466. doi: 10.1038/s41467-023-37159-8. PMID: 36928331Free PMC Article
Outcomes for Organ Preservation with Chemoradiation Therapy for T4 Larynx and Hypopharynx Cancer.
Eita A, Mohamed N, Rybkin A, Kang JJ, Fiasconaro M, Zhigang Z, Zakeri K, Yu Y, Sadaka E, Sherman E, Dunn L, Cracchiolo J, Wong RJ, Cohen M, Lee NY
Laryngoscope 2023 May;133(5):1138-1145. Epub 2022 Jul 8 doi: 10.1002/lary.30279. PMID: 35801573Free PMC Article
Symptoms and Signs, Staging and Co-Morbidity of Hypopharyngeal Cancer.
Bradley PJ
Adv Otorhinolaryngol 2019;83:15-26. Epub 2019 Feb 12 doi: 10.1159/000492304. PMID: 30943511
Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081
Long-term Results of a Multicenter Randomized Phase III Trial of Induction Chemotherapy With Cisplatin, 5-fluorouracil, ± Docetaxel for Larynx Preservation.
Janoray G, Pointreau Y, Garaud P, Chapet S, Alfonsi M, Sire C, Jadaud E, Calais G
J Natl Cancer Inst 2016 Apr;108(4) Epub 2015 Dec 16 doi: 10.1093/jnci/djv368. PMID: 26681800

Diagnosis

MR Imaging of Laryngeal and Hypopharyngeal Cancer.
Becker M, Monnier Y, de Vito C
Magn Reson Imaging Clin N Am 2022 Feb;30(1):53-72. doi: 10.1016/j.mric.2021.08.002. PMID: 34802581
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081
Hypopharyngeal cancer.
Wycliffe ND, Grover RS, Kim PD, Simental A Jr
Top Magn Reson Imaging 2007 Aug;18(4):243-58. doi: 10.1097/RMR.0b013e3181570c3f. PMID: 17893590

Therapy

Induction Toripalimab and Chemotherapy for Organ Preservation in Locally Advanced Laryngeal and Hypopharyngeal Cancer: A Single-Arm Phase II Clinical Trial.
Ou X, Zhai R, Wei W, Chen J, Ou D, Liao T, Xu T, Zhu Y, Wang Y, Huang S, Shi R, Wu B, Chen T, Li Y, Yang Z, Zhou C, Liu Y, Jiang Z, Zeng M, Liu X, Ji D, Ying H, Zhang Z, Hu C, Lu X, Ji Q, He X, Wang Y
Clin Cancer Res 2024 Jan 17;30(2):344-355. doi: 10.1158/1078-0432.CCR-23-2398. PMID: 37955629
Cancer of the Larynx and Hypopharynx.
Echanique KA, Evans LK, Han AY, Chhetri DK, St John MA
Hematol Oncol Clin North Am 2021 Oct;35(5):933-947. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.005. PMID: 34272102
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Long-term Results of a Multicenter Randomized Phase III Trial of Induction Chemotherapy With Cisplatin, 5-fluorouracil, ± Docetaxel for Larynx Preservation.
Janoray G, Pointreau Y, Garaud P, Chapet S, Alfonsi M, Sire C, Jadaud E, Calais G
J Natl Cancer Inst 2016 Apr;108(4) Epub 2015 Dec 16 doi: 10.1093/jnci/djv368. PMID: 26681800

Prognosis

Integrated transcriptome study of the tumor microenvironment for treatment response prediction in male predominant hypopharyngeal carcinoma.
Zhang Y, Liu G, Tao M, Ning H, Guo W, Yin G, Gao W, Feng L, Gu J, Xie Z, Huang Z
Nat Commun 2023 Mar 16;14(1):1466. doi: 10.1038/s41467-023-37159-8. PMID: 36928331Free PMC Article
Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis.
Petruzzi G, Costantino A, De Virgilio A, Zocchi J, Campo F, Mercante G, Spriano G, Pellini R
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1157-1166. Epub 2021 Aug 2 doi: 10.1007/s00405-021-07011-0. PMID: 34338877
Future Perspectives in Hypopharyngeal Cancer Care.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:167-175. Epub 2019 Feb 12 doi: 10.1159/000492361. PMID: 30943472
Long-term Results of a Multicenter Randomized Phase III Trial of Induction Chemotherapy With Cisplatin, 5-fluorouracil, ± Docetaxel for Larynx Preservation.
Janoray G, Pointreau Y, Garaud P, Chapet S, Alfonsi M, Sire C, Jadaud E, Calais G
J Natl Cancer Inst 2016 Apr;108(4) Epub 2015 Dec 16 doi: 10.1093/jnci/djv368. PMID: 26681800
Hypopharyngeal cancer.
Wycliffe ND, Grover RS, Kim PD, Simental A Jr
Top Magn Reson Imaging 2007 Aug;18(4):243-58. doi: 10.1097/RMR.0b013e3181570c3f. PMID: 17893590

Clinical prediction guides

Integrated transcriptome study of the tumor microenvironment for treatment response prediction in male predominant hypopharyngeal carcinoma.
Zhang Y, Liu G, Tao M, Ning H, Guo W, Yin G, Gao W, Feng L, Gu J, Xie Z, Huang Z
Nat Commun 2023 Mar 16;14(1):1466. doi: 10.1038/s41467-023-37159-8. PMID: 36928331Free PMC Article
Oncologic Outcomes After Clinically Node-Negative Salvage Laryngectomy.
Gross JH, Patel MR, Switchenko JM, Chan TG, Baddour HM, Kaka A, Boyce BJ, Saba NF, Beitler JJ, El-Deiry M
JAMA Otolaryngol Head Neck Surg 2023 Jan 1;149(1):24-33. doi: 10.1001/jamaoto.2022.3597. PMID: 36394866Free PMC Article
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Symptoms and Signs, Staging and Co-Morbidity of Hypopharyngeal Cancer.
Bradley PJ
Adv Otorhinolaryngol 2019;83:15-26. Epub 2019 Feb 12 doi: 10.1159/000492304. PMID: 30943511
Future Perspectives in Hypopharyngeal Cancer Care.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:167-175. Epub 2019 Feb 12 doi: 10.1159/000492361. PMID: 30943472

Recent systematic reviews

Neutrophil-to-lymphocyte and hypopharyngeal cancer prognosis: System review and meta-analysis.
Hu X, Tian T, Zhang X, Sun Q, Chen Y, Jiang W
Head Neck 2023 Feb;45(2):492-502. Epub 2022 Nov 11 doi: 10.1002/hed.27246. PMID: 36367335
Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis.
Petruzzi G, Costantino A, De Virgilio A, Zocchi J, Campo F, Mercante G, Spriano G, Pellini R
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1157-1166. Epub 2021 Aug 2 doi: 10.1007/s00405-021-07011-0. PMID: 34338877
Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081
Quality-of-life and functional outcomes following pharyngolaryngectomy: a systematic review of literature.
Mahalingam S, Srinivasan R, Spielmann P
Clin Otolaryngol 2016 Feb;41(1):25-43. doi: 10.1111/coa.12466. PMID: 26031311
A systematic review of current and emerging approaches in the field of larynx preservation.
Denaro N, Russi EG, Lefebvre JL, Merlano MC
Radiother Oncol 2014 Jan;110(1):16-24. Epub 2013 Oct 15 doi: 10.1016/j.radonc.2013.08.016. PMID: 24139733

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

    Consumer resources

    Reviews

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