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Malignant giant cell tumor

MedGen UID:
90745
Concept ID:
C0334229
Neoplastic Process
Synonyms: giant cell tumor, malignant; Malignant Giant Cell Neoplasm; malignant giant cell neoplasm; Malignant Giant Cell Tumor; malignant giant cell tumor; Malignant tumor - giant cell type; Malignant tumor, giant cell type; malignant tumor, giant cell type; malignant tumor, giant cell type (morphologic abnormality)
SNOMED CT: Malignant tumor - giant cell type (83950009); Malignant tumor, giant cell type (83950009)
 
Monarch Initiative: MONDO:0002402

Definition

A malignant neoplasm characterized by then presence of atypical giant cells. [from NCI]

Professional guidelines

PubMed

Hu X, Sun Z, Huang W, Sun Y, Yan W
Int J Surg 2022 Jun;102:106667. Epub 2022 May 10 doi: 10.1016/j.ijsu.2022.106667. PMID: 35562002
Kilpatrick SE, Ward WG, Bos GD, Chauvenet AR, Gold SH
Pediatr Pathol Mol Med 2001 May-Jun;20(3):175-87. PMID: 11486348
Malawer MM, Dunham W
Clin Orthop Relat Res 1991 Jan;(262):42-57. PMID: 1984931

Recent clinical studies

Etiology

Chen W, Yan Z, Tirumala V
J Orthop Res 2020 Oct;38(10):2139-2148. Epub 2020 Apr 22 doi: 10.1002/jor.24698. PMID: 32293747
Yin H, Cheng M, Li B, Li B, Wang P, Meng T, Wang J, Zhou W, Yan W, Xiao J
J Neurooncol 2015 Sep;124(2):275-81. Epub 2015 Jun 4 doi: 10.1007/s11060-015-1835-9. PMID: 26040486
Domovitov SV, Healey JH
Ann Surg Oncol 2010 Mar;17(3):694-701. Epub 2009 Nov 10 doi: 10.1245/s10434-009-0803-z. PMID: 19902306
Rock MG, Sim FH, Unni KK, Witrak GA, Frassica FJ, Schray MF, Beabout JW, Dahlin DC
J Bone Joint Surg Am 1986 Sep;68(7):1073-9. PMID: 3745247
Angervall L, Hagmar B, Kindblom LG, Merck C
Cancer 1981 Feb 15;47(4):736-47. doi: 10.1002/1097-0142(19810215)47:4<736::aid-cncr2820470419>3.0.co;2-q. PMID: 7226022

Diagnosis

Hashimoto K, Nishimura S, Ito T, Akagi M
Medicine (Baltimore) 2022 Jun 3;101(22):e29471. doi: 10.1097/MD.0000000000029471. PMID: 35665736Free PMC Article
Chen W, Yan Z, Tirumala V
J Orthop Res 2020 Oct;38(10):2139-2148. Epub 2020 Apr 22 doi: 10.1002/jor.24698. PMID: 32293747
Palmerini E, Picci P, Reichardt P, Downey G
Technol Cancer Res Treat 2019 Jan 1;18:1533033819840000. doi: 10.1177/1533033819840000. PMID: 30935298Free PMC Article
Yin H, Cheng M, Li B, Li B, Wang P, Meng T, Wang J, Zhou W, Yan W, Xiao J
J Neurooncol 2015 Sep;124(2):275-81. Epub 2015 Jun 4 doi: 10.1007/s11060-015-1835-9. PMID: 26040486
Shinjo K, Miyake N, Takahashi Y
Jpn J Clin Oncol 1993 Oct;23(5):317-24. PMID: 8230758

Therapy

Walcutt JE, Johnson CM, Ly QP, Downey RT
Clin Nucl Med 2022 Nov 1;47(11):963-964. Epub 2022 Jul 6 doi: 10.1097/RLU.0000000000004287. PMID: 35777978
Iwai T, Oebisu N, Hoshi M, Takada N, Nakamura H
Curr Oncol 2022 Jan 31;29(2):758-765. doi: 10.3390/curroncol29020064. PMID: 35200563Free PMC Article
Zhu X, Huang R, Hu P, Yan P, Zhai S, Zhang J, Zhuang J, Yin H, Meng T, Yang D, Huang Z
Med Sci Monit 2021 Feb 17;27:e929154. doi: 10.12659/MSM.929154. PMID: 33594036Free PMC Article
Wojcik J, Rosenberg AE, Bredella MA, Choy E, Hornicek FJ, Nielsen GP, Deshpande V
Am J Surg Pathol 2016 Jan;40(1):72-80. doi: 10.1097/PAS.0000000000000506. PMID: 26414220
Malawer MM, Dunham W
Clin Orthop Relat Res 1991 Jan;(262):42-57. PMID: 1984931

Prognosis

Chen W, Yan Z, Tirumala V
J Orthop Res 2020 Oct;38(10):2139-2148. Epub 2020 Apr 22 doi: 10.1002/jor.24698. PMID: 32293747
Palmerini E, Picci P, Reichardt P, Downey G
Technol Cancer Res Treat 2019 Jan 1;18:1533033819840000. doi: 10.1177/1533033819840000. PMID: 30935298Free PMC Article
Yin H, Cheng M, Li B, Li B, Wang P, Meng T, Wang J, Zhou W, Yan W, Xiao J
J Neurooncol 2015 Sep;124(2):275-81. Epub 2015 Jun 4 doi: 10.1007/s11060-015-1835-9. PMID: 26040486
Layfield LJ, Meloni-Ehrig A, Liu K, Shepard R, Harrelson JM
Arch Pathol Lab Med 2000 Nov;124(11):1636-41. doi: 10.5858/2000-124-1636-MGCTOS. PMID: 11079016
Shinjo K, Miyake N, Takahashi Y
Jpn J Clin Oncol 1993 Oct;23(5):317-24. PMID: 8230758

Clinical prediction guides

Hashimoto K, Nishimura S, Ito T, Akagi M
Medicine (Baltimore) 2022 Jun 3;101(22):e29471. doi: 10.1097/MD.0000000000029471. PMID: 35665736Free PMC Article
Pasricha S, Pruthi M, Jajodia A, Kumar A, Gupta G, Sharma A, Tiwari A, Rohela H, Durga G, Kamboj M, Koyyala VPB, Mehta A
Appl Immunohistochem Mol Morphol 2022 Jan 1;30(1):36-41. doi: 10.1097/PAI.0000000000000964. PMID: 34347625
Chen W, Yan Z, Tirumala V
J Orthop Res 2020 Oct;38(10):2139-2148. Epub 2020 Apr 22 doi: 10.1002/jor.24698. PMID: 32293747
Righi A, Mancini I, Gambarotti M, Picci P, Gamberi G, Marraccini C, Dei Tos AP, Simi L, Pinzani P, Franchi A
Hum Pathol 2017 Oct;68:128-135. Epub 2017 Sep 9 doi: 10.1016/j.humpath.2017.08.033. PMID: 28899740
Layfield LJ, Meloni-Ehrig A, Liu K, Shepard R, Harrelson JM
Arch Pathol Lab Med 2000 Nov;124(11):1636-41. doi: 10.5858/2000-124-1636-MGCTOS. PMID: 11079016

Recent systematic reviews

Palmerini E, Picci P, Reichardt P, Downey G
Technol Cancer Res Treat 2019 Jan 1;18:1533033819840000. doi: 10.1177/1533033819840000. PMID: 30935298Free PMC Article

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