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Metastatic Urothelial Carcinoma

MedGen UID:
926286
Concept ID:
C4288754
Neoplastic Process
Synonyms: Metastatic Transitional Cell Carcinoma of the Urinary Tract; Metastatic transitional cell carcinoma of the urinary tract; Metastatic urothelial carcinoma
SNOMED CT: Metastatic transitional cell carcinoma of the urinary tract (458321000124102); Metastatic urothelial carcinoma (458321000124102)

Definition

A carcinoma that arises from the urothelium and has spread from its original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

Nadal R, Bellmunt J
Cancer Treat Rev 2019 Jun;76:10-21. Epub 2019 Apr 15 doi: 10.1016/j.ctrv.2019.04.002. PMID: 31030123
Bukhari N, Al-Shamsi HO, Azam F
ScientificWorldJournal 2018;2018:5682078. Epub 2018 Jun 6 doi: 10.1155/2018/5682078. PMID: 29977169Free PMC Article
Galsky MD, Hahn NM, Rosenberg J, Sonpavde G, Hutson T, Oh WK, Dreicer R, Vogelzang N, Sternberg CN, Bajorin DF, Bellmunt J
J Clin Oncol 2011 Jun 10;29(17):2432-8. Epub 2011 May 9 doi: 10.1200/JCO.2011.34.8433. PMID: 21555688

Recent clinical studies

Etiology

Tagawa ST, Balar AV, Petrylak DP, Kalebasty AR, Loriot Y, Fléchon A, Jain RK, Agarwal N, Bupathi M, Barthelemy P, Beuzeboc P, Palmbos P, Kyriakopoulos CE, Pouessel D, Sternberg CN, Hong Q, Goswami T, Itri LM, Grivas P
J Clin Oncol 2021 Aug 1;39(22):2474-2485. Epub 2021 Apr 30 doi: 10.1200/JCO.20.03489. PMID: 33929895Free PMC Article
Powles T, Rosenberg JE, Sonpavde GP, Loriot Y, Durán I, Lee JL, Matsubara N, Vulsteke C, Castellano D, Wu C, Campbell M, Matsangou M, Petrylak DP
N Engl J Med 2021 Mar 25;384(12):1125-1135. Epub 2021 Feb 12 doi: 10.1056/NEJMoa2035807. PMID: 33577729Free PMC Article
Powles T, Park SH, Voog E, Caserta C, Valderrama BP, Gurney H, Kalofonos H, Radulović S, Demey W, Ullén A, Loriot Y, Sridhar SS, Tsuchiya N, Kopyltsov E, Sternberg CN, Bellmunt J, Aragon-Ching JB, Petrylak DP, Laliberte R, Wang J, Huang B, Davis C, Fowst C, Costa N, Blake-Haskins JA, di Pietro A, Grivas P
N Engl J Med 2020 Sep 24;383(13):1218-1230. Epub 2020 Sep 18 doi: 10.1056/NEJMoa2002788. PMID: 32945632
Loriot Y, Necchi A, Park SH, Garcia-Donas J, Huddart R, Burgess E, Fleming M, Rezazadeh A, Mellado B, Varlamov S, Joshi M, Duran I, Tagawa ST, Zakharia Y, Zhong B, Stuyckens K, Santiago-Walker A, De Porre P, O'Hagan A, Avadhani A, Siefker-Radtke AO; BLC2001 Study Group
N Engl J Med 2019 Jul 25;381(4):338-348. doi: 10.1056/NEJMoa1817323. PMID: 31340094
Balar AV, Galsky MD, Rosenberg JE, Powles T, Petrylak DP, Bellmunt J, Loriot Y, Necchi A, Hoffman-Censits J, Perez-Gracia JL, Dawson NA, van der Heijden MS, Dreicer R, Srinivas S, Retz MM, Joseph RW, Drakaki A, Vaishampayan UN, Sridhar SS, Quinn DI, Durán I, Shaffer DR, Eigl BJ, Grivas PD, Yu EY, Li S, Kadel EE 3rd, Boyd Z, Bourgon R, Hegde PS, Mariathasan S, Thåström A, Abidoye OO, Fine GD, Bajorin DF; IMvigor210 Study Group
Lancet 2017 Jan 7;389(10064):67-76. Epub 2016 Dec 8 doi: 10.1016/S0140-6736(16)32455-2. PMID: 27939400Free PMC Article

Diagnosis

Uchimoto T, Fukushima T, Komura K, Fukuokaya W, Adachi T, Hashimoto T, Yoshizawa A, Nakamura K, Yano Y, Nishimura K, Nishio K, Nakamori K, Iwatani K, Yamamoto S, Urabe F, Mori K, Yanagisawa T, Tsuduki S, Takahara K, Inamoto T, Miki J, Kimura T, Ohno Y, Shiroki R, Egawa S, Azuma H
BJU Int 2023 Apr;131(4):477-485. Epub 2022 Sep 26 doi: 10.1111/bju.15893. PMID: 36098556
Knowles M, Dyrskjøt L, Heath EI, Bellmunt J, Siefker-Radtke AO
Cancer Cell 2021 May 10;39(5):583-585. doi: 10.1016/j.ccell.2021.04.012. PMID: 33974855
Sheng X, Yan X, Wang L, Shi Y, Yao X, Luo H, Shi B, Liu J, He Z, Yu G, Ying J, Han W, Hu C, Ling Y, Chi Z, Cui C, Si L, Fang J, Zhou A, Guo J
Clin Cancer Res 2021 Jan 1;27(1):43-51. Epub 2020 Oct 27 doi: 10.1158/1078-0432.CCR-20-2488. PMID: 33109737
Yuen KC, Liu LF, Gupta V, Madireddi S, Keerthivasan S, Li C, Rishipathak D, Williams P, Kadel EE 3rd, Koeppen H, Chen YJ, Modrusan Z, Grogan JL, Banchereau R, Leng N, Thastrom A, Shen X, Hashimoto K, Tayama D, van der Heijden MS, Rosenberg JE, McDermott DF, Powles T, Hegde PS, Huseni MA, Mariathasan S
Nat Med 2020 May;26(5):693-698. Epub 2020 May 11 doi: 10.1038/s41591-020-0860-1. PMID: 32405063Free PMC Article
Loriot Y, Necchi A, Park SH, Garcia-Donas J, Huddart R, Burgess E, Fleming M, Rezazadeh A, Mellado B, Varlamov S, Joshi M, Duran I, Tagawa ST, Zakharia Y, Zhong B, Stuyckens K, Santiago-Walker A, De Porre P, O'Hagan A, Avadhani A, Siefker-Radtke AO; BLC2001 Study Group
N Engl J Med 2019 Jul 25;381(4):338-348. doi: 10.1056/NEJMoa1817323. PMID: 31340094

Therapy

Tagawa ST, Balar AV, Petrylak DP, Kalebasty AR, Loriot Y, Fléchon A, Jain RK, Agarwal N, Bupathi M, Barthelemy P, Beuzeboc P, Palmbos P, Kyriakopoulos CE, Pouessel D, Sternberg CN, Hong Q, Goswami T, Itri LM, Grivas P
J Clin Oncol 2021 Aug 1;39(22):2474-2485. Epub 2021 Apr 30 doi: 10.1200/JCO.20.03489. PMID: 33929895Free PMC Article
Powles T, Rosenberg JE, Sonpavde GP, Loriot Y, Durán I, Lee JL, Matsubara N, Vulsteke C, Castellano D, Wu C, Campbell M, Matsangou M, Petrylak DP
N Engl J Med 2021 Mar 25;384(12):1125-1135. Epub 2021 Feb 12 doi: 10.1056/NEJMoa2035807. PMID: 33577729Free PMC Article
Powles T, Park SH, Voog E, Caserta C, Valderrama BP, Gurney H, Kalofonos H, Radulović S, Demey W, Ullén A, Loriot Y, Sridhar SS, Tsuchiya N, Kopyltsov E, Sternberg CN, Bellmunt J, Aragon-Ching JB, Petrylak DP, Laliberte R, Wang J, Huang B, Davis C, Fowst C, Costa N, Blake-Haskins JA, di Pietro A, Grivas P
N Engl J Med 2020 Sep 24;383(13):1218-1230. Epub 2020 Sep 18 doi: 10.1056/NEJMoa2002788. PMID: 32945632
Loriot Y, Necchi A, Park SH, Garcia-Donas J, Huddart R, Burgess E, Fleming M, Rezazadeh A, Mellado B, Varlamov S, Joshi M, Duran I, Tagawa ST, Zakharia Y, Zhong B, Stuyckens K, Santiago-Walker A, De Porre P, O'Hagan A, Avadhani A, Siefker-Radtke AO; BLC2001 Study Group
N Engl J Med 2019 Jul 25;381(4):338-348. doi: 10.1056/NEJMoa1817323. PMID: 31340094
Balar AV, Galsky MD, Rosenberg JE, Powles T, Petrylak DP, Bellmunt J, Loriot Y, Necchi A, Hoffman-Censits J, Perez-Gracia JL, Dawson NA, van der Heijden MS, Dreicer R, Srinivas S, Retz MM, Joseph RW, Drakaki A, Vaishampayan UN, Sridhar SS, Quinn DI, Durán I, Shaffer DR, Eigl BJ, Grivas PD, Yu EY, Li S, Kadel EE 3rd, Boyd Z, Bourgon R, Hegde PS, Mariathasan S, Thåström A, Abidoye OO, Fine GD, Bajorin DF; IMvigor210 Study Group
Lancet 2017 Jan 7;389(10064):67-76. Epub 2016 Dec 8 doi: 10.1016/S0140-6736(16)32455-2. PMID: 27939400Free PMC Article

Prognosis

Liang Y, Tan Y, Guan B, Guo B, Xia M, Li J, Shi Y, Yu Z, Zhang Q, Liu D, Yang X, Hao J, Gong Y, Shakeel M, Zhou L, Ci W, Li X
Theranostics 2022;12(18):7745-7759. Epub 2022 Nov 14 doi: 10.7150/thno.77281. PMID: 36451860Free PMC Article
Heath EI, Rosenberg JE
Nat Rev Urol 2021 Feb;18(2):93-103. Epub 2020 Nov 25 doi: 10.1038/s41585-020-00394-5. PMID: 33239713
Rosenberg J, Sridhar SS, Zhang J, Smith D, Ruether D, Flaig TW, Baranda J, Lang J, Plimack ER, Sangha R, Heath EI, Merchan J, Quinn DI, Srinivas S, Milowsky M, Wu C, Gartner EM, Zuo P, Melhem-Bertrandt A, Petrylak DP
J Clin Oncol 2020 Apr 1;38(10):1041-1049. Epub 2020 Feb 7 doi: 10.1200/JCO.19.02044. PMID: 32031899Free PMC Article
Loriot Y, Necchi A, Park SH, Garcia-Donas J, Huddart R, Burgess E, Fleming M, Rezazadeh A, Mellado B, Varlamov S, Joshi M, Duran I, Tagawa ST, Zakharia Y, Zhong B, Stuyckens K, Santiago-Walker A, De Porre P, O'Hagan A, Avadhani A, Siefker-Radtke AO; BLC2001 Study Group
N Engl J Med 2019 Jul 25;381(4):338-348. doi: 10.1056/NEJMoa1817323. PMID: 31340094
Balar AV, Galsky MD, Rosenberg JE, Powles T, Petrylak DP, Bellmunt J, Loriot Y, Necchi A, Hoffman-Censits J, Perez-Gracia JL, Dawson NA, van der Heijden MS, Dreicer R, Srinivas S, Retz MM, Joseph RW, Drakaki A, Vaishampayan UN, Sridhar SS, Quinn DI, Durán I, Shaffer DR, Eigl BJ, Grivas PD, Yu EY, Li S, Kadel EE 3rd, Boyd Z, Bourgon R, Hegde PS, Mariathasan S, Thåström A, Abidoye OO, Fine GD, Bajorin DF; IMvigor210 Study Group
Lancet 2017 Jan 7;389(10064):67-76. Epub 2016 Dec 8 doi: 10.1016/S0140-6736(16)32455-2. PMID: 27939400Free PMC Article

Clinical prediction guides

Liang Y, Tan Y, Guan B, Guo B, Xia M, Li J, Shi Y, Yu Z, Zhang Q, Liu D, Yang X, Hao J, Gong Y, Shakeel M, Zhou L, Ci W, Li X
Theranostics 2022;12(18):7745-7759. Epub 2022 Nov 14 doi: 10.7150/thno.77281. PMID: 36451860Free PMC Article
Powles T, Csőszi T, Özgüroğlu M, Matsubara N, Géczi L, Cheng SY, Fradet Y, Oudard S, Vulsteke C, Morales Barrera R, Fléchon A, Gunduz S, Loriot Y, Rodriguez-Vida A, Mamtani R, Yu EY, Nam K, Imai K, Homet Moreno B, Alva A; KEYNOTE-361 Investigators
Lancet Oncol 2021 Jul;22(7):931-945. Epub 2021 May 26 doi: 10.1016/S1470-2045(21)00152-2. PMID: 34051178
Galsky MD, Arija JÁA, Bamias A, Davis ID, De Santis M, Kikuchi E, Garcia-Del-Muro X, De Giorgi U, Mencinger M, Izumi K, Panni S, Gumus M, Özgüroğlu M, Kalebasty AR, Park SH, Alekseev B, Schutz FA, Li JR, Ye D, Vogelzang NJ, Bernhard S, Tayama D, Mariathasan S, Mecke A, Thåström A, Grande E; IMvigor130 Study Group
Lancet 2020 May 16;395(10236):1547-1557. doi: 10.1016/S0140-6736(20)30230-0. PMID: 32416780
Rosenberg J, Sridhar SS, Zhang J, Smith D, Ruether D, Flaig TW, Baranda J, Lang J, Plimack ER, Sangha R, Heath EI, Merchan J, Quinn DI, Srinivas S, Milowsky M, Wu C, Gartner EM, Zuo P, Melhem-Bertrandt A, Petrylak DP
J Clin Oncol 2020 Apr 1;38(10):1041-1049. Epub 2020 Feb 7 doi: 10.1200/JCO.19.02044. PMID: 32031899Free PMC Article
Rosenberg JE, O'Donnell PH, Balar AV, McGregor BA, Heath EI, Yu EY, Galsky MD, Hahn NM, Gartner EM, Pinelli JM, Liang SY, Melhem-Bertrandt A, Petrylak DP
J Clin Oncol 2019 Oct 10;37(29):2592-2600. Epub 2019 Jul 29 doi: 10.1200/JCO.19.01140. PMID: 31356140Free PMC Article

Recent systematic reviews

Maisch P, Hwang EC, Kim K, Narayan VM, Bakker C, Kunath F, Dahm P
Cochrane Database Syst Rev 2023 Oct 9;10(10):CD013774. doi: 10.1002/14651858.CD013774.pub2. PMID: 37811690Free PMC Article
Mori K, Schuettfort VM, Yanagisawa T, Katayama S, Pradere B, Laukhtina E, Rajwa P, Mostafaei H, Sari Motlagh R, Quhal F, Moschini M, Soria F, Teoh JYC, D'Andrea D, Abufaraj M, Albisinni S, Krajewski W, Egawa S, Karakiewicz PI, Rink M, Shariat SF; European Association of Urology–Young Academic Urologists Urothelial Carcinoma Working Group (EAU-YAU)
Eur Urol Focus 2022 Nov;8(6):1687-1695. Epub 2022 Mar 9 doi: 10.1016/j.euf.2022.02.007. PMID: 35279408
Chierigo F, Wenzel M, Würnschimmel C, Flammia RS, Horlemann B, Tian Z, Saad F, Chun FKH, Tilki D, Shariat SF, Gallucci M, Borghesi M, Suardi N, Terrone C, Karakiewicz PI
Crit Rev Oncol Hematol 2022 Jan;169:103534. Epub 2021 Nov 22 doi: 10.1016/j.critrevonc.2021.103534. PMID: 34823022
Yanagisawa T, Mori K, Katayama S, Mostafaei H, Quhal F, Laukhtina E, Rajwa P, Motlagh RS, Aydh A, König F, Grossmann NC, Pradere B, Miki J, Kimura T, Egawa S, Shariat SF
Int J Clin Oncol 2022 Jan;27(1):59-71. Epub 2021 Nov 10 doi: 10.1007/s10147-021-02061-0. PMID: 34757531Free PMC Article
Di Nunno V, De Luca E, Buttigliero C, Tucci M, Vignani F, Gatto L, Zichi C, Ardizzoni A, Di Maio M, Massari F
Crit Rev Oncol Hematol 2018 Sep;129:124-132. Epub 2018 Jul 19 doi: 10.1016/j.critrevonc.2018.07.004. PMID: 30097230

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