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Granulosa cell tumor

MedGen UID:
6676
•Concept ID:
C0018206
•
Neoplastic Process
Synonyms: Granulosa Cell Tumor; Granulosa Cell Tumors; Tumor, Granulosa Cell; Tumors, Granulosa Cell
 
Monarch Initiative: MONDO:0006036

Definition

A slow-growing sex cord-stromal tumor characterized by the presence of granulosa-like cells and Call-Exner bodies. It is almost always found in the ovary and rarely in the testis. There are two types of granulosa cell tumors: the adult and the juvenile. [from NCI]

Professional guidelines

PubMed

Clinical outcomes of leuprolide acetate in the treatment of recurrent ovarian granulosa cell tumors.
Foster KI, Flores Legarreta A, Kamat R, Handley KF, Glassman D, How JA, Lawson BC, Westin SN, Ramondetta LM, Frumovitz M, Gershenson DM, Sood AK, Hillman RT
Am J Obstet Gynecol 2023 Jun;228(6):724.e1-724.e9. Epub 2023 Mar 11 doi: 10.1016/j.ajog.2023.02.029. PMID: 36907533Free PMC Article
DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary.
Zhao D, Zhang Y, Ou Z, Zhang R, Zheng S, Li B
J Ovarian Res 2020 Feb 14;13(1):19. doi: 10.1186/s13048-020-00619-6. PMID: 32059683Free PMC Article

Recent clinical studies

Etiology

Sex Cord-Stromal Tumors of the Ovary.
Sertic M, Devins KM, Oliva E, Lee SI, Kilcoyne A
Radiol Clin North Am 2023 Jul;61(4):595-608. Epub 2023 Mar 31 doi: 10.1016/j.rcl.2023.02.005. PMID: 37169426
Adult ovarian granulosa cell tumors: analysis of outcomes and risk factors for recurrence.
Plett H, Ricciardi E, Vacaru V, Ramspott JP, Colombo N, Sehouli J, du Bois A, Garbi A, Richter R, Ataseven B, Aletti G, Braicu E, Heitz F, Portuesi R, Muallem MZ, Dagres T, Parma G, Roser E, Traut A, Multinu F, Harter P
Int J Gynecol Cancer 2023 May 1;33(5):734-740. doi: 10.1136/ijgc-2022-003854. PMID: 36759002
Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature.
Dridi M, Chraiet N, Batti R, Ayadi M, Mokrani A, Meddeb K, Yahiaoui Y, Raies H, Mezlini A
Int J Surg Oncol 2018;2018:4547892. Epub 2018 Mar 29 doi: 10.1155/2018/4547892. PMID: 29796312Free PMC Article
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary.
Färkkilä A, Haltia UM, Tapper J, McConechy MK, Huntsman DG, Heikinheimo M
Ann Med 2017 Aug;49(5):435-447. Epub 2017 Mar 6 doi: 10.1080/07853890.2017.1294760. PMID: 28276867

Diagnosis

Sex Cord-Stromal Tumors of the Ovary.
Sertic M, Devins KM, Oliva E, Lee SI, Kilcoyne A
Radiol Clin North Am 2023 Jul;61(4):595-608. Epub 2023 Mar 31 doi: 10.1016/j.rcl.2023.02.005. PMID: 37169426
Juvenile granulosa cell tumor in pregnancy: case series and literature review.
Ndhlovu E, Deng H, Dai J, Dong X, Liu L, Chen B
Arch Gynecol Obstet 2022 May;305(5):1299-1310. Epub 2021 Oct 25 doi: 10.1007/s00404-021-06283-5. PMID: 34694430
Progress in the management of ovarian granulosa cell tumor: A review.
Li J, Chu R, Chen Z, Meng J, Yao S, Song K, Kong B
Acta Obstet Gynecol Scand 2021 Oct;100(10):1771-1778. Epub 2021 Jul 16 doi: 10.1111/aogs.14189. PMID: 34027996
Pediatric Gynecologic Cancers.
Pommert L, Bradley W
Curr Oncol Rep 2017 Jul;19(7):44. doi: 10.1007/s11912-017-0604-7. PMID: 28501984
Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary.
Färkkilä A, Haltia UM, Tapper J, McConechy MK, Huntsman DG, Heikinheimo M
Ann Med 2017 Aug;49(5):435-447. Epub 2017 Mar 6 doi: 10.1080/07853890.2017.1294760. PMID: 28276867

Therapy

Granulosa cell tumors (GCTs) of the ovary: What is the role of radiotherapy?
Barcellini A, Mangili G, Fodor A, Secondino S, Zerbetto F, Charalampopoulou A, Pignata S, Orlandi E, Bergamini A
Crit Rev Oncol Hematol 2023 Jan;181:103889. Epub 2022 Nov 26 doi: 10.1016/j.critrevonc.2022.103889. PMID: 36503888
Meigs' syndrome and adult-type granulosa cell tumor.
Yang ST, Cheng M, Lai CR, Shen SH, Lee WL, Wang PH
Taiwan J Obstet Gynecol 2021 Nov;60(6):1116-1120. doi: 10.1016/j.tjog.2021.09.028. PMID: 34794749
Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature.
Dridi M, Chraiet N, Batti R, Ayadi M, Mokrani A, Meddeb K, Yahiaoui Y, Raies H, Mezlini A
Int J Surg Oncol 2018;2018:4547892. Epub 2018 Mar 29 doi: 10.1155/2018/4547892. PMID: 29796312Free PMC Article
Hormone therapy in ovarian granulosa cell tumors: a systematic review.
van Meurs HS, van Lonkhuijzen LR, Limpens J, van der Velden J, Buist MR
Gynecol Oncol 2014 Jul;134(1):196-205. Epub 2014 Apr 5 doi: 10.1016/j.ygyno.2014.03.573. PMID: 24713548
Granulosa cell tumor of the ovary: tumor review.
Koukourakis GV, Kouloulias VE, Koukourakis MJ, Zacharias GA, Papadimitriou C, Mystakidou K, Pistevou-Gompaki K, Kouvaris J, Gouliamos A
Integr Cancer Ther 2008 Sep;7(3):204-15. doi: 10.1177/1534735408322845. PMID: 18815151

Prognosis

Update on Ovarian Sex Cord-Stromal Tumors.
Ordulu Z
Clin Lab Med 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001. PMID: 37169445
Sex Cord-Stromal Tumors of the Ovary.
Sertic M, Devins KM, Oliva E, Lee SI, Kilcoyne A
Radiol Clin North Am 2023 Jul;61(4):595-608. Epub 2023 Mar 31 doi: 10.1016/j.rcl.2023.02.005. PMID: 37169426
Progress in the management of ovarian granulosa cell tumor: A review.
Li J, Chu R, Chen Z, Meng J, Yao S, Song K, Kong B
Acta Obstet Gynecol Scand 2021 Oct;100(10):1771-1778. Epub 2021 Jul 16 doi: 10.1111/aogs.14189. PMID: 34027996
Natural history of Ollier disease and Maffucci syndrome: Patient survey and review of clinical literature.
El Abiad JM, Robbins SM, Cohen B, Levin AS, Valle DL, Morris CD, de Macena Sobreira NL
Am J Med Genet A 2020 May;182(5):1093-1103. Epub 2020 Mar 7 doi: 10.1002/ajmg.a.61530. PMID: 32144835Free PMC Article
Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary.
Färkkilä A, Haltia UM, Tapper J, McConechy MK, Huntsman DG, Heikinheimo M
Ann Med 2017 Aug;49(5):435-447. Epub 2017 Mar 6 doi: 10.1080/07853890.2017.1294760. PMID: 28276867

Clinical prediction guides

Epidemiology and nomogram for predicting the cancer-specific survival of ovarian granulosa cell tumor: A seer database study.
Xia L, Qiu S, Kong FB, Lai J, Huang H, Hu H, Liu X, Ye Z, Cao J
J Gynecol Obstet Hum Reprod 2023 Jun;52(6):102601. Epub 2023 May 6 doi: 10.1016/j.jogoh.2023.102601. PMID: 37156420
Immunohistochemical markers of prognosis in adult granulosa cell tumors of the ovary - a review.
Jung D, Almstedt K, Battista MJ, Seeger A, Jäkel J, Brenner W, Hasenburg A
J Ovarian Res 2023 Mar 3;16(1):50. doi: 10.1186/s13048-023-01125-1. PMID: 36869369Free PMC Article
Juvenile granulosa cell tumor: 20 years' experience of a Tertiary Center.
Hamzaoğlu Canbolat K, Biçer E, İlvan Ş, Beşe T, Çepni İ, Demirkıran F
Ginekol Pol 2022;93(10):787-792. doi: 10.5603/GP.a2022.0107. PMID: 36748172
Prognostic predictors in recurrent adult granulosa cell tumors of the ovary: a systematic review and meta-analysis.
Inzani F, Santoro A, Travaglino A, D'Alessandris N, Raffone A, Straccia P, Angelico G, Arciuolo D, Scaglione G, Valente M, Tralongo P, Gallotta V, Zannoni GF
Arch Gynecol Obstet 2022 Aug;306(2):315-321. Epub 2021 Nov 19 doi: 10.1007/s00404-021-06305-2. PMID: 34799743
Ovarian granulosa cell tumor: A National Cancer Database study.
Seagle BL, Ann P, Butler S, Shahabi S
Gynecol Oncol 2017 Aug;146(2):285-291. Epub 2017 May 19 doi: 10.1016/j.ygyno.2017.05.020. PMID: 28532858

Recent systematic reviews

The Prognostic Significance of Adjuvant Chemotherapy in Adult Ovarian Granulosa Cell Tumors: A Systematic Review and Meta-analysis.
Zhuang Y, Yang H
Cancer Control 2023 Jan-Dec;30:10732748231215165. doi: 10.1177/10732748231215165. PMID: 37957122Free PMC Article
Prognostic predictors in recurrent adult granulosa cell tumors of the ovary: a systematic review and meta-analysis.
Inzani F, Santoro A, Travaglino A, D'Alessandris N, Raffone A, Straccia P, Angelico G, Arciuolo D, Scaglione G, Valente M, Tralongo P, Gallotta V, Zannoni GF
Arch Gynecol Obstet 2022 Aug;306(2):315-321. Epub 2021 Nov 19 doi: 10.1007/s00404-021-06305-2. PMID: 34799743
Progress in the management of ovarian granulosa cell tumor: A review.
Li J, Chu R, Chen Z, Meng J, Yao S, Song K, Kong B
Acta Obstet Gynecol Scand 2021 Oct;100(10):1771-1778. Epub 2021 Jul 16 doi: 10.1111/aogs.14189. PMID: 34027996
Granulosa cell tumor of ovary: A systematic review of recent evidence.
Levin G, Zigron R, Haj-Yahya R, Matan LS, Rottenstreich A
Eur J Obstet Gynecol Reprod Biol 2018 Jun;225:57-61. Epub 2018 Apr 11 doi: 10.1016/j.ejogrb.2018.04.002. PMID: 29665458
Hormone therapy in ovarian granulosa cell tumors: a systematic review.
van Meurs HS, van Lonkhuijzen LR, Limpens J, van der Velden J, Buist MR
Gynecol Oncol 2014 Jul;134(1):196-205. Epub 2014 Apr 5 doi: 10.1016/j.ygyno.2014.03.573. PMID: 24713548

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