GRADE evidence profiles for all studies

National Guideline Alliance (UK)

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National Guideline Alliance (UK). Mental Health Problems in People with Learning Disabilities: Prevention, Assessment and Management. London: National Institute for Health and Care Excellence (NICE); 2016 Sep. (NICE Guideline, No. 54.)

Mental Health Problems in People with Learning Disabilities: Prevention, Assessment and Management.

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Appendix NGRADE evidence profiles for all studies

Abbreviations

AAMD: American Association on Mental Deficiency
ADHD: attention deficit hyperactivity disorder
A-PS: assertiveness then social problem-solving
BDI(-II): Beck Depression Inventory (revised)
CBT: cognitive behavioural therapy
CES-D: Center for Epidemiologic Studies - Depression scale
CGI: Clinical Global Impression scale
CI: confidence interval
GRADE: Grades of Recommendation Assessment, Development and Evaluation
GSI: Global Severity Index
HAM-A: Hamilton Anxiety Rating Scale
ITT: intention to treat
MD: mean difference
NCBRF: Nisonger Child Behavior Rating Form
PS-A: social problem-solving then assertiveness
PSI: Parenting Stress Index
PTSD: post-traumatic stress disorder
RCT: randomised controlled trial
RR: risk ratio
SAS-ID: Zung Self-Rating Anxiety Scale for Adults with Intellectual Disabilities
SCL-90-R: Symptom CheckList-90-Revised
SF-12: 12-Item Short Form Health Survey
SIB-R: Scales of Independent Behavior-Revised
SMD: standardised mean difference
SNAP-IV: Swanson, Nolan and Pelham Questionnaire - revised
TAU: treatment as usual

N.1. Psychological/psychosocial interventions

N.1.1. Psychological interventions versus control for mental health problems

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N.1.2. Social problem-solving than assertiveness training (PS-A) versus assertiveness then social problem-solving (A-PS) for mental health problems

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N.1.3. Psychodynamic psychotherapy (8 sessions) versus psychodynamic psychotherapy (12 or 24+ sessions) for mental health problems

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N.1.4. Psychological interventions versus control for substance misuse

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N.1.5. Assertiveness training versus modelling and social inference for substance misuse

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N.1.9. Cognitive behavioural therapy versus ABA/IBI for post-traumatic stress disorder

Download PDF (356K)

N.1.10. Cognitive behavioural therapy versus control for depressive symptoms

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N.1.11. Cognitive behavioural therapy versus behavioural strategies for depressive symptoms

Download PDF (319K)

N.1.12. Cognitive behavioural therapy versus cognitive strategies for depressive symptoms

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N.1.13. Psychodynamic psychotherapy versus no treatment for sexually inappropriate behaviour

Download PDF (316K)

N.1.14. Parent training versus control

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For the full GRADE evidence profiles for other pairwise comparisons relating to the quality of evidence for parent training, please refer to the NICE guideline Challenging Behaviour and Learning Disabilities, NG11.

N.2. Pharmacological interventions

N.2.1. Amphetamine versus placebo

Download PDF (302K)

N.2.2. Methylphenidate versus placebo

Download PDF (381K)

N.2.3. Methylphenidate plus behavioural modification training vs placebo plus behavioural modification training

Download PDF (426K)

N.2.4. Clonidine versus placebo

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N.2.5. Risperidone versus methylphenidate

Download PDF (445K)

N.3. Pharmacological interventions for dementia in Down’s syndrome

N.3.1. Donepezil versus placebo for prevention of dementia

Download PDF (408K)

N.3.2. Donepezil versus placebo for treatment of dementia

Download PDF (488K)

N.3.3. Memantine versus placebo for dementia in Down’s syndrome

Download PDF (426K)

N.3.4. Simvastatin versus placebo for dementia in Down’s syndrome

Download PDF (368K)

N.4. Other interventions

N.4.1. Annual health check versus treatment as usual

Download PDF (351K)

N.4.2. Acetyl-L-carnitine versus placebo for attention deficit hyperactivity disorder

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N.4.3. Acetyl-L-carnitine versus placebo for dementia

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N.4.4. Antioxidant plus acetylcholinesterase inhibitor versus placebo plus acetylcholinesterase inhibitor for dementia

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N.4.5. Exercise versus any control for anxiety symptoms

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N.4.6. Exercise versus painting control for depressive symptoms

Download PDF (338K)

N.4.7. Exercise and education versus control for depressive symptoms

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N.5. Organisation and Service Delivery

N.5.1. Assertive community treatment versus standard community treatment

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N.5.2. Active case management model versus standard model

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N.5.3. Liaison worker versus no liaison worker

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N.6. Interventions to enhance carer well-being

N.6.1. Interventions informed by cognitive behavioural principles versus control for family carers

Download PDF (479K)

N.6.2. Psychosocial support interventions versus control for parents

Download PDF (351K)

N.6.3. Psychoeducation versus control for parents

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N.6.4. Mindfulness versus control for staff

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N.6.5. Mindfulness versus control for parents

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N.6.6. Carer outcomes from parent training for child mental health

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All rights reserved. NICE copyright material can be downloaded for private research and study, and may be reproduced for educational and not-for-profit purposes. No reproduction by or for commercial organisations, or for commercial purposes, is allowed without the written permission of NICE.

Bookshelf ID: NBK401815

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