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Items: 15

1.

Identification of mechano- and/or 5Aza-sensitive genes in mouse carotid artery endothelium in vivo exposed to disturbed blood flow for 7 days

(Submitter supplied) Atherosclerosis preferentially occurs in arterial regions of disturbed blood flow (d-flow), which alters gene expression, endothelial function, and atherosclerosis. Here, we show that d-flow regulates genome-wide DNA methylation patterns in a DNA methyltransferase (DNMT)-dependent manner. D-flow induced expression of DNMT1 in mouse arterial endothelium in vivo and in cultured endothelial cells by oscillatory shear (OS) in vitro. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5651
Platform:
GPL6887
12 Samples
Download data: TXT
Series
Accession:
GSE56143
ID:
200056143
2.
Full record GDS5651

DNA methyltransferase inhibitor 5-Aza-2’deoxycytidine effect on partially-ligated left carotid artery

Analysis of arteries from C57BL/6 males pretreated with DNMT inhibitor 5Aza for 2 wk, then subjected to partial carotid ligation (PCL) and continued 5Aza treatment for 1 wk after ligation. PCL induces disturbed blood flow. Results provide insight into molecular basis of atherosclerosis development.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 protocol, 2 tissue sets
Platform:
GPL6887
Series:
GSE56143
12 Samples
Download data
3.

Illumina MouseWG-6 v2.0 expression beadchip

(Submitter supplied) The MouseWG-6 v2.0 Expression BeadChip offer the most up-to-date content for whole-genome expression profiling in the mouse. Featuring content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. more...
Organism:
Mus musculus
31 DataSets
1218 Series
8 Related Platforms
17115 Samples
Download data: BGX, TXT
Platform
Accession:
GPL6887
ID:
100006887
4.

AzaRCA4

Organism:
Mus musculus
Source name:
right carotid artery, 21 days of 5-Aza-2'deoxycytidine treatment (0.2mg/kg/day by I.P. injection), unligated contralateral control
Platform:
GPL6887
Series:
GSE56143
Dataset:
GDS5651
Download data
Sample
Accession:
GSM1356651
ID:
301356651
5.

AzaRCA3

Organism:
Mus musculus
Source name:
right carotid artery, 21 days of 5-Aza-2'deoxycytidine treatment (0.2mg/kg/day by I.P. injection), unligated contralateral control
Platform:
GPL6887
Series:
GSE56143
Dataset:
GDS5651
Download data
Sample
Accession:
GSM1356650
ID:
301356650
6.

AzaRCA1

Organism:
Mus musculus
Source name:
right carotid artery, 21 days of 5-Aza-2'deoxycytidine treatment (0.2mg/kg/day by I.P. injection), unligated contralateral control
Platform:
GPL6887
Series:
GSE56143
Dataset:
GDS5651
Download data
Sample
Accession:
GSM1356649
ID:
301356649
7.

AzaLCA4

Organism:
Mus musculus
Source name:
left carotid artery, 21 days of 5-Aza-2'deoxycytidine treatment (0.2mg/kg/day by I.P. injection), 7 days ligated
Platform:
GPL6887
Series:
GSE56143
Dataset:
GDS5651
Download data
Sample
Accession:
GSM1356648
ID:
301356648
8.

AzaLCA2

Organism:
Mus musculus
Source name:
left carotid artery, 21 days of 5-Aza-2'deoxycytidine treatment (0.2mg/kg/day by I.P. injection), 7 days ligated
Platform:
GPL6887
Series:
GSE56143
Dataset:
GDS5651
Download data
Sample
Accession:
GSM1356647
ID:
301356647
9.

AzaLCA1

Organism:
Mus musculus
Source name:
left carotid artery, 21 days of 5-Aza-2'deoxycytidine treatment (0.2mg/kg/day by I.P. injection), 7 days ligated
Platform:
GPL6887
Series:
GSE56143
Dataset:
GDS5651
Download data
Sample
Accession:
GSM1356646
ID:
301356646
10.

RCA4

Organism:
Mus musculus
Source name:
right carotid artery, saline-treated control, unligated contralateral control
Platform:
GPL6887
Series:
GSE56143
Dataset:
GDS5651
Download data
Sample
Accession:
GSM1356645
ID:
301356645
11.

RCA2

Organism:
Mus musculus
Source name:
right carotid artery, saline-treated control, unligated contralateral control
Platform:
GPL6887
Series:
GSE56143
Dataset:
GDS5651
Download data
Sample
Accession:
GSM1356644
ID:
301356644
12.

RCA1

Organism:
Mus musculus
Source name:
right carotid artery, saline-treated control, unligated contralateral control
Platform:
GPL6887
Series:
GSE56143
Dataset:
GDS5651
Download data
Sample
Accession:
GSM1356643
ID:
301356643
13.

LCA4

Organism:
Mus musculus
Source name:
left carotid artery, saline-treated control, 7 days ligated
Platform:
GPL6887
Series:
GSE56143
Dataset:
GDS5651
Download data
Sample
Accession:
GSM1356642
ID:
301356642
14.

LCA2

Organism:
Mus musculus
Source name:
left carotid artery, saline-treated control, 7 days ligated
Platform:
GPL6887
Series:
GSE56143
Dataset:
GDS5651
Download data
Sample
Accession:
GSM1356641
ID:
301356641
15.

LCA1

Organism:
Mus musculus
Source name:
left carotid artery, saline-treated control, 7 days ligated
Platform:
GPL6887
Series:
GSE56143
Dataset:
GDS5651
Download data
Sample
Accession:
GSM1356640
ID:
301356640
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