txid2731361[Organism:exp] - GEO DataSets

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Select item 2002276021.

MHV68 ORF50stop Vaccine Gene Expression

(Submitter supplied) RNA-sequencing from MHV68 ORF50 stop and WT virus infected 3T12 cells (timepoint) post infection.

Organism:: Mus musculus; Murid gammaherpesvirus 4

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33263
6 Samples

Download data: FA, GTF, TXT

Series

Accession:: GSE227602

ID:: 200227602

Select item 2002003692.

MicroRNA array studies in Hirschsprung disease

(Submitter supplied) To address the role of miRNAs in Hirschsprund disease (HSCR), we carried out microRNA (miRNA) array analysis by using human intestinal samples obtained from HSCR patients and controls, and identified dysregulated miRNAs involved in the pathogenesis of HSCR.

Organism:: Merkel cell polyomavirus; Herpesvirus saimiri (strain 11); JC polyomavirus; Human gammaherpesvirus 8; Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1; Human betaherpesvirus 6B

Type:: Non-coding RNA profiling by array

Platform:: GPL32145
10 Samples

Download data: GPR, TXT

Series

Accession:: GSE200369

ID:: 200200369

Select item 2002426363.

Aberrant RNA polymerase Initiation and Processivity on the Genome of a Herpes Simplex Virus 1 Mutant Lacking ICP27

(Submitter supplied) Within the first 15 minutes of infection, herpes simplex virus 1 (HSV-1) immediate early proteins repurpose cellular RNA polymerase (Pol II) for viral transcription. An important role of the viral infected cell protein 27 (ICP27) is to facilitate viral pre-mRNA processing and export of viral mRNA to the cytoplasm. Here, we use precision nuclear run-on followed by deep sequencing (PRO-seq) to characterize transcription of a viral ICP27 null mutant. more...

Organism:: Homo sapiens; Drosophila melanogaster; Human alphaherpesvirus 1

Type:: Other

Platform:: GPL29914
12 Samples

Download data: BW

Series

Accession:: GSE242636

ID:: 200242636

Select item 2002537474.

Aging aggravates aortic aneurysm and dissection via the miR-1204-MYLK signaling axis

(Submitter supplied) The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. A total of 430 subjects were recruited for screening of differentially expressed plasma microRNAs. We found that miR-1204 was significantly increased in both plasma and aorta of elder patients with AAD, and was positively correlated with age. Cell senescence induced the expression of miR-1204 through p53 interaction with plasmacytoma variant translocation 1, and miR-1204 induced vascular smooth muscle cell (VSMC) senescence to form a positive feedback loop. more...

Organism:: Human alphaherpesvirus 2; human gammaherpesvirus 4; Human betaherpesvirus 6B; Betapolyomavirus macacae; Herpesvirus saimiri (strain 11); JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus hominis; Homo sapiens; Human alphaherpesvirus 1; Macacine alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1; Merkel cell polyomavirus

Type:: Non-coding RNA profiling by array

Platform:: GPL21439
12 Samples

Download data: GPR, XLSX

Series

Accession:: GSE253747

ID:: 200253747

Analyze with GEO2R

Select item 2002216255.

Unstable EBV latency drives inflammation in multiple sclerosis patient derived spontaneous B cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: human gammaherpesvirus 4; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL34327 GPL18573
18 Samples

Download data: BW

Series

Accession:: GSE221625

ID:: 200221625

Select item 2002216246.

Unstable EBV latency drives inflammation in multiple sclerosis patient derived spontaneous B cells [EBV WGS]

(Submitter supplied) Epstein-Barr virus (EBV) is an etiologic risk factor, and likely prerequisite, for the development of multiple sclerosis (MS). However, the role of EBV infected B cells in the immunopathology of MS is not well understood. Here, we characterized spontaneous lymphoblastoid cell lines (SLCLs) isolated from MS patients and healthy controls (HC) ex vivo to study EBV and host gene expression in the context of an individual’s endogenous EBV. more...

Organism:: human gammaherpesvirus 4

Type:: Other

Platform:: GPL34327
9 Samples

Download data: BW, TXT

Series

Accession:: GSE221624

ID:: 200221624

Select item 2002455347.

A distinct isoform of lymphoid enhancer binding factor 1 (LEF1) epigenetically restricts EBV reactivation to maintain viral latency

(Submitter supplied) As a human tumor virus, EBV is present as a latent infection in its associated malignancies where genetic and epigenetic changes have been shown to impede cellular differentiation and viral reactivation. One such change is increased levels of the Wnt signaling effector, lymphoid enhancer binding factor 1 (LEF1) following EBV epithelial infection. In silico analysis of EBV type 1 and 2 genomes identified over 20 Wnt-response elements suggesting that LEF1 may directly bind the EBV genome and regulate the viral life cycle. more...

Organism:: human gammaherpesvirus 4

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL33849 GPL33850
31 Samples

Download data: BEDGRAPH

Series

Accession:: GSE245534

ID:: 200245534

PubMed Full text in PMC Similar studies

Select item 2002319468.

Chronic Active Epstein-Barr Virus Disease Originates from Infected Hematopoietic Stem Cells

(Submitter supplied) Chronic active Epstein-Barr Virus (EBV) disease (CAEBV) is lethal syndrome due to persistent EBV infection. When diagnosed as CAEBV, EBV infection was observed in multiple hematopoietic lineages, but the etiology of CAEBV is still elusive. Bone marrow and peripheral cells derived from five CAEBV patients, one EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH) patient, and two healthy controls were analyzed. more...

Organism:: Homo sapiens; human gammaherpesvirus 4

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL33393 GPL24676
32 Samples

Download data: MTX, TSV

Series

Accession:: GSE231946

ID:: 200231946

PubMed Similar studies

Select item 2002399959.

The three-dimensional structure of the EBV genome plays a crucial role in regulating viral gene expression in EBVaGC

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: human gammaherpesvirus 4; Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing

Platforms:: GPL25190 GPL23185
29 Samples

Download data: BEDPE, BW, NARROWPEAK, TXT

Series

Accession:: GSE239995

ID:: 200239995

PubMed Full text in PMC Similar studies

Select item 20023999410.

The three-dimensional structure of the EBV genome plays a crucial role in regulating viral gene expression in EBVaGC [RNA-seq]

(Submitter supplied) Epstein-Barr virus (EBV) establishes lifelong asymptomatic infection by replication of its chromatinized episomes with the host genome. EBV exhibits different latency-associated transcriptional repertoires, each with distinct three-dimensional structures. CTCF, Cohesin and PARP1 are involved in maintaining viral latency and establishing episome architecture. Epstein-Barr virus-associated gastric cancer (EBVaGC) represents 1.3% to 30.9% of all gastric cancers globally. more...

Organism:: human gammaherpesvirus 4; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23185
3 Samples

Download data: TXT

Series

Accession:: GSE239994

ID:: 200239994

PubMed Full text in PMC Similar studies

Select item 20023999211.

The three-dimensional structure of the EBV genome plays a crucial role in regulating viral gene expression in EBVaGC [HiChIP]

Organism:: human gammaherpesvirus 4; Homo sapiens

Type:: Other

Platform:: GPL23185
4 Samples

Download data: BEDPE, TXT

Series

Accession:: GSE239992

ID:: 200239992

PubMed Full text in PMC Similar studies

Select item 20023998912.

The three-dimensional structure of the EBV genome plays a crucial role in regulating viral gene expression in EBVaGC [HiC]

Organism:: human gammaherpesvirus 4

Type:: Other

Platform:: GPL25190
10 Samples

Download data: TXT

Series

Accession:: GSE239989

ID:: 200239989

PubMed Full text in PMC Similar studies

Select item 20023998713.

The three-dimensional structure of the EBV genome plays a crucial role in regulating viral gene expression in EBVaGC [ChIP-seq]

Organism:: human gammaherpesvirus 4

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL25190
12 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE239987

ID:: 200239987

PubMed Full text in PMC Similar studies

Select item 20023965914.

Increased pro-inflammatory phenotype of peripheral blood monocytes and monocyte-derived macrophages among patients with excessive ethanol intake

(Submitter supplied) Excessive alcohol consumption adversely affects the immune system and triggers the activation of peripheral blood (PB) monocytes and tissue macrophages, contributing to alcohol- related organ damage. This study aimed to analyze the M1/M2 and inflammatory phenotypes of circulating monocytes and macrophage-derived monocytes (MDMs). This single-center cross- sectional study included 20 excessive alcohol drinkers (EADs) and 22 healthy controls. more...

Organism:: Rattus norvegicus; Human alphaherpesvirus 2; Merkel cell polyomavirus; Mus musculus cytomegalovirus 2; human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1

Type:: Non-coding RNA profiling by array

Platform:: GPL11434
22 Samples

Download data: GPR, TXT

Series

Accession:: GSE239659

ID:: 200239659

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20017416115.

ac4C-seq of cellular and KSHV transcripts in iSLK-Puro, iSLK-KSHV (i.e. iSLK-RGB), iSLK-KSHV (WT), iSLK-KSHV (ΔNAT10) cells

(Submitter supplied) We used ac4C-seq to detedc cellular and KSHV transcripts in iSLK-Puro, iSLK-KSHV, iSLK-KSHV (WT), iSLK-KSHV (ΔNAT10) cells after after doxycycline and sodium butyrate treatment.

Organism:: Human gammaherpesvirus 8; Homo sapiens

Type:: Other

Platform:: GPL30065
24 Samples

Download data: TXT, XLS

Series

Accession:: GSE174161

ID:: 200174161

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017388916.

RIP-seq of NAT10 interacted cellular and KSHV transcripts in iSLK-KSHV cells

(Submitter supplied) Flag-RIP-seq was performed in NAT10-Flag overexpressing iSLK-KSHV cells.

Organism:: Homo sapiens; Human gammaherpesvirus 8

Type:: Other

Platform:: GPL30065
12 Samples

Download data: TXT

Series

Accession:: GSE173889

ID:: 200173889

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012921717.

m6A modification of EBV transcripts

(Submitter supplied) We examined the viral epitranscriptome in EBV transformed lymphoblastoid cell lines (LcLs) and EBV-positive Burkitt's lymphoma, Akata cells, using methylated RNA immunoprecipitation followed by sequencing (MeRIP-seq). Biological replicates of ribo-RNA deleted mRNA of each cell type were prepared for MeRIP-seq followed by peak calling using the exome Peak package with settings for stringent peak calling on both strands of the genome.