Similar studies for GEO DataSets (Select 200013176) - GEO DataSets

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Items: 20

Select item 2000131761.

The protein kinase Tor1 regulates adhesin expression in Candida albicans

(Submitter supplied) Eukaryotic cell growth is coordinated in response to nutrient availability, growth factors, and environmental stimuli, enabling cell–cell interactions that promote survival. The rapamycin-sensitive Tor1 protein kinase, which is conserved from yeasts to humans, participates in a signaling pathway central to cellular nutrient responses. To gain insight into Tor-mediated processes in human fungal pathogens, we have characterized Tor signaling in Candida albicans. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL7476
12 Samples

Download data: GPR

Series

Accession:: GSE13176

ID:: 200013176

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001821862.

Transcript profiling of Candida albicans tor1 kinase mutants

(Submitter supplied) This study analyses the effects of truncation of the gene encoding Tor1 kinase in Candida albicans. The study involves a mutant tetO-TOR1-Del381 which has the N terminal regulator HEAT repeats deleted compared to a full length tetO-TOR1 strain and a heterozygous TOR1/tor1 control. Cell were grown in vitro in YEPD broth at 30˚C. In shut off experiments, doxycycline (30 µg.ml) was added to cultures to shut off the tetO promoter and inhibit Tor1 expression.

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL24041
20 Samples

Download data: TXT

Series

Accession:: GSE182186

ID:: 200182186

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Select item 2000412663.

Comparative analysis between wild type and hap5-null mutant in response to rapamycin treatment

(Submitter supplied) To identify the potential Hap5-regulated genes, we treated wild type cells and hap5 mutant cells with rapamycin and their corespondent transcriptional profiles were compared. Total 608 significant genes were identified. Among them, 343 genes are upregulated in hap5 mutant in repsonse to rapamycin while 265 genes are downregulated in comparison with the wild type.

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL14575
8 Samples

Download data: TXT

Series

Accession:: GSE41266

ID:: 200041266

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Select item 2000258224.

Conjugated linoleic acid inhibits hyphal growth in Candida albicans by modulating Ras1 cellular levels and down-regulating TEC1 expression

(Submitter supplied) The polymorphic yeast Candida albicans exists in blastospore and filamentous forms. The switch from one morphological state to the other coincides with the expression of virulence factors, which makes the yeast-to-hypha transition an attractive target for the development of new antifungal agents. Because an untapped therapeutic potential resides in small molecules that hinder C. albicans filamentation, we characterized the inhibitory effect of conjugated linoleic acid (CLA) on hyphal growth and addressed its mechanism of action. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL9818
12 Samples

Download data: TXT

Series

Accession:: GSE25822

ID:: 200025822

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Select item 2000852765.

Genome-wide location of Candida albicans transcription factor Skn7p

(Submitter supplied) Skn7 is a conserved fungal heat shock factor-type transcriptional regulator. It participates in maintaining cell wall integrity and regulates the osmotic/oxidative stress response (OSR) in S. cerevisiae, where it is part of a two-component signal transduction system. Here, we comprehensively address the function of Skn7 in the human fungal pathogen Candida albicans. We provide evidence reinforcing functional divergence, with loss of the cell wall/osmotic stress-protective roles and acquisition of the ability to regulate morphogenesis on solid medium. more...

Organism:: Candida albicans

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL17892
2 Samples

Download data: GPR

Series

Accession:: GSE85276

ID:: 200085276

Select item 2000852756.

Genome-wide expression profiling of Candida albicans transcription factor Skn7p

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL19932
16 Samples

Download data: GPR

Series

Accession:: GSE85275

ID:: 200085275

Select item 2002276547.

The Rfg1 and Bcr1 transcription factors regulate acidic pH-induced filamentous growth in Candida albicans

(Submitter supplied) To investigate the function of Rfg1 in sensing acidic pH and regulating filamentation in C. albicans, we performed the global gene expression profile analysis of WT and rfg1/rfg1 mutant.We reveal that Rfg1 is an essential acidic pH sensor in C. albicans. Rfg1 regulates filamentous growth in acidic pH condition via co-regulation of Rim101-Phr1 pathway, cAMP signaling pathway,and the transcription factors Bcr1, Efg1, Flo8, and Hgc1.

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15645
4 Samples

Download data: TXT

Series

Accession:: GSE227654

ID:: 200227654

PubMed Full text in PMC Similar studies

Select item 2000376828.

Identification and functional characterization of Rca1, a transcription factor involved in both antifungal susceptibility and host response in Candida albicans

(Submitter supplied) The identification of novel transcription factors associated to antifungal response may allow the discovery of fungal specific targets for new therapeutic strategies. A collection of 241 C. albicans transcriptional regulators mutants was screened for altered susceptibility to fluconazole, caspofungin, amphotericin B, and 5-fluorocytosine. Thirteen of these mutants not yet identified in their role in antifungal response were further investigated, and the function of one of them, mutant for orf19.6102 (RCA1) was characterized by transcriptome analysis. more...

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15149
4 Samples

Download data: TXT

Series

Accession:: GSE37682

ID:: 200037682

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000291289.

Gene profile of mid-log phase of SD medium grown Candida albicans rhb1 gene deletion strain

(Submitter supplied) Candida albicans is an opportunistic pathogenic yeast that is commensally found in variety of host niches. Rhb1 serves as an positive regulator of Tor1 kinase which is the central component of the TOR signaling in controlling several virulence factors. Here, we used microarray to determined changes in transcript profile while the cell lacks the RHB1 gene.

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL13503
10 Samples

Download data: TXT

Series

Accession:: GSE29128

ID:: 200029128

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Select item 20010203910.

Integration of the tricarboxylic acid (TCA) cycle with cAMP signaling and Sfl2 pathways in the regulation of CO2 sensing, filamentation, and virulence in Candida albicans

(Submitter supplied) Candida albicans is the most common opportunistic fungal pathogen of humans and is also a benign member of the gastrointestinal (GI) tract microbiota. Morphological transitions and metabolic regulation are critical for C. albicans to adapt to the changing host environment. We generated a library of central metabolic pathway mutants in the tricarboxylic acid (TCA) cycle, and investigated the functional consequences of these gene deletions on C. more...

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15645
8 Samples

Download data: XLS

Series

Accession:: GSE102039

ID:: 200102039

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010514811.

A metabolic checkpoint controls hyphal development in Candida albicans via nitric oxide signaling

(Submitter supplied) We investigated the roles of mitochondrial dynamics in hyphal growth of C. albicans using the small molecule inhibitor MDIVI-1. Strikingly, the small molecule inhibitor represses both the yeast-to hyphae transition and ongoing filamentation, and its effects on morphogenesis can be uncoupled from general growth inhibition. RNAseq experiments of inhibitor-treated cells coupled with Candida mutant analyses suggest the existence of a novel mechanism of action to represses hyphal growth. more...

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23573
28 Samples

Download data: CSV

Series

Accession:: GSE105148

ID:: 200105148

PubMed Similar studies SRA Run Selector

Select item 20012922712.

The TOR pathway plays pleiotropic roles in growth and stress responses of the fungal pathogen Cryptococcus neoformans

(Submitter supplied) The target of rapamycin (TOR) pathway is an evolutionarily conserved signal transduction system that is activated by varying nutrient and environmental signals and governs a plethora of eukaryotic biological processes, but its role in Cryptococcus neoformans remains elusive. In this study, we investigated the TOR pathway by functionally characterizing two Tor-like kinases, Tor1 and Tlk1, in C. neoformans. more...

Organism:: Cryptococcus neoformans var. grubii H99

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23176
9 Samples

Download data: TXT, XLSX

Series

Accession:: GSE129227

ID:: 200129227

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007034013.

Transcriptional profiling of putative ABC Transporter gene orf19.4531 knockout in Candida albicans

(Submitter supplied) Since, ABC transporters do perform various physiological roles.To get better insight about possible involvement of putative ABC transporter orf19.4531 in different functions transcriptional profiling have been peformed and compared between WT(SC5314) Candida albicans cells vs putative orf19.4531 knockout cells after 6hrs growth of culture.The assay as peformed in biological duplicate sample.

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL20624
4 Samples

Download data: TXT

Series

Accession:: GSE70340

ID:: 200070340

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Select item 20012121014.

Transcriptional profiling of Mms21 deleted (mms21Δ/Δ) mutant Candida albicans strains

(Submitter supplied) Mms21 deletion in Candida albicans resulted in invasveness and filamentatation in YPD media at 30 degrees Celsius. Wild type SN148 do not make any Filaments in YPD at 30 degrees Celsius. The aim was to look for transcription profiling mms21 dleleted mutant against wild type to find genes up and down regulated in the mutant especially thoseones critical for filamentation

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23041
4 Samples

Download data: TSV

Series

Accession:: GSE121210

ID:: 200121210

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011654415.

Transcriptional profiling of Mms21 deleted (mms21Δ/Δ) mutant Candida albicans strains

(Submitter supplied) Mms21 deleteion in Candida albicans resulted in invasveness and filamentatation in YPD media at 30 degrees Celsius. Wild type SN148 do not make any Filaments in YPD at 30 degrees Celsius. The aim was to look for transcription profiling mms21 dleleted mutant against wild type to find genes up and down regulated in the mutant especially thoseones critical for filamentation. Mms21 deleteion in Candida albicans resulted in invasveness and filamentatation in YPD media at 30 degrees Celsius. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL19196
2 Samples

Download data: TXT

Series

Accession:: GSE116544

ID:: 200116544

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Select item 20015545016.

The Ndr/LATS kinase Cbk1 regulates a specific subset of Ace2 functions and suppresses the hyphae-to-yeast transition in Candida albicans

(Submitter supplied) The Regulation of Ace2 and Morphogenesis (RAM) pathway is an important regulatory network in the human fungal pathogen Candida albicans. The RAM pathway’s two most well-studied components, the NDR/Lats kinase Cbk1 and its putative substrate, the transcription factor Ace2, have a wide range of phenotypes and functions. It is not clear, however, which of these functions are specifically due to the phosphorylation of Ace2 by Cbk1. more...