Similar studies for GEO DataSets (Select 200063301) - GEO DataSets

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Items: 20

Select item 2000633011.

Heterochromatin assembly and transcriptome repression by Set1 in coordination with a class II histone deacetylase

(Submitter supplied) Gene expression profiling of S. pombe set1/COMPASS/H3K4 mutants, atf1 and set1 atf1 deletion mutants, set1 clr3 deletion mutants; ChIP-chip tiling microarray profiling of S. pombe Set1, Atf1, H3K4me3 in wt/atf1 deletion mutants, H3K9me2 in wt/set1 clr3 deletion mutants

Organism:: Schizosaccharomyces pombe

Type:: Expression profiling by array; Genome binding/occupancy profiling by array

Platform:: GPL6503
40 Samples

Download data: TXT

Series

Accession:: GSE63301

ID:: 200063301

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002465972.

The Cross-Regulation Between Set1, Clr4, and Lsd1/2 in Schizosaccharomyces pombe

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Schizosaccharomyces pombe

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL28961
34 Samples

Download data

Series

Accession:: GSE246597

ID:: 200246597

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Select item 2002465963.

The Cross-Regulation Between Set1, Clr4, and Lsd1/2 in Schizosaccharomyces pombe [ChIP-seq]

(Submitter supplied) Eukaryotic chromatin is organized into either silenced heterochromatin or relaxed euchromatin regions, which controls the accessibility of transcriptional machinery and thus regulates gene expression. In fission yeast, Schizosaccharomyces pombe, Set1 is the sole H3K4 methyltransferase and is mainly enriched at the promoters of actively transcribed genes. In contrast, Clr4 methyltransferase initiates H3K9 methylation, which has long been regarded as a hallmark of heterochromatic silencing. more...

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL28961
22 Samples

Download data: BW

Series

Accession:: GSE246596

ID:: 200246596

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Select item 2002465954.

The Cross-Regulation Between Set1, Clr4, and Lsd1/2 in Schizosaccharomyces pombe [RNA-seq]

Organism:: Schizosaccharomyces pombe

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28961
12 Samples

Download data: TXT

Series

Accession:: GSE246595

ID:: 200246595

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Select item 2000466495.

The Mi-2 homolog, Mit1, actively positions nucleosomes within heterochromatic domains to suppress transcription

(Submitter supplied) Nucleosome positioning is both active and passive and regulates access to the genome for replication, transcription and repair. Here we report that Mit1, a subunit of the fission yeast SHREC complex similar to Mi-2/NuRD, regulates transcription at regions of heterochromatin by positioning nucleosomes to preclude access to RNA Polymerase II. Purified Mit1 is a nucleosome remodeling factor capable of mobilizing histone octamers on short DNA fragments and requires ATP hydrolysis and chromatin tethering domains to remodel nucleosomes and silence transcription. more...

Organism:: Schizosaccharomyces pombe

Type:: Expression profiling by genome tiling array

Platform:: GPL7715
4 Samples

Download data: BAR, BED, CEL, TXT

Series

Accession:: GSE46649

ID:: 200046649

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Select item 2000953566.

Determinants of H3K4me pattern establishment

(Submitter supplied) A hallmark of genes transcribed by RNA polymerase II (RNApII) is a "gradient" of histone H3 lysine 4 (H3K4) methylation. Various factors differentially bind to H3K4me3 near promoters, H3K4me2 just downstream, and H3K4me1 further downstream to modulate gene expression. Set1/COMPASS, the single S. cerevisiae H3K4 methyltransferase, binds transcribing RNApII, but COMPASS may also be allosterically regulated by specific subunits and histone H2B ubiquitylation. more...

Organism:: Saccharomyces cerevisiae

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13821
99 Samples

Download data: BEDGRAPH

Series

Accession:: GSE95356

ID:: 200095356

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000394047.

CENP-B cooperates with Set1 in bidirectional transcriptional silencing and genome organization of retrotransposons

(Submitter supplied) Expression profiling of mutant cells compared to wild-type cells. Expression profiling of S. pombe CENP-B homolog cbp1∆ (abp1/SPBC1105.04c) and histone deacetylase double mutant clr3∆ clr6-1 (SPBC800.03 SPBC36.05c) cells.

Organism:: Schizosaccharomyces pombe

Type:: Expression profiling by array

Platform:: GPL6503
4 Samples

Download data: TXT

Series

Accession:: GSE39404

ID:: 200039404

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000572078.

An in vivo screen identifies compounds that disrupt heterochromatin integrity

(Submitter supplied) Heterochromatin plays a key role in gene repression, maintaining genome integrity and chromosome segregation. Fission yeast, Schizosaccharomyces pombe, utilizes conserved components to direct heterochromatin formation using siRNA generated by RNA interference (RNAi) to guide a histone H3 lysine 9 methyltransferase to cognate chromatin. To identify compounds that inhibit heterochromatin formation, an in vivo phenotypic screen for loss of silencing was performed. more...

Organism:: Schizosaccharomyces pombe

Type:: Expression profiling by genome tiling array

Platform:: GPL7715
16 Samples

Download data: BAR, CEL, TXT

Series

Accession:: GSE57207

ID:: 200057207

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Select item 2001231449.

CPF is required for heterochromatin assembly and gene silencing

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Schizosaccharomyces pombe

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16192 GPL20584
23 Samples

Download data: BEDGRAPH, BW, TXT

Series

Accession:: GSE123144

ID:: 200123144

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Select item 20012313810.

CPF is required for heterochromatin assembly and gene silencing [RNA-seq]

(Submitter supplied) RNA sequencing in Schizosaccharomyces pombe

Organism:: Schizosaccharomyces pombe

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20584
4 Samples

Download data: TXT

Series

Accession:: GSE123138

ID:: 200123138

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Select item 20012313711.

CPF is required for heterochromatin assembly and gene silencing [ChIP-seq]

(Submitter supplied) Mapping of H3K9me2, 3' RNA processing and termination factors, and terminating RNA polymerase II in Schizosaccharomyces pombe

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL20584 GPL16192
19 Samples

Download data: BEDGRAPH, BW

Series

Accession:: GSE123137

ID:: 200123137

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20001727112.

Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs

(Submitter supplied) Expression profile of mutant cells compared to wild-type cells: Expression profile of Schizosaccharomyces pombe genome in ∆pht1, ∆ago1, ∆clr4, rik1, ∆pht1rik1, ∆pht1∆ago1 and ∆pht1∆clr4 cells. Expression profile of Schizosaccharomyces pombe genome in ∆rrp6, ∆cid14, ∆swi6, ∆swr1, ∆set1, ∆pht1∆swi6 and ∆pht1∆set1 cells. Expression profile of Schizosaccharomyces pombe genome in ∆alp13, ∆cph1, ∆set2, clr6-1 and ∆cph1∆pht1 cells. more...

Organism:: Schizosaccharomyces pombe

Type:: Expression profiling by genome tiling array; Genome binding/occupancy profiling by genome tiling array

Platforms:: GPL8908 GPL6503
30 Samples

Download data: TXT

Series

Accession:: GSE17271

ID:: 200017271

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20018446613.

Histone deacetylation primes chromatin to preserve epigenetic memory for self-propagation of heterochromatin domains

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by genome tiling array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL20584 GPL6503
4 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE184466

ID:: 200184466

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Select item 20003340414.

RNA elimination machinery targeting meiotic mRNAs promotes facultative heterochromatin formation

(Submitter supplied) Occupancy profiling of lysine 9 dimethylated histone H3 in fission yeast.

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL6503
5 Samples

Download data: TXT

Series

Accession:: GSE33404

ID:: 200033404

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20017464115.

The histone chaperone FACT facilitates heterochromatin spreading through regulation of histone turnover and H3K9 methylation states

(Submitter supplied) Heterochromatin formation requires several steps involving: nucleation followed by spreading of large, silent domains and its faithful re-establishment and maintenance after each replication cycle. The essential histone chaperone FACT has been implicated in heterochromatin silencing, however, little is known about the specificity of FACT in this process. Here, by applying single cell assays, ChIP and genetics, we show that FACT mutants have defects in the spreading of heterochromatin at subtelomeres and mating type locus in fission yeast. more...

Organism:: Schizosaccharomyces pombe

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13988
8 Samples

Download data: BW

Series

Accession:: GSE174641

ID:: 200174641

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Select item 20009412916.

Accumulation of RNA on chromatin disrupts heterochromatic silencing

(Submitter supplied) Long non-coding RNAs (lncRNAs) play a conserved role in regulating gene expression, chromatin dynamics and cell differentiation. They serve as a platform for RNA interference (RNAi)-mediated heterochromatin formation or DNA methylation in many eukaryotic organisms. We found in Schizosaccharomyces pombe, that heterochromatin is lost at transcribed regions in absence of RNA degradation, although establishment is not affected. more...

Organism:: Schizosaccharomyces pombe

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other; Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL9453 GPL22681
70 Samples

Download data: TDF

Series

Accession:: GSE94129

ID:: 200094129

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010471317.

Total RNA-Seq in WT and rrp6-delta strains of S. pombe

(Submitter supplied) Recent studies have revealed that eukaryotic genomes are pervasively transcribed by RNA polymerase II, producing a plethora of non-coding RNAs which frequently overlap protein-coding genes. Despite the fact that overlapping transcription is well known to repress transcription initiation from downstream promoters, the mechanism behind this phenomenon has remained elusive. It was proposed that transcriptional interference relies on the act of transcription rather than the RNA itself to block access of the transcription machinery to downstream promoters. more...

Organism:: Schizosaccharomyces pombe

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17225
4 Samples

Download data: FA, TAB

Series

Accession:: GSE104713

ID:: 200104713

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Select item 20010471218.

Effect of HDAC inhibition on nascent transcription by RNAPII in fission yeast

Organism:: Schizosaccharomyces pombe

Type:: Other

Platform:: GPL17225
8 Samples

Download data: FA, TAB

Series

Accession:: GSE104712

ID:: 200104712

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Select item 20014092019.

An RNA Endonuclease-Kinase Complex Required for Spreading and Epigenetic Inheritance of Heterochromatin

(Submitter supplied) The highly conserved multienzyme Rix1-containing complex (hereafter referred to as the rixosome), is required for ribosomal RNA (rRNA) processing and also localizes to heterochromatin in fission yeast, but its role in heterochromatin formation is unknown. Here we report the isolation of separation of function mutations in subunits of the rixosome that abolish its physical association with Swi6/HP1 and localization to heterochromatin, but do not affect growth or rRNA processing. more...