Similar studies for GEO DataSets (Select 200068126) - GEO DataSets

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Items: 12

Select item 2000681261.

Integrative genomics identifies novel associations with APOL1 risk genotype in African American NEPTUNE subjects [tubulointerstitium]

(Submitter supplied) Tubulointersitial expression data from human kidney biopsy in African American subjects with glomerulopathies We used microarrays to analyze the transcriptome of African American subjects with glomerulopathies and the association of expression with APOL1 risk alleles (G1 and G2)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17692
55 Samples

Download data: CEL, TXT

Series

Accession:: GSE68126

ID:: 200068126

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000681272.

Integrative genomics identifies novel associations with APOL1 risk genotype in African American NEPTUNE subjects

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17692
99 Samples

Download data: CEL

Series

Accession:: GSE68127

ID:: 200068127

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000681253.

Integrative genomics identifies novel associations with APOL1 risk genotype in African American NEPTUNE subjects [glomerulus]

(Submitter supplied) Glomerular expression data from human kidney biopsy in African American subjects with glomerulopathies We used microarrays to analyze the transcriptome of African American subjects with glomerulopathies and the association of expression with APOL1 risk alleles (G1 and G2)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17692
44 Samples

Download data: CEL, TXT

Series

Accession:: GSE68125

ID:: 200068125

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000814924.

APOL1 variant expression in mouse podocytes cause kidney disease

(Submitter supplied) Next-generation sequencing (NGS) has become an important tool in molecular charactarization of animal models. APOL1 variants are associated with end stage renal disease in African Americans. We developed a mouse model with podocyte specific over expression of APOL1. Differential molecular signatures were identified between the groups by RNA-Sequencing on kidney.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
10 Samples

Download data: TXT

Series

Accession:: GSE81492

ID:: 200081492

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000859215.

APOL1 renal-risk variants induce mitochondrial dysfunction

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL10558 GPL17586
60 Samples

Download data: CEL, IDAT

Series

Accession:: GSE85921

ID:: 200085921

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Select item 2000859206.

APOL1 renal-risk variants induce mitochondrial dysfunction (Affymetrix 2)

(Submitter supplied) To assess differential gene expression by APOL1 renal-risk (2 risk alleles) vs. non-risk (G0G0) genotypes in primary proximal tubule cells (PTCs), global gene expression (mRNA) levels were examined on Affymetrix HTA 2.0 arrays in primary PTCs cultured from non-diseased kidney in African Americans without CKD who underwent nephrectomy for localized renal cell carcinoma.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
30 Samples

Download data: CEL

Series

Accession:: GSE85920

ID:: 200085920

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Select item 2000859197.

APOL1 renal-risk variants induce mitochondrial dysfunction (Affymetrix 1)

(Submitter supplied) To elucidate pathways whereby apolipoprotein L1 gene (APOL1) G1 and G2 variants facilitate kidney disease in African Americans, human embryonic kidney cells (HEK293) were used to establish doxycycline-inducible (Tet-on) cell lines stably expressing reference APOL1 G0 and its G1 and G2 renal-risk variants. Illumina human HT-12-v4 arrays and Affymetrix HTA 2.0 arrays were employed to generate global gene expression data with doxycycline induction. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
6 Samples

Download data: CEL

Series

Accession:: GSE85919

ID:: 200085919

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Select item 2000859188.

APOL1 renal-risk variants induce mitochondrial dysfunction (Illumina)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
24 Samples

Download data: IDAT, TXT

Series

Accession:: GSE85918

ID:: 200085918

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001943379.

Transcriptomic analysis of human podocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL16791 GPL24676
48 Samples

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Series

Accession:: GSE194337

ID:: 200194337

PubMed Full text in PMC Similar studies

Select item 20019433610.

Transcriptomic analysis of human podocytes [small RNA]

(Submitter supplied) We analyzed the small RNA profiles of human podocyte-like epithelial cells (HUPEC) obtained from urine of two subjects with APOL1 low-risk (G0/G0) genotypes and two subjects with APOL1 high-risk (G1/G2) genotypes.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL16791
24 Samples

Download data: XLSX

Series

Accession:: GSE194336

ID:: 200194336

PubMed Full text in PMC Similar studies

Select item 20019433011.

Transcriptomic analysis of human podocytes [total RNA]

(Submitter supplied) We analyzed the transcriptomic profiles of human podocyte-like epithelial cells (HUPEC) obtained from urine of two subjects with APOL1 low-risk (G0/G0) genotypes and two subjects with APOL1 high-risk (G1/G2) genotypes.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
24 Samples

Download data: XLSX

Series

Accession:: GSE194330

ID:: 200194330

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Select item 20017646512.

Urine single cell RNA-sequencing in focal segmental glomerulosclerosis reveals inflammatory signatures in immune cells and podocytes

(Submitter supplied) The diagnosis of focal segmental glomerulosclerosis (FSGS) requires a renal biopsy which is invasive and can be problematic in children and in some adults. We used single cell RNA-sequencing to explore disease-related cellular signatures in 17 urine samples from 12 FSGS subjects. We identified immune cells in urine predominantly monocytes and renal epithelial cells including podocytes. Analysis revealed M1 and M2 monocyte subsets and podocytes showing increased expression of genes involved in epithelial-to-mesenchymal transition (EMT). more...