GEO DataSets

(Submitter supplied) Ultraconserved regions (UCRs) are segments of the human genome located in both intragenic and intergenic regions that are highly conserved in orthologous regions of the human, rat, and mouse genomes. Their transcriptional products, called T-UCRs, compose a new category of long noncoding RNA (lncRNAs). Most importantly, recent data suggests that T-UCRs are altered at the transcriptional level in human tumorigenesis and the aberrant T-UCRs expression profiles can be used to differentiate human cancer types. more...

Organism:

Mus musculus; Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL20120

53 Samples

Download data: GPR

(Submitter supplied) Expression profiling of 8 normal pancreatic and 14 PDAC tissues. Data was generated from Affymetrix arrays. Results provide a global profile of over 50,000 genes in normal and tumorous tissues, and comparison of the differentially expressed genes between the normal and tumor groups.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

22 Samples

Download data: CEL, CHP

(Submitter supplied) MicroRNAs (miRs) are small non-coding RNAs that can function as tumor suppressor genes. We previously reported that miR-1 is among the most consistently down-regulated miRs in primary human prostate tumors. In this follow-up study, we further corroborated this finding in an independent dataset and made the novel observation that miR-1 expression is further reduced in distant metastasis and is a predictor of disease recurrence. more...

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL571 GPL14184

34 Samples

Download data: CEL, GPR

(Submitter supplied) BACKGROUND. Perineural invasion (PNI) is the dominant pathway for local invasion in prostate cancer. To date, only few studies have investigated the molecular differences between prostate tumors with PNI and those without it. METHODS. To evaluate the involvement of both microRNAs and protein-coding genes in PNI, we determined their genome-wide expression with a custom microRNA microarray and Affymetrix GeneChips in 50 prostate adenocarcinomas with PNI and 7 without it. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL4700 GPL571

114 Samples

Download data: CEL, GPR

(Submitter supplied) To test the hypothesis that there are specific miRNA/UCR expression signature which characterizes Barrett's esophagus development and progression, we performed miRNA/UCR microarray analysis comparing normal esophageal squamous epithelium with all the phenotypic lesions seen in the Barrett's carcinogenic process

Organism:

Homo sapiens; Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL8871

51 Samples

Download data: GPR

(Submitter supplied) Wnt/b-catening dependent HCC mouse models was used to assess microRNA profiles downstream of Wnt/b-catening pathway in mice HCC

Organism:

Mus musculus

Type:

Other

Platform:

GPL17873

6 Samples

Download data: TXT

(Submitter supplied) Wnt/b-catening dependent HCC mouse models was used to assess T-UCR profiles in mice HCC downstream of Wnt/b-catening pathway.

Organism:

Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL15691

6 Samples

Download data: TXT

(Submitter supplied) Normal human hepatocytes and 3 different HCC cell lines have been analyzed for the global expression of long non coding RNA (lncRNA). Total RNA was extracted from each sample using RNeasy Kit (Qiagen) according to the manufacturer’s instructions. RNA quality was assessed by Nanodrop ND-1000 and Bioanalyser2100. DNA microarray The Human Long Non-coding RNA Array was manufactured by Roche NimbleGen. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL11269

4 Samples

Download data: PAIR

(Submitter supplied) To explore circular RNA (circRNA) expression profiling and their biological functions in bladder cancer, we surveyed the circRNA expression signature of 4 pairs of matched bladder cancer and para-cancer tissues from clinical patients using microarray. Hundreds of significantly changed circRNAs were identified. Our findings provide a novel perspective on transcriptional group and lay the foundation for future research of potential roles of circRNAs in bladder carcinoma.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL19978

8 Samples

Download data: TXT

(Submitter supplied) To further explore the differential expression profile of Transcribed ultra-conserved region (TUCR) in human colorectal cancer, we have employed TUCR microarray expression profiling as a discovery platform to identify potential differential expression profile of TUCR between human colorectal cancer tissue (CCRT) and human normal mucosal epithelial tissue of the colorectal (NT). Results showed that multiple differentially expressed TUCRs were found between CCRT and NT. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL18564

2 Samples

Download data: TXT

(Submitter supplied) To identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, esophageal cancer, tongue squamous cell carcinoma, hypopharyngeal squamous cell carcinoma and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20844

16 Samples

Download data: TXT

(Submitter supplied) To identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, esophageal cancer, bladder cancer, prostate cancer, renal cell carcinoma and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20844

32 Samples

Download data: TXT, XLSX

(Submitter supplied) In the present study we evaluated the miRNA expression profile of 31 high risk, stage 4 neuroblastoma patients.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8227

31 Samples

Download data: TXT

(Submitter supplied) We performed array CGH in high-risk neuroblastoma tumors in order to compare genome aberrations with expression of small non-coding RNAs.

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platforms:

GPL2873 GPL5477

33 Samples

Download data: TXT

(Submitter supplied) To identify target genes of tumor suppressive microRNAs in human cancer, several cell lines (bladder cancer, prostate cancer, renal cell carcinoma, and head and neck squamous cell carcinoma) were subjected to Agilent whole genome microarrays. miR-517a, miR-218, miR-145, miR-1 and miR-874 function as tumor suppressors.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL4133 GPL10332

13 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Rattus norvegicus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL19112 GPL14746

14 Samples

Download data: TXT

(Submitter supplied) To further characterize the downstream targets of uc.323, we performed global microarray analysis after knockdown of uc.323 in cardiomyocytes to gain broad insight into uc.323-mediated transcriptome changes.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL14746

6 Samples

Download data: TXT

(Submitter supplied) To investigate the changes in T-UCR (transcribed ultraconserved regions) transcription during aortic banding-induced cardiac hypertrophy, we performed lncRNA microarray analysis on the hearts of mice subjected to sham or aortic banding surgery.

Organism:

Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL19112

8 Samples

Download data: TXT

(Submitter supplied) To identify lncRNAs dysregulated in BC, we assessed the lncRNA expression profile in pooled urine samples of 10 BC patients and 10 controls by microarray. A total of 3093 lncRNAs determined differential expression (fold change>=2.0) between BC patients and controls. Among them, 1680 lncRNAs were up-regulated and 1413 lncRNAs were down-regulated in BC. Of all the differentially expressed lncRNAs indicated by lncRNA expression profiling, 26 lncRNAs (fold change>25) were firstly selected for further evaluation, in which 16 lncRNAs were up-regulated and 10 lncRNAs were down-regulated in BC.

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL16956

2 Samples

Download data: TXT

(Submitter supplied) A seven-lncRNA signature was identified in the training set, which is significantly associated with overall survival (OS) (Hazard Ratio [HR]: 3.535, 95% confidence interval [CI]: 2.113-5.915, P < 0.001) and disease-free survival (DFS) (Hazard Ratio [HR]: 2.413, 95% confidence interval [CI]: 1.573-3.703, P < 0.001). Patients in high-risk group have shorter overall survival (HR: 3.555, 95% CI: 2.195-5.757, p < 0.001) and disease-free survival (HR: 2.537, 95% CI: 1.646-3.909, p < 0.001) in the training set, and we found the same conclusion in the independent set for OS (HR 2.665, p < 0.001) and DFS (HR 2.360, p = 0.001). more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL22868

222 Samples

Download data: GPR