Similar studies for GEO DataSets (Select 200205864) - GEO DataSets

(Submitter supplied) The colon is densely innervated by nociceptor neurons. Single cell RNA sequencing (scRNA-seq) of colon epithelial cells was performed to analyze the role of nociceptor neurons and Ramp1 signaling in regulating colonic epithelial cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE208762

ID:: 200208762

PubMed Full text in PMC Similar studies

Select item 2002085946.

Gene expression profile at single cell level of small intestine epithelial cells from the distal ileum

(Submitter supplied) Small intestine is highly innervated by nociceptor neurons. Single cell RNA sequencing (scRNA-seq) of ileal epithelial cells was performed to analyze the role of nociceptor neurons in regulating small intestinal epithelial cells.

Organism:: Mus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23642
2 Samples

Download data: XLSX

Series

Accession:: GSE208594

ID:: 200208594

PubMed Full text in PMC Similar studies

Select item 2001237397.

Nr4a transcription factors limit CAR-T cell function in solid tumors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL17021
138 Samples

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Series

Accession:: GSE123739

ID:: 200123739

PubMed Full text in PMC Similar studies

Select item 2001237388.

Nr4a transcription factors limit CAR-T cell function in solid tumors [RNA-Seq]

(Submitter supplied) Chromatin accessibility with ATAC-seq and gene expression with RNA-seq for CD8 T cells expressing chimeric antigen receptors in solid tumors or after in vitro culture.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
47 Samples

Download data: TSV

Series

Accession:: GSE123738

ID:: 200123738

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001236299.

Nr4a transcription factors limit CAR-T cell function in solid tumors [ATAC-Seq]

(Submitter supplied) Chromatin accessibility with ATAC-seq and gene expression with RNA-seq for CD8 T cells expressing chimeric antigen receptors in solid tumors or after in vitro culture.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
91 Samples

Download data: TSV

Series

Accession:: GSE123629

ID:: 200123629

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018556610.

Combinatorial Immunotherapy Induces Tumor Infiltrating CD8+ T Cells with Distinct Functional, Migratory, and Stem-Like Properties III

(Submitter supplied) This study reveals supeior efficiacy of triple combination treatment (TCT) based on anti-PD-(L)1 and anti-4-1BB/OX40 and describes immunological mechanisms underlying synergism between the treatment components

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
27 Samples

Download data: TXT

Series

Accession:: GSE185566

ID:: 200185566

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018115211.

Combinatorial Immunotherapy Induces Tumor Infiltrating CD8+ T Cells with Distinct Functional, Migratory, and Stem-Like Properties

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL24247
32 Samples

Download data: MTX, TSV

Series

Accession:: GSE181152

ID:: 200181152

PubMed Full text in PMC Similar studies

Select item 20018115012.

Combinatorial Immunotherapy Induces Tumor Infiltrating CD8+ T Cells with Distinct Functional, Migratory, and Stem-Like Properties II

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
1 Sample

Download data: MTX, TSV

Series

Accession:: GSE181150

ID:: 200181150

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018114213.

Combinatorial Immunotherapy Induces Tumor Infiltrating CD8+ T Cells with Distinct Functional, Migratory, and Stem-Like Properties I

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE181142

ID:: 200181142

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010948514.

Anti-PD-1/anti-CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+ T cell trafficking

(Submitter supplied) Intracranial B16 melanoma tumors isolated from C57Bl6 mice were analyzed by mRNAseq. Four experimental groups were analyzed: (1) Mice with intracranial tumors receiving IgG; (2) Mice with intracranial tumors receiving anti-PD-1 plus anti-CTLA-4 therapy; (3) Mice with intracranial plus extracranial tumors receiving IgG; (4) Mice with intracranial plus extracranial tumors receiving anti-PD-1 plus anti-CTLA-4 therapy. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TXT

Series

Accession:: GSE109485

ID:: 200109485

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20025306315.

The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota

(Submitter supplied) The somatosensory nervous system surveils external stimuli at barrier tissues, regulating innate immune cells under infection and inflammation. The roles of sensory neurons in controlling the adaptive immune system, and more specifically immunity to the microbiota, however, remain elusive. Here, we identified a novel mechanism for direct neuroimmune communication between commensal-specific T lymphocytes and somatosensory neurons mediated by the neuropeptide calcitonin gene-related peptide (CGRP) in the skin. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL19057
2 Samples

Download data: CSV, MTX, RDS, TSV

Series

Accession:: GSE253063

ID:: 200253063

PubMed Similar studies

Select item 20025304116.

The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21626 GPL21103
12 Samples

Download data: TXT

Series

Accession:: GSE253041

ID:: 200253041

PubMed Similar studies

Select item 20022168117.

Bacteria hijack a neuro-immune axis in meninges to facilitate brain invasion

(Submitter supplied) The meninges are densely innervated by nociceptive sensory neurons that mediate pain and headache. How pain and neuro-immune interactions impact meningeal host defenses is unclear. Bacterial meningitis causes life-threatening infections of the meninges and central nervous system (CNS), affecting over one million people a year. Here we find that Nav1.8+ neuron signaling to immune cells in the meninges via the neuropeptide calcitonin gene-related peptide (CGRP) exacerbates bacterial meningitis. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
31 Samples

Download data: H5, RDA

Series

Accession:: GSE221681

ID:: 200221681

PubMed Full text in PMC Similar studies

Select item 20025504918.

CGRP sensory neurons promote tissue healing by modulating neutrophils and macrophages

(Submitter supplied) Since the immune system plays a critical role in orchestrating tissue healing, regenerative strategies that control immune components have proven effective. This is particularly relevant when immune dysregulation resulting from conditions such as diabetes or advanced age impairs tissue healing following injury. Nociceptive sensory neurons play a crucial role as immunoregulators, exerting both protective and harmful effects depending on the context. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
12 Samples

Download data: CSV

Series

Accession:: GSE255049

ID:: 200255049

PubMed Full text in PMC Similar studies

Select item 20003870419.

Regulation of gene expression by RORgamma in Th17 cells

(Submitter supplied) We observed significant growth inhibition of melanoma tumor in RORγ-/- mice, suggesting an important role for the T helper 17 cell (TH17) pathway in tumor immunity. Though RORgamma t (RORγt) plays a critical role in the development of IL-17-secreting Th17 cells, the role of other genes remained an open question. To explore the expression of unknown genes with anti-tumor properties, gene expression analysis was performed.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
4 Samples

Download data: TXT

Series

Accession:: GSE38704

ID:: 200038704

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002453620.

Molecular signature of CD8+ T cell exhaustion in metastases but not in peripheral blood from melanoma patients

(Submitter supplied) In chronic viral infections such as HIV-1, HBV and HCV, CD8+ T cells may become ”exhausted”, characterized by progressive functional deficiency. Recently, the underlying mechanisms have been characterized by molecular profiling of virus-specific CD8+ T cells. In contrast, only little is known of self/tumor-specific CD8+ T cells from cancer patients, likely because they are much more difficult to assess. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
52 Samples

Download data: TXT

Series

Accession:: GSE24536

ID:: 200024536

PubMed Full text in PMC Similar studies Analyze with GEO2R

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