Similar studies for GEO DataSets (Select 3176) - GEO DataSets

Select item 31761.

Analysis of skin grafts lacking pRb, p107, or both genes. pRb and p107 belong to the retinoblastoma family important in cell cycle regulation. Results provide insight into the role of p107 in epidermal tumor development when pRb is absent.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:: GPL339
Series:: GSE9567
8 Samples

Download data: CEL

DataSet

Accession:: GDS3176

ID:: 3176

Select item 2000095672.

p107 acts as a tumor suppressor in pRb-deficient epidermis.

(Submitter supplied) The specific deletion of Rb gene in epidermis leads to altered proliferation and differentiation, but not to the development of spontaneous tumors. Our previous data have demonstrated the existence of a functional compensation of Rb loss by Rbl1 (p107) in as the phenotypic differences with respect to controls are intensified. However, the possible evolution of this aggravated phenotype, in particular in relationship with tumorigenesis, has not been evaluated due to the premature death of the double deficient mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3176
Platform:: GPL339
8 Samples

Download data: CEL

Series

Accession:: GSE9567

ID:: 200009567

Select item 2000095623.

Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis

(Submitter supplied) The epidermal-specific ablation of Rb gene leads to increased proliferation, aberrant differentiation, and the disengagement of these processes in vivo and in vitro. These differences in phenotype are more severe with the loss of p107, demonstrating the functional compensation between pRb and p107. As p107 and p130 also exert overlapping functions in epidermis, we have generated Rb(F19/F19)K14cre;Rbl2-/- (pRb-;p130-) mice to analyze possible functional redundancies between pRb and p130. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL339
10 Samples

Download data: CEL

Series

Accession:: GSE9562

ID:: 200009562

Select item 2000091444.

Spontaneous SCC induced by the somatic inactivation of Rb1 and Trp53 tumor suppressors in mouse stratified epithelia

(Submitter supplied) The squamous cell carcinomas represent the aggressive type of non melanoma skin cancer, the most frequent malignancy among human population. We have studied here the possible relationship between these two pathways in skin using epidermal-specific mutant mice. Loss of p53, but not pRb, produces spontaneous tumor development, indicating that, contrary to pRb, p53 is the predominant tumor suppressor acting in mouse epidermis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL339
8 Samples

Download data: CEL

Series

Accession:: GSE9144

ID:: 200009144

Select item 2000382575.

A Novel Tumor suppressor network in squamous malignancies

(Submitter supplied) The specific ablation of Rb1 gene in stratified epithelia (RbF/F;K14cre) promotes proliferation and altered differentiation but is insufficient to produce spontaneous tumors. The pRb relative, p107, compensates some of the functions of pRb in these tissues, however RbF/F;K14cre;p107-/- mice die postnatally. Acute pRb loss in stratified epithelia, using an inducible mouse model (RbF/F;K14creERTM), shows that p107 exerts specific tumor suppressor functions in its absence. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
14 Samples

Download data: CEL

Series

Accession:: GSE38257

ID:: 200038257

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000031586.

Mouse Tumor Dataset

(Submitter supplied) previously published mouse data Pubmed IDS: 12754511, 12839964 Keywords: disease state analysis

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL75 GPL76
56 Samples

Download data

Series

Accession:: GSE3158

ID:: 200003158

Select item 2000380487.

E2F1 loss induces spontaneous tumour development in Rb-deficient epidermis

(Submitter supplied) The specific ablation of Rb1 gene in epidermis (RbF/F;K14cre) promotes proliferation and altered differentiation but does not produce spontaneous tumour development. These phenotypic changes are associated with increased expression of E2F members and E2F-dependent transcriptional activity. Here, we have focused on the possible dependence on E2F1 gene function. We have generated mice that lack Rb1 in epidermis in an inducible manner (RbF/F;K14creERTM). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
20 Samples

Download data: CEL

Series

Accession:: GSE38048

ID:: 200038048

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