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Lip and oral cavity squamous cell carcinoma

MedGen UID:
124714
•Concept ID:
C0280297
•
Neoplastic Process
Synonyms: lip and oral cavity squamous cell cancer; Lip and Oral Cavity Squamous Cell Carcinoma; lip and oral cavity squamous cell carcinoma; lip/oral cavity squam. cell car.; squamous cell carcinoma of oral cavity and lip; Squamous cell carcinoma of oral cavity and lip
 
Monarch Initiative: MONDO:0044710
Orphanet: ORPHA502369

Definition

A squamous cell carcinoma arising from the lip or the oral cavity. The oral cavity squamous cell carcinoma usually arises from the buccal mucosa, tongue, or gums. It occurs predominantly in adults who use tobacco and alcohol and has a tendency to metastasize early to lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLip and oral cavity squamous cell carcinoma

Professional guidelines

PubMed

Lip cancer: Reconsidering the at-risk patients with pathological assessment.
Ant A, Kilic C, Baltu Y, Duran AB, Tunccan T, Ozlugedik S, Bozdogan N
Oral Dis 2019 Apr;25(3):742-749. Epub 2019 Jan 23 doi: 10.1111/odi.13017. PMID: 30548899
Management of high-risk squamous cell carcinoma of the skin.
Samarasinghe V, Madan V, Lear JT
Expert Rev Anticancer Ther 2011 May;11(5):763-9. doi: 10.1586/era.11.36. PMID: 21554051
Current treatment options in squamous cell carcinoma of the oral cavity.
Palme CE, Gullane PJ, Gilbert RW
Surg Oncol Clin N Am 2004 Jan;13(1):47-70. doi: 10.1016/S1055-3207(03)00123-6. PMID: 15062361

Recent clinical studies

Etiology

Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Squamous cell carcinoma of the head and neck in children.
Dombrowski ND, Wolter NE, Irace AL, Robson CD, Perez-Atayde AR, Mack JW, Rahbar R
Int J Pediatr Otorhinolaryngol 2019 Feb;117:131-137. Epub 2018 Nov 20 doi: 10.1016/j.ijporl.2018.11.019. PMID: 30579067
Lymphangiogenesis and angiogenesis in oral cavity and lower lip squamous cell carcinoma.
Alaeddini M, Etemad-Moghadam S
Braz J Otorhinolaryngol 2016 Jul-Aug;82(4):385-90. Epub 2015 Nov 5 doi: 10.1016/j.bjorl.2015.06.008. PMID: 26614046Free PMC Article
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013
Oral squamous cell carcinoma in patients twenty years of age or younger--review and analysis of 186 reported cases.
Bodner L, Manor E, Friger MD, van der Waal I
Oral Oncol 2014 Feb;50(2):84-9. Epub 2013 Dec 2 doi: 10.1016/j.oraloncology.2013.11.001. PMID: 24296165

Diagnosis

Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Oral Biopsy Techniques.
Shanti RM, Tanaka T, Stanton DC
Dermatol Clin 2020 Oct;38(4):421-427. Epub 2020 Aug 10 doi: 10.1016/j.det.2020.05.003. PMID: 32892851
Squamous cell carcinoma of the head and neck in children.
Dombrowski ND, Wolter NE, Irace AL, Robson CD, Perez-Atayde AR, Mack JW, Rahbar R
Int J Pediatr Otorhinolaryngol 2019 Feb;117:131-137. Epub 2018 Nov 20 doi: 10.1016/j.ijporl.2018.11.019. PMID: 30579067
Characterization of dendritic cells in lip and oral cavity squamous cell carcinoma.
Costa NL, Gonçalves AS, Martins AF, Arantes DA, Silva TA, Batista AC
J Oral Pathol Med 2016 Jul;45(6):418-24. Epub 2015 Oct 30 doi: 10.1111/jop.12380. PMID: 26514660
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects.
Vieira RA, Minicucci EM, Marques ME, Marques SA
An Bras Dermatol 2012 Jan-Feb;87(1):105-14. doi: 10.1590/s0365-05962012000100013. PMID: 22481658

Therapy

5-Aminolevulinic acid photodynamic therapy for early-stage lip squamous cell carcinoma.
Wang P, Zhang G, Zhang L, Zhou Z, Shi L, Zeng Q, Zhu L, Wang X
Photodiagnosis Photodyn Ther 2021 Sep;35:102321. Epub 2021 May 17 doi: 10.1016/j.pdpdt.2021.102321. PMID: 34015543
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Squamous cell carcinoma of the head and neck in children.
Dombrowski ND, Wolter NE, Irace AL, Robson CD, Perez-Atayde AR, Mack JW, Rahbar R
Int J Pediatr Otorhinolaryngol 2019 Feb;117:131-137. Epub 2018 Nov 20 doi: 10.1016/j.ijporl.2018.11.019. PMID: 30579067
A Review of Photodynamic Therapy for Neoplasms of the Head and Neck.
Civantos FJ, Karakullukcu B, Biel M, Silver CE, Rinaldo A, Saba NF, Takes RP, Vander Poorten V, Ferlito A
Adv Ther 2018 Mar;35(3):324-340. Epub 2018 Feb 7 doi: 10.1007/s12325-018-0659-3. PMID: 29417455
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects.
Vieira RA, Minicucci EM, Marques ME, Marques SA
An Bras Dermatol 2012 Jan-Feb;87(1):105-14. doi: 10.1590/s0365-05962012000100013. PMID: 22481658

Prognosis

Epidemiology and survival outcomes of lip, oral cavity, and oropharyngeal squamous cell carcinoma in a southeast Brazilian population.
Louredo BV, Vargas PA, Pérez-de-Oliveira ME, Lopes MA, Kowalski LP, Curado MP
Med Oral Patol Oral Cir Bucal 2022 May 1;27(3):e274-e284. doi: 10.4317/medoral.25147. PMID: 35368013Free PMC Article
Characterization of dendritic cells in lip and oral cavity squamous cell carcinoma.
Costa NL, Gonçalves AS, Martins AF, Arantes DA, Silva TA, Batista AC
J Oral Pathol Med 2016 Jul;45(6):418-24. Epub 2015 Oct 30 doi: 10.1111/jop.12380. PMID: 26514660
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013
Oral squamous cell carcinoma in patients twenty years of age or younger--review and analysis of 186 reported cases.
Bodner L, Manor E, Friger MD, van der Waal I
Oral Oncol 2014 Feb;50(2):84-9. Epub 2013 Dec 2 doi: 10.1016/j.oraloncology.2013.11.001. PMID: 24296165
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects.
Vieira RA, Minicucci EM, Marques ME, Marques SA
An Bras Dermatol 2012 Jan-Feb;87(1):105-14. doi: 10.1590/s0365-05962012000100013. PMID: 22481658

Clinical prediction guides

miR-340-5p affects oral squamous cell carcinoma (OSCC) cells proliferation and invasion by targeting endoplasmic reticulum stress proteins.
Ou D, Wu Y, Zhang J, Liu J, Liu Z, Shao M, Guo X, Cui S
Eur J Pharmacol 2022 Apr 5;920:174820. Epub 2022 Feb 25 doi: 10.1016/j.ejphar.2022.174820. PMID: 35227681
Opium use and the risk of head and neck squamous cell carcinoma.
Mohebbi E, Hadji M, Rashidian H, Rezaianzadeh A, Marzban M, Haghdoost AA, Naghibzadeh Tahami A, Moradi A, Gholipour M, Najafi F, Safari-Faramani R, Alizadeh-Navaei R, Ansari-Moghaddam A, Bakhshi M, Nejatizadeh A, Mahmoudi M, Shahidsales S, Ahmadi-Simab S, Arabi Mianroodi AA, Seyyedsalehi MS, Hosseini B, Peyghambari V, Shirkhoda M, Shirkoohi R, Ebrahimi E, Manifar S, Mohagheghi MA, Rozek L, Brennan P, Poustchi H, Etemadi A, Pukkala E, Schüz J, Malekzadeh R, Weiderpass E, Rahimi-Movaghar A, Boffetta P, Kamanagar F, Zendehdel K
Int J Cancer 2021 Mar 1;148(5):1066-1076. Epub 2020 Oct 9 doi: 10.1002/ijc.33289. PMID: 32895947
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013
Distinctive clinical and microscopic features of squamous cell carcinoma of oral cavity and lip.
Batista AC, Costa NL, Oton-Leite AF, Mendonça EF, Alencar Rde C, Silva TA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 Mar;109(3):e74-9. doi: 10.1016/j.tripleo.2009.10.034. PMID: 20219590

Recent systematic reviews

Hydrochlorothiazide use is associated with the risk of cutaneous and lip squamous cell carcinoma: A systematic review and meta-analysis.
de Macedo Andrade AC, Felix FA, França GM, Ribeiro ILA, Barboza CAG, de Castro RD, de Lisboa Lopes Costa A
Eur J Clin Pharmacol 2022 Jun;78(6):919-930. Epub 2022 Mar 8 doi: 10.1007/s00228-022-03299-x. PMID: 35258665
Primary Intraosseous Squamous Cell Carcinoma Involving the Jaw Bones: A Systematic Review and Update.
de Morais EF, Carlan LM, de Farias Morais HG, Pinheiro JC, Martins HDD, Barboza CAG, de Almeida Freitas R
Head Neck Pathol 2021 Jun;15(2):608-616. Epub 2020 Oct 12 doi: 10.1007/s12105-020-01234-z. PMID: 33044723Free PMC Article
Identifying risk factors for the prognosis of head and neck cutaneous squamous cell carcinoma: A systematic review and meta-analysis.
Zeng S, Fu L, Zhou P, Ling H
PLoS One 2020;15(9):e0239586. Epub 2020 Sep 29 doi: 10.1371/journal.pone.0239586. PMID: 32991600Free PMC Article
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Macey R, Walsh T, Brocklehurst P, Kerr AR, Liu JL, Lingen MW, Ogden GR, Warnakulasuriya S, Scully C
Cochrane Database Syst Rev 2015 May 29;2015(5):CD010276. doi: 10.1002/14651858.CD010276.pub2. PMID: 26021841Free PMC Article
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013

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