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Lip and oral cavity squamous cell carcinoma

MedGen UID:
124714
Concept ID:
C0280297
Neoplastic Process
Synonyms: lip and oral cavity squamous cell cancer; Lip and Oral Cavity Squamous Cell Carcinoma; lip and oral cavity squamous cell carcinoma; lip/oral cavity squam. cell car.; squamous cell carcinoma of oral cavity and lip; Squamous cell carcinoma of oral cavity and lip
 
Monarch Initiative: MONDO:0044710
Orphanet: ORPHA502369

Definition

A squamous cell carcinoma arising from the lip or the oral cavity. The oral cavity squamous cell carcinoma usually arises from the buccal mucosa, tongue, or gums. It occurs predominantly in adults who use tobacco and alcohol and has a tendency to metastasize early to lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLip and oral cavity squamous cell carcinoma

Professional guidelines

PubMed

Afshari K, Sohal KS
Cancer Control 2023 Jan-Dec;30:10732748231185003. doi: 10.1177/10732748231185003. PMID: 37328298Free PMC Article
Ant A, Kilic C, Baltu Y, Duran AB, Tunccan T, Ozlugedik S, Bozdogan N
Oral Dis 2019 Apr;25(3):742-749. Epub 2019 Jan 23 doi: 10.1111/odi.13017. PMID: 30548899
Samarasinghe V, Madan V, Lear JT
Expert Rev Anticancer Ther 2011 May;11(5):763-9. doi: 10.1586/era.11.36. PMID: 21554051

Recent clinical studies

Etiology

Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Adalsteinsson JA, Olafsdottir E, Ratner D, Waldman R, Feng H, Ungar J, Silverberg JI, Kristjansson AK, Jonasson JG, Tryggvadottir L
Br J Dermatol 2021 Sep;185(3):537-547. Epub 2021 May 9 doi: 10.1111/bjd.19879. PMID: 33609287
Mohebbi E, Hadji M, Rashidian H, Rezaianzadeh A, Marzban M, Haghdoost AA, Naghibzadeh Tahami A, Moradi A, Gholipour M, Najafi F, Safari-Faramani R, Alizadeh-Navaei R, Ansari-Moghaddam A, Bakhshi M, Nejatizadeh A, Mahmoudi M, Shahidsales S, Ahmadi-Simab S, Arabi Mianroodi AA, Seyyedsalehi MS, Hosseini B, Peyghambari V, Shirkhoda M, Shirkoohi R, Ebrahimi E, Manifar S, Mohagheghi MA, Rozek L, Brennan P, Poustchi H, Etemadi A, Pukkala E, Schüz J, Malekzadeh R, Weiderpass E, Rahimi-Movaghar A, Boffetta P, Kamanagar F, Zendehdel K
Int J Cancer 2021 Mar 1;148(5):1066-1076. Epub 2020 Oct 9 doi: 10.1002/ijc.33289. PMID: 32895947
Unsal AA, Unsal AB, Henn TE, Baredes S, Eloy JA
Laryngoscope 2018 Jan;128(1):84-90. Epub 2017 Jun 2 doi: 10.1002/lary.26704. PMID: 28573764
Al-Jaber A, Al-Nasser L, El-Metwally A
Saudi Med J 2016 Mar;37(3):249-55. doi: 10.15537/smj.2016.3.11388. PMID: 26905345Free PMC Article

Diagnosis

Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Shanti RM, Tanaka T, Stanton DC
Dermatol Clin 2020 Oct;38(4):421-427. Epub 2020 Aug 10 doi: 10.1016/j.det.2020.05.003. PMID: 32892851
Borges JF, Lanaro ND, Bernardo VG, Albano RM, Dias F, de Faria PA, Pinto LF, Lourenço SQ
Med Oral Patol Oral Cir Bucal 2018 Jan 1;23(1):e7-e12. doi: 10.4317/medoral.21960. PMID: 29274161Free PMC Article
Al-Jaber A, Al-Nasser L, El-Metwally A
Saudi Med J 2016 Mar;37(3):249-55. doi: 10.15537/smj.2016.3.11388. PMID: 26905345Free PMC Article
Merglová V, Mukensnabl P, Andrle P
BMJ Case Rep 2012 Jul 9;2012 doi: 10.1136/bcr.01.2012.5483. PMID: 22778448Free PMC Article

Therapy

Mishra A, Shankar R, Prakash G, Banerjee S, Daga D, Birmiwal KG, Tiwari N, Gupta M, Sahu GC, Das A
Head Neck 2022 Nov;44(11):2473-2480. Epub 2022 Aug 3 doi: 10.1002/hed.27164. PMID: 35920377
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Unsal AA, Unsal AB, Henn TE, Baredes S, Eloy JA
Laryngoscope 2018 Jan;128(1):84-90. Epub 2017 Jun 2 doi: 10.1002/lary.26704. PMID: 28573764
Mazeron JJ, Ardiet JM, Haie-Méder C, Kovács G, Levendag P, Peiffert D, Polo A, Rovirosa A, Strnad V
Radiother Oncol 2009 May;91(2):150-6. Epub 2009 Mar 28 doi: 10.1016/j.radonc.2009.01.005. PMID: 19329209
Harrison LB
Semin Surg Oncol 1997 May-Jun;13(3):177-84. doi: 10.1002/(sici)1098-2388(199705/06)13:3<177::aid-ssu4>3.0.co;2-4. PMID: 9143055

Prognosis

Liu K, Lin C, Zhang L
J Oral Maxillofac Surg 2021 Nov;79(11):2358-2369. Epub 2021 Jun 22 doi: 10.1016/j.joms.2021.06.023. PMID: 34331871
Mehta NK, Nguyen SA, Chang BA, Nathan CA
JAMA Otolaryngol Head Neck Surg 2021 Jul 1;147(7):624-631. doi: 10.1001/jamaoto.2021.0760. PMID: 33983364Free PMC Article
Unsal AA, Unsal AB, Henn TE, Baredes S, Eloy JA
Laryngoscope 2018 Jan;128(1):84-90. Epub 2017 Jun 2 doi: 10.1002/lary.26704. PMID: 28573764
Mazeron JJ, Ardiet JM, Haie-Méder C, Kovács G, Levendag P, Peiffert D, Polo A, Rovirosa A, Strnad V
Radiother Oncol 2009 May;91(2):150-6. Epub 2009 Mar 28 doi: 10.1016/j.radonc.2009.01.005. PMID: 19329209
Popović B, Jekić B, Novaković I, Luković LJ, Tepavcević Z, Jurisić V, Vukadinović M, Milasin J
Ann N Y Acad Sci 2007 Jan;1095:19-25. doi: 10.1196/annals.1397.003. PMID: 17404013

Clinical prediction guides

Liu K, Lin C, Zhang L
J Oral Maxillofac Surg 2021 Nov;79(11):2358-2369. Epub 2021 Jun 22 doi: 10.1016/j.joms.2021.06.023. PMID: 34331871
Chiang TY, Huang CH, Kuan CH, Horng SY, Hsieh JH, Wu YF, Chuang SY, Yu YH, Ho CC, Cheng NC, Tai HC
Ann Plast Surg 2021 Feb 1;86(2S Suppl 1):S108-S112. doi: 10.1097/SAP.0000000000002652. PMID: 33438960
Mohebbi E, Hadji M, Rashidian H, Rezaianzadeh A, Marzban M, Haghdoost AA, Naghibzadeh Tahami A, Moradi A, Gholipour M, Najafi F, Safari-Faramani R, Alizadeh-Navaei R, Ansari-Moghaddam A, Bakhshi M, Nejatizadeh A, Mahmoudi M, Shahidsales S, Ahmadi-Simab S, Arabi Mianroodi AA, Seyyedsalehi MS, Hosseini B, Peyghambari V, Shirkhoda M, Shirkoohi R, Ebrahimi E, Manifar S, Mohagheghi MA, Rozek L, Brennan P, Poustchi H, Etemadi A, Pukkala E, Schüz J, Malekzadeh R, Weiderpass E, Rahimi-Movaghar A, Boffetta P, Kamanagar F, Zendehdel K
Int J Cancer 2021 Mar 1;148(5):1066-1076. Epub 2020 Oct 9 doi: 10.1002/ijc.33289. PMID: 32895947
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Popović B, Jekić B, Novaković I, Luković LJ, Tepavcević Z, Jurisić V, Vukadinović M, Milasin J
Ann N Y Acad Sci 2007 Jan;1095:19-25. doi: 10.1196/annals.1397.003. PMID: 17404013

Recent systematic reviews

Mohebbi E, Alimoradi Z, Rozek LS, Mohebbi A, Jafari E
Arch Oral Biol 2024 Jan;157:105846. Epub 2023 Nov 8 doi: 10.1016/j.archoralbio.2023.105846. PMID: 37980840
de Macedo Andrade AC, Felix FA, França GM, Ribeiro ILA, Barboza CAG, de Castro RD, de Lisboa Lopes Costa A
Eur J Clin Pharmacol 2022 Jun;78(6):919-930. Epub 2022 Mar 8 doi: 10.1007/s00228-022-03299-x. PMID: 35258665
de Morais EF, Carlan LM, de Farias Morais HG, Pinheiro JC, Martins HDD, Barboza CAG, de Almeida Freitas R
Head Neck Pathol 2021 Jun;15(2):608-616. Epub 2020 Oct 12 doi: 10.1007/s12105-020-01234-z. PMID: 33044723Free PMC Article
Macey R, Walsh T, Brocklehurst P, Kerr AR, Liu JL, Lingen MW, Ogden GR, Warnakulasuriya S, Scully C
Cochrane Database Syst Rev 2015 May 29;2015(5):CD010276. doi: 10.1002/14651858.CD010276.pub2. PMID: 26021841Free PMC Article
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013

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