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Neoplasm of oropharynx

MedGen UID:
14519
•Concept ID:
C0029295
•
Neoplastic Process
Synonyms: Neoplasm, Oropharyngeal; Neoplasm, Oropharynx; Neoplasms, Oropharyngeal; Neoplasms, Oropharynx; Oropharyngeal Neoplasm; Oropharyngeal Neoplasms; Oropharynx Neoplasm; Oropharynx Neoplasms
SNOMED CT: Neoplasm of oropharynx (126809003); Tumor of oropharynx (126809003)
 
Monarch Initiative: MONDO:0021364

Definition

A benign or malignant neoplasm that affects the oropharynx. [from NCI]

Professional guidelines

PubMed

HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.
Lechner M, Liu J, Masterson L, Fenton TR
Nat Rev Clin Oncol 2022 May;19(5):306-327. Epub 2022 Feb 1 doi: 10.1038/s41571-022-00603-7. PMID: 35105976Free PMC Article
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
SEOM clinical guidelines for the treatment of head and neck cancer (2020).
Mesia R, Iglesias L, Lambea J, Martínez-Trufero J, Soria A, Taberna M, Trigo J, Chaves M, García-Castaño A, Cruz J
Clin Transl Oncol 2021 May;23(5):913-921. Epub 2021 Feb 26 doi: 10.1007/s12094-020-02533-1. PMID: 33635468Free PMC Article

Recent clinical studies

Etiology

Cancer of the Oropharynx and the Association with Human Papillomavirus.
Rettig EM, Sethi RKV
Hematol Oncol Clin North Am 2021 Oct;35(5):913-931. Epub 2021 Jul 7 doi: 10.1016/j.hoc.2021.05.004. PMID: 34244016
Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual.
Lydiatt WM, Patel SG, O'Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, Loomis AM, Shah JP
CA Cancer J Clin 2017 Mar;67(2):122-137. Epub 2017 Jan 27 doi: 10.3322/caac.21389. PMID: 28128848
Oral and oropharyngeal cancer.
Huber MA, Tantiwongkosi B
Med Clin North Am 2014 Nov;98(6):1299-321. Epub 2014 Sep 20 doi: 10.1016/j.mcna.2014.08.005. PMID: 25443678
Epidemiology of cancer from the oral cavity and oropharynx.
Lambert R, Sauvaget C, de Camargo Cancela M, Sankaranarayanan R
Eur J Gastroenterol Hepatol 2011 Aug;23(8):633-41. doi: 10.1097/MEG.0b013e3283484795. PMID: 21654320
Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma.
Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J, Calais G
J Clin Oncol 2004 Jan 1;22(1):69-76. Epub 2003 Dec 2 doi: 10.1200/JCO.2004.08.021. PMID: 14657228

Diagnosis

Cancer of the Oropharynx and the Association with Human Papillomavirus.
Rettig EM, Sethi RKV
Hematol Oncol Clin North Am 2021 Oct;35(5):913-931. Epub 2021 Jul 7 doi: 10.1016/j.hoc.2021.05.004. PMID: 34244016
Diagnostic approaches to carcinoma of unknown primary of the head and neck.
Ye W, Arnaud EH, Langerman A, Mannion K, Topf MC
Eur J Cancer Care (Engl) 2021 Nov;30(6):e13459. Epub 2021 May 1 doi: 10.1111/ecc.13459. PMID: 33932056
Human Papillomavirus and Oropharyngeal Cancer.
Tanaka TI, Alawi F
Dent Clin North Am 2018 Jan;62(1):111-120. Epub 2017 Oct 7 doi: 10.1016/j.cden.2017.08.008. PMID: 29126488
Reoperative maxillofacial oncology.
Petrisor D, Fernandes R
Oral Maxillofac Surg Clin North Am 2011 Feb;23(1):161-8, vii. doi: 10.1016/j.coms.2010.11.002. PMID: 21272772
Oropharyngeal cancer.
Psyrri A, Prezas L, Burtness B
Clin Adv Hematol Oncol 2008 Aug;6(8):604-12. PMID: 18820604

Therapy

Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma: The ORATOR2 Phase 2 Randomized Clinical Trial.
Palma DA, Prisman E, Berthelet E, Tran E, Hamilton S, Wu J, Eskander A, Higgins K, Karam I, Poon I, Husain Z, Enepekides D, Hier M, Sultanem K, Richardson K, Mlynarek A, Johnson-Obaseki S, Odell M, Bayley A, Dowthwaite S, Jackson JE, Dzienis M, O'Neil J, Chandarana S, Banerjee R, Hart R, Chung J, Tenenholtz T, Krishnan S, Le H, Yoo J, Mendez A, Winquist E, Kuruvilla S, Stewart P, Warner A, Mitchell S, Chen J, Parker C, Wehrli B, Kwan K, Theurer J, Sathya J, Hammond JA, Read N, Venkatesan V, MacNeil SD, Fung K, Nichols AC
JAMA Oncol 2022 Jun 1;8(6):1-7. doi: 10.1001/jamaoncol.2022.0615. PMID: 35482348Free PMC Article
Randomized Trial of Radiotherapy Versus Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Long-Term Results of the ORATOR Trial.
Nichols AC, Theurer J, Prisman E, Read N, Berthelet E, Tran E, Fung K, de Almeida JR, Bayley A, Goldstein DP, Hier M, Sultanem K, Richardson K, Mlynarek A, Krishnan S, Le H, Yoo J, MacNeil SD, Winquist E, Hammond JA, Venkatesan V, Kuruvilla S, Warner A, Mitchell S, Chen J, Corsten M, Johnson-Obaseki S, Odell M, Parker C, Wehrli B, Kwan K, Palma DA
J Clin Oncol 2022 Mar 10;40(8):866-875. Epub 2022 Jan 7 doi: 10.1200/JCO.21.01961. PMID: 34995124
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Present and Future of De-intensification Strategies in the Treatment of Oropharyngeal Carcinoma.
De Virgilio A, Costantino A, Mercante G, Petruzzi G, Sebastiani D, Franzese C, Scorsetti M, Pellini R, Malvezzi L, Spriano G
Curr Oncol Rep 2020 Jul 9;22(9):91. doi: 10.1007/s11912-020-00948-1. PMID: 32643045
Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma.
Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J, Calais G
J Clin Oncol 2004 Jan 1;22(1):69-76. Epub 2003 Dec 2 doi: 10.1200/JCO.2004.08.021. PMID: 14657228

Prognosis

Current state of play for HPV-positive oropharyngeal cancers.
Deutsch F, Regina Bullen I, Nguyen K, Tran NH, Elliott M, Tran N
Cancer Treat Rev 2022 Nov;110:102439. Epub 2022 Jul 26 doi: 10.1016/j.ctrv.2022.102439. PMID: 36126367
Reduced-Dose Radiation Therapy for HPV-Associated Oropharyngeal Carcinoma (NRG Oncology HN002).
Yom SS, Torres-Saavedra P, Caudell JJ, Waldron JN, Gillison ML, Xia P, Truong MT, Kong C, Jordan R, Subramaniam RM, Yao M, Chung CH, Geiger JL, Chan JW, O'Sullivan B, Blakaj DM, Mell LK, Thorstad WL, Jones CU, Banerjee RN, Lominska C, Le QT
J Clin Oncol 2021 Mar 20;39(9):956-965. Epub 2021 Jan 28 doi: 10.1200/JCO.20.03128. PMID: 33507809Free PMC Article
Oral and oropharyngeal cancer.
Huber MA, Tantiwongkosi B
Med Clin North Am 2014 Nov;98(6):1299-321. Epub 2014 Sep 20 doi: 10.1016/j.mcna.2014.08.005. PMID: 25443678
HPV-associated head and neck cancer: a virus-related cancer epidemic.
Marur S, D'Souza G, Westra WH, Forastiere AA
Lancet Oncol 2010 Aug;11(8):781-9. Epub 2010 May 5 doi: 10.1016/S1470-2045(10)70017-6. PMID: 20451455Free PMC Article
Cancer of the oral cavity and oropharynx.
Tshering Vogel DW, Zbaeren P, Thoeny HC
Cancer Imaging 2010 Mar 16;10(1):62-72. doi: 10.1102/1470-7330.2010.0008. PMID: 20233682Free PMC Article

Clinical prediction guides

Prognostic and Predictive Clinical and Biological Factors in HPV Malignancies.
Sud S, Weiner AA, Wang AZ, Gupta GP, Shen CJ
Semin Radiat Oncol 2021 Oct;31(4):309-323. doi: 10.1016/j.semradonc.2021.03.008. PMID: 34455986
MRI Dynamic Contrast Imaging of Oral Cavity and Oropharyngeal Tumors.
Sideras P, Singh G
Top Magn Reson Imaging 2021 Apr 1;30(2):97-104. doi: 10.1097/RMR.0000000000000283. PMID: 33828061
Radiotherapy in Metastatic Oropharyngeal Cancer.
Nguy S, Oh C, Karp JM, Wu SP, Li Z, Persky MJ, Hu KS, Givi B, Tam MM
Laryngoscope 2021 Jun;131(6):E1847-E1853. Epub 2020 Nov 3 doi: 10.1002/lary.29245. PMID: 33141455
Quality of life in oropharyngeal cancer: a structured review of the literature.
Roets E, Tukanova K, Govarts A, Specenier P
Support Care Cancer 2018 Aug;26(8):2511-2518. Epub 2018 May 3 doi: 10.1007/s00520-018-4227-9. PMID: 29725802
Controversies in the locoregional management of head and neck cancer.
Brizel DM, Lydiatt W, Colevas AD
J Natl Compr Canc Netw 2011 Jun 1;9(6):653-62. doi: 10.6004/jnccn.2011.0054. PMID: 21636537

Recent systematic reviews

Dental extraction, intensity-modulated radiotherapy of head and neck cancer, and osteoradionecrosis : A systematic review and meta-analysis.
Balermpas P, van Timmeren JE, Knierim DJ, Guckenberger M, Ciernik IF
Strahlenther Onkol 2022 Mar;198(3):219-228. Epub 2022 Jan 14 doi: 10.1007/s00066-021-01896-w. PMID: 35029717Free PMC Article
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
The primary site of head and neck squamous cell carcinoma predicts survival benefits of EGFR inhibitors: A systematic review and meta-analysis.
Nie D, Wang X, Sun M, Feng Z, Pei F, Liu W, Wang Z, Han F
Radiother Oncol 2021 May;158:13-20. Epub 2021 Feb 13 doi: 10.1016/j.radonc.2021.02.001. PMID: 33587969
Swallowing exercises for head and neck cancer patients: A systematic review and meta-analysis of randomized control trials.
Banda KJ, Chu H, Kao CC, Voss J, Chiu HL, Chang PC, Chen R, Chou KR
Int J Nurs Stud 2021 Feb;114:103827. Epub 2020 Nov 11 doi: 10.1016/j.ijnurstu.2020.103827. PMID: 33352439
Association between physical activity and digestive-system cancer: An updated systematic review and meta-analysis.
Xie F, You Y, Huang J, Guan C, Chen Z, Fang M, Yao F, Han J
J Sport Health Sci 2021 Jan;10(1):4-13. Epub 2020 Sep 30 doi: 10.1016/j.jshs.2020.09.009. PMID: 33010525Free PMC Article

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