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Neoplasm of oropharynx

MedGen UID:
14519
•Concept ID:
C0029295
•
Neoplastic Process
Synonyms: Neoplasm, Oropharyngeal; Neoplasm, Oropharynx; Neoplasms, Oropharyngeal; Neoplasms, Oropharynx; Oropharyngeal Neoplasm; Oropharyngeal Neoplasms; Oropharynx Neoplasm; Oropharynx Neoplasms
SNOMED CT: Neoplasm of oropharynx (126809003); Tumor of oropharynx (126809003)
 
Monarch Initiative: MONDO:0021364

Definition

A benign or malignant neoplasm that affects the oropharynx. [from NCI]

Professional guidelines

PubMed

HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.
Lechner M, Liu J, Masterson L, Fenton TR
Nat Rev Clin Oncol 2022 May;19(5):306-327. Epub 2022 Feb 1 doi: 10.1038/s41571-022-00603-7. PMID: 35105976Free PMC Article
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076
HPV: diagnosis, prevention, and treatment.
Hathaway JK
Clin Obstet Gynecol 2012 Sep;55(3):671-80. doi: 10.1097/GRF.0b013e31825caa36. PMID: 22828099

Recent clinical studies

Etiology

Cancer of the Oropharynx and the Association with Human Papillomavirus.
Rettig EM, Sethi RKV
Hematol Oncol Clin North Am 2021 Oct;35(5):913-931. Epub 2021 Jul 7 doi: 10.1016/j.hoc.2021.05.004. PMID: 34244016
Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual.
Lydiatt WM, Patel SG, O'Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, Loomis AM, Shah JP
CA Cancer J Clin 2017 Mar;67(2):122-137. Epub 2017 Jan 27 doi: 10.3322/caac.21389. PMID: 28128848
Oral and oropharyngeal cancer.
Huber MA, Tantiwongkosi B
Med Clin North Am 2014 Nov;98(6):1299-321. Epub 2014 Sep 20 doi: 10.1016/j.mcna.2014.08.005. PMID: 25443678
Epidemiology of cancer from the oral cavity and oropharynx.
Lambert R, Sauvaget C, de Camargo Cancela M, Sankaranarayanan R
Eur J Gastroenterol Hepatol 2011 Aug;23(8):633-41. doi: 10.1097/MEG.0b013e3283484795. PMID: 21654320
Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma.
Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J, Calais G
J Clin Oncol 2004 Jan 1;22(1):69-76. Epub 2003 Dec 2 doi: 10.1200/JCO.2004.08.021. PMID: 14657228

Diagnosis

Cancer of the Oropharynx and the Association with Human Papillomavirus.
Rettig EM, Sethi RKV
Hematol Oncol Clin North Am 2021 Oct;35(5):913-931. Epub 2021 Jul 7 doi: 10.1016/j.hoc.2021.05.004. PMID: 34244016
Human papillomavirus-associated oropharyngeal cancer: review of current evidence and management.
You EL, Henry M, Zeitouni AG
Curr Oncol 2019 Apr;26(2):119-123. Epub 2019 Apr 1 doi: 10.3747/co.26.4819. PMID: 31043814Free PMC Article
Human Papillomavirus and Oropharyngeal Cancer.
Tanaka TI, Alawi F
Dent Clin North Am 2018 Jan;62(1):111-120. Epub 2017 Oct 7 doi: 10.1016/j.cden.2017.08.008. PMID: 29126488
Oral and oropharyngeal cancer.
Huber MA, Tantiwongkosi B
Med Clin North Am 2014 Nov;98(6):1299-321. Epub 2014 Sep 20 doi: 10.1016/j.mcna.2014.08.005. PMID: 25443678
Oropharyngeal cancer.
Psyrri A, Prezas L, Burtness B
Clin Adv Hematol Oncol 2008 Aug;6(8):604-12. PMID: 18820604

Therapy

Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma: The ORATOR2 Phase 2 Randomized Clinical Trial.
Palma DA, Prisman E, Berthelet E, Tran E, Hamilton S, Wu J, Eskander A, Higgins K, Karam I, Poon I, Husain Z, Enepekides D, Hier M, Sultanem K, Richardson K, Mlynarek A, Johnson-Obaseki S, Odell M, Bayley A, Dowthwaite S, Jackson JE, Dzienis M, O'Neil J, Chandarana S, Banerjee R, Hart R, Chung J, Tenenholtz T, Krishnan S, Le H, Yoo J, Mendez A, Winquist E, Kuruvilla S, Stewart P, Warner A, Mitchell S, Chen J, Parker C, Wehrli B, Kwan K, Theurer J, Sathya J, Hammond JA, Read N, Venkatesan V, MacNeil SD, Fung K, Nichols AC
JAMA Oncol 2022 Jun 1;8(6):1-7. doi: 10.1001/jamaoncol.2022.0615. PMID: 35482348Free PMC Article
Randomized Trial of Radiotherapy Versus Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Long-Term Results of the ORATOR Trial.
Nichols AC, Theurer J, Prisman E, Read N, Berthelet E, Tran E, Fung K, de Almeida JR, Bayley A, Goldstein DP, Hier M, Sultanem K, Richardson K, Mlynarek A, Krishnan S, Le H, Yoo J, MacNeil SD, Winquist E, Hammond JA, Venkatesan V, Kuruvilla S, Warner A, Mitchell S, Chen J, Corsten M, Johnson-Obaseki S, Odell M, Parker C, Wehrli B, Kwan K, Palma DA
J Clin Oncol 2022 Mar 10;40(8):866-875. Epub 2022 Jan 7 doi: 10.1200/JCO.21.01961. PMID: 34995124
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Oral and oropharyngeal cancer.
Huber MA, Tantiwongkosi B
Med Clin North Am 2014 Nov;98(6):1299-321. Epub 2014 Sep 20 doi: 10.1016/j.mcna.2014.08.005. PMID: 25443678
Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma.
Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J, Calais G
J Clin Oncol 2004 Jan 1;22(1):69-76. Epub 2003 Dec 2 doi: 10.1200/JCO.2004.08.021. PMID: 14657228

Prognosis

Flashback Foreword: Human Papillomavirus and Incidence and Survival of Oropharyngeal Cancers.
Gillison ML
J Clin Oncol 2023 Jun 10;41(17):3079-3080. doi: 10.1200/JCO.23.00224. PMID: 37285652
Current state of play for HPV-positive oropharyngeal cancers.
Deutsch F, Regina Bullen I, Nguyen K, Tran NH, Elliott M, Tran N
Cancer Treat Rev 2022 Nov;110:102439. Epub 2022 Jul 26 doi: 10.1016/j.ctrv.2022.102439. PMID: 36126367
Reduced-Dose Radiation Therapy for HPV-Associated Oropharyngeal Carcinoma (NRG Oncology HN002).
Yom SS, Torres-Saavedra P, Caudell JJ, Waldron JN, Gillison ML, Xia P, Truong MT, Kong C, Jordan R, Subramaniam RM, Yao M, Chung CH, Geiger JL, Chan JW, O'Sullivan B, Blakaj DM, Mell LK, Thorstad WL, Jones CU, Banerjee RN, Lominska C, Le QT
J Clin Oncol 2021 Mar 20;39(9):956-965. Epub 2021 Jan 28 doi: 10.1200/JCO.20.03128. PMID: 33507809Free PMC Article
Oral and oropharyngeal cancer.
Huber MA, Tantiwongkosi B
Med Clin North Am 2014 Nov;98(6):1299-321. Epub 2014 Sep 20 doi: 10.1016/j.mcna.2014.08.005. PMID: 25443678
HPV-associated head and neck cancer: a virus-related cancer epidemic.
Marur S, D'Souza G, Westra WH, Forastiere AA
Lancet Oncol 2010 Aug;11(8):781-9. Epub 2010 May 5 doi: 10.1016/S1470-2045(10)70017-6. PMID: 20451455Free PMC Article

Clinical prediction guides

Prognostic and Predictive Clinical and Biological Factors in HPV Malignancies.
Sud S, Weiner AA, Wang AZ, Gupta GP, Shen CJ
Semin Radiat Oncol 2021 Oct;31(4):309-323. doi: 10.1016/j.semradonc.2021.03.008. PMID: 34455986
MRI Dynamic Contrast Imaging of Oral Cavity and Oropharyngeal Tumors.
Sideras P, Singh G
Top Magn Reson Imaging 2021 Apr 1;30(2):97-104. doi: 10.1097/RMR.0000000000000283. PMID: 33828061
Radiotherapy in Metastatic Oropharyngeal Cancer.
Nguy S, Oh C, Karp JM, Wu SP, Li Z, Persky MJ, Hu KS, Givi B, Tam MM
Laryngoscope 2021 Jun;131(6):E1847-E1853. Epub 2020 Nov 3 doi: 10.1002/lary.29245. PMID: 33141455
Quality of life in oropharyngeal cancer: a structured review of the literature.
Roets E, Tukanova K, Govarts A, Specenier P
Support Care Cancer 2018 Aug;26(8):2511-2518. Epub 2018 May 3 doi: 10.1007/s00520-018-4227-9. PMID: 29725802
A PET-based nomogram for oropharyngeal cancers.
Castelli J, Depeursinge A, Ndoh V, Prior JO, Ozsahin M, Devillers A, Bouchaab H, Chajon E, de Crevoisier R, Scher N, Jegoux F, Laguerre B, De Bari B, Bourhis J
Eur J Cancer 2017 Apr;75:222-230. Epub 2017 Feb 24 doi: 10.1016/j.ejca.2017.01.018. PMID: 28237868

Recent systematic reviews

Global prevalence of human papillomavirus-related oral and oropharyngeal squamous cell carcinomas: a systematic review and meta-analysis.
Fonsêca TC, Jural LA, Marañón-Vásquez GA, Magno MB, Roza ALOC, Ferreira DMTP, Maia LC, Romañach MJ, Agostini M, Abrahão AC
Clin Oral Investig 2023 Dec 30;28(1):62. doi: 10.1007/s00784-023-05425-0. PMID: 38158517
Dental extraction, intensity-modulated radiotherapy of head and neck cancer, and osteoradionecrosis : A systematic review and meta-analysis.
Balermpas P, van Timmeren JE, Knierim DJ, Guckenberger M, Ciernik IF
Strahlenther Onkol 2022 Mar;198(3):219-228. Epub 2022 Jan 14 doi: 10.1007/s00066-021-01896-w. PMID: 35029717Free PMC Article
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Swallowing exercises for head and neck cancer patients: A systematic review and meta-analysis of randomized control trials.
Banda KJ, Chu H, Kao CC, Voss J, Chiu HL, Chang PC, Chen R, Chou KR
Int J Nurs Stud 2021 Feb;114:103827. Epub 2020 Nov 11 doi: 10.1016/j.ijnurstu.2020.103827. PMID: 33352439
Association between physical activity and digestive-system cancer: An updated systematic review and meta-analysis.
Xie F, You Y, Huang J, Guan C, Chen Z, Fang M, Yao F, Han J
J Sport Health Sci 2021 Jan;10(1):4-13. Epub 2020 Sep 30 doi: 10.1016/j.jshs.2020.09.009. PMID: 33010525Free PMC Article

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