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Metastatic Malignant Neoplasm in the Neck

MedGen UID:
146889
•Concept ID:
C0684817
•
Neoplastic Process
Synonyms: Metastases to Neck; Metastasis to the Neck; Metastatic malignant neoplasm of neck; Metastatic malignant neoplasm to neck; Metastatic Malignant Neoplasm to the Neck; Metastatic Neoplasm to the Neck; Metastatic Tumor to the Neck; Secondary malignant neoplasm of neck
SNOMED CT: Secondary malignant neoplasm of neck (94441008); Metastatic malignant neoplasm to neck (94441008); Metastatic malignant neoplasm of neck (94441008)

Definition

A malignant neoplasm that has spread to the neck region from a malignancy in a local or distant anatomic site. [from NCI]

Professional guidelines

PubMed

Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

Upper-neck irradiation versus standard whole-neck irradiation in nasopharyngeal carcinoma: A systematic review and meta-analysis.
De Felice F, Marchetti C, Serpone M, Camarda A, Vischioni B, Ingargiola R, Musio D, Orlandi E
Tumori 2023 Dec;109(6):529-536. Epub 2023 Feb 16 doi: 10.1177/03008916231154765. PMID: 36794709
Angiosarcomas of the head and neck: Impact of large data analysis on clinical management.
Wreesmann VB, Oomen KP, Brennan PA
J Oral Pathol Med 2022 Nov;51(10):904-910. Epub 2022 Sep 20 doi: 10.1111/jop.13354. PMID: 36066314
Thyroidectomy without Radioiodine in Patients with Low-Risk Thyroid Cancer.
Leboulleux S, Bournaud C, Chougnet CN, Zerdoud S, Al Ghuzlan A, Catargi B, Do Cao C, Kelly A, Barge ML, Lacroix L, Dygai I, Vera P, Rusu D, Schneegans O, Benisvy D, Klein M, Roux J, Eberle MC, Bastie D, Nascimento C, Giraudet AL, Le Moullec N, Bardet S, Drui D, Roudaut N, Godbert Y, Morel O, Drutel A, Lamartina L, Schvartz C, Velayoudom FL, Schlumberger MJ, Leenhardt L, Borget I
N Engl J Med 2022 Mar 10;386(10):923-932. doi: 10.1056/NEJMoa2111953. PMID: 35263518
Management of lateral neck nodes in common and aggressive variants of thyroid cancer.
Shaha AR
Curr Opin Otolaryngol Head Neck Surg 2022 Apr 1;30(2):130-136. doi: 10.1097/MOO.0000000000000790. PMID: 35255050
Assessment of Neck Lumps in Relation to Dentistry.
Siddiqui S, Osher J
Prim Dent J 2017 Aug 31;6(3):44-50. doi: 10.1308/205016817821931079. PMID: 30188316

Diagnosis

Current topics and management of head and neck sarcomas.
Kobayashi K, Hanai N, Yoshimoto S, Saito Y, Homma A
Jpn J Clin Oncol 2023 Aug 30;53(9):743-756. doi: 10.1093/jjco/hyad048. PMID: 37309253Free PMC Article
Autoimmune disease of head and neck, imaging, and clinical review.
Paydar A, Jenner ZB, Simkins TJ, Chang YM, Hacein-Bey L, Ozturk A, Birkeland A, Assadsangabi R, Raslan O, Shadmani G, Apperson M, Ivanovic V
Neuroradiol J 2022 Oct;35(5):545-562. Epub 2022 May 22 doi: 10.1177/19714009221100983. PMID: 35603923Free PMC Article
Classification and Staging of Melanoma in the Head and Neck.
Bunnell AM, Nedrud SM, Fernandes RP
Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234. doi: 10.1016/j.coms.2021.12.001. PMID: 35491079
Lymph Node Dissection: Principles and Postoperative Imaging.
Joyner D, Rizvi T, Kalelioglu T, Jameson MJ, Mukherjee S
Neuroimaging Clin N Am 2022 Feb;32(1):19-36. doi: 10.1016/j.nic.2021.09.001. PMID: 34809838
The neck.
Mancuso AA, Dillon WP
Radiol Clin North Am 1989 Mar;27(2):407-34. PMID: 2645610

Therapy

Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group.
Lacas B, Carmel A, Landais C, Wong SJ, Licitra L, Tobias JS, Burtness B, Ghi MG, Cohen EEW, Grau C, Wolf G, Hitt R, Corvò R, Budach V, Kumar S, Laskar SG, Mazeron JJ, Zhong LP, Dobrowsky W, Ghadjar P, Fallai C, Zakotnik B, Sharma A, Bensadoun RJ, Ruo Redda MG, Racadot S, Fountzilas G, Brizel D, Rovea P, Argiris A, Nagy ZT, Lee JW, Fortpied C, Harris J, Bourhis J, Aupérin A, Blanchard P, Pignon JP; MACH-NC Collaborative Group
Radiother Oncol 2021 Mar;156:281-293. Epub 2021 Jan 27 doi: 10.1016/j.radonc.2021.01.013. PMID: 33515668Free PMC Article
Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study.
Cohen EEW, Soulières D, Le Tourneau C, Dinis J, Licitra L, Ahn MJ, Soria A, Machiels JP, Mach N, Mehra R, Burtness B, Zhang P, Cheng J, Swaby RF, Harrington KJ; KEYNOTE-040 investigators
Lancet 2019 Jan 12;393(10167):156-167. Epub 2018 Nov 30 doi: 10.1016/S0140-6736(18)31999-8. PMID: 30509740
Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients.
Pignon JP, le Maître A, Maillard E, Bourhis J; MACH-NC Collaborative Group
Radiother Oncol 2009 Jul;92(1):4-14. Epub 2009 May 14 doi: 10.1016/j.radonc.2009.04.014. PMID: 19446902
Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501).
Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL
Head Neck 2005 Oct;27(10):843-50. doi: 10.1002/hed.20279. PMID: 16161069

Prognosis

Angiosarcomas of the head and neck: Impact of large data analysis on clinical management.
Wreesmann VB, Oomen KP, Brennan PA
J Oral Pathol Med 2022 Nov;51(10):904-910. Epub 2022 Sep 20 doi: 10.1111/jop.13354. PMID: 36066314
Classification and Staging of Melanoma in the Head and Neck.
Bunnell AM, Nedrud SM, Fernandes RP
Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234. doi: 10.1016/j.coms.2021.12.001. PMID: 35491079
Thyroidectomy without Radioiodine in Patients with Low-Risk Thyroid Cancer.
Leboulleux S, Bournaud C, Chougnet CN, Zerdoud S, Al Ghuzlan A, Catargi B, Do Cao C, Kelly A, Barge ML, Lacroix L, Dygai I, Vera P, Rusu D, Schneegans O, Benisvy D, Klein M, Roux J, Eberle MC, Bastie D, Nascimento C, Giraudet AL, Le Moullec N, Bardet S, Drui D, Roudaut N, Godbert Y, Morel O, Drutel A, Lamartina L, Schvartz C, Velayoudom FL, Schlumberger MJ, Leenhardt L, Borget I
N Engl J Med 2022 Mar 10;386(10):923-932. doi: 10.1056/NEJMoa2111953. PMID: 35263518
Diffusion-Weighted Imaging in Head and Neck Cancer: Technique, Limitations, and Applications.
Connolly M, Srinivasan A
Magn Reson Imaging Clin N Am 2018 Feb;26(1):121-133. Epub 2017 Oct 14 doi: 10.1016/j.mric.2017.08.011. PMID: 29128000
Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial.
Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, Heath K, McClanahan T, Lunceford J, Gause C, Cheng JD, Chow LQ
Lancet Oncol 2016 Jul;17(7):956-965. Epub 2016 May 27 doi: 10.1016/S1470-2045(16)30066-3. PMID: 27247226

Clinical prediction guides

Classification and Staging of Melanoma in the Head and Neck.
Bunnell AM, Nedrud SM, Fernandes RP
Oral Maxillofac Surg Clin North Am 2022 May;34(2):221-234. doi: 10.1016/j.coms.2021.12.001. PMID: 35491079
Cervical Fibrosis as a Predictor of Dysphagia.
Nachalon Y, Nativ-Zeltzer N, Evangelista LM, Dhar SI, Lin SJ, Shen SC, Belafsky PC
Laryngoscope 2021 Mar;131(3):548-552. Epub 2020 Jul 6 doi: 10.1002/lary.28880. PMID: 32628787
Diffusion-Weighted Imaging in Head and Neck Cancer: Technique, Limitations, and Applications.
Connolly M, Srinivasan A
Magn Reson Imaging Clin N Am 2018 Feb;26(1):121-133. Epub 2017 Oct 14 doi: 10.1016/j.mric.2017.08.011. PMID: 29128000
Cervicothoracoscopic Approach in Esophagectomy.
Okamura A, Watanabe M, Imamura Y, Hayami M, Yuda M, Yamashita K, Shoji Y, Mine S
Ann Surg Oncol 2018 Jan;25(1):333. Epub 2017 Oct 30 doi: 10.1245/s10434-017-6119-5. PMID: 29086127
Nodal metastases: predictive factors.
Kowalski LP, Medina JE
Otolaryngol Clin North Am 1998 Aug;31(4):621-37. doi: 10.1016/s0030-6665(05)70076-1. PMID: 9687325

Recent systematic reviews

Hyperbaric oxygen therapy for late radiation tissue injury.
Lin ZC, Bennett MH, Hawkins GC, Azzopardi CP, Feldmeier J, Smee R, Milross C
Cochrane Database Syst Rev 2023 Aug 15;8(8):CD005005. doi: 10.1002/14651858.CD005005.pub5. PMID: 37585677Free PMC Article
Cannabis-based medicines and medical cannabis for adults with cancer pain.
Häuser W, Welsch P, Radbruch L, Fisher E, Bell RF, Moore RA
Cochrane Database Syst Rev 2023 Jun 5;6(6):CD014915. doi: 10.1002/14651858.CD014915.pub2. PMID: 37283486Free PMC Article
Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer.
Bible KC, Kebebew E, Brierley J, Brito JP, Cabanillas ME, Clark TJ Jr, Di Cristofano A, Foote R, Giordano T, Kasperbauer J, Newbold K, Nikiforov YE, Randolph G, Rosenthal MS, Sawka AM, Shah M, Shaha A, Smallridge R, Wong-Clark CK
Thyroid 2021 Mar;31(3):337-386. doi: 10.1089/thy.2020.0944. PMID: 33728999Free PMC Article
Prevalence of pain in patients with cancer: a systematic review of the past 40 years.
van den Beuken-van Everdingen MH, de Rijke JM, Kessels AG, Schouten HC, van Kleef M, Patijn J
Ann Oncol 2007 Sep;18(9):1437-49. Epub 2007 Mar 12 doi: 10.1093/annonc/mdm056. PMID: 17355955

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