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Recurrent Leukemia

MedGen UID:
1652854
•Concept ID:
C0920028
•
Neoplastic Process

Definition

The reemergence of leukemia after a period of remission. [from NCI]

Professional guidelines

PubMed

Neoplastic meningitis: diagnosis and treatment considerations.
Blaney SM, Poplack DG
Med Oncol 2000 Aug;17(3):151-62. doi: 10.1007/BF02780522. PMID: 10962524
Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia.
Sullivan KM, Weiden PL, Storb R, Witherspoon RP, Fefer A, Fisher L, Buckner CD, Anasetti C, Appelbaum FR, Badger C
Blood 1989 May 1;73(6):1720-8. PMID: 2653460
Facial paralysis in children: differential diagnosis.
May M, Fria TJ, Blumenthal F, Curtin H
Otolaryngol Head Neck Surg 1981 Sep-Oct;89(5):841-8. doi: 10.1177/019459988108900528. PMID: 6799919

Recent clinical studies

Etiology

Relapsed acute lymphoblastic leukemia: Is it crucial to achieve molecular remission prior to transplant?
Eapen M
Best Pract Res Clin Haematol 2017 Dec;30(4):317-319. Epub 2017 Sep 22 doi: 10.1016/j.beha.2017.09.007. PMID: 29156202
Early identification and management of graft failure after unrelated cord blood transplantation.
Chan KW, Grimley MS, Taylor C, Wall DA
Bone Marrow Transplant 2008 Jul;42(1):35-41. Epub 2008 Mar 10 doi: 10.1038/bmt.2008.40. PMID: 18332909
Post-radiation glioma in a child. Case report and review of the literature.
Palma L, Vagnozzi R, Annino L, Ciapetta P, Maleci A, Cantore G
Childs Nerv Syst 1988 Oct;4(5):296-301. PMID: 3072075
Autologous unpurged bone marrow transplantation for acute non-lymphoblastic leukaemia in first complete remission.
Carella AM, Gaozza E, Santini G, Martinengo M, Pungolino E, Piatti G, Congiu A, Nati S, Carlier P, Giordano D
Bone Marrow Transplant 1988 Nov;3(6):537-41. PMID: 3063322
Allogeneic marrow transplantation for acute nonlymphoblastic leukemia after first relapse.
Appelbaum FR, Clift RA, Buckner CD, Stewart P, Storb R, Sullivan KM, Thomas ED
Blood 1983 May;61(5):949-53. PMID: 6338977

Diagnosis

Relapsed acute lymphoblastic leukemia: Is it crucial to achieve molecular remission prior to transplant?
Eapen M
Best Pract Res Clin Haematol 2017 Dec;30(4):317-319. Epub 2017 Sep 22 doi: 10.1016/j.beha.2017.09.007. PMID: 29156202
Analysis of chimerism within specific leukocyte subsets for detection of residual or recurrent leukemia in pediatric patients after allogeneic stem cell transplantation.
Lion T, Daxberger H, Dubovsky J, Filipcik P, Fritsch G, Printz D, Peters C, Matthes-Martin S, Lawitschka A, Gadner H
Leukemia 2001 Feb;15(2):307-10. doi: 10.1038/sj.leu.2402017. PMID: 11236951
Herpes simplex thymidine kinase (HStk) transgenic donor lymphocytes.
Burt RK, Drobyski WR, Traynor AE, Link CJ Jr
Bone Marrow Transplant 1999 Nov;24(10):1043-51. doi: 10.1038/sj.bmt.1702020. PMID: 10578153
Identification of leukemic cells in the cerebrospinal fluid from children with acute lymphoblastic leukemia: advances and dilemmas.
Lauer SJ, Kirchner PA, Camitta BM
Am J Pediatr Hematol Oncol 1989 Spring;11(1):64-73. doi: 10.1097/00043426-198921000-00016. PMID: 2653078
Obstructive jaundice after bone marrow transplantation.
Lipshutz GR, Katon RM, Lee TG
Gastroenterology 1977 Sep;73(3):565-9. PMID: 19336

Therapy

HA-1-targeted T-cell receptor T-cell therapy for recurrent leukemia after hematopoietic stem cell transplantation.
Krakow EF, Brault M, Summers C, Cunningham TM, Biernacki MA, Black RG, Woodward KB, Vartanian N, Kanaan SB, Yeh AC, Dossa RG, Bar M, Cassaday RD, Dahlberg A, Till BG, Denker AE, Yeung CCS, Gooley TA, Maloney DG, Riddell SR, Greenberg PD, Chapuis AG, Newell EW, Furlan SN, Bleakley M
Blood 2024 Sep 5;144(10):1069-1082. doi: 10.1182/blood.2024024105. PMID: 38683966Free PMC Article
Relapsed acute lymphoblastic leukemia: Is it crucial to achieve molecular remission prior to transplant?
Eapen M
Best Pract Res Clin Haematol 2017 Dec;30(4):317-319. Epub 2017 Sep 22 doi: 10.1016/j.beha.2017.09.007. PMID: 29156202
Early identification and management of graft failure after unrelated cord blood transplantation.
Chan KW, Grimley MS, Taylor C, Wall DA
Bone Marrow Transplant 2008 Jul;42(1):35-41. Epub 2008 Mar 10 doi: 10.1038/bmt.2008.40. PMID: 18332909
Acute basophilic leukemia.
Giagounidis AA, Hildebrandt B, Heinsch M, Germing U, Aivado M, Aul C
Eur J Haematol 2001 Aug;67(2):72-6. doi: 10.1034/j.1600-0609.2001.t01-1-00487.x. PMID: 11722593
Herpes simplex thymidine kinase (HStk) transgenic donor lymphocytes.
Burt RK, Drobyski WR, Traynor AE, Link CJ Jr
Bone Marrow Transplant 1999 Nov;24(10):1043-51. doi: 10.1038/sj.bmt.1702020. PMID: 10578153

Prognosis

Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.
Yuki H, Kikuzato K, Koda Y, Mikuni J, Tomabechi Y, Kukimoto-Niino M, Tanaka A, Shirai F, Shirouzu M, Koyama H, Honma T
Bioorg Med Chem 2017 Aug 15;25(16):4259-4264. Epub 2017 Jun 16 doi: 10.1016/j.bmc.2017.05.053. PMID: 28662963
Early identification and management of graft failure after unrelated cord blood transplantation.
Chan KW, Grimley MS, Taylor C, Wall DA
Bone Marrow Transplant 2008 Jul;42(1):35-41. Epub 2008 Mar 10 doi: 10.1038/bmt.2008.40. PMID: 18332909
Acute basophilic leukemia.
Giagounidis AA, Hildebrandt B, Heinsch M, Germing U, Aivado M, Aul C
Eur J Haematol 2001 Aug;67(2):72-6. doi: 10.1034/j.1600-0609.2001.t01-1-00487.x. PMID: 11722593
Allogeneic liver transplantation for hepatic veno-occlusive disease after bone marrow transplantation--clinical and immunological considerations.
Schlitt HJ, Tischler HJ, Ringe B, Raddatz G, Maschek H, Dietrich H, Kuse E, Pichlmayr R, Link H
Bone Marrow Transplant 1995 Sep;16(3):473-8. PMID: 8535323
Autologous unpurged bone marrow transplantation for acute non-lymphoblastic leukaemia in first complete remission.
Carella AM, Gaozza E, Santini G, Martinengo M, Pungolino E, Piatti G, Congiu A, Nati S, Carlier P, Giordano D
Bone Marrow Transplant 1988 Nov;3(6):537-41. PMID: 3063322

Clinical prediction guides

Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.
Yuki H, Kikuzato K, Koda Y, Mikuni J, Tomabechi Y, Kukimoto-Niino M, Tanaka A, Shirai F, Shirouzu M, Koyama H, Honma T
Bioorg Med Chem 2017 Aug 15;25(16):4259-4264. Epub 2017 Jun 16 doi: 10.1016/j.bmc.2017.05.053. PMID: 28662963
Antibody-targeted chemotherapy of acute myeloid leukemia using gemtuzumab ozogamicin (Mylotarg).
Sievers EL
Blood Cells Mol Dis 2003 Jul-Aug;31(1):7-10. doi: 10.1016/s1079-9796(03)00117-7. PMID: 12850477
Acute basophilic leukemia.
Giagounidis AA, Hildebrandt B, Heinsch M, Germing U, Aivado M, Aul C
Eur J Haematol 2001 Aug;67(2):72-6. doi: 10.1034/j.1600-0609.2001.t01-1-00487.x. PMID: 11722593
Donor leukocyte transfusions for leukemic relapse.
van Rhee F, Kolb HJ
Curr Opin Hematol 1995 Nov;2(6):423-30. doi: 10.1097/00062752-199502060-00005. PMID: 9372031
Bone marrow transplantation between mixed lymphocyte culture-reactive individuals.
Gale RP, Opelz G, Sparkes R
Transplantation 1975 Sep;20(3):194-7. doi: 10.1097/00007890-197509000-00003. PMID: 125939

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