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Recurrent Childhood Malignant Neoplasm

MedGen UID:: 1703882
•Concept ID:: C5206756
•: Neoplastic Process

Definition

The reemergence of a childhood malignant neoplasm after a period of remission. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRecurrent Childhood Malignant Neoplasm

Pathological process
- Disease
  - Neoplasm
    - Neoplasm by Special Category
      - Childhood neoplasm
        Childhood malignant neoplasm
        Recurrent Childhood Malignant Neoplasm
        Recurrent Childhood Acute Lymphoblastic Leukemia
        Recurrent Childhood T Acute Lymphoblastic Leukemia
        Recurrent Childhood Acute Myeloid Leukemia
        Recurrent Childhood Anaplastic Astrocytoma
        Recurrent Childhood Anaplastic Oligoastrocytoma
        Recurrent Childhood Anaplastic Oligodendroglioma
        Recurrent Childhood Central Nervous System Embryonal Neoplasm
        Recurrent Childhood Medulloblastoma
        Recurrent Childhood Pineoblastoma
        Recurrent Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified
        Recurrent Childhood Glioblastoma
        Recurrent Childhood Giant Cell Glioblastoma
        Recurrent Childhood Gliosarcoma
        Recurrent Childhood Gliomatosis Cerebri
        Recurrent Childhood Hodgkin Lymphoma
        Recurrent Childhood Malignant Germ Cell Tumor
        Recurrent Childhood Malignant Liver Neoplasm
        Recurrent Childhood Hepatocellular Carcinoma
        Recurrent Hepatoblastoma
        Recurrent Childhood Malignant Solid Neoplasm
        Recurrent Childhood Non-Hodgkin Lymphoma
        Recurrent Childhood Anaplastic Large Cell Lymphoma
        Recurrent Childhood Burkitt Lymphoma
        Recurrent Childhood Grade III Lymphomatoid Granulomatosis
        Recurrent Childhood Lymphoblastic Lymphoma
        Recurrent Childhood Soft Tissue Sarcoma
        Recurrent Childhood Rhabdomyosarcoma
        Recurrent Extrarenal Rhabdoid Tumor of the Ovary
        Recurrent Rhabdoid Tumor of the Kidney

Professional guidelines

PubMed

Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement.

Boguszewski MCS, Boguszewski CL, Chemaitilly W, Cohen LE, Gebauer J, Higham C, Hoffman AR, Polak M, Yuen KCJ, Alos N, Antal Z, Bidlingmaier M, Biller BMK, Brabant G, Choong CSY, Cianfarani S, Clayton PE, Coutant R, Cardoso-Demartini AA, Fernandez A, Grimberg A, Guðmundsson K, Guevara-Aguirre J, Ho KKY, Horikawa R, Isidori AM, Jørgensen JOL, Kamenicky P, Karavitaki N, Kopchick JJ, Lodish M, Luo X, McCormack AI, Meacham L, Melmed S, Mostoufi Moab S, Müller HL, Neggers SJCMM, Aguiar Oliveira MH, Ozono K, Pennisi PA, Popovic V, Radovick S, Savendahl L, Touraine P, van Santen HM, Johannsson G
Eur J Endocrinol 2022 Apr 21;186(6):P35-P52. doi: 10.1530/EJE-21-1186. PMID: 35319491 Free PMC Article

Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.

Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590 Free PMC Article

Treatment of Childhood Acute Lymphoblastic Leukemia: Prognostic Factors and Clinical Advances.

Vrooman LM, Silverman LB
Curr Hematol Malig Rep 2016 Oct;11(5):385-94. doi: 10.1007/s11899-016-0337-y. PMID: 27502091

See all (388)

Recent clinical studies

Etiology

Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions.

Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325 Free PMC Article

Anti-GD2 Directed Immunotherapy for High-Risk and Metastatic Neuroblastoma.

Chan GC, Chan CM
Biomolecules 2022 Feb 24;12(3) doi: 10.3390/biom12030358. PMID: 35327550 Free PMC Article

The genomic landscape of pediatric cancers: Implications for diagnosis and treatment.

Sweet-Cordero EA, Biegel JA
Science 2019 Mar 15;363(6432):1170-1175. doi: 10.1126/science.aaw3535. PMID: 30872516 Free PMC Article

Clinical presentation of childhood leukaemia: a systematic review and meta-analysis.

Clarke RT, Van den Bruel A, Bankhead C, Mitchell CD, Phillips B, Thompson MJ
Arch Dis Child 2016 Oct;101(10):894-901. doi: 10.1136/archdischild-2016-311251. PMID: 27647842

Treatment of Childhood Acute Lymphoblastic Leukemia: Prognostic Factors and Clinical Advances.

Vrooman LM, Silverman LB
Curr Hematol Malig Rep 2016 Oct;11(5):385-94. doi: 10.1007/s11899-016-0337-y. PMID: 27502091

See all (2556)

Diagnosis

Integrating RNA-seq and scRNA-seq to explore the biological significance of NAD + metabolism-related genes in the initial diagnosis and relapse of childhood B-cell acute lymphoblastic leukemia.

Lin C, Xu JQ, Zhong GC, Chen H, Xue HM, Yang M, Chen C
Front Immunol 2022;13:1043111. Epub 2022 Nov 11 doi: 10.3389/fimmu.2022.1043111. PMID: 36439178 Free PMC Article

How I treat relapsed acute lymphoblastic leukemia in the pediatric population.

Hunger SP, Raetz EA
Blood 2020 Oct 15;136(16):1803-1812. doi: 10.1182/blood.2019004043. PMID: 32589723

The genomic landscape of pediatric cancers: Implications for diagnosis and treatment.

Sweet-Cordero EA, Biegel JA
Science 2019 Mar 15;363(6432):1170-1175. doi: 10.1126/science.aaw3535. PMID: 30872516 Free PMC Article

Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.

Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797

Clinical presentation of childhood leukaemia: a systematic review and meta-analysis.

Clarke RT, Van den Bruel A, Bankhead C, Mitchell CD, Phillips B, Thompson MJ
Arch Dis Child 2016 Oct;101(10):894-901. doi: 10.1136/archdischild-2016-311251. PMID: 27647842

See all (2547)

Therapy

Three-Year Update of Tisagenlecleucel in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia in the ELIANA Trial.

Laetsch TW, Maude SL, Rives S, Hiramatsu H, Bittencourt H, Bader P, Baruchel A, Boyer M, De Moerloose B, Qayed M, Buechner J, Pulsipher MA, Myers GD, Stefanski HE, Martin PL, Nemecek E, Peters C, Yanik G, Khaw SL, Davis KL, Krueger J, Balduzzi A, Boissel N, Tiwari R, O'Donovan D, Grupp SA
J Clin Oncol 2023 Mar 20;41(9):1664-1669. Epub 2022 Nov 18 doi: 10.1200/JCO.22.00642. PMID: 36399695 Free PMC Article

Anti-GD2 Directed Immunotherapy for High-Risk and Metastatic Neuroblastoma.

Chan GC, Chan CM
Biomolecules 2022 Feb 24;12(3) doi: 10.3390/biom12030358. PMID: 35327550 Free PMC Article

How I treat relapsed acute lymphoblastic leukemia in the pediatric population.

Hunger SP, Raetz EA
Blood 2020 Oct 15;136(16):1803-1812. doi: 10.1182/blood.2019004043. PMID: 32589723

Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.

Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590 Free PMC Article

Treatment of Childhood Acute Lymphoblastic Leukemia: Prognostic Factors and Clinical Advances.

Vrooman LM, Silverman LB
Curr Hematol Malig Rep 2016 Oct;11(5):385-94. doi: 10.1007/s11899-016-0337-y. PMID: 27502091

See all (1636)

Prognosis

Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions.

Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325 Free PMC Article

How I treat relapsed acute lymphoblastic leukemia in the pediatric population.

Hunger SP, Raetz EA
Blood 2020 Oct 15;136(16):1803-1812. doi: 10.1182/blood.2019004043. PMID: 32589723

Late mortality and chronic health conditions in long-term survivors of early-adolescent and young adult cancers: a retrospective cohort analysis from the Childhood Cancer Survivor Study.

Suh E, Stratton KL, Leisenring WM, Nathan PC, Ford JS, Freyer DR, McNeer JL, Stock W, Stovall M, Krull KR, Sklar CA, Neglia JP, Armstrong GT, Oeffinger KC, Robison LL, Henderson TO
Lancet Oncol 2020 Mar;21(3):421-435. Epub 2020 Feb 14 doi: 10.1016/S1470-2045(19)30800-9. PMID: 32066543 Free PMC Article

Improved CNS Control of Childhood Acute Lymphoblastic Leukemia Without Cranial Irradiation: St Jude Total Therapy Study 16.

Jeha S, Pei D, Choi J, Cheng C, Sandlund JT, Coustan-Smith E, Campana D, Inaba H, Rubnitz JE, Ribeiro RC, Gruber TA, Raimondi SC, Khan RB, Yang JJ, Mullighan CG, Downing JR, Evans WE, Relling MV, Pui CH
J Clin Oncol 2019 Dec 10;37(35):3377-3391. Epub 2019 Oct 28 doi: 10.1200/JCO.19.01692. PMID: 31657981 Free PMC Article

Wilms tumor.

Green DM, D'Angio GJ, Beckwith JB, Breslow NE, Grundy PE, Ritchey ML, Thomas PR
CA Cancer J Clin 1996 Jan-Feb;46(1):46-63. doi: 10.3322/canjclin.46.1.46. PMID: 8548525

See all (2295)

Clinical prediction guides

Childhood-onset Craniopharyngioma.

Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900

How I treat relapsed acute lymphoblastic leukemia in the pediatric population.

Hunger SP, Raetz EA
Blood 2020 Oct 15;136(16):1803-1812. doi: 10.1182/blood.2019004043. PMID: 32589723

Pilomatrixoma: A Comprehensive Review of the Literature.

Jones CD, Ho W, Robertson BF, Gunn E, Morley S
Am J Dermatopathol 2018 Sep;40(9):631-641. doi: 10.1097/DAD.0000000000001118. PMID: 30119102

Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.

Pui CH, Yang JJ, Hunger SP, Pieters R, Schrappe M, Biondi A, Vora A, Baruchel A, Silverman LB, Schmiegelow K, Escherich G, Horibe K, Benoit YC, Izraeli S, Yeoh AE, Liang DC, Downing JR, Evans WE, Relling MV, Mullighan CG
J Clin Oncol 2015 Sep 20;33(27):2938-48. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.1636. PMID: 26304874 Free PMC Article

Craniopharyngiomas.

Karavitaki N, Cudlip S, Adams CB, Wass JA
Endocr Rev 2006 Jun;27(4):371-97. Epub 2006 Mar 16 doi: 10.1210/er.2006-0002. PMID: 16543382

See all (1147)

Recent systematic reviews

Head and neck lipoblastoma in children: A case report and systematic review.

Tyra J, Mierzwińska-Dolny P, Fishman AJ, Mierzwiński J
Int J Pediatr Otorhinolaryngol 2023 Oct;173:111699. Epub 2023 Aug 16 doi: 10.1016/j.ijporl.2023.111699. PMID: 37597314

Systematic Review and Meta-analysis of CD19-Specific CAR-T Cell Therapy in Relapsed/Refractory Acute Lymphoblastic Leukemia in the Pediatric and Young Adult Population: Safety and Efficacy Outcomes.

Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914

Homeopathic Preparations for Preventing and Treating Acute Upper Respiratory Tract Infections in Children: A Systematic Review and Meta-Analysis.

King D, Hawke K, McGuire TM, van Driel M
Acad Pediatr 2021 Mar;21(2):211-220. Epub 2020 Jul 19 doi: 10.1016/j.acap.2020.07.016. PMID: 32698039

Clinical presentation of childhood leukaemia: a systematic review and meta-analysis.

Clarke RT, Van den Bruel A, Bankhead C, Mitchell CD, Phillips B, Thompson MJ
Arch Dis Child 2016 Oct;101(10):894-901. doi: 10.1136/archdischild-2016-311251. PMID: 27647842

Biomarkers for Wilms Tumor: A Systematic Review.

Cone EB, Dalton SS, Van Noord M, Tracy ET, Rice HE, Routh JC
J Urol 2016 Nov;196(5):1530-1535. Epub 2016 May 31 doi: 10.1016/j.juro.2016.05.100. PMID: 27259655 Free PMC Article

See all (34)

MedGen

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Recurrent Childhood Malignant Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity