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Advanced Squamous Cell Carcinoma

MedGen UID:
1706788
•Concept ID:
C5206722
•
Neoplastic Process

Definition

Squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Treatment Considerations for Patients With Advanced Squamous Cell Carcinoma of the Lung.
Santos ES, Rodriguez E
Clin Lung Cancer 2022 Sep;23(6):457-466. Epub 2022 Jun 21 doi: 10.1016/j.cllc.2022.06.002. PMID: 35872084
New Emerging Treatment Options for Advanced Basal Cell Carcinoma and Squamous Cell Carcinoma.
Villani A, Potestio L, Fabbrocini G, Scalvenzi M
Adv Ther 2022 Mar;39(3):1164-1178. Epub 2022 Jan 28 doi: 10.1007/s12325-022-02044-1. PMID: 35089534Free PMC Article
Japanese Clinical Practice Guideline for Head and Neck Cancer.
Nibu KI, Hayashi R, Asakage T, Ojiri H, Kimata Y, Kodaira T, Nagao T, Nakashima T, Fujii T, Fujii H, Homma A, Matsuura K, Monden N, Beppu T, Hanai N, Kirita T, Kamei Y, Otsuki N, Kiyota N, Zenda S, Omura K, Omori K, Akimoto T, Kawabata K, Kishimoto S, Kitano H, Tohnai I, Nakatsuka T
Auris Nasus Larynx 2017 Aug;44(4):375-380. Epub 2017 Mar 18 doi: 10.1016/j.anl.2017.02.004. PMID: 28325607

Recent clinical studies

Etiology

Extended follow-up of a phase 2 trial of xevinapant plus chemoradiotherapy in high-risk locally advanced squamous cell carcinoma of the head and neck: a randomised clinical trial.
Tao Y, Sun XS, Pointreau Y, Le Tourneau C, Sire C, Kaminsky MC, Coutte A, Alfonsi M, Calderon B, Boisselier P, Martin L, Miroir J, Ramee JF, Delord JP, Clatot F, Rolland F, Villa J, Magne N, Elicin O, Gherga E, Nguyen F, Lafond C, Bera G, Calugaru V, Geoffrois L, Chauffert B, Damstrup L, Crompton P, Ennaji A, Gollmer K, Nauwelaerts H, Bourhis J
Eur J Cancer 2023 Apr;183:24-37. Epub 2023 Jan 9 doi: 10.1016/j.ejca.2022.12.015. PMID: 36796234
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lee NY, Ferris RL, Psyrri A, Haddad RI, Tahara M, Bourhis J, Harrington K, Chang PM, Lin JC, Razaq MA, Teixeira MM, Lövey J, Chamois J, Rueda A, Hu C, Dunn LA, Dvorkin MV, De Beukelaer S, Pavlov D, Thurm H, Cohen E
Lancet Oncol 2021 Apr;22(4):450-462. doi: 10.1016/S1470-2045(20)30737-3. PMID: 33794205
Debio 1143 and high-dose cisplatin chemoradiotherapy in high-risk locoregionally advanced squamous cell carcinoma of the head and neck: a double-blind, multicentre, randomised, phase 2 study.
Sun XS, Tao Y, Le Tourneau C, Pointreau Y, Sire C, Kaminsky MC, Coutte A, Alfonsi M, Boisselier P, Martin L, Miroir J, Ramee JF, Delord JP, Clatot F, Rolland F, Villa J, Magne N, Elicin O, Gherga E, Nguyen F, Lafond C, Bera G, Calugaru V, Geoffrois L, Chauffert B, Zubel A, Zanna C, Brienza S, Crompton P, Rouits E, Gollmer K, Szyldergemajn S, Bourhis J
Lancet Oncol 2020 Sep;21(9):1173-1187. Epub 2020 Aug 3 doi: 10.1016/S1470-2045(20)30327-2. PMID: 32758455
A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907).
Ando N, Kato H, Igaki H, Shinoda M, Ozawa S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, Ikeda K, Kanda T, Tsujinaka T, Nakamura K, Fukuda H
Ann Surg Oncol 2012 Jan;19(1):68-74. Epub 2011 Aug 31 doi: 10.1245/s10434-011-2049-9. PMID: 21879261
Head and neck cancer.
Argiris A, Karamouzis MV, Raben D, Ferris RL
Lancet 2008 May 17;371(9625):1695-709. doi: 10.1016/S0140-6736(08)60728-X. PMID: 18486742Free PMC Article

Diagnosis

Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design.
Bourhis J, Burtness B, Licitra LF, Nutting C, Schoenfeld JD, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen EE
Future Oncol 2022 May;18(14):1669-1678. Epub 2022 Feb 17 doi: 10.2217/fon-2021-1634. PMID: 35172587
Locally advanced squamous cell carcinoma of the vulva: A challenging question for gynecologic oncologists.
Gadducci A, Aletti GD
Gynecol Oncol 2020 Jul;158(1):208-217. Epub 2020 May 25 doi: 10.1016/j.ygyno.2020.05.021. PMID: 32460996
Advanced squamous cell carcinoma in an asymptomatic, large, epiphrenic esophageal diverticulum.
Yoshida T, Hashimoto S, Mizuno KI, Ichikawa H, Yokoyama J, Umezu H, Terai S
Clin J Gastroenterol 2020 Aug;13(4):477-482. Epub 2020 Jan 27 doi: 10.1007/s12328-020-01098-4. PMID: 31989447
Myiasis on squamous cell carcinoma of skin.
Wollina U
Wien Med Wochenschr 2015 Feb;165(3-4):79-82. Epub 2014 Nov 12 doi: 10.1007/s10354-014-0326-5. PMID: 25387871
Head and neck cancer.
Argiris A, Karamouzis MV, Raben D, Ferris RL
Lancet 2008 May 17;371(9625):1695-709. doi: 10.1016/S0140-6736(08)60728-X. PMID: 18486742Free PMC Article

Therapy

Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design.
Bourhis J, Burtness B, Licitra LF, Nutting C, Schoenfeld JD, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen EE
Future Oncol 2022 May;18(14):1669-1678. Epub 2022 Feb 17 doi: 10.2217/fon-2021-1634. PMID: 35172587
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lee NY, Ferris RL, Psyrri A, Haddad RI, Tahara M, Bourhis J, Harrington K, Chang PM, Lin JC, Razaq MA, Teixeira MM, Lövey J, Chamois J, Rueda A, Hu C, Dunn LA, Dvorkin MV, De Beukelaer S, Pavlov D, Thurm H, Cohen E
Lancet Oncol 2021 Apr;22(4):450-462. doi: 10.1016/S1470-2045(20)30737-3. PMID: 33794205
Debio 1143 and high-dose cisplatin chemoradiotherapy in high-risk locoregionally advanced squamous cell carcinoma of the head and neck: a double-blind, multicentre, randomised, phase 2 study.
Sun XS, Tao Y, Le Tourneau C, Pointreau Y, Sire C, Kaminsky MC, Coutte A, Alfonsi M, Boisselier P, Martin L, Miroir J, Ramee JF, Delord JP, Clatot F, Rolland F, Villa J, Magne N, Elicin O, Gherga E, Nguyen F, Lafond C, Bera G, Calugaru V, Geoffrois L, Chauffert B, Zubel A, Zanna C, Brienza S, Crompton P, Rouits E, Gollmer K, Szyldergemajn S, Bourhis J
Lancet Oncol 2020 Sep;21(9):1173-1187. Epub 2020 Aug 3 doi: 10.1016/S1470-2045(20)30327-2. PMID: 32758455
Comparison of gefitinib, erlotinib and afatinib in non-small cell lung cancer: A meta-analysis.
Yang Z, Hackshaw A, Feng Q, Fu X, Zhang Y, Mao C, Tang J
Int J Cancer 2017 Jun 15;140(12):2805-2819. Epub 2017 Mar 27 doi: 10.1002/ijc.30691. PMID: 28295308
Head and neck cancer.
Argiris A, Karamouzis MV, Raben D, Ferris RL
Lancet 2008 May 17;371(9625):1695-709. doi: 10.1016/S0140-6736(08)60728-X. PMID: 18486742Free PMC Article

Prognosis

Extended follow-up of a phase 2 trial of xevinapant plus chemoradiotherapy in high-risk locally advanced squamous cell carcinoma of the head and neck: a randomised clinical trial.
Tao Y, Sun XS, Pointreau Y, Le Tourneau C, Sire C, Kaminsky MC, Coutte A, Alfonsi M, Calderon B, Boisselier P, Martin L, Miroir J, Ramee JF, Delord JP, Clatot F, Rolland F, Villa J, Magne N, Elicin O, Gherga E, Nguyen F, Lafond C, Bera G, Calugaru V, Geoffrois L, Chauffert B, Damstrup L, Crompton P, Ennaji A, Gollmer K, Nauwelaerts H, Bourhis J
Eur J Cancer 2023 Apr;183:24-37. Epub 2023 Jan 9 doi: 10.1016/j.ejca.2022.12.015. PMID: 36796234
Debio 1143 and high-dose cisplatin chemoradiotherapy in high-risk locoregionally advanced squamous cell carcinoma of the head and neck: a double-blind, multicentre, randomised, phase 2 study.
Sun XS, Tao Y, Le Tourneau C, Pointreau Y, Sire C, Kaminsky MC, Coutte A, Alfonsi M, Boisselier P, Martin L, Miroir J, Ramee JF, Delord JP, Clatot F, Rolland F, Villa J, Magne N, Elicin O, Gherga E, Nguyen F, Lafond C, Bera G, Calugaru V, Geoffrois L, Chauffert B, Zubel A, Zanna C, Brienza S, Crompton P, Rouits E, Gollmer K, Szyldergemajn S, Bourhis J
Lancet Oncol 2020 Sep;21(9):1173-1187. Epub 2020 Aug 3 doi: 10.1016/S1470-2045(20)30327-2. PMID: 32758455
Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial.
Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Lordick F, D'Journo XB, Cerfolio RJ, Korst RJ, Novoa NM, Swanson SJ, Brunelli A, Ismail M, Fernando HC, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M, Fu J; AME Thoracic Surgery Collaborative Group
J Clin Oncol 2018 Sep 20;36(27):2796-2803. Epub 2018 Aug 8 doi: 10.1200/JCO.2018.79.1483. PMID: 30089078Free PMC Article
A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907).
Ando N, Kato H, Igaki H, Shinoda M, Ozawa S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, Ikeda K, Kanda T, Tsujinaka T, Nakamura K, Fukuda H
Ann Surg Oncol 2012 Jan;19(1):68-74. Epub 2011 Aug 31 doi: 10.1245/s10434-011-2049-9. PMID: 21879261
Head and neck cancer.
Argiris A, Karamouzis MV, Raben D, Ferris RL
Lancet 2008 May 17;371(9625):1695-709. doi: 10.1016/S0140-6736(08)60728-X. PMID: 18486742Free PMC Article

Clinical prediction guides

Photodynamic therapy for squamous cell carcinoma of the head and neck: narrative review focusing on photosensitizers.
Ibarra AMC, Cecatto RB, Motta LJ, Dos Santos Franco AL, de Fátima Teixeira da Silva D, Nunes FD, Hamblin MR, Rodrigues MFSD
Lasers Med Sci 2022 Apr;37(3):1441-1470. Epub 2021 Dec 2 doi: 10.1007/s10103-021-03462-3. PMID: 34855034
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lee NY, Ferris RL, Psyrri A, Haddad RI, Tahara M, Bourhis J, Harrington K, Chang PM, Lin JC, Razaq MA, Teixeira MM, Lövey J, Chamois J, Rueda A, Hu C, Dunn LA, Dvorkin MV, De Beukelaer S, Pavlov D, Thurm H, Cohen E
Lancet Oncol 2021 Apr;22(4):450-462. doi: 10.1016/S1470-2045(20)30737-3. PMID: 33794205
Therapy of advanced squamous cell carcinoma of the skin.
Bejar C, Maubec E
Curr Treat Options Oncol 2014 Jun;15(2):302-20. doi: 10.1007/s11864-014-0280-x. PMID: 24643778
Cetuximab in the treatment of squamous cell carcinoma of the head and neck.
Specenier P, Vermorken JB
Expert Rev Anticancer Ther 2011 Apr;11(4):511-24. doi: 10.1586/era.11.20. PMID: 21504318
Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival.
Bonner JA, Harari PM, Giralt J, Cohen RB, Jones CU, Sur RK, Raben D, Baselga J, Spencer SA, Zhu J, Youssoufian H, Rowinsky EK, Ang KK
Lancet Oncol 2010 Jan;11(1):21-8. Epub 2009 Nov 10 doi: 10.1016/S1470-2045(09)70311-0. PMID: 19897418

Recent systematic reviews

Locally advanced squamous cell carcinoma of the head and neck: A systematic review and Bayesian network meta-analysis of the currently available treatment options.
Iocca O, Farcomeni A, Di Rocco A, Di Maio P, Golusinski P, Pardiñas López S, Savo A, Pellini R, Spriano G
Oral Oncol 2018 May;80:40-51. Epub 2018 Mar 27 doi: 10.1016/j.oraloncology.2018.03.001. PMID: 29706187
Weekly Low-Dose Versus Three-Weekly High-Dose Cisplatin for Concurrent Chemoradiation in Locoregionally Advanced Non-Nasopharyngeal Head and Neck Cancer: A Systematic Review and Meta-Analysis of Aggregate Data.
Szturz P, Wouters K, Kiyota N, Tahara M, Prabhash K, Noronha V, Castro A, Licitra L, Adelstein D, Vermorken JB
Oncologist 2017 Sep;22(9):1056-1066. Epub 2017 May 22 doi: 10.1634/theoncologist.2017-0015. PMID: 28533474Free PMC Article
Comparison of gefitinib, erlotinib and afatinib in non-small cell lung cancer: A meta-analysis.
Yang Z, Hackshaw A, Feng Q, Fu X, Zhang Y, Mao C, Tang J
Int J Cancer 2017 Jun 15;140(12):2805-2819. Epub 2017 Mar 27 doi: 10.1002/ijc.30691. PMID: 28295308
Concomitant platinum-based chemotherapy or cetuximab with radiotherapy for locally advanced head and neck cancer: a systematic review and meta-analysis of published studies.
Petrelli F, Coinu A, Riboldi V, Borgonovo K, Ghilardi M, Cabiddu M, Lonati V, Sarti E, Barni S
Oral Oncol 2014 Nov;50(11):1041-8. Epub 2014 Aug 28 doi: 10.1016/j.oraloncology.2014.08.005. PMID: 25176576
Postoperative chemoradiotherapy for advanced squamous cell carcinoma of the head and neck: a systematic review with meta-analysis.
Winquist E, Oliver T, Gilbert R
Head Neck 2007 Jan;29(1):38-46. doi: 10.1002/hed.20465. PMID: 17103410

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