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Metastatic Pharyngeal Squamous Cell Carcinoma

MedGen UID:
1768945
•Concept ID:
C5420336
•
Neoplastic Process

Definition

Pharyngeal squamous cell carcinoma that has spread from the original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Current management of carcinoma of the oropharynx.
Gluckman JL, Zitsch RP
Oncology (Williston Park) 1990 Apr;4(4):23-30; discussion 32, 34, 43. PMID: 2143928
Percutaneous treatment of pulmonary tumors by electrolysis.
Samuelsson L, Jönsson L, Ståhl E
Radiologe 1983 Jun;23(6):284-7. PMID: 6308708

Recent clinical studies

Etiology

Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Special groups: head and neck cancer.
Arrese LC, Lazarus CL
Otolaryngol Clin North Am 2013 Dec;46(6):1123-36. Epub 2013 Oct 23 doi: 10.1016/j.otc.2013.08.009. PMID: 24262964
Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival.
Warnakulasuriya S
Oral Oncol 2010 Jun;46(6):407-10. Epub 2010 Apr 18 doi: 10.1016/j.oraloncology.2010.02.015. PMID: 20403722
Carcinoma of the hypopharynx.
Shah JP, Shaha AR, Spiro RH, Strong EW
Am J Surg 1976 Oct;132(4):439-43. doi: 10.1016/0002-9610(76)90315-9. PMID: 1015533

Diagnosis

Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Special groups: head and neck cancer.
Arrese LC, Lazarus CL
Otolaryngol Clin North Am 2013 Dec;46(6):1123-36. Epub 2013 Oct 23 doi: 10.1016/j.otc.2013.08.009. PMID: 24262964
Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival.
Warnakulasuriya S
Oral Oncol 2010 Jun;46(6):407-10. Epub 2010 Apr 18 doi: 10.1016/j.oraloncology.2010.02.015. PMID: 20403722
Bazex syndrome (acrokeratosis paraneoplastica).
Sarkar B, Knecht R, Sarkar C, Weidauer H
Eur Arch Otorhinolaryngol 1998;255(4):205-10. doi: 10.1007/s004050050044. PMID: 9592679

Therapy

Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Pharyngocutaneous fistulas after total laryngectomy or pharyngolaryngectomy: Place of video-fluoroscopic swallowing study.
Carsuzaa F, Capitaine AL, Ferrié JC, Apert V, Tonnerre D, Frasca D, Dufour X
Head Neck 2020 Dec;42(12):3638-3646. Epub 2020 Aug 30 doi: 10.1002/hed.26429. PMID: 32864848
Syphilis of the oropharynx: Case series of "The Great Masquerader".
Jategaonkar A, Klimczak J, Agarwal J, Badhey A, Portnoy WM, Damiano A, Chai RL
Am J Otolaryngol 2019 Mar-Apr;40(2):143-146. Epub 2019 Jan 16 doi: 10.1016/j.amjoto.2019.01.005. PMID: 30661890
Complications of total laryngectomy in the era of chemoradiation.
Klozar J, Cada Z, Koslabova E
Eur Arch Otorhinolaryngol 2012 Jan;269(1):289-93. Epub 2011 Apr 17 doi: 10.1007/s00405-011-1598-7. PMID: 21499870
Closure of post-laryngectomy pharyngocutaneous fistulae.
Bohannon IA, Carroll WR, Magnuson JS, Rosenthal EL
Head Neck Oncol 2011 May 26;3:29. doi: 10.1186/1758-3284-3-29. PMID: 21615952Free PMC Article

Prognosis

Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Special groups: head and neck cancer.
Arrese LC, Lazarus CL
Otolaryngol Clin North Am 2013 Dec;46(6):1123-36. Epub 2013 Oct 23 doi: 10.1016/j.otc.2013.08.009. PMID: 24262964
Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival.
Warnakulasuriya S
Oral Oncol 2010 Jun;46(6):407-10. Epub 2010 Apr 18 doi: 10.1016/j.oraloncology.2010.02.015. PMID: 20403722

Clinical prediction guides

Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Pharyngocutaneous fistulas after total laryngectomy or pharyngolaryngectomy: Place of video-fluoroscopic swallowing study.
Carsuzaa F, Capitaine AL, Ferrié JC, Apert V, Tonnerre D, Frasca D, Dufour X
Head Neck 2020 Dec;42(12):3638-3646. Epub 2020 Aug 30 doi: 10.1002/hed.26429. PMID: 32864848
The nodal response to chemoselection predicts the risk of recurrence following definitive chemoradiotherapy for pharyngeal cancer.
Hanai N, Ozawa T, Hirakawa H, Suzuki H, Fukuda Y, Hasegawa Y
Acta Otolaryngol 2014 Aug;134(8):865-71. doi: 10.3109/00016489.2014.894252. PMID: 25022795
Follow up after IMRT in oral cavity cancer: update.
Studer G, Brown M, Bredell M, Graetz KW, Huber G, Linsenmeier C, Najafi Y, Riesterer O, Rordorf T, Schmid S, Glanzmann C
Radiat Oncol 2012 Jun 11;7:84. doi: 10.1186/1748-717X-7-84. PMID: 22686297Free PMC Article
Complications of total laryngectomy in the era of chemoradiation.
Klozar J, Cada Z, Koslabova E
Eur Arch Otorhinolaryngol 2012 Jan;269(1):289-93. Epub 2011 Apr 17 doi: 10.1007/s00405-011-1598-7. PMID: 21499870

Recent systematic reviews

Squamous cell carcinoma metastatic to the lymph nodes of the parapharyngeal space: case series and systematic review.
Fermi M, Botti C, Chiari F, Abeshi A, Presutti L, Miglio M, Mattioli F, Filippini DM, Valerini S, Marchioni D, Molteni G, Serafini E
Acta Otorhinolaryngol Ital 2024 Aug;44(4):223-232. doi: 10.14639/0392-100X-N2993. PMID: 39347547Free PMC Article
Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Association of Unilateral Radiotherapy With Contralateral Lymph Node Failure Among Patients With Squamous Cell Carcinoma of the Tonsil: A Systematic Review and Meta-analysis.
Razavian NB, D'Agostino RB Jr, Steber CR, Helis CA, Hughes RT
JAMA Netw Open 2023 Feb 1;6(2):e2255209. doi: 10.1001/jamanetworkopen.2022.55209. PMID: 36753275Free PMC Article
Nodal tumor volume as a prognostic factor for head and neck squamous cell carcinoma: a systematic review.
Moumoulidis PT, Pavlopoulou A, Ünal R, Mavragani I, Georgakilas AG, Kyrodimos E
Front Biosci (Landmark Ed) 2021 Jul 30;26(7):235-245. doi: 10.52586/4937. PMID: 34340270
Bilateral chylothorax following neck dissection: case report and systematic review of the literature.
Zhang H, Dziegielewski PT, Romanovsky A, Seikaly H
J Otolaryngol Head Neck Surg 2012 Aug;41(4):E26-30. PMID: 22935186

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