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Metastatic Pharyngeal Squamous Cell Carcinoma

MedGen UID:
1768945
•Concept ID:
C5420336
•
Neoplastic Process

Definition

Pharyngeal squamous cell carcinoma that has spread from the original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Early stage squamous cell carcinoma of the pyriform sinus: a review of treatment options.
Krstevska V
Indian J Cancer 2012 Apr-Jun;49(2):236-44. doi: 10.4103/0019-509X.102920. PMID: 23107977

Recent clinical studies

Etiology

Case series report: radiation-induced oropharyngeal carcinoma.
Salman S, Doweck I, Taha T, Billan S
Anticancer Drugs 2023 Feb 1;34(2):325-331. Epub 2022 Nov 15 doi: 10.1097/CAD.0000000000001411. PMID: 36730617
Prevalence and prognosis of synchronous distant metastatic tonsil squamous cell carcinomas.
Li Y, Hu C
Int J Med Sci 2021;18(2):528-533. Epub 2021 Jan 1 doi: 10.7150/ijms.50966. PMID: 33390822Free PMC Article
Multifactorial Contribution of Notch Signaling in Head and Neck Squamous Cell Carcinoma.
Porcheri C, Meisel CT, Mitsiadis T
Int J Mol Sci 2019 Mar 26;20(6) doi: 10.3390/ijms20061520. PMID: 30917608Free PMC Article
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406

Diagnosis

Case series report: radiation-induced oropharyngeal carcinoma.
Salman S, Doweck I, Taha T, Billan S
Anticancer Drugs 2023 Feb 1;34(2):325-331. Epub 2022 Nov 15 doi: 10.1097/CAD.0000000000001411. PMID: 36730617
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Unilateral tonsillar enlargement.
Cortez EA, Mattox DE, Holt GR, Gates GA
Otolaryngol Head Neck Surg (1979) 1979 Nov-Dec;87(6):707-16. doi: 10.1177/019459987908700603. PMID: 530694

Therapy

Multicenter prospective phase II trial of concurrent chemoradiotherapy with weekly low-dose carboplatin for cisplatin-ineligible patients with advanced head and neck squamous cell carcinoma.
Ueki Y, Ohshima S, Yokoyama Y, Takahashi T, Shodo R, Yamazaki K, Ohtaki K, Saijo K, Tanaka R, Togashi T, Sato Y, Takano S, Omata J, Takahashi N, Okabe R, Horii A
Int J Clin Oncol 2024 Jan;29(1):20-26. Epub 2023 Oct 16 doi: 10.1007/s10147-023-02423-w. PMID: 37843751
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Volumetric changes in pharyngeal structures following head and neck cancer chemoradiation therapy.
Hinther A, Samson N, Lau H, Quon H, Banerjee R, Lysack JT, Grendarova P, Matthews TW, Randall DR
Laryngoscope 2020 Mar;130(3):597-602. Epub 2019 Jul 1 doi: 10.1002/lary.28164. PMID: 31260128
Risk factor of pharyngocutaneous fistula.
Kedous S, Turki S, Elhedhili F, Dhambri S, Jbeli S, Touati S, Gritli S
Tunis Med 2019 Mar;97(3):491-499. PMID: 31729725
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512

Prognosis

The prognosis of HPV-associated metastatic pharyngeal patients by primary and distant site.
Wang J, Tian Y, Huang H, Huang D, Liu Y, Tian Y, Zhu G, Zhang X, Ferris RL
Oral Oncol 2022 Feb;125:105675. Epub 2021 Dec 27 doi: 10.1016/j.oraloncology.2021.105675. PMID: 34968864Free PMC Article
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Multifactorial Contribution of Notch Signaling in Head and Neck Squamous Cell Carcinoma.
Porcheri C, Meisel CT, Mitsiadis T
Int J Mol Sci 2019 Mar 26;20(6) doi: 10.3390/ijms20061520. PMID: 30917608Free PMC Article
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406

Clinical prediction guides

Squamous cell carcinoma metastatic to the lymph nodes of the parapharyngeal space: case series and systematic review.
Fermi M, Botti C, Chiari F, Abeshi A, Presutti L, Miglio M, Mattioli F, Filippini DM, Valerini S, Marchioni D, Molteni G, Serafini E
Acta Otorhinolaryngol Ital 2024 Aug;44(4):223-232. doi: 10.14639/0392-100X-N2993. PMID: 39347547Free PMC Article
The prognosis of HPV-associated metastatic pharyngeal patients by primary and distant site.
Wang J, Tian Y, Huang H, Huang D, Liu Y, Tian Y, Zhu G, Zhang X, Ferris RL
Oral Oncol 2022 Feb;125:105675. Epub 2021 Dec 27 doi: 10.1016/j.oraloncology.2021.105675. PMID: 34968864Free PMC Article
Prevalence and prognosis of synchronous distant metastatic tonsil squamous cell carcinomas.
Li Y, Hu C
Int J Med Sci 2021;18(2):528-533. Epub 2021 Jan 1 doi: 10.7150/ijms.50966. PMID: 33390822Free PMC Article
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Opposing Effects of Heparanase and Heparanase-2 in Head & Neck Cancer.
Doweck I, Feibish N
Adv Exp Med Biol 2020;1221:847-856. doi: 10.1007/978-3-030-34521-1_37. PMID: 32274741

Recent systematic reviews

Squamous cell carcinoma metastatic to the lymph nodes of the parapharyngeal space: case series and systematic review.
Fermi M, Botti C, Chiari F, Abeshi A, Presutti L, Miglio M, Mattioli F, Filippini DM, Valerini S, Marchioni D, Molteni G, Serafini E
Acta Otorhinolaryngol Ital 2024 Aug;44(4):223-232. doi: 10.14639/0392-100X-N2993. PMID: 39347547Free PMC Article
Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Association of Unilateral Radiotherapy With Contralateral Lymph Node Failure Among Patients With Squamous Cell Carcinoma of the Tonsil: A Systematic Review and Meta-analysis.
Razavian NB, D'Agostino RB Jr, Steber CR, Helis CA, Hughes RT
JAMA Netw Open 2023 Feb 1;6(2):e2255209. doi: 10.1001/jamanetworkopen.2022.55209. PMID: 36753275Free PMC Article
Nodal tumor volume as a prognostic factor for head and neck squamous cell carcinoma: a systematic review.
Moumoulidis PT, Pavlopoulou A, Ünal R, Mavragani I, Georgakilas AG, Kyrodimos E
Front Biosci (Landmark Ed) 2021 Jul 30;26(7):235-245. doi: 10.52586/4937. PMID: 34340270
Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin: A systematic review and meta-analysis.
Di Maio P, Iocca O, De Virgilio A, Ferreli F, Cristalli G, Pellini R, Golusinski P, Ricci G, Spriano G
Head Neck 2019 Apr;41(4):1112-1121. Epub 2018 Dec 21 doi: 10.1002/hed.25522. PMID: 30575162

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