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Endometrial cancer

MedGen UID:
2840
Concept ID:
C0007103
Neoplastic Process
Synonyms: Endometrial cancer, somatic; malignant endometrial neoplasm
SNOMED CT: Malignant neoplasm of endometrium of corpus uteri (188192002); Cancer of endometrium (188192002)
 
Related genes: MLH3, MSH3, MSH6, CDH1
 
Monarch Initiative: MONDO:0011962

Definition

Primary or metastatic malignant neoplasm involving the endometrium (mucous membrane that lines the endometrial cavity). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Vitale SG, Haimovich S, Laganà AS, Alonso L, Di Spiezio Sardo A, Carugno J; From the Global Community of Hysteroscopy Guidelines Committee
Eur J Obstet Gynecol Reprod Biol 2021 May;260:70-77. Epub 2021 Mar 13 doi: 10.1016/j.ejogrb.2021.03.017. PMID: 33756339
Klein DA, Paradise SL, Reeder RM
Am Fam Physician 2019 Jul 1;100(1):39-48. PMID: 31259490
Braun MM, Overbeek-Wager EA, Grumbo RJ
Am Fam Physician 2016 Mar 15;93(6):468-74. PMID: 26977831

Curated

UK NICE Diagnostics Guidance DG42, Testing strategies for Lynch syndrome in people with endometrial cancer, 2020

Recent clinical studies

Etiology

Wang X, Glubb DM, O'Mara TA
Nutrients 2023 Jan 24;15(3) doi: 10.3390/nu15030603. PMID: 36771310Free PMC Article
van den Heerik ASVM, Horeweg N, de Boer SM, Bosse T, Creutzberg CL
Int J Gynecol Cancer 2021 Apr;31(4):594-604. Epub 2020 Oct 20 doi: 10.1136/ijgc-2020-001822. PMID: 33082238Free PMC Article
Nougaret S, Horta M, Sala E, Lakhman Y, Thomassin-Naggara I, Kido A, Masselli G, Bharwani N, Sadowski E, Ertmer A, Otero-Garcia M, Kubik-Huch RA, Cunha TM, Rockall A, Forstner R
Eur Radiol 2019 Feb;29(2):792-805. Epub 2018 Jul 11 doi: 10.1007/s00330-018-5515-y. PMID: 29995239
Braun MM, Overbeek-Wager EA, Grumbo RJ
Am Fam Physician 2016 Mar 15;93(6):468-74. PMID: 26977831
Amant F, Moerman P, Neven P, Timmerman D, Van Limbergen E, Vergote I
Lancet 2005 Aug 6-12;366(9484):491-505. doi: 10.1016/S0140-6736(05)67063-8. PMID: 16084259

Diagnosis

Yen TT, Wang TL, Fader AN, Shih IM, Gaillard S
Int J Gynecol Pathol 2020 Jan;39(1):26-35. doi: 10.1097/PGP.0000000000000585. PMID: 30741844Free PMC Article
Passarello K, Kurian S, Villanueva V
Semin Oncol Nurs 2019 Apr;35(2):157-165. Epub 2019 Mar 11 doi: 10.1016/j.soncn.2019.02.002. PMID: 30867105
Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou M
Int J Cancer 2019 Oct 1;145(7):1719-1730. Epub 2019 Feb 20 doi: 10.1002/ijc.31961. PMID: 30387875
Braun MM, Overbeek-Wager EA, Grumbo RJ
Am Fam Physician 2016 Mar 15;93(6):468-74. PMID: 26977831
Amant F, Moerman P, Neven P, Timmerman D, Van Limbergen E, Vergote I
Lancet 2005 Aug 6-12;366(9484):491-505. doi: 10.1016/S0140-6736(05)67063-8. PMID: 16084259

Therapy

Peng H, He X, Wang Q
Acta Obstet Gynecol Scand 2022 Sep;101(9):941-951. Epub 2022 Jun 25 doi: 10.1111/aogs.14412. PMID: 35751489Free PMC Article
O'Malley DM, Bariani GM, Cassier PA, Marabelle A, Hansen AR, De Jesus Acosta A, Miller WH Jr, Safra T, Italiano A, Mileshkin L, Xu L, Jin F, Norwood K, Maio M
J Clin Oncol 2022 Mar 1;40(7):752-761. Epub 2022 Jan 6 doi: 10.1200/JCO.21.01874. PMID: 34990208Free PMC Article
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Enomoto T, Takehara K, Denys H, Nout RA, Lorusso D, Vaughan MM, Bini M, Takano M, Provencher D, Indini A, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Candido Dos Reis FJ, Lopez S, Mariani A, Leitao MM Jr, Raspagliesi F, Panici PB, Di Donato V, Muzii L, Colombo N, Scambia G, Pignata S, Monk BJ
Gynecol Oncol 2021 Jul;162(1):226-234. Epub 2021 Apr 30 doi: 10.1016/j.ygyno.2021.04.029. PMID: 33934848Free PMC Article
León-Castillo A, de Boer SM, Powell ME, Mileshkin LR, Mackay HJ, Leary A, Nijman HW, Singh N, Pollock PM, Bessette P, Fyles A, Haie-Meder C, Smit VTHBM, Edmondson RJ, Putter H, Kitchener HC, Crosbie EJ, de Bruyn M, Nout RA, Horeweg N, Creutzberg CL, Bosse T; TransPORTEC consortium
J Clin Oncol 2020 Oct 10;38(29):3388-3397. Epub 2020 Aug 4 doi: 10.1200/JCO.20.00549. PMID: 32749941Free PMC Article
Chargari C, Deutsch E, Blanchard P, Gouy S, Martelli H, Guérin F, Dumas I, Bossi A, Morice P, Viswanathan AN, Haie-Meder C
CA Cancer J Clin 2019 Sep;69(5):386-401. Epub 2019 Jul 30 doi: 10.3322/caac.21578. PMID: 31361333

Prognosis

Paleari L
Int J Mol Sci 2023 Mar 30;24(7) doi: 10.3390/ijms24076462. PMID: 37047434Free PMC Article
O'Malley DM, Bariani GM, Cassier PA, Marabelle A, Hansen AR, De Jesus Acosta A, Miller WH Jr, Safra T, Italiano A, Mileshkin L, Xu L, Jin F, Norwood K, Maio M
J Clin Oncol 2022 Mar 1;40(7):752-761. Epub 2022 Jan 6 doi: 10.1200/JCO.21.01874. PMID: 34990208Free PMC Article
Muaddi H, Hafid ME, Choi WJ, Lillie E, de Mestral C, Nathens A, Stukel TA, Karanicolas PJ
Ann Surg 2021 Mar 1;273(3):467-473. doi: 10.1097/SLA.0000000000003915. PMID: 32398482
Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou M
Int J Cancer 2019 Oct 1;145(7):1719-1730. Epub 2019 Feb 20 doi: 10.1002/ijc.31961. PMID: 30387875
Sorosky JI
Obstet Gynecol 2008 Feb;111(2 Pt 1):436-47. doi: 10.1097/AOG.0b013e318162f690. PMID: 18238985

Clinical prediction guides

Wang X, Glubb DM, O'Mara TA
EBioMedicine 2022 Mar;77:103895. Epub 2022 Feb 23 doi: 10.1016/j.ebiom.2022.103895. PMID: 35219087Free PMC Article
Konno Y, Asano H, Shikama A, Aoki D, Tanikawa M, Oki A, Horie K, Mitsuhashi A, Kikuchi A, Tokunaga H, Terao Y, Satoh T, Ushijima K, Ishikawa M, Yaegashi N, Watari H
J Gynecol Oncol 2021 Mar;32(2):e25. Epub 2021 Jan 7 doi: 10.3802/jgo.2021.32.e25. PMID: 33470067Free PMC Article
Cusimano MC, Vicus D, Pulman K, Maganti M, Bernardini MQ, Bouchard-Fortier G, Laframboise S, May T, Hogen LF, Covens AL, Gien LT, Kupets R, Rouzbahman M, Clarke BA, Mirkovic J, Cesari M, Turashvili G, Zia A, Ene GEV, Ferguson SE
JAMA Surg 2021 Feb 1;156(2):157-164. doi: 10.1001/jamasurg.2020.5060. PMID: 33175109Free PMC Article
Kommoss S, McConechy MK, Kommoss F, Leung S, Bunz A, Magrill J, Britton H, Kommoss F, Grevenkamp F, Karnezis A, Yang W, Lum A, Krämer B, Taran F, Staebler A, Lax S, Brucker SY, Huntsman DG, Gilks CB, McAlpine JN, Talhouk A
Ann Oncol 2018 May 1;29(5):1180-1188. doi: 10.1093/annonc/mdy058. PMID: 29432521
Sorosky JI
Obstet Gynecol 2008 Feb;111(2 Pt 1):436-47. doi: 10.1097/AOG.0b013e318162f690. PMID: 18238985

Recent systematic reviews

Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Farvid MS, Sidahmed E, Spence ND, Mante Angua K, Rosner BA, Barnett JB
Eur J Epidemiol 2021 Sep;36(9):937-951. Epub 2021 Aug 29 doi: 10.1007/s10654-021-00741-9. PMID: 34455534
Lee KH, Seong HJ, Kim G, Jeong GH, Kim JY, Park H, Jung E, Kronbichler A, Eisenhut M, Stubbs B, Solmi M, Koyanagi A, Hong SH, Dragioti E, de Rezende LFM, Jacob L, Keum N, van der Vliet HJ, Cho E, Veronese N, Grosso G, Ogino S, Song M, Radua J, Jung SJ, Thompson T, Jackson SE, Smith L, Yang L, Oh H, Choi EK, Shin JI, Giovannucci EL, Gamerith G
Adv Nutr 2020 Sep 1;11(5):1134-1149. doi: 10.1093/advances/nmaa055. PMID: 32488249Free PMC Article
Hill DA, Crider M, Hill SR
Am Fam Physician 2016 Dec 1;94(11):884-889. PMID: 27929271

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE Diagnostics Guidance DG42, Testing strategies for Lynch syndrome in people with endometrial cancer, 2020

    Consumer resources

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