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Dementia: Assessment, management and support for people living with dementia and their carers. London: National Institute for Health and Care Excellence (NICE); 2018 Jun. (NICE Guideline, No. 97.)

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Dementia: Assessment, management and support for people living with dementia and their carers.

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P.2GRADE tables

P.2.1. Dementia versus no dementia

P.2.1.1. 10-point Cognitive Screener (10-CS) (≤5)

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P.2.1.2. 10-point Cognitive Screener (10-CS) (≤7)

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P.2.1.3. 10-point Cognitive Screener (10-CS) (≤8)

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P.2.1.4. 6 item screener (≥0)

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P.2.1.5. 6 item screener (≥1)

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P.2.1.6. 6 item screener (≥2)

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P.2.1.7. 6 item screener (≥3)

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P.2.1.8. 6 item screener (≥4)

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P.2.1.9. 6 item screener (≥5)

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P.2.1.10. 6 item screener (≥6)

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P.2.1.11. 6-item Cognitive Impairment Test (6CIT) (>9)

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P.2.1.12. 99mTc-HMPAO SPECT

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P.2.1.13. Addenbrooke’s Cognitive Examination, ACE (<75)

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P.2.1.14. Addenbrooke’s Cognitive Examination, ACE (<83)

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P.2.1.15. Addenbrooke’s Cognitive Examination, ACE (<88)

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P.2.1.16. Addenbrooke’s Cognitive Examination-III, ACE- III (<81)

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P.2.1.17. Addenbrooke’s Cognitive Examination-III, ACE- III (<82)

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P.2.1.18. Addenbrooke’s Cognitive Examination-III, ACE- III (<84)

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P.2.1.19. Addenbrooke’s Cognitive Examination-III, ACE- III (<88)

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P.2.1.20. Addenbrooke’s Cognitive Examination-Revised, ACE-R (<74)

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P.2.1.21. Addenbrooke’s Cognitive Examination-Revised, ACE-R (<83)

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P.2.1.22. Addenbrooke’s Cognitive Examination-Revised, ACE-R (<85)

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P.2.1.23. Addenbrooke’s Cognitive Examination-Revised, ACE-R (<89)

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P.2.1.24. AD8 (≥2)

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P.2.1.25. Abbreviated Mental Test, AMT (<10)

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P.2.1.26. Abbreviated Mental Test, AMT (<7)

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P.2.1.27. Abbreviated Mental Test, AMT (<8)

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P.2.1.28. Abbreviated Mental Test, AMT (<9)

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P.2.1.29. Amyloid Beta 1-42 and total tau

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P.2.1.30. Applause sign (<3)

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P.2.1.31. Boston Naming Test, BNT (<13)

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P.2.1.32. Boston Naming Test, BNT (<14)

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P.2.1.33. Boston Naming Test, BNT (<15)

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P.2.1.34. Brief Neuropsychological Test Battery

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P.2.1.35. Clock Drawing Test, CDT, Shulman scoring method (>0)

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P.2.1.36. Clock Drawing Test, CDT, Shulman scoring method (>1)

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P.2.1.37. Clock Drawing Test, CDT, Shulman scoring method (>2)

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P.2.1.38. Clock Drawing Test, CDT, Shulman scoring method (>3)

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P.2.1.39. Clock Drawing Test, CDT, Watson scoring method (>4)

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P.2.1.40. Clock Drawing Test, CDT, Wolf-Klein scoring method (<7)

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P.2.1.41. Clock Drawing Test, CDT, scoring method unclear (<8)

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P.2.1.42. Clock Drawing Test, CDT, Manos and Wu scoring method (<8)

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P.2.1.43. Clock Drawing Test, Clock Drawing Test, CDT, Manos and Wu scoring method (<9)

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P.2.1.44. Clock Drawing Test, CDT, Lin scoring method (<3)

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P.2.1.45. CERAD battery

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P.2.1.46. Computed Tomography, CT

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P.2.1.47. Functional Activities Questionnaire, FAQ (<9)

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P.2.1.48. FDG-PET

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P.2.1.49. Free recall score of 5- word test, ≤ 6 for all dementia

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P.2.1.50. Informant Questionnaire on Cognitive Decline, IQCODE (16 item, >3.5)

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P.2.1.51. Informant Questionnaire on Cognitive Decline, IQCODE (16 item, >4.1)

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P.2.1.52. Informant Questionnaire on Cognitive Decline, IQCODE (26 item, >3.5)

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P.2.1.53. Informant Questionnaire on Cognitive Decline, IQCODE (26 item, >3.6)

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P.2.1.54. Informant Questionnaire on Cognitive Decline, IQCODE (26 item, >3.7)

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P.2.1.55. Informant Questionnaire on Cognitive Decline, IQCODE (26 item, >3.8)

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P.2.1.56. Informant Questionnaire on Cognitive Decline, IQCODE (26 item, >3.9)

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P.2.1.57. Informant Questionnaire on Cognitive Decline, IQCODE (26 item, >4.0)

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P.2.1.58. Informant Questionnaire on Cognitive Decline, IQCODE (26 item, >4.1)

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P.2.1.59. Letter Sorting Test, LST (<1)

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P.2.1.60. Letter Sorting Test, LST (<2)

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P.2.1.61. Letter Sorting Test, LST (<3)

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P.2.1.62. Mini-ACE (<26)

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P.2.1.63. Mini-Cog (≤2)

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P.2.1.64. Mini-Cog (Scanlan and Borson algorithm)

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P.2.1.65. Memory Impairment Screen, MIS (<4)

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P.2.1.66. Memory Impairment Screen, MIS (<5)

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P.2.1.67. Memory Impairment Screen, MIS (<6)

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P.2.1.68. Memory Impairment Screen, MIS (<7)

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P.2.1.69. Memory Impairment Screen, MIS (<8)

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P.2.1.70. MMSE (<17)

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P.2.1.71. MMSE (<18)

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P.2.1.72. MMSE (<19)

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P.2.1.73. MMSE (<20)

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P.2.1.74. MMSE (<21)

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P.2.1.75. MMSE (<22)

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P.2.1.76. MMSE (<23)

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P.2.1.77. MMSE (<24)

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P.2.1.78. MMSE (<25)

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P.2.1.79. MMSE (<26)

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P.2.1.80. MMSE (<27)

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P.2.1.81. MMSE (<28)

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P.2.1.82. Montreal Cognitive Assessment, MoCA (<19)

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P.2.1.83. Montreal Cognitive Assessment, MoCA (<22)

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P.2.1.84. Montreal Cognitive Assessment, MoCA (<24)

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P.2.1.85. Montreal Cognitive Assessment, MoCA (<25)

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P.2.1.86. Montreal Cognitive Assessment, MoCA (<26)

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P.2.1.87. MRI

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P.2.1.88. Orientation, OR (<7)

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P.2.1.89. Orientation, OR (<8)

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P.2.1.90. Palmo-Mental Reflex

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P.2.1.91. Palmo-Mental Reflex and Short smell test, 1 positive

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P.2.1.92. Palmo-Mental Reflex and Short smell test, both positive

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P.2.1.93. Phototest (<27)

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P.2.1.94. Rowland Universal Dementia Assessment Scale, RUDAS (<21)

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P.2.1.95. Rowland Universal Dementia Assessment Scale, RUDAS (<22)

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P.2.1.96. Rowland Universal Dementia Assessment Scale, RUDAS (<23)

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P.2.1.97. Rowland Universal Dementia Assessment Scale, RUDAS (<24)

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P.2.1.98. Rowland Universal Dementia Assessment Scale, RUDAS (<25)

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P.2.1.99. Rowland Universal Dementia Assessment Scale, RUDAS (<26)

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P.2.1.100. Seven Minute Screen (P>0.6)

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P.2.1.101. Seven Minute Screen (P>0.7)

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P.2.1.102. Seven Minute Screen (P>0.8)

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P.2.1.103. Short smell test

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P.2.1.104. Short Portable Mental Status Questionnaire, SPMSQ (≥4)

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P.2.1.105. Short Portable Mental Status Questionnaire, SPMSQ (≥5)

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P.2.1.106. Short Portable Mental Status Questionnaire, SPMSQ (≥6)

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P.2.1.107. Syndrom Kurztest (≥7)

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P.2.1.108. Syndrom Kurztest (≥8)

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P.2.1.109. Syndrom Kurztest (≥9)

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P.2.1.110. Total recall score of 5-word test, ≤ 9

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P.2.1.111. Total weighted score of 5-word test, ≤ 15

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P.2.1.112. Test Your Memory, TYM (≤30)

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P.2.1.113. Test Your Memory, TYM (≤42)

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P.2.1.114. Test Your Memory (≤39)

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P.2.1.115. Verbal category fluency (animal naming), VF (<14)

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P.2.1.116. Verbal category fluency (animal naming), VF (<19)

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P.2.1.117. Verbal category fluency (animal naming), VF (<20)

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P.2.1.118. Verbal category fluency (animal naming), VF (<21)

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P.2.1.119. Verbal category fluency (animal naming), VF (<22)

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P.2.1.120. Verbal category fluency (animal naming), VF (<23)

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P.2.1.121. Verbal category fluency (animal naming), VF (<24)

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P.2.2. AD versus DLB

P.2.2.1. Amyloid Beta 1-42

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P.2.2.2. FDG-PET

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P.2.2.3. MRI

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P.2.3. AD versus FTD

P.2.3.1. 99mTc-HMPAO SPECT

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P.2.3.2. Amyloid Beta 1-42 and Total Tau

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P.2.3.3. FDG-PET

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P.2.3.4. MRI

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P.2.3.5. p-tau 181

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P.2.4. AD versus no dementia

P.2.4.1. Amyloid Beta 1-42

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P.2.4.2. FDG-PET

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P.2.5. Free recall score of 5- word test, ≤ 5 for AD

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P.2.5.1. Informant Questionnaire on Cognitive Decline, IQCODE (16 item, >3.2)

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P.2.5.2. Informant Questionnaire on Cognitive Decline, IQCODE (16 item, >3.3)

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P.2.5.3. Informant Questionnaire on Cognitive Decline, IQCODE (16 item, >3.4)

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P.2.5.4. Informant Questionnaire on Cognitive Decline, IQCODE (16 item, >3.5)

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P.2.5.5. Informant Questionnaire on Cognitive Decline, IQCODE (16 item, >3.6)

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P.2.5.6. MMSE (<28)

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P.2.5.7. p-tau 181

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P.2.5.8. p-tau/Amyloid Beta 1-42

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P.2.5.9. Total recall score of 5-word test, ≤ 9

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P.2.5.10. Total Tau

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P.2.5.11. Total weighted score of 5-word test, ≤ 15

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P.2.6. AD versus non-AD dementia plus unclassifiable

P.2.6.1. 99mTc-HMPAO SPECT

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P.2.6.2. MRI

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P.2.7. AD versus non-AD

P.2.7.1. ≥ 2 of 3 biomarkers abnormal (Amyloid Beta 1-42, t-tau, p-tau)

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P.2.7.2. 2 out of 3 abnormal (Amyloid Beta 1–42, Total Tau, p-tau)

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P.2.7.3. Amyloid Beta 1–42, Total Tau, p-tau abnormal

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P.2.7.4. 99mTc-ECD SPECT, visual assessment method

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P.2.7.5. 99mTc-ECD SPECT, all information method

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P.2.7.6. 99mTc-ECD SPECT, automated method

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P.2.7.7. 99mTc-HMPAO SPECT

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P.2.7.8. Amyloid Beta 1-42

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P.2.7.9. Amyloid Beta 1-42 and total tau

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P.2.7.10. Amyloid Beta 1-42 and t-tau and/or p-tau abnormal

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P.2.7.11. Amyloid Beta 1-42/p-tau 181

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P.2.7.12. Amyloid Beta 1-42/Total Tau

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P.2.7.13. Amyloid Beta 1-42/1- 40

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P.2.7.14. EEG

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P.2.7.15. FDG-PET

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P.2.7.16. FDG-PET/CT

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P.2.7.17. [18F] flutemetamol PET

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P.2.7.18. Formula Hulstaert (biomarkers)

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P.2.7.19. Formula Mattson (biomarkers)

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P.2.7.20. Formula Mulder (biomarkers)

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P.2.7.21. Formula Schoonenboom (biomarkers)

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P.2.7.22. Mass Spectrometry

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P.2.7.23. MRI

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P.2.7.24. MRI Total Hippocampal grey matter volume, Hv. Cut off 4.95ml

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P.2.7.25. MRI Hippocampal grey matter volume left, HVL. Cut- off 2.69 ml

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P.2.7.26. MRI Hippocampal grey matter volume left/ total grey matter volume (HVL/GMV). Cut-off 4.69 per mille

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P.2.7.27. MRI Hippocampal grey matter volume right, HVR. Cut off 2.70ml

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P.2.7.28. MRI Hippocampal grey matter volume right/ total grey matter volume (HVR/GMV). Cut-off 4.54 per mille

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P.2.7.29. MRI Total hippocampal grey matter volume/total grey matter volume (HV/GMV). Cut-off 8.36 per mille

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P.2.7.30. Olfactory Test ≥ 3 errors

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P.2.7.31. Olfactory Test ≥ 4 errors

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P.2.7.32. Olfactory Test ≥ 5 errors

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P.2.7.33. p-tau 181

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P.2.7.34. p-tau and Amyloid Beta 1-42 combined then in case of discrepancy between p-tau and Amyloid Beta 1-42 the Amyloid Beta 42/40 ratio was used in place of Amyloid Beta 1-42

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P.2.7.35. p-tau and Amyloid Beta 42/40

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P.2.7.36. p-tau/Amyloid Beta 1-42

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P.2.7.37. Total Tau

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P.2.7.38. Total Tau/Amyloid Beta 1-42

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P.2.7.39. Urinary AD7c-NTP (22ug/ml)

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P.2.8. AD versus other dementias

P.2.8.1. 99mTc-HMPAO SPECT

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P.2.8.2. AD scale (≥6)

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P.2.8.3. Amyloid Beta 1-42

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P.2.8.4. Amyloid Beta 1-42 and total tau

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P.2.8.5. Apo E (≥1 allele)

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P.2.8.6. CSF 14-3-3, total Tau and p-tau

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P.2.8.7. Computed Tomography, CT

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P.2.8.8. FDG-PET

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P.2.8.9. MRI

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P.2.8.10. p-tau 181

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P.2.8.11. p-tau/Amyloid Beta 1-42

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P.2.8.12. Total tau

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P.2.8.13. Total Tau/Amyloid Beta 1-42

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P.2.9. AD versus VaD

P.2.9.1. 99mTc-HMPAO SPECT

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P.2.9.2. Amyloid Beta 1-42

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P.2.9.3. Computed Tomography, CT

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P.2.9.4. MRI

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P.2.10. bv-FTD versus non-bv-FTD

P.2.10.1. FDG-PET

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P.2.10.2. FDG-PET and MRI

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P.2.10.3. FTDC criteria for bv FTD

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P.2.10.4. FTDC criteria for possible bvFTD

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P.2.10.5. FTDC criteria for probable bvFTD

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P.2.10.6. MRI

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P.2.11. bvFTD/fd+ versus non-bvFTD/fd+

P.2.11.1. FDG-PET

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P.2.12. CADASIL versus CADASIL-like syndromes

P.2.12.1. Skin biopsy

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P.2.13. CBD versus non-CBD

P.2.13.1. CBD consensus criteria

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P.2.14. CJD versus non-CJD

P.2.14.1. Amyloid Beta 1-42 and total tau

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P.2.14.2. CSF 14-3-3 Automated Capillary Western Assay

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P.2.14.3. CSF 14-3-3 (multiple methods)

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P.2.14.4. CSF 14-3-3 ELISA

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P.2.14.5. CSF 14-3-3 immunoblotting

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P.2.14.6. CSF 14-3-3 (presence) and S100B (>1.0ng/ml)

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P.2.14.7. CSF 14-3-3 and Amyloid Beta 1-42

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P.2.14.8. CSF 14-3-3 and total Tau

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P.2.14.9. CSF 14-3-3, total Tau and S100B

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P.2.14.10. EEG

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P.2.14.11. European criteria for CJD

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P.2.14.12. French criteria for CJD

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P.2.14.13. Master’s criteria for CJD

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P.2.14.14. MRI

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P.2.14.15. MRI, DWI

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P.2.14.16. Neuron-specific enolase

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P.2.14.17. New criteria for sporadic CJD

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P.2.14.18. p-tau 181/total tau

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P.2.14.19. RT-QuIC

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P.2.14.20. S100B, 1.0ng/ml

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P.2.14.21. S100B, 2.5ng/ml

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P.2.14.22. S100B, 4.2ng/ml

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P.2.14.23. Total Tau

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P.2.14.24. Total Tau and S100B

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P.2.14.25. WHO CJD criteria

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P.2.15. DLB versus AD

P.2.15.1. Lewy body composite risk score, LBCRS, ≥ 3

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P.2.15.2. MRI

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P.2.16. DLB versus FTD

P.2.16.1. MRI

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P.2.17. DLB versus non-DLB

P.2.17.1. 123I-FP-CIT SPECT

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P.2.17.2. 123I-IMP SPECT

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P.2.17.3. 123I-IMP SPECT and 123I-MIBG cardiac scintigraphy combined

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P.2.17.4. 123I-MIBG cardiac scintigraphy

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P.2.17.5. EEG

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P.2.17.6. FDG-PET

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P.2.17.7. MRI

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P.2.17.8. RBD or two or more of visual hallucinations, Parkinsonism, and fluctuating attention and concentration

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P.2.17.9. Two or more of fluctuating attention and concentration, visual hallucinations and Parkinsonism

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P.2.17.10. Two or more of visual hallucinations, Parkinsonism or RBD

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P.2.17.11. Two or more of visual hallucinations, Parkinsonism, fluctuating attention and concentration or RBD

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P.2.18. DLB versus other dementias

P.2.18.1. 123I-FP-CIT SPECT

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P.2.18.2. 123I-MIBG cardiac scintigraphy

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P.2.18.3. DLB consensus criteria

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P.2.18.4. FDG-PET

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P.2.18.5. Lewy body composite risk score, LBCRS, ≥ 3

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P.2.18.6. MRI

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P.2.19. DLB versus VaD

P.2.19.1. MRI

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P.2.20. FTD versus AD

P.2.20.1. 99mTc-HMPAO SPECT

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P.2.20.2. MRI

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P.2.20.3. FTD versus DLB

P.2.20.4. FDG-PET

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P.2.20.5. MRI

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P.2.21. FTD versus non-FTD dementia plus unclassifiable

P.2.21.1. 99mTc-HMPAO SPECT

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P.2.22. MRI

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P.2.23. FTD versus non-FTD

P.2.23.1. 99mTc-ECD SPECT, visual assessment

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P.2.23.2. 99mTc-HMPAO SPECT

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P.2.23.3. SPECT/PET

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P.2.23.4. FDG-PET

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P.2.23.5. FTD consensus criteria

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P.2.23.6. MRI

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P.2.24. FTD versus other dementias

P.2.24.1. 99mTc-HMPAO SPECT

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P.2.24.2. FDG-PET

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P.2.24.3. FTD scale (≥6)

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P.2.24.4. MRI

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P.2.25. FTD versus VaD

P.2.25.1. 99mTc-HMPAO SPECT

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P.2.25.2. MRI

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P.2.26. HAND versus other neurological disorders in HIV+ people

P.2.26.1. HIV dementia scale (<10)

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P.2.26.2. HIV dementia scale (<11)

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P.2.26.3. International HIV Dementia scale (IHDS) (<10)

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P.2.26.4. Grooved pegboard test

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P.2.26.5. Modified HIV dementia scale (m-HDS) (<7.5)

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P.2.26.6. Modified HIV dementia scale (m-HDS) and grooved pegboard combined

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P.2.27. Neurosyphilis versus not neurosyphilis

P.2.27.1. CSF EIA

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P.2.27.2. FTA-ABS

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P.2.27.3. INNO-LIA

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P.2.27.4. PCR for T. pallidum genes: polA, Tpp47, and bmp

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P.2.27.5. TPPA

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P.2.28. PDD and DLB versus other dementias

P.2.28.1. 123I-MIBG cardiac scintigraphy

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P.2.29. PDD versus non-PDD

P.2.29.1. FCSRT-IR 3- FR (≤22)

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P.2.29.2. Movement disorders criteria for PDD (≤120)

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P.2.29.3. Movement disorders criteria for PDD (≤123)

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P.2.29.4. Movement disorders criteria for PDD (≤132)

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P.2.29.5. Rey-Osterrieth complex figure test, ROCF (≤22)

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P.2.30. PPA versus non-PPA

P.2.30.1. FDG-PET

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P.2.31. VaD and mixed dementias versus AD

P.2.31.1. Hachinski ischemic score, HIS (≥5)

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P.2.32. VaD versus AD and mixed dementia (AD plus VaD)

P.2.32.1. ADDTC (possible)

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P.2.32.2. ADDTC (probable)

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P.2.32.3. ADDTC criteria

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P.2.32.4. Hachinski ischemic score, HIS (≥7)

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P.2.32.5. NINDS-AIREN (possible)

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P.2.32.6. NINDS-AIREN (probable)

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P.2.32.7. NINDS-AIREN criteria

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P.2.33. VaD versus AD

P.2.33.1. 99mTc-HMPAO SPECT

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P.2.33.2. MRI

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P.2.34. VaD versus DLB

P.2.34.1. MRI

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P.2.35. VaD versus FTD

P.2.35.1. 99mTc-HMPAO SPECT

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P.2.35.2. MRI

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P.2.36. VaD versus non-VaD dementia plus unclassifiable

P.2.36.1. MRI

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P.2.37. VaD versus non-VaD

P.2.37.1. 99mTc-HMPAO SPECT

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P.2.38. MRI

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P.2.39. VaD versus other dementias

P.2.39.1. HIS (≥7)

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P.2.39.2. MRI

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Copyright © NICE 2018.
Bookshelf ID: NBK555504

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