U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 338

1.

Transcriptomics-based anti-tuberculous mechanism of traditional Chinese polyherbal preparation NiuBeiXiaoHe intermediates

(Submitter supplied) To further investigate the therapeutic potential of NBXH in treating tuberculosis, we employ whole genome microarray expression profiling as a discovery platform. The study aimed to explore the impact of NBXH treatment on the gene expression profile of tuberculosis-infected animal models. The animal models were treated with high, medium, and low doses of NBXH. Following three months of treatment, PBMCs from each treatment group were used for whole genome microarray expression profiling analysis, alongside a control group. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
18 Samples
Download data: TXT, XLS
Series
Accession:
GSE276937
ID:
200276937

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

Cardiomyocyte S1pr1 regulates cardiac regeneration via AKT/mTOR signaling pathway

(Submitter supplied) Mammalian hearts had the capability to regenerate cardiomyocyte and completely recover after heart injury within a limited time window after birth. It has been shown that sphingosine 1-phospahte receptor 1 (S1pr1) was highly expressed in cardiomyocytes and played an important role in heart development and pathological cardiac remodeling. Herein, we aim to investigate the role of CM-S1pr1 for cardiac regeneration and tissue repair after heart injury. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
4 Samples
Download data: TXT, XLS
Series
Accession:
GSE241722
ID:
200241722

Analyze with GEO2R

3.

Chronic sleep fragmentation reduces left ventricular contractile function and alters gene expression related to innate immune response and circadian rhythm in the mouse heart

(Submitter supplied) Purpose: The purpose of this study was to comprehensively identify the gene expression changes that occur after chronic sleep fragmentation. Method: We conducted total microarray analysis of the heart in mice following 5 weeks of sleep fragmentation. Results: The microarray analysis revealed significant and dramatic gene expression changes in the mouse heart as a result of chronic sleep fragmentation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
6 Samples
Download data: TXT
Series
Accession:
GSE236358
ID:
200236358

Analyze with GEO2R

4.

Transcriptome analysis of embryos of STAT3-K177R/K180R mutant mice

(Submitter supplied) Total RNA from embryos (12 days) of STAT3 homozygous and heterozygote mutant mice (K177/180R) and STAT3 wild type mice which come from the same womb were extracted using TRIzol reagent (Invitrogen) following the manufacturer’s protocols. RNA quantity, quality and integrity were analyzed with NanoDrop ND-1000 and standard denaturing agarose gel electrophoresis. Sample labeling and array hybridization were performed according to the Agilent One-Color Microarray-Based Gene Expression Analysis protocol of Agilent Technology. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
6 Samples
Download data: TXT
Series
Accession:
GSE271656
ID:
200271656

Analyze with GEO2R

5.

Loss of SIRPα promotes podocytes presenting antigen to activate specific T cell immune responses in lupus nephritis via activating spleen tyrosine kinase

(Submitter supplied) To investigate the role of SIRPα in podocytes, we generated podocyte-specific SIRPα knockout mice, Subsequent studies have found that SIRPa is deeply involved in the adaptive immune process of podocytes, and the loss of SIRPa promotes the ability of podocytes to present antigens,furthermore, the loss of SIRPa in podocytes can promote the increase of antigen presentation ability of podocytes and promote the progression of lupus nephrin
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
2 Samples
Download data: TXT
Series
Accession:
GSE240916
ID:
200240916

PubMed Similar studies Analyze with GEO2R

6.

HSP27 (Heat Shock Protein 27, HSPB1) overexpression effect on bleomycin-induced PF (Pulmonary fibrosis) mice model

(Submitter supplied) To analyze the role of HSP27 in bleomycin (BLM)-induced pulmonary fibrosis in vivo, we used TG mice that conventionally overexpressed HSP27. Our previously reported that HSP27 plays an important role in pulmonary fibrosis. In mice overexpressing HSPB1, BLM-induced fibrotic regions and collagen deposits were increased compared with those in control BL6 mice. Following intratracheal treatment of BLM, the HSP25 TG mice showed an abundance of mononuclear and neutrophils cells in the alveoli, greater destruction of alveolar septa, intra-alveolar hyaline membrane formation, and a marked increase in collagen deposition compared with control BL6 mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
2 Samples
Download data: TXT
Series
Accession:
GSE233735
ID:
200233735

Analyze with GEO2R

7.

Effect of the autoimmune suppressor Gadd45a on radiation biodosimetry

(Submitter supplied) Radiation biodosimetry based on transcriptomic analysis of peripheral blood is a valuable tool to detect radiation exposure after a radiological/nuclear event and obtain useful biological information that could predict tissue and organismal injury. However, confounding factors, including inflammation, can potentially obscure the predictive power of the method. The Gadd45 (growth arrest and DNA damage-inducible genes) family is composed of three members, Gadd45a, Gadd45b, and Gadd45g, that play important roles in cell growth control, differentiation, DNA repair, and apoptosis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
24 Samples
Download data: TXT
Series
Accession:
GSE196400
ID:
200196400

PubMed Full text in PMC Similar studies Analyze with GEO2R

8.

Irisin regulated genes in mouse liver derived AML12 cells

(Submitter supplied) To find genes regulated by irisin in culture media in AML12 cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
8 Samples
Download data: TXT
Series
Accession:
GSE232188
ID:
200232188

PubMed Full text in PMC Similar studies Analyze with GEO2R

9.

Analysis of the effect of prenatal alcohol exposure on the Placenta—Cortex transcriptomic signature

(Submitter supplied) Although alcohol consumption during pregnancy is a major cause of behavioral and learning disabilities, most FASD infants are late- or even misdiagnosed due to clinician’s difficulties achieving early detection of alcohol-induced neurodevelopmental impairments. Neuroplacentology has emerged as a new field of research focusing on the role of the placenta in fetal brain development. Several studies have reported that prenatal alcohol exposure (PAE) dysregulates a functional placenta–cortex axis, which is involved in the control of angiogenesis and leads to neurovascular-related defects.   However, these studies were focused on PlGF, a pro-angiogenic factor. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
16 Samples
Download data: TXT
Series
Accession:
GSE241836
ID:
200241836

PubMed Full text in PMC Similar studies Analyze with GEO2R

10.

Assessment of the molecular mechanism associated with osteogenic and angiogenic differentiation induced by FeMnSi scaffold

(Submitter supplied) To investigate the molecular mechanism underlying osteogenic and angiogenic differentiation induced by the De-HA scaffold, we conducted an in-depth gene microarray analysis on day 3 of MC3T3-E1 culture. We found that De-HA could enhance the transcription of osteogenic and angiogenic genes by activating FAK and downstream MAPK/ERK signaling to induce MC3T3-E1 differentiation. More importantly, our findings indicated that EGFR, a kind of transmembrane glycoprotein, played a key role in the osteogenic differentiation of MC3T3-E1, suggesting that the activation of the FAK/MAPK/ERK signaling cascade might be driven by EGFR.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
6 Samples
Download data: TXT
Series
Accession:
GSE235166
ID:
200235166

Analyze with GEO2R

11.

Analysis of Gene Expression Profile Alterations During NBXH Treatment for Tuberculosis

(Submitter supplied) To further investigate the therapeutic potential of NBXH in treating tuberculosis, we employ whole genome microarray expression profiling as a discovery platform. The study aimed to explore the impact of NBXH treatment on the gene expression profile of tuberculosis-infected animal models. The animal models were treated with high, medium, and low doses of NBXH. Following three months of treatment, PBMCs from each treatment group were used for whole genome microarray expression profiling analysis, alongside a control group. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
21 Samples
Download data: TXT
Series
Accession:
GSE233364
ID:
200233364

Analyze with GEO2R

12.

Murine lenses:βB2-crystallin W151C knock-in mice vs.wild type control mice

(Submitter supplied) Transcriptional profiling of the lens in βB2-crystallin W151C mutation mice compared with wild type lenses
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
6 Samples
Download data: TXT, XLS
Series
Accession:
GSE225548
ID:
200225548

PubMed Full text in PMC Similar studies Analyze with GEO2R

13.

Muscle-specific gene expression changes in spinal and bulbar muscular atrophy (SBMA) at presymptomatic timepoint

(Submitter supplied) The pattern of gene expression changes were analyzed in the skeletal muscle of knock-in mouse models of SBMA at 3 month of age.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
7 Samples
Download data: TXT
Series
Accession:
GSE220080
ID:
200220080

PubMed Full text in PMC Similar studies Analyze with GEO2R

14.

Effects on gene expression by Aff3-deficiency

(Submitter supplied) To analyze the effect of Aff3-deficeincy on gene expression in B cells, we employed cDNA microarray analysis. The data indicated that the deficiency altered the expressions of very limited number of genes.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
4 Samples
Download data: TXT
Series
Accession:
GSE193735
ID:
200193735

Analyze with GEO2R

15.

Effects of deproteinized extract of calf blood on the energy metabolism of acute hypoxia model mice and its targets

(Submitter supplied) Deproteinized extract of calf blood (DECB) can improve the transport and utilization of blood oxygen and glucose in hypoxic tissue cells, and accelerate the oxidative phosphorylation process of mitochondria, to improve the energy metabolism of cells. Due to its complex composition, the mechanism of DECB on energy metabolism is not entirely clear yet. Effects of DECB on the energy metabolism of acute hypoxia model mice were observed by detecting glucose, lactic acid, and protein and ATP contents in the brain, heart and liver of the mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
6 Samples
Download data: TXT
Series
Accession:
GSE142545
ID:
200142545

Analyze with GEO2R

16.

Gene expression in BMDM treated with GW4064

(Submitter supplied) We have employed whole genome microarray expression profiling with the samplaes prepared by treating BMDM with GW4064, an fxr agonist. Some genes upregulated in GW4064 treated sample were used for qPCR to confirm the change of expression level.
Organism:
Mus; Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
2 Samples
Download data: TXT
Series
Accession:
GSE216995
ID:
200216995

PubMed Full text in PMC Similar studies Analyze with GEO2R

17.

Comparative genomic analysis focused on early and intermediate phases of cellular reprogramming

(Submitter supplied) Mechanistic interpretation of the reprogramming process is still remained elusive. Thus, we compared two reprogramming processes, pluripotent cell-specific factor-mediated direct reprogramming (PDR) and induced pluripotent stem cells reprogramming (iPSCR), to figure out how and when these processes are bifurcated from each other during the reprogramming. Until day 6, all samples showed a similar pattern of gene expression, but the pattern has changed dramatically after day 6 regardless of dox-induction or specific cues for cell fate determination. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
58 Samples
Download data: TXT
Series
Accession:
GSE156888
ID:
200156888

PubMed Full text in PMC Similar studies Analyze with GEO2R

18.

Loss of LOXL2 promotes uterine hypertrophy and tumor progression

(Submitter supplied) Gene expression microarray was used to evaluate altered genes related to LOXL2 expression level in order to identify potential molecular mechanism in uterus.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6480 GPL11202
12 Samples
Download data: TXT
Series
Accession:
GSE213868
ID:
200213868

Analyze with GEO2R

19.

Transformed cells after senescence give rise to more severe tumor phenotypes than transformed non-senescent cells

(Submitter supplied) Oncogenic stress-induced senescence initially inhibits tumor initiation by blocking proliferation. If these cells are not eliminated they may resume proliferation upon loss-of-tumor suppressors, and be at risk of transformation. During tumor formation, depending on the sequence of events of gain-of-oncogenes and/or loss-of-tumor suppressors, cancer cells may emerge from senescent cells. The goal of this study is to determine if transformed cells after senescence (TS) display more aggressive tumorigenic features, with a greater capacity to migrate and a higher resistance to anti-tumoral drugs than cells having undergone transformation without senescence. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
12 Samples
Download data: TXT
Series
Accession:
GSE210060
ID:
200210060

Analyze with GEO2R

20.

Ameliorative effect of the oil components derived from sweet potato shochu on impaired short-term memory in mice after amyloid ß25-35 injection

(Submitter supplied) In this study, we first analyzed the components of shochu oil and then investigated the effects of shochu oil on short-term memory, using a mouse model exhibiting spontaneous alternating behavior caused by the intracerebroventricular administration of Aß25-35. On the last day of the experiment, we examined gene expression in the mouse hippocampus using DNA microarrays. We confirmed the effect of the oil components derived from sweet potato shochu on impaired short-term memory in mice after amyloid ß25-35 injection. more...
Organism:
Mus; Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
3 Samples
Download data: TXT
Series
Accession:
GSE208013
ID:
200208013

Analyze with GEO2R

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Filters: Manage Filters

db=gds|term=GPL11202[RGSE]|query=28|qty=10|blobid=MCID_671f8e44e158b40557c252c8|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Important Links

Recent activity

Clear Turn Off Turn On

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
You are here: NCBI > Genes & Expression > Gene Expression Omnibus (GEO) Datasets
Support Center