Similar studies for GEO DataSets (Select 200024073) - GEO DataSets

(Submitter supplied) Ace2 transcription factor family genes are found in many fungal genomes and are required for regulation of expression of genes involved in cell separation. We used transcriptional profiling to identify the targets of Ace2 in Candida albicans, and we show that these include several cell wall components, such as glucanases and glycosylphosphatidylinositol-anchored proteins. Expression is downregulated in ace2 deletion mutants in both yeast and hyphal cells. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL3727
12 Samples

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Series

Accession:: GSE7105

ID:: 200007105

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000071006.

WT vs. ACE2 knockout (grown in hyphal form)

(Submitter supplied) We have used DNA microarray technology to compare the expression of over 6000 genes between C. albicans WT and ACE2 knockout strains in the hyphal form. Keywords: Gene expression comparison

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL3727
5 Samples

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Series

Accession:: GSE7100

ID:: 200007100

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Select item 2000070997.

WT vs. ACE2 knockout (grown in yeast form)

(Submitter supplied) We have used DNA microarray technology to compare the expression of over 6000 genes between C. albicans WT and ACE2 knockout strains in the yeast form. Keywords: Gene expression comparison

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL3727
7 Samples

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Series

Accession:: GSE7099

ID:: 200007099

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Select item 2000113208.

Mutation in Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Fluconazole Resistance

(Submitter supplied) In the pathogenic yeast Candida albicans, the zinc cluster transcription factor Upc2p has been shown to regulate expression of ERG11 and other genes involved in ergosterol biosynthesis upon exposure to azole antifungals. ERG11 encodes lanosterol demethylase, the target enzyme of this antifungal class. Over-expression of UPC2 reduces azole susceptibility, whereas its disruption results in hypersusceptibility to azoles and reduced accumulation of exogenous sterols. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platforms:: GPL5723 GPL6808
18 Samples

Download data: CEL, CHP

Series

Accession:: GSE11320

ID:: 200011320

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Select item 2000334909.

Conserved and divergent roles of Bcr1 and CFEM proteins in Candida parapsilosis and Candida albicans

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Candida parapsilosis; Candida albicans

Type:: Expression profiling by array

Platforms:: GPL13192 GPL10903
18 Samples

Download data: GPR

Series

Accession:: GSE33490

ID:: 200033490

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Select item 20003346210.

Transcriptional profile of Candida parapsilosis CLIB214 culture in low iron conditions

(Submitter supplied) Whole genome microarrays were used to generate the transcriptional profile of Candida parapsilosis in low iron conditions

Organism:: Candida parapsilosis

Type:: Expression profiling by array

Platform:: GPL13192
7 Samples

Download data: GPR

Series

Accession:: GSE33462

ID:: 200033462

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Select item 20003346111.

Transcriptional profile of Candida parapsilosis bcr1 knockout.

(Submitter supplied) Whole genome microarrays were used to compare the transcriptional profile of Candida parapsilosis bcr1 knockout to wild type cells.

Organism:: Candida parapsilosis

Type:: Expression profiling by array

Platform:: GPL13192
7 Samples

Download data: GPR

Series

Accession:: GSE33461

ID:: 200033461

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003346012.

Transcriptional profile of Candida albicans bcr1 knockout.

(Submitter supplied) Whole genome microarrays were used to compare the transcriptional profile of Candida albicans bcr1 knockout to wild type cells.

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL10903
4 Samples

Download data: GPR

Series

Accession:: GSE33460

ID:: 200033460

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Select item 20007190413.

Function and regulation of Cph2 in Candida albicans

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Candida albicans

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL19036
10 Samples

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Series

Accession:: GSE71904

ID:: 200071904

PubMed Full text in PMC Similar studies

Select item 20007190214.

Function and regulation of Cph2 in Candida albicans [RNA-Seq]

(Submitter supplied) Candida albicans is associated with humans as both a harmless commensal organism and a pathogen. Cph2 is a transcription factor whose DNA binding domain is similar to mammalian sterol response element binding proteins (SREBPs). SREBPs are master regulators of cellular cholesterol levels, and are highly conserved from fungi to mammals. However, ergosterol biosynthesis is regulated by the zinc finger transcription factor Upc2 in C. more...

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19036
4 Samples

Download data: TXT

Series

Accession:: GSE71902

ID:: 200071902

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007172815.

Function and regulation of Cph2 in Candida albicans [ChIP-Seq]

Organism:: Candida albicans

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19036
6 Samples

Download data: TXT

Series

Accession:: GSE71728

ID:: 200071728

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004743316.

Zinc finger transcription factors displaced SREBP proteins as the major sterol regulators during Saccharomycotina evolution

(Submitter supplied) All but a few eukaryotes die without oxygen and respond dynamically to changes in the level of oxygen available to them. One ancient oxygen-requiring biochemical pathway in eukaryotes is the pathway for the biosynthesis of sterols, leading to cholesterol in animals and ergosterol in fungi. Mutations in this pathway are a frequent cause of azole drug resistance in pathogenic fungi. The regulatory mechanism for the sterol pathway is also widely conserved between animals and fungi and is centred on a transcription activator, SREBP, that forms part of a sterol-sensing complex. more...

Organism:: Yarrowia lipolytica

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17209 GPL17208
14 Samples

Download data: TXT

Series

Accession:: GSE47433

ID:: 200047433

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013765517.

A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen Candida albicans

(Submitter supplied) Inside the human host, the pathogenic yeast Candida albicans colonizes predominantly oxygen-poor niches such as the gastrointestinal and vaginal tracts, but also oxygen-rich environments such as cutaneous epithelial cells and oral mucosa. This suppleness requires an effective mechanism to reprogram reversibly the primary metabolism in response to oxygen variation. Here, we have uncovered that Snf5, a subunit of SWI/SNF chromatin remodeling complex, is a major transcriptional regulator that links oxygen status to the metabolic capacity of C. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL9818
4 Samples

Download data: TXT

Series

Accession:: GSE137655

ID:: 200137655

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Select item 20001317618.

The protein kinase Tor1 regulates adhesin expression in Candida albicans

(Submitter supplied) Eukaryotic cell growth is coordinated in response to nutrient availability, growth factors, and environmental stimuli, enabling cell–cell interactions that promote survival. The rapamycin-sensitive Tor1 protein kinase, which is conserved from yeasts to humans, participates in a signaling pathway central to cellular nutrient responses. To gain insight into Tor-mediated processes in human fungal pathogens, we have characterized Tor signaling in Candida albicans. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL7476
12 Samples

Download data: GPR

Series

Accession:: GSE13176

ID:: 200013176

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Select item 20001383219.

Hypoxia and biofilms in Candida parapsilosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Candida parapsilosis

Type:: Expression profiling by array

Platforms:: GPL4574 GPL7693
10 Samples

Download data: GPR

Series

Accession:: GSE13832

ID:: 200013832

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Select item 20001372220.

Transcriptional response of Candida parapsilosis in low oxygen (hypoxic) conditions in SD media

(Submitter supplied) Whole genome microarray was used to compare the transcriptional profile of C. parapsilosis growing in normoxic (21% oxygen) and hypoxic (1% oxygen) conditions.