Similar studies for GEO DataSets (Select 200066494) - GEO DataSets

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Items: 20

Select item 2000664941.

Development of gene expression profiles in human chronic kidney disease

(Submitter supplied) A microarray analysis with renal biopsy specimens from CKD patients was conducted in order to identify the responsible genes associated with tubulointerstitial fibrosis and tubular cell injury in CKD. This study showed microarray profiles in total 53 biopsy specimens of CKD patients. In the discovery set, 554 down-regulated and 226 up-regulated signatures were identified. Then, the expressional changes of these genes were examined in the validation set.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
61 Samples

Download data: TXT

Series

Accession:: GSE66494

ID:: 200066494

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000537732.

Molecular regulation of acute kidney injury

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: synthetic construct; Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL16686 GPL16384
72 Samples

Download data: CEL

Series

Accession:: GSE53773

ID:: 200053773

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Select item 2000537713.

Molecular regulation of acute kidney injury (miRNA)

(Submitter supplied) 18 zero-hour and 18 selected post-transplant (Tx) biopsy samples from 18 kidney allografts (8 acute kidney injury (AKI), 10 PBx - protocol biopsies - controls) were analyzed by using the Affymetrix GeneChip® miRNA 3.0 Array.

Organism:: synthetic construct; Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL16384
36 Samples

Download data: CEL

Series

Accession:: GSE53771

ID:: 200053771

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Select item 2000537694.

Molecular regulation of acute kidney injury (mRNA)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
36 Samples

Download data: CEL

Series

Accession:: GSE53769

ID:: 200053769

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Select item 2000986225.

Transcriptome profile of a murine renal bilateral ischemia reperfusion model 2 hours to 12 months post injury

(Submitter supplied) Acute kidney injury (AKI) is associated with an increased risk of chronic kidney disease (CKD). To extend our understanding of renal repair, and its limits, we performed a detailed molecular characterization of a murine ischemia reperfusion injury (IRI) model for 12 months post injury. RNA-seq analysis highlights a cascade of temporal specific gene expression patterns related to tubular injury/repair, fibrosis, innate and adaptive immunity.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL13112
49 Samples

Download data: XLSX

Series

Accession:: GSE98622

ID:: 200098622

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000573876.

Transcriptome signature in early biopsies of stably functioning kidney allografts identify patients at risk for chronic injury

(Submitter supplied) Chronic injury in kidney transplants remains a major cause of graft loss. The aim of this study was to identify a predictive gene set capable of classifying renal grafts at risk for progressive injury due to fibrosis.The Genomics of Chronic Allograft Rejection (GoCAR) study is a prospective, multicenter study. Biopsies obtained prospectively 3 months after transplantation from renal allograft recipients (n=159) with stable renal function were analyzed for gene expression by microarray. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
159 Samples

Download data: CEL

Series

Accession:: GSE57387

ID:: 200057387

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Select item 2002122337.

Single cell analysis on the HIV-infected kidney cells

(Submitter supplied) HIV-vpr expression was mainly detected in tubule cells after infection. By comparing the HIV-infected and wild type kidney cells on single cell level, a strong shift was observed in the PT S3 segment cell population. Transcription factor analysis revealed Trp53 playing important regulation role in HIV infected cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
5 Samples

Download data: TXT

Series

Accession:: GSE212233

ID:: 200212233

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Select item 2002171768.

HDAC9-mediated Epithelial Cell Cycle Arrest in G2/M Contributes to Kidney Fibrosis

(Submitter supplied) Renal tubulointerstitial fibrosis is the pathological feature of AAN. Aristolochic acid nephropathy (AAN)was induced by a one-time intraperitoneal injection of aristolochic acid in PBS. By RNA sequencing analysis in AAN mice, we observed the significant changes of genes important in regulating cell cycle.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
10 Samples

Download data: TXT

Series

Accession:: GSE217176

ID:: 200217176

PubMed Full text in PMC Similar studies

Select item 2001506419.

RNAseq of kidneys from a mice model of chronic leptospirosis infection and induced a secondary nephrotoxic injury by adenine feeding

(Submitter supplied) Background The mysterious chronic kidney disease is multifactorial causes. One of the risk factors is leptospirosis, a re-emerging infectious disease caused by Leptospira spp., for endemic leptospirosis tend to coincide with high-incidence regions of chronic kidney disease of unknown etiology. This study aims to investigate the role of leptospirosis as an emerging culprit in which chronic subclinical kidney injury, may predispose to progressive kidney disease when superimposed on secondary nephrotoxic injury. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23479
18 Samples

Download data: TXT

Series

Accession:: GSE150641

ID:: 200150641

PubMed Similar studies SRA Run Selector

Select item 20021402410.

Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney

(Submitter supplied) Mouse E18.5 wildtype kidney single-cell reference.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: MTX, TSV

Series

Accession:: GSE214024

ID:: 200214024

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Select item 20019862111.

Single-cell transcriptional profiling of advanced renal fibrosis identifies novel specific fibroblast marker and disease target

(Submitter supplied) Dissecting the molecular and cellular nature of advanced renal fibrosis is principal for mechanistic understanding of chronic kidney disease (CKD) and developing targeted strategies against its progression. Aberrant renal fibroblast activation and unresolved tubular epithelial injury are key contributors to excessive extracellular matrix (ECM) production and kidney function loss. However, the transcriptional and cellular identities of activated renal fibroblasts remain poorly characterized. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
11 Samples

Download data: MTX, TSV

Series

Accession:: GSE198621

ID:: 200198621

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Select item 20013597712.

CPP stimulation

(Submitter supplied) HK2 treated with CPP

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21185
16 Samples

Download data: TXT

Series

Accession:: GSE135977

ID:: 200135977

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Select item 20012121113.

Transcriptome analysis of tubular tissues of focal segmental glomerulosclerosis patients

(Submitter supplied) Transcriptome comparison of tubular tissues from kidneys with focal segmental glomerulosclerosis (FSGS) and tubular tissues from the unaffected portion of tumor nephrectomies. High-density Affymetrix Human Transcriptome Arrays (HTA) 2.0 were used for the gene expression analysis.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
10 Samples

Download data: CEL

Series

Accession:: GSE121211

ID:: 200121211

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009819714.

Sav1 Loss Induces Senescence and Stat3 Activation Coinciding with Tubulointerstitial Fibrosis

(Submitter supplied) Our mouse model (Ksp-CreER/Sav1fl/fl ) offers novel insights into molecular events that are linked to fibrosis development from Sav1 loss.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
8 Samples

Download data: TXT

Series

Accession:: GSE98197

ID:: 200098197

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013708615.

Connectivity mapping of a chronic kidney disease progression signature identified lysine deacetylases as novel therapeutic targets

(Submitter supplied) Motivation and design: Renal tubulointerstitial injury is an important determinant of chronic kidney disease (CKD) progression, yet treatment is limited to renin angiotensin system blockade. Accordingly, we performed global expression profiling in a 2 × 2 factorial design (N = 8 in each group) on RNA extracted from male Col4a3–/– mice and littermate controls on a 129X1/SvJ background at 4 and 7 weeks of age. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
32 Samples

Download data: CEL, CHP

Series

Accession:: GSE137086

ID:: 200137086

Select item 20003875216.

Identification of differential gene expression in blood vessels from patients with uremia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
44 Samples

Download data: CEL

Series

Accession:: GSE38752

ID:: 200038752

Select item 20003875117.

Identification of differential gene expression in blood vessels from patients with uremia (data set 2)

(Submitter supplied) Identification of differential gene expression in blood vessels from patients with uremia

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
10 Samples

Download data: CEL

Series

Accession:: GSE38751

ID:: 200038751

Select item 20003875018.

Identification of differential gene expression in blood vessels from patients with uremia (data set 1)

(Submitter supplied) Identification of differential gene expression in blood vessels from patients with uremia

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
34 Samples

Download data: CEL

Series

Accession:: GSE38750

ID:: 200038750

Select item 20020759419.

The injury-induced transcription factor SOX9 alters the expression of LBR, HMGA2, and HIPK3 in human kidney

(Submitter supplied) Induction of SRY box transcription factor 9 (SOX9) has been shown to occur in response to kidney injury in rodents, where SOX9-positive cells proliferate and regenerate the proximal tubules of injured kidneys. Additionally, SOX9-positive cells demonstrate a capacity to differentiate toward other nephron segments. Here, we characterized the role of SOX9 in normal and injured human kidneys. SOX9 expression was found to colocalize with a proportion of so-called scattered tubular cells in the uninjured kidney, a cell population previously shown to be involved in kidney injury and regeneration. more...