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| Status |
Public on Jan 23, 2015 |
| Title |
A Novel miRNA-Based Predictive Model for Biochemical Failure Following Post-Prostatectomy Salvage Radiation Therapy |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
Radical prostatectomy remains one of the more widely-used treatment options for men with prostate cancer. However, few molecular biomarkers have been established to predict patients who are at high risk of biochemical failure. To our knowledge, this is the first such report on miRNA profiling in radical prostatectomy tissue using Nanostring. In addition, this is the first report to look at the prognostic value of miRNAs in the setting of biochemical failure and salvage radiation therapy post-radical prostatectomy.
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| Overall design |
RNA was extracted from tumor-enriched 1mm cores from 43 radical prostatectomy paraffin tissue blocks. 800 miRNAs were profiled using the NanoString nCounter human miRNA assay. mirNAs were then correlated to clinical outcomes.
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| Contributor(s) |
Bell EH, Kirste S, Fleming J, Stegmaier P, Drendel V, Mo X, Werner M, Grosu A, Chakravarti A |
| Citation(s) |
25760964 |
| |
| Submission date |
Jan 16, 2015 |
| Last update date |
May 06, 2016 |
| Contact name |
Erica Hlavin Bell |
| E-mail(s) |
erica.bell@osumc.edu
|
| Organization name |
The Ohio State University
|
| Street address |
410 W 12th Ave
|
| City |
Columbus |
| State/province |
Ohio |
| ZIP/Postal code |
43210 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17537 |
nCounter Human miRNA Expression Assay, V2 |
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| Samples (43)
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| Relations |
| BioProject |
PRJNA272812 |
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