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Consciousness Disorders

MedGen UID:
1099
Concept ID:
C0009792
Mental or Behavioral Dysfunction
Synonyms: Consciousness Disorder; Disorder of Consciousness; Disorders of Consciousness

Definition

Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respond to environmental stimuli. Dysfunction of the cerebral hemispheres or brain stem RETICULAR FORMATION may result in this condition. [from MeSH]

Professional guidelines

PubMed

Lefaucheur JP, Antal A, Ayache SS, Benninger DH, Brunelin J, Cogiamanian F, Cotelli M, De Ridder D, Ferrucci R, Langguth B, Marangolo P, Mylius V, Nitsche MA, Padberg F, Palm U, Poulet E, Priori A, Rossi S, Schecklmann M, Vanneste S, Ziemann U, Garcia-Larrea L, Paulus W
Clin Neurophysiol 2017 Jan;128(1):56-92. Epub 2016 Oct 29 doi: 10.1016/j.clinph.2016.10.087. PMID: 27866120
Hodelín-Tablada R
MEDICC Rev 2016 Oct;18(4):43-46. doi: 10.37757/MR2016.V18.N4.9. PMID: 27829654
Lefaucheur JP, André-Obadia N, Antal A, Ayache SS, Baeken C, Benninger DH, Cantello RM, Cincotta M, de Carvalho M, De Ridder D, Devanne H, Di Lazzaro V, Filipović SR, Hummel FC, Jääskeläinen SK, Kimiskidis VK, Koch G, Langguth B, Nyffeler T, Oliviero A, Padberg F, Poulet E, Rossi S, Rossini PM, Rothwell JC, Schönfeldt-Lecuona C, Siebner HR, Slotema CW, Stagg CJ, Valls-Sole J, Ziemann U, Paulus W, Garcia-Larrea L
Clin Neurophysiol 2014 Nov;125(11):2150-2206. Epub 2014 Jun 5 doi: 10.1016/j.clinph.2014.05.021. PMID: 25034472

Recent clinical studies

Etiology

Vitello MM, Szymkowicz E, Laureys S, Alnagger N, Gosseries O, Thibaut A
Dev Med Child Neurol 2022 Jun;64(6):681-690. Epub 2022 Jan 28 doi: 10.1111/dmcn.15150. PMID: 35089596
Bellon PA, Bosso MJ, Echegaray JEC, Larocca F, Gagliardi J, Primosich WA, Pavón HM, Yorio RD, Cancino JJ
Respir Care 2022 Feb;67(2):209-215. Epub 2021 Nov 30 doi: 10.4187/respcare.08301. PMID: 34848544
Ismail FY, Saleem GT, Ljubisavljevic MR
J Clin Neurophysiol 2022 Jan 1;39(1):49-58. doi: 10.1097/WNP.0000000000000772. PMID: 34474425
Kotchoubey B
Conscious Cogn 2017 Sep;54:155-167. Epub 2017 Jun 26 doi: 10.1016/j.concog.2017.05.002. PMID: 28663011
Frazee JG
Emerg Med Clin North Am 1986 Nov;4(4):859-74. PMID: 3536442

Diagnosis

Babalova L, Ruzinak R, Ballova J, Sivak S, Kantorova E, Kurca E, Zelenak K, Nosal V
Bratisl Lek Listy 2021;122(9):618-620. doi: 10.4149/BLL_2021_098. PMID: 34463105
Mehta R; GP trainee, Chinthapalli K; consultant neurologist
BMJ 2019 May 2;365:l1296. doi: 10.1136/bmj.l1296. PMID: 31048343
Septien S, Rubin MA
Semin Neurol 2018 Oct;38(5):548-554. Epub 2018 Oct 15 doi: 10.1055/s-0038-1667384. PMID: 30321893
Horton E, Krishnamoorthy S, Reynolds L
BMJ Case Rep 2014 Jul 30;2014 doi: 10.1136/bcr-2014-205336. PMID: 25080547Free PMC Article
Giacino JT, Fins JJ, Laureys S, Schiff ND
Nat Rev Neurol 2014 Feb;10(2):99-114. Epub 2014 Jan 28 doi: 10.1038/nrneurol.2013.279. PMID: 24468878

Therapy

Wang H, Wang K, Xue Q, Peng M, Yin L, Gu X, Leng H, Lu J, Liu H, Wang D, Xiao J, Sun Z, Li N, Dong K, Zhang Q, Zhan S, Fan C, Min B, Zhou A, Xie Y, Song H, Ye J, Liu A, Gao R, Huang L, Jiao L, Song Y, Dong H, Tian Z, Si T, Zhang X, Li X, Kamiya A, Cosci F, Gao K, Wang Y
Brain 2022 Mar 29;145(1):83-91. doi: 10.1093/brain/awab252. PMID: 35353887
Babalova L, Ruzinak R, Ballova J, Sivak S, Kantorova E, Kurca E, Zelenak K, Nosal V
Bratisl Lek Listy 2021;122(9):618-620. doi: 10.4149/BLL_2021_098. PMID: 34463105
Thibaut A, Schiff N, Giacino J, Laureys S, Gosseries O
Lancet Neurol 2019 Jun;18(6):600-614. Epub 2019 Apr 16 doi: 10.1016/S1474-4422(19)30031-6. PMID: 31003899
Bomalaski MN, Claflin ES, Townsend W, Peterson MD
JAMA Neurol 2017 Sep 1;74(9):1130-1139. doi: 10.1001/jamaneurol.2017.1133. PMID: 28655027
Lefaucheur JP, Antal A, Ayache SS, Benninger DH, Brunelin J, Cogiamanian F, Cotelli M, De Ridder D, Ferrucci R, Langguth B, Marangolo P, Mylius V, Nitsche MA, Padberg F, Palm U, Poulet E, Priori A, Rossi S, Schecklmann M, Vanneste S, Ziemann U, Garcia-Larrea L, Paulus W
Clin Neurophysiol 2017 Jan;128(1):56-92. Epub 2016 Oct 29 doi: 10.1016/j.clinph.2016.10.087. PMID: 27866120

Prognosis

Edlow BL, Claassen J, Schiff ND, Greer DM
Nat Rev Neurol 2021 Mar;17(3):135-156. Epub 2020 Dec 14 doi: 10.1038/s41582-020-00428-x. PMID: 33318675Free PMC Article
Gershkovich B, English SW, Doyle MA, Menon K, McIntyre L
Syst Rev 2019 Sep 3;8(1):228. doi: 10.1186/s13643-019-1130-5. PMID: 31481108Free PMC Article
Mehta R; GP trainee, Chinthapalli K; consultant neurologist
BMJ 2019 May 2;365:l1296. doi: 10.1136/bmj.l1296. PMID: 31048343
Septien S, Rubin MA
Semin Neurol 2018 Oct;38(5):548-554. Epub 2018 Oct 15 doi: 10.1055/s-0038-1667384. PMID: 30321893
Giacino JT, Fins JJ, Laureys S, Schiff ND
Nat Rev Neurol 2014 Feb;10(2):99-114. Epub 2014 Jan 28 doi: 10.1038/nrneurol.2013.279. PMID: 24468878

Clinical prediction guides

Bodien YG, Barra A, Temkin NR, Barber J, Foreman B, Vassar M, Robertson C, Taylor SR, Markowitz AJ, Manley GT, Giacino JT, Edlow BL; TRACK-TBI Investigators
J Neurotrauma 2021 Dec;38(23):3295-3305. doi: 10.1089/neu.2021.0199. PMID: 34605668Free PMC Article
Edlow BL, Claassen J, Schiff ND, Greer DM
Nat Rev Neurol 2021 Mar;17(3):135-156. Epub 2020 Dec 14 doi: 10.1038/s41582-020-00428-x. PMID: 33318675Free PMC Article
Septien S, Rubin MA
Semin Neurol 2018 Oct;38(5):548-554. Epub 2018 Oct 15 doi: 10.1055/s-0038-1667384. PMID: 30321893
Thibaut A, Wannez S, Deltombe T, Martens G, Laureys S, Chatelle C
NeuroRehabilitation 2018;42(2):199-205. doi: 10.3233/NRE-172229. PMID: 29562552
Frazee JG
Emerg Med Clin North Am 1986 Nov;4(4):859-74. PMID: 3536442

Recent systematic reviews

Bai Y, Lin Y, Ziemann U
J Neurol 2021 Nov;268(11):4033-4065. Epub 2020 Sep 11 doi: 10.1007/s00415-020-10095-z. PMID: 32915309Free PMC Article
Gagnon DJ, Leclerc AM, Riker RR, Brown CS, May T, Nocella K, Cote J, Eldridge A, Seder DB
Neurocrit Care 2020 Aug;33(1):283-297. doi: 10.1007/s12028-020-00977-5. PMID: 32394130
Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL
Crit Care 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. PMID: 29137682Free PMC Article
Vanhoecke J, Hariz M
Brain Stimul 2017 Nov-Dec;10(6):1013-1023. Epub 2017 Aug 24 doi: 10.1016/j.brs.2017.08.006. PMID: 28966051
Bomalaski MN, Claflin ES, Townsend W, Peterson MD
JAMA Neurol 2017 Sep 1;74(9):1130-1139. doi: 10.1001/jamaneurol.2017.1133. PMID: 28655027

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