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Vulvar carcinoma

MedGen UID:
146159
Concept ID:
C0677055
Neoplastic Process
Synonyms: Cancer of the Vulva; Cancer of Vulva; carcinoma of mammalian vulva; Carcinoma of the Vulva; carcinoma of the vulva; Carcinoma of Vulva; Carcinoma of vulva; carcinoma of vulva; mammalian vulva carcinoma; Vulva Cancer; Vulva Carcinoma; vulva carcinoma; Vulvar Cancer; Vulvar Carcinoma; vulvar carcinoma
 
Monarch Initiative: MONDO:0005215
Orphanet: ORPHA494418

Definition

A group of rare tumors of the vulva comprising HPV-associated and HPV-independent squamous cell carcinomas as the most frequent malignant vulvar tumors, basal cell carcinomas, adenocarcinomas, and Bartholin gland carcinomas. Depending on the type of tumor and disease stage, patients may present with a painless vulvar mass or ulcer, or with pruritus, a burning sensation, pain, or bleeding. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar carcinoma

Professional guidelines

PubMed

Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Tomao F, Di Tucci C, Marchetti C, Perniola G, Bellati F, Panici PB
Crit Rev Oncol Hematol 2012 Apr;82(1):25-39. Epub 2011 May 20 doi: 10.1016/j.critrevonc.2011.04.008. PMID: 21601474

Recent clinical studies

Etiology

Viktora Libor, Minář Luboš, Felsinger Michal, Weinberger Vít
Ceska Gynekol 2022;87(6):401-407. doi: 10.48095/cccg2022401. PMID: 36543587
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Zweizig S, Korets S, Cain JM
Best Pract Res Clin Obstet Gynaecol 2014 Oct;28(7):959-66. Epub 2014 Jul 17 doi: 10.1016/j.bpobgyn.2014.07.001. PMID: 25151473
Longpre MJ, Lange PH, Kwon JS, Black PC
J Urol 2013 Jan;189(1):17-24. Epub 2012 Nov 16 doi: 10.1016/j.juro.2012.08.082. PMID: 23158472
Anderson JM, Cassady JR, Shimm DS, Stea B
Int J Radiat Oncol Biol Phys 1995 Jul 30;32(5):1351-7. doi: 10.1016/0360-3016(95)00090-L. PMID: 7635775

Diagnosis

Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article
van der Linden M, Meeuwis KA, Bulten J, Bosse T, van Poelgeest MI, de Hullu JA
Crit Rev Oncol Hematol 2016 May;101:60-74. Epub 2016 Mar 4 doi: 10.1016/j.critrevonc.2016.03.008. PMID: 26971063
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Schwartz PE
Menopause 2011 Oct;18(10):1042-3. doi: 10.1097/gme.0b013e31822a8966. PMID: 22046600
Anderson JM, Cassady JR, Shimm DS, Stea B
Int J Radiat Oncol Biol Phys 1995 Jul 30;32(5):1351-7. doi: 10.1016/0360-3016(95)00090-L. PMID: 7635775

Therapy

Naumann RW, Hollebecque A, Meyer T, Devlin MJ, Oaknin A, Kerger J, López-Picazo JM, Machiels JP, Delord JP, Evans TRJ, Boni V, Calvo E, Topalian SL, Chen T, Soumaoro I, Li B, Gu J, Zwirtes R, Moore KN
J Clin Oncol 2019 Nov 1;37(31):2825-2834. Epub 2019 Sep 5 doi: 10.1200/JCO.19.00739. PMID: 31487218Free PMC Article
Vaupel P, Piazena H, Müller W, Notter M
Int J Hyperthermia 2018;35(1):26-36. Epub 2018 May 10 doi: 10.1080/02656736.2018.1469169. PMID: 29745269
Manchana T, Ittiwut C, Mutirangura A, Kavanagh JJ
Lancet Oncol 2010 Jul;11(7):685-93. Epub 2010 Mar 31 doi: 10.1016/S1470-2045(09)70368-7. PMID: 20362508
Coleman RL, Santoso JT
Curr Treat Options Oncol 2000 Jun;1(2):177-90. doi: 10.1007/s11864-000-0063-4. PMID: 12057056
Boente MP, Schilder R, Ozols RF
Cancer Chemother Biol Response Modif 1997;17:536-61. PMID: 9551230

Prognosis

Menczer J
Arch Gynecol Obstet 2017 Jan;295(1):9-15. Epub 2016 Oct 6 doi: 10.1007/s00404-016-4212-9. PMID: 27714462
van der Linden M, Meeuwis KA, Bulten J, Bosse T, van Poelgeest MI, de Hullu JA
Crit Rev Oncol Hematol 2016 May;101:60-74. Epub 2016 Mar 4 doi: 10.1016/j.critrevonc.2016.03.008. PMID: 26971063
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Zweizig S, Korets S, Cain JM
Best Pract Res Clin Obstet Gynaecol 2014 Oct;28(7):959-66. Epub 2014 Jul 17 doi: 10.1016/j.bpobgyn.2014.07.001. PMID: 25151473
Anderson JM, Cassady JR, Shimm DS, Stea B
Int J Radiat Oncol Biol Phys 1995 Jul 30;32(5):1351-7. doi: 10.1016/0360-3016(95)00090-L. PMID: 7635775

Clinical prediction guides

Prieske K, Alawi M, Oliveira-Ferrer L, Jaeger A, Eylmann K, Burandt E, Schmalfeldt B, Joosse SA, Woelber L
Gynecol Oncol 2020 Sep;158(3):547-554. Epub 2020 Jun 24 doi: 10.1016/j.ygyno.2020.06.482. PMID: 32591094
Zięba S, Chechlińska M, Kowalik A, Kowalewska M
Gynecol Oncol 2020 Aug;158(2):498-506. Epub 2020 Jun 7 doi: 10.1016/j.ygyno.2020.05.034. PMID: 32522421
Naumann RW, Hollebecque A, Meyer T, Devlin MJ, Oaknin A, Kerger J, López-Picazo JM, Machiels JP, Delord JP, Evans TRJ, Boni V, Calvo E, Topalian SL, Chen T, Soumaoro I, Li B, Gu J, Zwirtes R, Moore KN
J Clin Oncol 2019 Nov 1;37(31):2825-2834. Epub 2019 Sep 5 doi: 10.1200/JCO.19.00739. PMID: 31487218Free PMC Article
Vaupel P, Piazena H, Müller W, Notter M
Int J Hyperthermia 2018;35(1):26-36. Epub 2018 May 10 doi: 10.1080/02656736.2018.1469169. PMID: 29745269
Dittmer C, Katalinic A, Mundhenke C, Thill M, Fischer D
Arch Gynecol Obstet 2011 Jul;284(1):169-74. Epub 2011 Feb 22 doi: 10.1007/s00404-011-1850-9. PMID: 21340687

Recent systematic reviews

Lancellotta V, Macchia G, Garganese G, Fionda B, Fragomeni SM, D'Aviero A, Casà C, Gui B, Gentileschi S, Corrado G, Inzani F, Rovirosa A, Morganti AG, Gambacorta MA, Tagliaferri L
Clin Transl Oncol 2021 Aug;23(8):1611-1619. Epub 2021 Mar 1 doi: 10.1007/s12094-021-02557-1. PMID: 33650029
Te Grootenhuis NC, Pouwer AW, de Bock GH, Hollema H, Bulten J, van der Zee AGJ, de Hullu JA, Oonk MHM
Gynecol Oncol 2018 Mar;148(3):622-631. Epub 2017 Nov 12 doi: 10.1016/j.ygyno.2017.11.006. PMID: 29137809
Sznurkowski JJ
Eur J Cancer Care (Engl) 2016 Jul;25(4):638-46. Epub 2016 Feb 16 doi: 10.1111/ecc.12455. PMID: 26880231
van Seters M, van Beurden M, de Craen AJ
Gynecol Oncol 2005 May;97(2):645-51. doi: 10.1016/j.ygyno.2005.02.012. PMID: 15863172

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