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Vulvar carcinoma

MedGen UID:
146159
Concept ID:
C0677055
Neoplastic Process
Synonyms: Cancer of the Vulva; Cancer of Vulva; carcinoma of mammalian vulva; Carcinoma of the Vulva; carcinoma of the vulva; Carcinoma of Vulva; Carcinoma of vulva; carcinoma of vulva; mammalian vulva carcinoma; Vulva Cancer; Vulva Carcinoma; vulva carcinoma; Vulvar Cancer; Vulvar Carcinoma; vulvar carcinoma
 
Monarch Initiative: MONDO:0005215
Orphanet: ORPHA494418

Definition

A group of rare tumors of the vulva comprising HPV-associated and HPV-independent squamous cell carcinomas as the most frequent malignant vulvar tumors, basal cell carcinomas, adenocarcinomas, and Bartholin gland carcinomas. Depending on the type of tumor and disease stage, patients may present with a painless vulvar mass or ulcer, or with pruritus, a burning sensation, pain, or bleeding. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar carcinoma

Professional guidelines

PubMed

Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article
Sznurkowski JJ
Eur J Cancer Care (Engl) 2016 Jul;25(4):638-46. Epub 2016 Feb 16 doi: 10.1111/ecc.12455. PMID: 26880231
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Vulvar Cancer, 2024

Recent clinical studies

Etiology

Cao D, Zhang S, Zhang Y, Shao M, Yang Q, Wang P
BMC Cancer 2024 Aug 21;24(1):1032. doi: 10.1186/s12885-024-12787-5. PMID: 39169299Free PMC Article
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Coleman RL, Santoso JT
Curr Treat Options Oncol 2000 Jun;1(2):177-90. doi: 10.1007/s11864-000-0063-4. PMID: 12057056
Edwards CL, Tortolero-Luna G, Linares AC, Malpica A, Baker VV, Cook E, Johnson E, Follen Mitchell M
Obstet Gynecol Clin North Am 1996 Jun;23(2):295-324. PMID: 8784883
Anderson JM, Cassady JR, Shimm DS, Stea B
Int J Radiat Oncol Biol Phys 1995 Jul 30;32(5):1351-7. doi: 10.1016/0360-3016(95)00090-L. PMID: 7635775

Diagnosis

Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article
van der Linden M, Meeuwis KA, Bulten J, Bosse T, van Poelgeest MI, de Hullu JA
Crit Rev Oncol Hematol 2016 May;101:60-74. Epub 2016 Mar 4 doi: 10.1016/j.critrevonc.2016.03.008. PMID: 26971063
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Schwartz PE
Menopause 2011 Oct;18(10):1042-3. doi: 10.1097/gme.0b013e31822a8966. PMID: 22046600
Anderson JM, Cassady JR, Shimm DS, Stea B
Int J Radiat Oncol Biol Phys 1995 Jul 30;32(5):1351-7. doi: 10.1016/0360-3016(95)00090-L. PMID: 7635775

Therapy

Cao D, Zhang S, Zhang Y, Shao M, Yang Q, Wang P
BMC Cancer 2024 Aug 21;24(1):1032. doi: 10.1186/s12885-024-12787-5. PMID: 39169299Free PMC Article
Naumann RW, Hollebecque A, Meyer T, Devlin MJ, Oaknin A, Kerger J, López-Picazo JM, Machiels JP, Delord JP, Evans TRJ, Boni V, Calvo E, Topalian SL, Chen T, Soumaoro I, Li B, Gu J, Zwirtes R, Moore KN
J Clin Oncol 2019 Nov 1;37(31):2825-2834. Epub 2019 Sep 5 doi: 10.1200/JCO.19.00739. PMID: 31487218Free PMC Article
Vaupel P, Piazena H, Müller W, Notter M
Int J Hyperthermia 2018;35(1):26-36. Epub 2018 May 10 doi: 10.1080/02656736.2018.1469169. PMID: 29745269
Manchana T, Ittiwut C, Mutirangura A, Kavanagh JJ
Lancet Oncol 2010 Jul;11(7):685-93. Epub 2010 Mar 31 doi: 10.1016/S1470-2045(09)70368-7. PMID: 20362508
Coleman RL, Santoso JT
Curr Treat Options Oncol 2000 Jun;1(2):177-90. doi: 10.1007/s11864-000-0063-4. PMID: 12057056

Prognosis

Chargari C, Wasserman J, Gabro A, Canlobre G, Spano JP, Uzan C, Maingon P
J Clin Oncol 2024 Mar 10;42(8):961-972. Epub 2024 Feb 5 doi: 10.1200/JCO.23.01187. PMID: 38315939
van der Linden M, Meeuwis KA, Bulten J, Bosse T, van Poelgeest MI, de Hullu JA
Crit Rev Oncol Hematol 2016 May;101:60-74. Epub 2016 Mar 4 doi: 10.1016/j.critrevonc.2016.03.008. PMID: 26971063
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Zweizig S, Korets S, Cain JM
Best Pract Res Clin Obstet Gynaecol 2014 Oct;28(7):959-66. Epub 2014 Jul 17 doi: 10.1016/j.bpobgyn.2014.07.001. PMID: 25151473
Anderson JM, Cassady JR, Shimm DS, Stea B
Int J Radiat Oncol Biol Phys 1995 Jul 30;32(5):1351-7. doi: 10.1016/0360-3016(95)00090-L. PMID: 7635775

Clinical prediction guides

Thuijs NB, van Beurden M, Duin S, Heideman DAM, Berkhof J, Steenbergen RDM, Bleeker MCG
Histopathology 2024 Jan;84(2):301-314. Epub 2023 Sep 19 doi: 10.1111/his.15050. PMID: 37726173
Wanka G, Jueckstock J, Wild CM, Vattai A, Fürst S, Heidegger HH, Kuhn C, Schmoeckel E, Jeschke U, Dannecker C
J Cancer Res Clin Oncol 2023 Aug;149(9):6191-6201. Epub 2023 Jan 23 doi: 10.1007/s00432-023-04579-4. PMID: 36689059Free PMC Article
Zięba S, Chechlińska M, Kowalik A, Kowalewska M
Gynecol Oncol 2020 Aug;158(2):498-506. Epub 2020 Jun 7 doi: 10.1016/j.ygyno.2020.05.034. PMID: 32522421
Naumann RW, Hollebecque A, Meyer T, Devlin MJ, Oaknin A, Kerger J, López-Picazo JM, Machiels JP, Delord JP, Evans TRJ, Boni V, Calvo E, Topalian SL, Chen T, Soumaoro I, Li B, Gu J, Zwirtes R, Moore KN
J Clin Oncol 2019 Nov 1;37(31):2825-2834. Epub 2019 Sep 5 doi: 10.1200/JCO.19.00739. PMID: 31487218Free PMC Article
Vaupel P, Piazena H, Müller W, Notter M
Int J Hyperthermia 2018;35(1):26-36. Epub 2018 May 10 doi: 10.1080/02656736.2018.1469169. PMID: 29745269

Recent systematic reviews

Turetta C, Mazzeo R, Capalbo G, Miano S, Fruscio R, Di Donato V, Falcone F, Mangili G, Pignata S, Palaia I
Tumori 2024 Apr;110(2):96-108. Epub 2023 Nov 13 doi: 10.1177/03008916231208308. PMID: 37953636
Lancellotta V, Macchia G, Garganese G, Fionda B, Fragomeni SM, D'Aviero A, Casà C, Gui B, Gentileschi S, Corrado G, Inzani F, Rovirosa A, Morganti AG, Gambacorta MA, Tagliaferri L
Clin Transl Oncol 2021 Aug;23(8):1611-1619. Epub 2021 Mar 1 doi: 10.1007/s12094-021-02557-1. PMID: 33650029
Te Grootenhuis NC, Pouwer AW, de Bock GH, Hollema H, Bulten J, van der Zee AGJ, de Hullu JA, Oonk MHM
Gynecol Oncol 2018 Mar;148(3):622-631. Epub 2017 Nov 12 doi: 10.1016/j.ygyno.2017.11.006. PMID: 29137809
Sznurkowski JJ
Eur J Cancer Care (Engl) 2016 Jul;25(4):638-46. Epub 2016 Feb 16 doi: 10.1111/ecc.12455. PMID: 26880231
van Seters M, van Beurden M, de Craen AJ
Gynecol Oncol 2005 May;97(2):645-51. doi: 10.1016/j.ygyno.2005.02.012. PMID: 15863172

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Vulvar Cancer, 2024

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