U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Renal Cell Carcinoma

MedGen UID:
1661275
Concept ID:
C4721698
Neoplastic Process
Synonym: Metastatic renal cell carcinoma
SNOMED CT: Metastatic renal cell carcinoma (702392008); Metastatic renal cell carcinoma (838281000)

Definition

Renal cell carcinoma that has spread from the kidney to other anatomic sites. [from NCI]

Professional guidelines

PubMed

Santoni M, Buti S, Myint ZW, Maruzzo M, Iacovelli R, Pichler M, Kopecky J, Kucharz J, Rizzo M, Galli L, Büttner T, De Giorgi U, Kanesvaran R, Fiala O, Grande E, Zucali PA, Kopp RM, Fornarini G, Bourlon MT, Scagliarini S, Molina-Cerrillo J, Aurilio G, Matrana MR, Pichler R, Cattrini C, Büchler T, Massari F, Seront E, Calabrò F, Pinto A, Berardi R, Zgura A, Mammone G, Ansari J, Atzori F, Chiari R, Bamias A, Caffo O, Procopio G, Sunela K, Bassanelli M, Ortega C, Grillone F, Landmesser J, Milella M, Messina C, Küronya Z, Mosca A, Bhuva D, Santini D, Vau N, Morelli F, Incorvaia L, Rebuzzi SE, Roviello G, Soares A, Bisonni R, Bimbatti D, Zabalza IO, Rizzo A, Mollica V, Sorgentoni G, Monteiro FSM, Battelli N, Bracarda S, Porta C
Eur Urol Oncol 2024 Feb;7(1):102-111. Epub 2023 Jul 21 doi: 10.1016/j.euo.2023.07.003. PMID: 37481365
Gebrael G, Sahu KK, Agarwal N, Maughan BL
Hum Vaccin Immunother 2023 Dec 31;19(1):2193528. Epub 2023 Apr 16 doi: 10.1080/21645515.2023.2193528. PMID: 37062953Free PMC Article
Dizman N, Adashek JJ, Hsu J, Bergerot PG, Bergerot CD, Pal SK
Clin Adv Hematol Oncol 2018 Aug;16(8):555-563. PMID: 30148828

Recent clinical studies

Etiology

Lemelin A, Takemura K, Heng DYC, Ernst MS
Hematol Oncol Clin North Am 2023 Oct;37(5):925-935. Epub 2023 Jun 1 doi: 10.1016/j.hoc.2023.04.016. PMID: 37270385
Pan E, Urman D, Malvar C, McKay RR
Hematol Oncol Clin North Am 2023 Oct;37(5):943-949. Epub 2023 May 29 doi: 10.1016/j.hoc.2023.04.017. PMID: 37258352
Grünwald V, Powles T, Kopyltsov E, Kozlov V, Alonso-Gordoa T, Eto M, Hutson T, Motzer R, Winquist E, Maroto P, Keam B, Procopio G, Wong S, Melichar B, Rolland F, Oya M, Rodriguez-Lopez K, Saito K, McKenzie J, Porta C
Eur Urol Oncol 2023 Aug;6(4):437-446. Epub 2023 Jan 29 doi: 10.1016/j.euo.2023.01.010. PMID: 36720658Free PMC Article
Motzer RJ, Hutson TE, Glen H, Michaelson MD, Molina A, Eisen T, Jassem J, Zolnierek J, Maroto JP, Mellado B, Melichar B, Tomasek J, Kremer A, Kim HJ, Wood K, Dutcus C, Larkin J
Lancet Oncol 2015 Nov;16(15):1473-1482. Epub 2015 Oct 22 doi: 10.1016/S1470-2045(15)00290-9. PMID: 26482279
Heng DY, Xie W, Regan MM, Harshman LC, Bjarnason GA, Vaishampayan UN, Mackenzie M, Wood L, Donskov F, Tan MH, Rha SY, Agarwal N, Kollmannsberger C, Rini BI, Choueiri TK
Lancet Oncol 2013 Feb;14(2):141-8. Epub 2013 Jan 9 doi: 10.1016/S1470-2045(12)70559-4. PMID: 23312463Free PMC Article

Diagnosis

Bakouny Z, El Zarif T, Dudani S, Connor Wells J, Gan CL, Donskov F, Shapiro J, Davis ID, Parnis F, Ravi P, Steinharter JA, Agarwal N, Alva A, Wood L, Kapoor A, Ruiz Morales JM, Kollmannsberger C, Beuselinck B, Xie W, Heng DYC, Choueiri TK
Eur Urol 2023 Feb;83(2):145-151. Epub 2022 Oct 20 doi: 10.1016/j.eururo.2022.10.004. PMID: 36272943
Mateos-Soria A, Castro-Alonso FJ, Senser Y, Quintero-Bustos G, Licano-Zubiate M, Bourlon R, Lam ET, Bourlon MT
Oncology (Williston Park) 2022 Apr 6;36(4):221-225. doi: 10.46883/2022.25920955. PMID: 35436063
Kotecha RR, Motzer RJ, Voss MH
Nat Rev Clin Oncol 2019 Oct;16(10):621-633. doi: 10.1038/s41571-019-0209-1. PMID: 30992569
Cavaliere C, D'Aniello C, Pepa CD, Pisconti S, Berretta M, Facchini G
Curr Cancer Drug Targets 2018;18(5):468-479. doi: 10.2174/1568009617666170209094030. PMID: 28183256
Heng DY, Xie W, Regan MM, Harshman LC, Bjarnason GA, Vaishampayan UN, Mackenzie M, Wood L, Donskov F, Tan MH, Rha SY, Agarwal N, Kollmannsberger C, Rini BI, Choueiri TK
Lancet Oncol 2013 Feb;14(2):141-8. Epub 2013 Jan 9 doi: 10.1016/S1470-2045(12)70559-4. PMID: 23312463Free PMC Article

Therapy

Pal SK, Albiges L, Tomczak P, Suárez C, Voss MH, de Velasco G, Chahoud J, Mochalova A, Procopio G, Mahammedi H, Zengerling F, Kim C, Osawa T, Angel M, Gupta S, Khan O, Bergthold G, Liu B, Kalaitzidou M, Huseni M, Scheffold C, Powles T, Choueiri TK
Lancet 2023 Jul 15;402(10397):185-195. Epub 2023 Jun 5 doi: 10.1016/S0140-6736(23)00922-4. PMID: 37290461Free PMC Article
Dizman N, Meza L, Bergerot P, Alcantara M, Dorff T, Lyou Y, Frankel P, Cui Y, Mira V, Llamas M, Hsu J, Zengin Z, Salgia N, Salgia S, Malhotra J, Chawla N, Chehrazi-Raffle A, Muddasani R, Gillece J, Reining L, Trent J, Takahashi M, Oka K, Higashi S, Kortylewski M, Highlander SK, Pal SK
Nat Med 2022 Apr;28(4):704-712. Epub 2022 Feb 28 doi: 10.1038/s41591-022-01694-6. PMID: 35228755Free PMC Article
Motzer RJ, Powles T, Atkins MB, Escudier B, McDermott DF, Alekseev BY, Lee JL, Suarez C, Stroyakovskiy D, De Giorgi U, Donskov F, Mellado B, Banchereau R, Hamidi H, Khan O, Craine V, Huseni M, Flinn N, Dubey S, Rini BI
JAMA Oncol 2022 Feb 1;8(2):275-280. doi: 10.1001/jamaoncol.2021.5981. PMID: 34940781Free PMC Article
Chowdhury N, Drake CG
Urol Clin North Am 2020 Nov;47(4):419-431. doi: 10.1016/j.ucl.2020.07.009. PMID: 33008493
Motzer RJ, Rini BI, McDermott DF, Arén Frontera O, Hammers HJ, Carducci MA, Salman P, Escudier B, Beuselinck B, Amin A, Porta C, George S, Neiman V, Bracarda S, Tykodi SS, Barthélémy P, Leibowitz-Amit R, Plimack ER, Oosting SF, Redman B, Melichar B, Powles T, Nathan P, Oudard S, Pook D, Choueiri TK, Donskov F, Grimm MO, Gurney H, Heng DYC, Kollmannsberger CK, Harrison MR, Tomita Y, Duran I, Grünwald V, McHenry MB, Mekan S, Tannir NM; CheckMate 214 investigators
Lancet Oncol 2019 Oct;20(10):1370-1385. Epub 2019 Aug 16 doi: 10.1016/S1470-2045(19)30413-9. PMID: 31427204Free PMC Article

Prognosis

Yanagisawa T, Mori K, Matsukawa A, Kawada T, Katayama S, Bekku K, Laukhtina E, Rajwa P, Quhal F, Pradere B, Fukuokaya W, Iwatani K, Murakami M, Bensalah K, Grünwald V, Schmidinger M, Shariat SF, Kimura T
Cancer Immunol Immunother 2024 Jan 30;73(2):38. doi: 10.1007/s00262-023-03621-1. PMID: 38289361Free PMC Article
Plimack ER, Powles T, Stus V, Gafanov R, Nosov D, Waddell T, Alekseev B, Pouliot F, Melichar B, Soulières D, Borchiellini D, McDermott RS, Vynnychenko I, Chang YH, Tamada S, Atkins MB, Li C, Perini R, Molife LR, Bedke J, Rini BI
Eur Urol 2023 Nov;84(5):449-454. Epub 2023 Jul 25 doi: 10.1016/j.eururo.2023.06.006. PMID: 37500340
Albiges L, Tannir NM, Burotto M, McDermott D, Plimack ER, Barthélémy P, Porta C, Powles T, Donskov F, George S, Kollmannsberger CK, Gurney H, Grimm MO, Tomita Y, Castellano D, Rini BI, Choueiri TK, Saggi SS, McHenry MB, Motzer RJ
ESMO Open 2020 Nov;5(6):e001079. doi: 10.1136/esmoopen-2020-001079. PMID: 33246931Free PMC Article
Motzer RJ, Rini BI, McDermott DF, Arén Frontera O, Hammers HJ, Carducci MA, Salman P, Escudier B, Beuselinck B, Amin A, Porta C, George S, Neiman V, Bracarda S, Tykodi SS, Barthélémy P, Leibowitz-Amit R, Plimack ER, Oosting SF, Redman B, Melichar B, Powles T, Nathan P, Oudard S, Pook D, Choueiri TK, Donskov F, Grimm MO, Gurney H, Heng DYC, Kollmannsberger CK, Harrison MR, Tomita Y, Duran I, Grünwald V, McHenry MB, Mekan S, Tannir NM; CheckMate 214 investigators
Lancet Oncol 2019 Oct;20(10):1370-1385. Epub 2019 Aug 16 doi: 10.1016/S1470-2045(19)30413-9. PMID: 31427204Free PMC Article
Heng DY, Xie W, Regan MM, Harshman LC, Bjarnason GA, Vaishampayan UN, Mackenzie M, Wood L, Donskov F, Tan MH, Rha SY, Agarwal N, Kollmannsberger C, Rini BI, Choueiri TK
Lancet Oncol 2013 Feb;14(2):141-8. Epub 2013 Jan 9 doi: 10.1016/S1470-2045(12)70559-4. PMID: 23312463Free PMC Article

Clinical prediction guides

Santoni M, Buti S, Myint ZW, Maruzzo M, Iacovelli R, Pichler M, Kopecky J, Kucharz J, Rizzo M, Galli L, Büttner T, De Giorgi U, Kanesvaran R, Fiala O, Grande E, Zucali PA, Kopp RM, Fornarini G, Bourlon MT, Scagliarini S, Molina-Cerrillo J, Aurilio G, Matrana MR, Pichler R, Cattrini C, Büchler T, Massari F, Seront E, Calabrò F, Pinto A, Berardi R, Zgura A, Mammone G, Ansari J, Atzori F, Chiari R, Bamias A, Caffo O, Procopio G, Sunela K, Bassanelli M, Ortega C, Grillone F, Landmesser J, Milella M, Messina C, Küronya Z, Mosca A, Bhuva D, Santini D, Vau N, Morelli F, Incorvaia L, Rebuzzi SE, Roviello G, Soares A, Bisonni R, Bimbatti D, Zabalza IO, Rizzo A, Mollica V, Sorgentoni G, Monteiro FSM, Battelli N, Bracarda S, Porta C
Eur Urol Oncol 2024 Feb;7(1):102-111. Epub 2023 Jul 21 doi: 10.1016/j.euo.2023.07.003. PMID: 37481365
Pan E, Urman D, Malvar C, McKay RR
Hematol Oncol Clin North Am 2023 Oct;37(5):943-949. Epub 2023 May 29 doi: 10.1016/j.hoc.2023.04.017. PMID: 37258352
Naito S, Kato T, Tsuchiya N
Int J Urol 2022 Jun;29(6):494-501. Epub 2022 Mar 26 doi: 10.1111/iju.14841. PMID: 35340081
Graham J, Heng DY
Tumori 2018 Mar-Apr;104(2):76-82. Epub 2018 Mar 23 doi: 10.1177/0300891618761004. PMID: 29714652
Leibovich BC, Lohse CM, Cheville JC, Zaid HB, Boorjian SA, Frank I, Thompson RH, Parker WP
Eur Urol 2018 May;73(5):772-780. Epub 2018 Feb 3 doi: 10.1016/j.eururo.2018.01.005. PMID: 29398265

Recent systematic reviews

Yanagisawa T, Mori K, Matsukawa A, Kawada T, Katayama S, Bekku K, Laukhtina E, Rajwa P, Quhal F, Pradere B, Fukuokaya W, Iwatani K, Murakami M, Bensalah K, Grünwald V, Schmidinger M, Shariat SF, Kimura T
Cancer Immunol Immunother 2024 Jan 30;73(2):38. doi: 10.1007/s00262-023-03621-1. PMID: 38289361Free PMC Article
Aldin A, Besiroglu B, Adams A, Monsef I, Piechotta V, Tomlinson E, Hornbach C, Dressen N, Goldkuhle M, Maisch P, Dahm P, Heidenreich A, Skoetz N
Cochrane Database Syst Rev 2023 May 4;5(5):CD013798. doi: 10.1002/14651858.CD013798.pub2. PMID: 37146227Free PMC Article
Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020
Bui TO, Dao VT, Nguyen VT, Feugeas JP, Pamoukdjian F, Bousquet G
Eur Urol 2022 Apr;81(4):349-361. Epub 2022 Jan 3 doi: 10.1016/j.eururo.2021.12.010. PMID: 34991918
Unverzagt S, Moldenhauer I, Nothacker M, Roßmeißl D, Hadjinicolaou AV, Peinemann F, Greco F, Seliger B
Cochrane Database Syst Rev 2017 May 15;5(5):CD011673. doi: 10.1002/14651858.CD011673.pub2. PMID: 28504837Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...