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Urinary tract non-invasive transitional cell neoplasm

MedGen UID:
273592
•Concept ID:
C1518361
•
Neoplastic Process
Synonyms: Non-Invasive Transitional Cell Neoplasm of the Urinary Tract; non-invasive transitional cell neoplasm of the urinary tract; Non-Invasive Urothelial Neoplasm; non-invasive urothelial neoplasm; urinary tract non-invasive transitional cell neoplasm
 
Monarch Initiative: MONDO:0003755

Definition

A non-invasive neoplasm affecting the urothelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUrinary tract non-invasive transitional cell neoplasm

Professional guidelines

PubMed

Sequential endoluminal gemcitabine and docetaxel for the treatment of clinically non-invasive high-grade upper tract urothelial carcinoma.
McElree IM, Belzer A, Mott SL, Packiam VT, O'Donnell MA, Steinberg RL
Urol Oncol 2024 Jan;42(1):20.e9-20.e15. Epub 2023 Oct 5 doi: 10.1016/j.urolonc.2023.08.013. PMID: 37805338Free PMC Article
Consultation on UTUC, Stockholm 2018: aspects of treatment.
Jung H, Giusti G, Fajkovic H, Herrmann T, Jones R, Straub M, Baard J, Osther PJS, Brehmer M
World J Urol 2019 Nov;37(11):2279-2287. Epub 2019 May 23 doi: 10.1007/s00345-019-02811-w. PMID: 31123852Free PMC Article
Long-term endoscopic management of upper tract urothelial carcinoma: 20-year single-centre experience.
Cutress ML, Stewart GD, Wells-Cole S, Phipps S, Thomas BG, Tolley DA
BJU Int 2012 Dec;110(11):1608-17. Epub 2012 May 7 doi: 10.1111/j.1464-410X.2012.11169.x. PMID: 22564677

Recent clinical studies

Etiology

Urinary Tract Cytopathology: Current and Future Impact on Patient Care.
Jorda M, Kryvenko ON, Hanly F, Zuo Y
Surg Pathol Clin 2024 Sep;17(3):383-394. Epub 2024 Jul 14 doi: 10.1016/j.path.2024.06.001. PMID: 39129138
Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma.
Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C
Cell Rep Med 2023 Sep 19;4(9):101166. Epub 2023 Aug 25 doi: 10.1016/j.xcrm.2023.101166. PMID: 37633276Free PMC Article
MOLECULAR CHARACTERISTICS OF THE HETEROGENEITY OF NON-INVASIVE PAPILLARY UROTHELIAL CARCINOMAS AND THE MARKERS OF THEIR RECURRENCE.
Kajaia D, Kochiashvili D, Muzashvili T, Gachechiladze M, Burkadze G
Georgian Med News 2021 Jul-Aug;(316-317):178-184. PMID: 34511468
Consultation on UTUC, Stockholm 2018: aspects of treatment.
Jung H, Giusti G, Fajkovic H, Herrmann T, Jones R, Straub M, Baard J, Osther PJS, Brehmer M
World J Urol 2019 Nov;37(11):2279-2287. Epub 2019 May 23 doi: 10.1007/s00345-019-02811-w. PMID: 31123852Free PMC Article
Precursor lesions of the urinary bladder.
McKenney JK
Histopathology 2019 Jan;74(1):68-76. doi: 10.1111/his.13762. PMID: 30565304

Diagnosis

Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma.
Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C
Cell Rep Med 2023 Sep 19;4(9):101166. Epub 2023 Aug 25 doi: 10.1016/j.xcrm.2023.101166. PMID: 37633276Free PMC Article
Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease.
Rose KM, Huelster HL, Meeks JJ, Faltas BM, Sonpavde GP, Lerner SP, Ross JS, Spiess PE, Grass GD, Jain RK, Kamat AM, Vosoughi A, Wang L, Wang X, Li R
Nat Rev Urol 2023 Jul;20(7):406-419. Epub 2023 Mar 28 doi: 10.1038/s41585-023-00725-2. PMID: 36977797
News in the classification of WHO 2022 bladder tumors.
Raspollini MR, Comperat EM, Lopez-Beltran A, Montironi R, Cimadamore A, Tsuzuki T, Netto GJ
Pathologica 2022 Feb;115(1):32-40. Epub 2023 Jan 25 doi: 10.32074/1591-951X-838. PMID: 36704871Free PMC Article
Precursor lesions of the urinary bladder.
McKenney JK
Histopathology 2019 Jan;74(1):68-76. doi: 10.1111/his.13762. PMID: 30565304
The occult urothelial cancer.
Ragonese M, Racioppi M, D'Agostino D, Di Gianfrancesco L, Lenci N, Bientinesi R, Palermo G, Sacco E, Pinto F, Bassi PF
Urologia 2016 May 24;83(2):55-60. Epub 2016 Mar 14 doi: 10.5301/uro.5000131. PMID: 26481721

Therapy

MRI-based automated machine learning model for preoperative identification of variant histology in muscle-invasive bladder carcinoma.
Huang J, Chen G, Liu H, Jiang W, Mai S, Zhang L, Zeng H, Wu S, Chen CY, Wu Z
Eur Radiol 2024 Mar;34(3):1804-1815. Epub 2023 Sep 2 doi: 10.1007/s00330-023-10137-w. PMID: 37658139
Evaluation of grade and invasiveness of bladder urothelial carcinoma using infrared imaging and machine learning.
Kujdowicz M, Perez-Guaita D, Chlosta P, Okon K, Malek K
Analyst 2023 Jan 16;148(2):278-285. doi: 10.1039/d2an01583h. PMID: 36525038
5-year outcomes after stereotactic ablative body radiotherapy for primary renal cell carcinoma: an individual patient data meta-analysis from IROCK (the International Radiosurgery Consortium of the Kidney).
Siva S, Ali M, Correa RJM, Muacevic A, Ponsky L, Ellis RJ, Lo SS, Onishi H, Swaminath A, McLaughlin M, Morgan SC, Cury FL, Teh BS, Mahadevan A, Kaplan ID, Chu W, Grubb W, Hannan R, Staehler M, Warner A, Louie AV
Lancet Oncol 2022 Dec;23(12):1508-1516. Epub 2022 Nov 16 doi: 10.1016/S1470-2045(22)00656-8. PMID: 36400098
Challenging dilemmas of low grade, non-invasive bladder cancer: a narrative review.
Korkes F, Spiess PE, Garcia-Perdomo HA, Necchi A
Int Braz J Urol 2022 May-Jun;48(3):397-405. doi: 10.1590/S1677-5538.IBJU.2021.0259. PMID: 34156188Free PMC Article
Consultation on UTUC, Stockholm 2018: aspects of treatment.
Jung H, Giusti G, Fajkovic H, Herrmann T, Jones R, Straub M, Baard J, Osther PJS, Brehmer M
World J Urol 2019 Nov;37(11):2279-2287. Epub 2019 May 23 doi: 10.1007/s00345-019-02811-w. PMID: 31123852Free PMC Article

Prognosis

Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma.
Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C
Cell Rep Med 2023 Sep 19;4(9):101166. Epub 2023 Aug 25 doi: 10.1016/j.xcrm.2023.101166. PMID: 37633276Free PMC Article
Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review.
Aveta A, Cilio S, Contieri R, Spena G, Napolitano L, Manfredi C, Franco A, Crocerossa F, Cerrato C, Ferro M, Del Giudice F, Verze P, Lasorsa F, Salonia A, Nair R, Walz J, Lucarelli G, Pandolfo SD
Int J Mol Sci 2023 Jun 29;24(13) doi: 10.3390/ijms241310846. PMID: 37446024Free PMC Article
Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease.
Rose KM, Huelster HL, Meeks JJ, Faltas BM, Sonpavde GP, Lerner SP, Ross JS, Spiess PE, Grass GD, Jain RK, Kamat AM, Vosoughi A, Wang L, Wang X, Li R
Nat Rev Urol 2023 Jul;20(7):406-419. Epub 2023 Mar 28 doi: 10.1038/s41585-023-00725-2. PMID: 36977797
The occult urothelial cancer.
Ragonese M, Racioppi M, D'Agostino D, Di Gianfrancesco L, Lenci N, Bientinesi R, Palermo G, Sacco E, Pinto F, Bassi PF
Urologia 2016 May 24;83(2):55-60. Epub 2016 Mar 14 doi: 10.5301/uro.5000131. PMID: 26481721
A clinical and molecular review of inverted papilloma of the urinary tract: how to handle?
Jørgensen PH, Vainer B, Hermann GG
APMIS 2015 Nov;123(11):920-9. Epub 2015 Sep 11 doi: 10.1111/apm.12456. PMID: 26358542

Clinical prediction guides

Quantitative differentiation of non-invasive bladder urothelial carcinoma and inverted papilloma based on CT urography.
Jin P, Yang L, Liu Y, Huang J, Wang X
BMC Urol 2024 Mar 26;24(1):73. doi: 10.1186/s12894-024-01459-y. PMID: 38532363Free PMC Article
Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma.
Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C
Cell Rep Med 2023 Sep 19;4(9):101166. Epub 2023 Aug 25 doi: 10.1016/j.xcrm.2023.101166. PMID: 37633276Free PMC Article
Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review.
Aveta A, Cilio S, Contieri R, Spena G, Napolitano L, Manfredi C, Franco A, Crocerossa F, Cerrato C, Ferro M, Del Giudice F, Verze P, Lasorsa F, Salonia A, Nair R, Walz J, Lucarelli G, Pandolfo SD
Int J Mol Sci 2023 Jun 29;24(13) doi: 10.3390/ijms241310846. PMID: 37446024Free PMC Article
Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease.
Rose KM, Huelster HL, Meeks JJ, Faltas BM, Sonpavde GP, Lerner SP, Ross JS, Spiess PE, Grass GD, Jain RK, Kamat AM, Vosoughi A, Wang L, Wang X, Li R
Nat Rev Urol 2023 Jul;20(7):406-419. Epub 2023 Mar 28 doi: 10.1038/s41585-023-00725-2. PMID: 36977797
The occult urothelial cancer.
Ragonese M, Racioppi M, D'Agostino D, Di Gianfrancesco L, Lenci N, Bientinesi R, Palermo G, Sacco E, Pinto F, Bassi PF
Urologia 2016 May 24;83(2):55-60. Epub 2016 Mar 14 doi: 10.5301/uro.5000131. PMID: 26481721

Recent systematic reviews

Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review.
Aveta A, Cilio S, Contieri R, Spena G, Napolitano L, Manfredi C, Franco A, Crocerossa F, Cerrato C, Ferro M, Del Giudice F, Verze P, Lasorsa F, Salonia A, Nair R, Walz J, Lucarelli G, Pandolfo SD
Int J Mol Sci 2023 Jun 29;24(13) doi: 10.3390/ijms241310846. PMID: 37446024Free PMC Article
Diagnostic and prognostic roles of CK20 in the pathology of urothelial lesions. A systematic review.
Sanguedolce F, Russo D, Calò B, Cindolo L, Carrieri G, Cormio L
Pathol Res Pract 2019 Jun;215(6):152413. Epub 2019 Apr 6 doi: 10.1016/j.prp.2019.04.005. PMID: 30987832

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