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Invasive Prostate Carcinoma

MedGen UID:
353823
•Concept ID:
C1708566
•
Neoplastic Process
Synonym: Infiltrating Prostate Carcinoma

Definition

A carcinoma that is not confined to the prostatic epithelium but has spread to the surrounding stroma of the prostate gland. The vast majority of invasive prostate carcinomas are adenocarcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive Prostate Carcinoma

Professional guidelines

PubMed

Immunotherapy in the Treatment of Localized Genitourinary Cancers.
Necchi A, Faltas BM, Slovin SF, Meeks JJ, Pal SK, Schwartz LH, Huang RSP, Li R, Manley B, Chahoud J, Ross JS, Spiess PE
JAMA Oncol 2023 Oct 1;9(10):1447-1454. doi: 10.1001/jamaoncol.2023.2174. PMID: 37561425
Bladder Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology.
Flaig TW, Spiess PE, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, Chang S, Downs TM, Efstathiou JA, Friedlander T, Greenberg RE, Guru KA, Guzzo T, Herr HW, Hoffman-Censits J, Hoimes C, Inman BA, Jimbo M, Kader AK, Lele SM, Michalski J, Montgomery JS, Nandagopal L, Pagliaro LC, Pal SK, Patterson A, Plimack ER, Pohar KS, Preston MA, Sexton WJ, Siefker-Radtke AO, Tward J, Wright JL, Gurski LA, Johnson-Chilla A
J Natl Compr Canc Netw 2020 Mar;18(3):329-354. doi: 10.6004/jnccn.2020.0011. PMID: 32135513
The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System.
Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA; Grading Committee
Am J Surg Pathol 2016 Feb;40(2):244-52. doi: 10.1097/PAS.0000000000000530. PMID: 26492179

Recent clinical studies

Etiology

Intraductal carcinoma of the prostate in the absence of high-grade invasive carcinoma represents a molecularly distinct type of in situ carcinoma enriched with oncogenic driver mutations.
Khani F, Wobker SE, Hicks JL, Robinson BD, Barbieri CE, De Marzo AM, Epstein JI, Pritchard CC, Lotan TL
J Pathol 2019 Sep;249(1):79-89. Epub 2019 May 24 doi: 10.1002/path.5283. PMID: 30993692
Role of Magnetic Resonance Imaging Targeted Biopsy in Detection of Prostate Cancer Harboring Adverse Pathological Features of Intraductal Carcinoma and Invasive Cribriform Carcinoma.
Prendeville S, Gertner M, Maganti M, Pintilie M, Perlis N, Toi A, Evans AJ, Finelli A, van der Kwast TH, Ghai S
J Urol 2018 Jul;200(1):104-113. Epub 2018 Feb 2 doi: 10.1016/j.juro.2018.01.081. PMID: 29408568
Prostate Biopsy Specimens With Gleason 3+3=6 and Intraductal Carcinoma: Radical Prostatectomy Findings and Clinical Outcomes.
Khani F, Epstein JI
Am J Surg Pathol 2015 Oct;39(10):1383-9. doi: 10.1097/PAS.0000000000000465. PMID: 26076065
Macrophage scavenger receptor 1 999C>T (R293X) mutation and risk of prostate cancer.
Hope Q, Bullock S, Evans C, Meitz J, Hamel N, Edwards SM, Severi G, Dearnaley D, Jhavar S, Southgate C, Falconer A, Dowe A, Muir K, Houlston RS, Engert JC, Roquis D, Sinnett D, Simard J, Heimdal K, Møller P, Maehle L, Badzioch M, Eeles RA, Easton DF, English DR, Southey MC, Hopper JL, Foulkes WD, Giles GG; Cancer Research UK/British Association of Urological Surgeons' Section of Oncology Collaborators
Cancer Epidemiol Biomarkers Prev 2005 Feb;14(2):397-402. doi: 10.1158/1055-9965.EPI-04-0202. PMID: 15734964
Comparison of methods of microvascular staining and quantification in prostate carcinoma: relevance to prognosis.
Offersen BV, Borre M, Sørensen FB, Overgaard J
APMIS 2002 Feb;110(2):177-85. doi: 10.1034/j.1600-0463.2002.100209.x. PMID: 12064874

Diagnosis

Role of Magnetic Resonance Imaging Targeted Biopsy in Detection of Prostate Cancer Harboring Adverse Pathological Features of Intraductal Carcinoma and Invasive Cribriform Carcinoma.
Prendeville S, Gertner M, Maganti M, Pintilie M, Perlis N, Toi A, Evans AJ, Finelli A, van der Kwast TH, Ghai S
J Urol 2018 Jul;200(1):104-113. Epub 2018 Feb 2 doi: 10.1016/j.juro.2018.01.081. PMID: 29408568
Prostate Biopsy Specimens With Gleason 3+3=6 and Intraductal Carcinoma: Radical Prostatectomy Findings and Clinical Outcomes.
Khani F, Epstein JI
Am J Surg Pathol 2015 Oct;39(10):1383-9. doi: 10.1097/PAS.0000000000000465. PMID: 26076065
Intraductal carcinoma of the prostate: a comprehensive and updated review.
Tsuzuki T
Int J Urol 2015 Feb;22(2):140-5. Epub 2014 Oct 31 doi: 10.1111/iju.12657. PMID: 25358604
Macrophage scavenger receptor 1 999C>T (R293X) mutation and risk of prostate cancer.
Hope Q, Bullock S, Evans C, Meitz J, Hamel N, Edwards SM, Severi G, Dearnaley D, Jhavar S, Southgate C, Falconer A, Dowe A, Muir K, Houlston RS, Engert JC, Roquis D, Sinnett D, Simard J, Heimdal K, Møller P, Maehle L, Badzioch M, Eeles RA, Easton DF, English DR, Southey MC, Hopper JL, Foulkes WD, Giles GG; Cancer Research UK/British Association of Urological Surgeons' Section of Oncology Collaborators
Cancer Epidemiol Biomarkers Prev 2005 Feb;14(2):397-402. doi: 10.1158/1055-9965.EPI-04-0202. PMID: 15734964
Comparison of methods of microvascular staining and quantification in prostate carcinoma: relevance to prognosis.
Offersen BV, Borre M, Sørensen FB, Overgaard J
APMIS 2002 Feb;110(2):177-85. doi: 10.1034/j.1600-0463.2002.100209.x. PMID: 12064874

Prognosis

Role of Magnetic Resonance Imaging Targeted Biopsy in Detection of Prostate Cancer Harboring Adverse Pathological Features of Intraductal Carcinoma and Invasive Cribriform Carcinoma.
Prendeville S, Gertner M, Maganti M, Pintilie M, Perlis N, Toi A, Evans AJ, Finelli A, van der Kwast TH, Ghai S
J Urol 2018 Jul;200(1):104-113. Epub 2018 Feb 2 doi: 10.1016/j.juro.2018.01.081. PMID: 29408568
Prostate Biopsy Specimens With Gleason 3+3=6 and Intraductal Carcinoma: Radical Prostatectomy Findings and Clinical Outcomes.
Khani F, Epstein JI
Am J Surg Pathol 2015 Oct;39(10):1383-9. doi: 10.1097/PAS.0000000000000465. PMID: 26076065
Intraductal carcinoma of the prostate: a comprehensive and updated review.
Tsuzuki T
Int J Urol 2015 Feb;22(2):140-5. Epub 2014 Oct 31 doi: 10.1111/iju.12657. PMID: 25358604
Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1.
Denkert C, Thoma A, Niesporek S, Weichert W, Koch I, Noske A, Schicktanz H, Burkhardt M, Jung K, Dietel M, Kristiansen G
Prostate 2007 Mar 1;67(4):361-9. doi: 10.1002/pros.20467. PMID: 17265445
Comparison of methods of microvascular staining and quantification in prostate carcinoma: relevance to prognosis.
Offersen BV, Borre M, Sørensen FB, Overgaard J
APMIS 2002 Feb;110(2):177-85. doi: 10.1034/j.1600-0463.2002.100209.x. PMID: 12064874

Clinical prediction guides

Intraductal carcinoma of the prostate in the absence of high-grade invasive carcinoma represents a molecularly distinct type of in situ carcinoma enriched with oncogenic driver mutations.
Khani F, Wobker SE, Hicks JL, Robinson BD, Barbieri CE, De Marzo AM, Epstein JI, Pritchard CC, Lotan TL
J Pathol 2019 Sep;249(1):79-89. Epub 2019 May 24 doi: 10.1002/path.5283. PMID: 30993692
Role of Magnetic Resonance Imaging Targeted Biopsy in Detection of Prostate Cancer Harboring Adverse Pathological Features of Intraductal Carcinoma and Invasive Cribriform Carcinoma.
Prendeville S, Gertner M, Maganti M, Pintilie M, Perlis N, Toi A, Evans AJ, Finelli A, van der Kwast TH, Ghai S
J Urol 2018 Jul;200(1):104-113. Epub 2018 Feb 2 doi: 10.1016/j.juro.2018.01.081. PMID: 29408568
Prostate Biopsy Specimens With Gleason 3+3=6 and Intraductal Carcinoma: Radical Prostatectomy Findings and Clinical Outcomes.
Khani F, Epstein JI
Am J Surg Pathol 2015 Oct;39(10):1383-9. doi: 10.1097/PAS.0000000000000465. PMID: 26076065
Intraductal carcinoma of the prostate: a comprehensive and updated review.
Tsuzuki T
Int J Urol 2015 Feb;22(2):140-5. Epub 2014 Oct 31 doi: 10.1111/iju.12657. PMID: 25358604
Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1.
Denkert C, Thoma A, Niesporek S, Weichert W, Koch I, Noske A, Schicktanz H, Burkhardt M, Jung K, Dietel M, Kristiansen G
Prostate 2007 Mar 1;67(4):361-9. doi: 10.1002/pros.20467. PMID: 17265445

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