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Vaginal carcinoma

MedGen UID:
82653
Concept ID:
C0262659
Neoplastic Process
Synonyms: Cancer of the Vagina; Cancer of Vagina; Carcinoma of the Vagina; carcinoma of the vagina; Carcinoma of vagina; Carcinoma of Vagina; carcinoma of vagina; Vagina Cancer; Vagina Carcinoma; vagina carcinoma; Vaginal Cancer; Vaginal Carcinoma; vaginal carcinoma; Vaginal malignant epithelial tumor
SNOMED CT: Carcinoma of vagina (254893005)
 
Monarch Initiative: MONDO:0015867
Orphanet: ORPHA180247

Definition

A group of rare vaginal tumors comprising HPV-associated and HPV-independent squamous cell carcinoma, glandular tumors (including HPV-associated adenocarcinoma, endometrioid carcinoma, clear cell carcinoma, gastric type and intestinal type mucinous carcinoma, and mesonephric adenocarcinoma), adenocarcinoma of Skene gland origin, adenosquamous carcinoma, and adenoid basal carcinoma. Depending on the type of tumor and disease stage, patients may present with symptoms related to a vaginal mass, vaginal bleeding and/or discharge, postcoital bleeding, urinary symptoms, pelvic pain, and a foreign body sensation within the vagina. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal carcinoma
Follow this link to review classifications for Vaginal carcinoma in Orphanet.

Professional guidelines

PubMed

Kulkarni A, Dogra N, Zigras T
Curr Oncol 2022 Apr 27;29(5):3082-3092. doi: 10.3390/curroncol29050250. PMID: 35621640Free PMC Article
Expert Panel on GYN and OB Imaging, Kilcoyne A, Gottumukkala RV, Kang SK, Akin EA, Hauck C, Hindman NM, Huang C, Khanna N, Paspulati R, Rauch GM, Said T, Shinagare AB, Stein EB, Venkatesan AM, Maturen KE
J Am Coll Radiol 2021 Nov;18(11S):S442-S455. doi: 10.1016/j.jacr.2021.08.011. PMID: 34794599
Rountis A, Pergialiotis V, Tsetsa P, Rodolakis A, Haidopoulos D
Int J Clin Pract 2020 Nov;74(11):e13598. Epub 2020 Aug 4 doi: 10.1111/ijcp.13598. PMID: 32602195

Recent clinical studies

Etiology

Frigerio M, Inzoli A, Barba M
Int J Gynaecol Obstet 2022 Nov;159(2):365-371. Epub 2022 Feb 28 doi: 10.1002/ijgo.14137. PMID: 35167139
Garganese G, Romito A, Scambia G, Fagotti A
Curr Opin Oncol 2021 Sep 1;33(5):485-492. doi: 10.1097/CCO.0000000000000757. PMID: 34319290
Rountis A, Pergialiotis V, Tsetsa P, Rodolakis A, Haidopoulos D
Int J Clin Pract 2020 Nov;74(11):e13598. Epub 2020 Aug 4 doi: 10.1111/ijcp.13598. PMID: 32602195
Di Donato V, Bellati F, Fischetti M, Plotti F, Perniola G, Panici PB
Crit Rev Oncol Hematol 2012 Mar;81(3):286-95. Epub 2011 May 14 doi: 10.1016/j.critrevonc.2011.04.004. PMID: 21571543
Lilic V, Lilic G, Filipovic S, Visnjic M, Zivadinovic R
J BUON 2010 Apr-Jun;15(2):241-7. PMID: 20658716

Diagnosis

Shen Y, Meng X, Wang L, Wang X, Chang H
Front Immunol 2022;13:1007462. Epub 2022 Nov 22 doi: 10.3389/fimmu.2022.1007462. PMID: 36483563Free PMC Article
Garganese G, Romito A, Scambia G, Fagotti A
Curr Opin Oncol 2021 Sep 1;33(5):485-492. doi: 10.1097/CCO.0000000000000757. PMID: 34319290
Lilic V, Lilic G, Filipovic S, Visnjic M, Zivadinovic R
J BUON 2010 Apr-Jun;15(2):241-7. PMID: 20658716
Grigsby PW
Curr Opin Oncol 2009 Sep;21(5):420-4. doi: 10.1097/CCO.0b013e32832ec63f. PMID: 19553814
Fetters MD, Fischer G, Reed BD
JAMA 1996 Mar 27;275(12):940-7. PMID: 8598623

Therapy

Rountis A, Pergialiotis V, Tsetsa P, Rodolakis A, Haidopoulos D
Int J Clin Pract 2020 Nov;74(11):e13598. Epub 2020 Aug 4 doi: 10.1111/ijcp.13598. PMID: 32602195
Rouvroye MD, Tack GJ, Mom CH, Lissenberg-Witte BI, Pierik MJ, Neefjes-Borst EA, de Boer NKH; Dutch Workgroup on IBD and Vulvovaginal neoplasia
Dig Liver Dis 2020 Feb;52(2):149-155. Epub 2019 Nov 11 doi: 10.1016/j.dld.2019.10.002. PMID: 31718933
Di Donato V, Bellati F, Fischetti M, Plotti F, Perniola G, Panici PB
Crit Rev Oncol Hematol 2012 Mar;81(3):286-95. Epub 2011 May 14 doi: 10.1016/j.critrevonc.2011.04.004. PMID: 21571543
Grigsby PW
Curr Treat Options Oncol 2002 Apr;3(2):125-30. doi: 10.1007/s11864-002-0058-4. PMID: 12057075
Boente MP, Schilder R, Ozols RF
Cancer Chemother Biol Response Modif 1997;17:536-61. PMID: 9551230

Prognosis

Expert Panel on GYN and OB Imaging, Kilcoyne A, Gottumukkala RV, Kang SK, Akin EA, Hauck C, Hindman NM, Huang C, Khanna N, Paspulati R, Rauch GM, Said T, Shinagare AB, Stein EB, Venkatesan AM, Maturen KE
J Am Coll Radiol 2021 Nov;18(11S):S442-S455. doi: 10.1016/j.jacr.2021.08.011. PMID: 34794599
Garganese G, Romito A, Scambia G, Fagotti A
Curr Opin Oncol 2021 Sep 1;33(5):485-492. doi: 10.1097/CCO.0000000000000757. PMID: 34319290
Rouvroye MD, Tack GJ, Mom CH, Lissenberg-Witte BI, Pierik MJ, Neefjes-Borst EA, de Boer NKH; Dutch Workgroup on IBD and Vulvovaginal neoplasia
Dig Liver Dis 2020 Feb;52(2):149-155. Epub 2019 Nov 11 doi: 10.1016/j.dld.2019.10.002. PMID: 31718933
Gadducci A, Fabrini MG, Lanfredini N, Sergiampietri C
Crit Rev Oncol Hematol 2015 Mar;93(3):211-24. Epub 2014 Oct 5 doi: 10.1016/j.critrevonc.2014.09.002. PMID: 25476235
Lilic V, Lilic G, Filipovic S, Visnjic M, Zivadinovic R
J BUON 2010 Apr-Jun;15(2):241-7. PMID: 20658716

Clinical prediction guides

Garganese G, Romito A, Scambia G, Fagotti A
Curr Opin Oncol 2021 Sep 1;33(5):485-492. doi: 10.1097/CCO.0000000000000757. PMID: 34319290
Nomura H, Tanaka Y, Omi M, Netsu S, Aoki Y, Tanigawa T, Kurita T, Matoda M, Okamoto S, Omatsu K, Kanao H, Takeshima N
Int J Clin Oncol 2020 Jul;25(7):1412-1417. Epub 2020 Mar 27 doi: 10.1007/s10147-020-01663-4. PMID: 32219631
Gadducci A, Fabrini MG, Lanfredini N, Sergiampietri C
Crit Rev Oncol Hematol 2015 Mar;93(3):211-24. Epub 2014 Oct 5 doi: 10.1016/j.critrevonc.2014.09.002. PMID: 25476235
Dittmer C, Katalinic A, Mundhenke C, Thill M, Fischer D
Arch Gynecol Obstet 2011 Jul;284(1):169-74. Epub 2011 Feb 22 doi: 10.1007/s00404-011-1850-9. PMID: 21340687
Kirkbride P, Fyles A, Rawlings GA, Manchul L, Levin W, Murphy KJ, Simm J
Gynecol Oncol 1995 Mar;56(3):435-43. doi: 10.1006/gyno.1995.1077. PMID: 7705681

Recent systematic reviews

Frigerio M, Inzoli A, Barba M
Int J Gynaecol Obstet 2022 Nov;159(2):365-371. Epub 2022 Feb 28 doi: 10.1002/ijgo.14137. PMID: 35167139
Bryan S, Barbara C, Thomas J, Olaitan A
BMC Womens Health 2019 Jan 7;19(1):3. doi: 10.1186/s12905-018-0707-9. PMID: 30616555Free PMC Article
Guerri S, Perrone AM, Buwenge M, Ferioli M, Macchia G, Tagliaferri L, Ferrandina G, Galuppi A, Andrulli AD, Frakulli R, Cammelli S, Arcelli A, De Iaco P, Morganti AG
Oncologist 2019 Jan;24(1):132-141. Epub 2018 Aug 23 doi: 10.1634/theoncologist.2017-0546. PMID: 30139838Free PMC Article
Tranoulis A, Laios A, Mitsopoulos V, Lutchman-Singh K, Thomakos N
Eur J Obstet Gynecol Reprod Biol 2017 Nov;218:129-136. Epub 2017 Sep 27 doi: 10.1016/j.ejogrb.2017.09.020. PMID: 28985547

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