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Osteoporosis

MedGen UID:
14535
Concept ID:
C0029456
Disease or Syndrome
Synonym: Osteoporoses
SNOMED CT: Osteoporosis (64859006)
 
CALCR (7q21.3); COL1A1 (17q21.33); COL1A2 (7q21.3); PDLIM4 (5q31.1)
NHERF1, SLC34A1
 
HPO: HP:0000939
Monarch Initiative: MONDO:0005298
OMIM®: 166710

Definition

Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy adults (a T-score below -2.5 SD). [from HPO]

Clinical features

From HPO

Conditions with this feature

Professional guidelines

PubMed

Montero-Odasso MM, Kamkar N, Pieruccini-Faria F, Osman A, Sarquis-Adamson Y, Close J, Hogan DB, Hunter SW, Kenny RA, Lipsitz LA, Lord SR, Madden KM, Petrovic M, Ryg J, Speechley M, Sultana M, Tan MP, van der Velde N, Verghese J, Masud T; Task Force on Global Guidelines for Falls in Older Adults
JAMA Netw Open 2021 Dec 1;4(12):e2138911. doi: 10.1001/jamanetworkopen.2021.38911. PMID: 34910151Free PMC Article
Menopause 2021 Sep 1;28(9):973-997. doi: 10.1097/GME.0000000000001831. PMID: 34448749
Izquierdo M, Merchant RA, Morley JE, Anker SD, Aprahamian I, Arai H, Aubertin-Leheudre M, Bernabei R, Cadore EL, Cesari M, Chen LK, de Souto Barreto P, Duque G, Ferrucci L, Fielding RA, García-Hermoso A, Gutiérrez-Robledo LM, Harridge SDR, Kirk B, Kritchevsky S, Landi F, Lazarus N, Martin FC, Marzetti E, Pahor M, Ramírez-Vélez R, Rodriguez-Mañas L, Rolland Y, Ruiz JG, Theou O, Villareal DT, Waters DL, Won Won C, Woo J, Vellas B, Fiatarone Singh M
J Nutr Health Aging 2021;25(7):824-853. doi: 10.1007/s12603-021-1665-8. PMID: 34409961

Recent clinical studies

Etiology

Brown JP
Endocrinol Metab (Seoul) 2021 Jun;36(3):544-552. Epub 2021 Jun 22 doi: 10.3803/EnM.2021.301. PMID: 34154042Free PMC Article
Yong EL, Logan S
Singapore Med J 2021 Apr;62(4):159-166. doi: 10.11622/smedj.2021036. PMID: 33948669Free PMC Article
Muñoz M, Robinson K, Shibli-Rahhal A
Clin Obstet Gynecol 2020 Dec;63(4):770-787. doi: 10.1097/GRF.0000000000000572. PMID: 33017332
Johnston CB, Dagar M
Med Clin North Am 2020 Sep;104(5):873-884. Epub 2020 Jul 15 doi: 10.1016/j.mcna.2020.06.004. PMID: 32773051
Adami G, Fassio A, Rossini M, Caimmi C, Giollo A, Orsolini G, Viapiana O, Gatti D
Int J Mol Sci 2019 Nov 22;20(23) doi: 10.3390/ijms20235867. PMID: 31766755Free PMC Article

Diagnosis

Gopinath V
Med Clin North Am 2023 Mar;107(2):213-225. Epub 2023 Jan 5 doi: 10.1016/j.mcna.2022.10.013. PMID: 36759092
Akid I, Doberman DJ
Clin Geriatr Med 2021 Nov;37(4):683-696. Epub 2021 Aug 23 doi: 10.1016/j.cger.2021.05.012. PMID: 34600731
Arceo-Mendoza RM, Camacho PM
Endocrinol Metab Clin North Am 2021 Jun;50(2):167-178. doi: 10.1016/j.ecl.2021.03.009. PMID: 34023036
Yong EL, Logan S
Singapore Med J 2021 Apr;62(4):159-166. doi: 10.11622/smedj.2021036. PMID: 33948669Free PMC Article
Muñoz M, Robinson K, Shibli-Rahhal A
Clin Obstet Gynecol 2020 Dec;63(4):770-787. doi: 10.1097/GRF.0000000000000572. PMID: 33017332

Therapy

Ma ML, Ma ZJ, He YL, Sun H, Yang B, Ruan BJ, Zhan WD, Li SX, Dong H, Wang YX
Front Public Health 2022;10:979649. Epub 2022 Aug 11 doi: 10.3389/fpubh.2022.979649. PMID: 36033779Free PMC Article
Roux C, Cortet B, Bousson V, Thomas T
RMD Open 2021 Jun;7(2) doi: 10.1136/rmdopen-2021-001655. PMID: 34193518Free PMC Article
Cagnacci A, Venier M
Medicina (Kaunas) 2019 Sep 18;55(9) doi: 10.3390/medicina55090602. PMID: 31540401Free PMC Article
Handoll HH, Elliott J
Cochrane Database Syst Rev 2015 Sep 25;2015(9):CD003324. doi: 10.1002/14651858.CD003324.pub3. PMID: 26403335Free PMC Article
Howe TE, Shea B, Dawson LJ, Downie F, Murray A, Ross C, Harbour RT, Caldwell LM, Creed G
Cochrane Database Syst Rev 2011 Jul 6;(7):CD000333. doi: 10.1002/14651858.CD000333.pub2. PMID: 21735380

Prognosis

Wanionok NE, Morel GR, Fernández JM
Ageing Res Rev 2024 Aug;99:102408. Epub 2024 Jul 3 doi: 10.1016/j.arr.2024.102408. PMID: 38969142
Ala M, Jafari RM, Dehpour AR
Curr Diabetes Rev 2020;16(9):984-1001. doi: 10.2174/1573399816666200324152517. PMID: 32208120
Radner H
Wien Klin Wochenschr 2016 Nov;128(21-22):786-790. Epub 2016 Oct 13 doi: 10.1007/s00508-016-1090-x. PMID: 27738754Free PMC Article
Gennari L, Bilezikian JP
Endocrinol Metab Clin North Am 2007 Jun;36(2):399-419. doi: 10.1016/j.ecl.2007.03.008. PMID: 17543726
Selby P
Curr Osteoporos Rep 2004 Sep;2(3):101-6. doi: 10.1007/s11914-004-0018-y. PMID: 16036090

Clinical prediction guides

Holmes CJ, Racette SB
Nutrients 2021 Jul 22;13(8) doi: 10.3390/nu13082493. PMID: 34444653Free PMC Article
Borges JLC, de M Miranda IS, Lewiecki EM
J Clin Densitom 2017 Jul-Sep;20(3):304-308. Epub 2017 Jul 18 doi: 10.1016/j.jocd.2017.06.016. PMID: 28729044
Jain RK, Vokes T
J Clin Densitom 2017 Jul-Sep;20(3):291-303. Epub 2017 Jul 14 doi: 10.1016/j.jocd.2017.06.014. PMID: 28716497
Roux C, Dougados M
Curr Opin Rheumatol 2000 Jul;12(4):336-45. doi: 10.1097/00002281-200007000-00018. PMID: 10910188
Genant HK, Wu CY, van Kuijk C, Nevitt MC
J Bone Miner Res 1993 Sep;8(9):1137-48. doi: 10.1002/jbmr.5650080915. PMID: 8237484

Recent systematic reviews

Ayers C, Kansagara D, Lazur B, Fu R, Kwon A, Harrod C
Ann Intern Med 2023 Feb;176(2):182-195. Epub 2023 Jan 3 doi: 10.7326/M22-0684. PMID: 36592455
Linhares DG, Borba-Pinheiro CJ, Castro JBP, Santos AOBD, Santos LLD, Cordeiro LS, Drigo AJ, Nunes RAM, Vale RGS
Int J Environ Res Public Health 2022 Oct 30;19(21) doi: 10.3390/ijerph192114195. PMID: 36361073Free PMC Article
Xiao PL, Cui AY, Hsu CJ, Peng R, Jiang N, Xu XH, Ma YG, Liu D, Lu HD
Osteoporos Int 2022 Oct;33(10):2137-2153. Epub 2022 Jun 10 doi: 10.1007/s00198-022-06454-3. PMID: 35687123
Singh S, Dutta S, Khasbage S, Kumar T, Sachin J, Sharma J, Varthya SB
Osteoporos Int 2022 Jan;33(1):1-12. Epub 2021 Aug 25 doi: 10.1007/s00198-021-06095-y. PMID: 34432115Free PMC Article
Su Y, Chen Z, Xie W
Biomed Res Int 2020;2020:6210201. Epub 2020 May 15 doi: 10.1155/2020/6210201. PMID: 32509864Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

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