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Rectum adenocarcinoma

MedGen UID:
56214
Concept ID:
C0149978
Neoplastic Process
Synonym: Rectal Adenocarcinoma
SNOMED CT: Adenocarcinoma of rectum (254582000)
 
Monarch Initiative: MONDO:0002169

Definition

An adenocarcinoma arising from the rectum. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, rectal adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma. [from NCI]

Professional guidelines

PubMed

Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Cetin E, Ozturk AS, Orhun H, Ulger S
World J Gastroenterol 2014 Apr 21;20(15):4341-4. doi: 10.3748/wjg.v20.i15.4341. PMID: 24764671Free PMC Article
Perrotta S, Quarto G, Desiato V, Benassai G, Amato B, Benassai G
BMC Surg 2013;13 Suppl 2(Suppl 2):S56. Epub 2013 Oct 8 doi: 10.1186/1471-2482-13-S2-S56. PMID: 24267977Free PMC Article

Recent clinical studies

Etiology

Yu J, Gong Y, Xu Z, Chen L, Li S, Cui Y
PeerJ 2024;12:e17629. Epub 2024 Jun 24 doi: 10.7717/peerj.17629. PMID: 38938617Free PMC Article
Ling ZN, Hong LL, Wu J, Ling ZQ
Sci Rep 2024 Feb 6;14(1):3030. doi: 10.1038/s41598-024-53489-z. PMID: 38321173Free PMC Article
Liu Y, Yang Y, Ni F, Tai G, Yu C, Jiang X, Wang D
J Transl Med 2023 Nov 27;21(1):856. doi: 10.1186/s12967-023-04753-9. PMID: 38012642Free PMC Article
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Reynolds IS, O'Connell E, Fichtner M, McNamara DA, Kay EW, Prehn JHM, Furney SJ, Burke JP
J Surg Oncol 2019 Dec;120(8):1427-1435. Epub 2019 Nov 14 doi: 10.1002/jso.25764. PMID: 31729037

Diagnosis

Liu Y, Yang Y, Ni F, Tai G, Yu C, Jiang X, Wang D
J Transl Med 2023 Nov 27;21(1):856. doi: 10.1186/s12967-023-04753-9. PMID: 38012642Free PMC Article
Zhao P, Zhen H, Zhao H, Huang Y, Cao B
J Transl Med 2023 Mar 6;21(1):176. doi: 10.1186/s12967-023-04029-2. PMID: 36879254Free PMC Article
Dong Q, Zhang S, Zhang H, Sun J, Lu J, Wang G, Wang X
Int Immunopharmacol 2023 Mar;116:109783. Epub 2023 Feb 9 doi: 10.1016/j.intimp.2023.109783. PMID: 36773567
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Lin A, Zhang J, Luo P
Front Immunol 2020;11:2039. Epub 2020 Aug 12 doi: 10.3389/fimmu.2020.02039. PMID: 32903444Free PMC Article

Therapy

Liu Y, Yang Y, Ni F, Tai G, Yu C, Jiang X, Wang D
J Transl Med 2023 Nov 27;21(1):856. doi: 10.1186/s12967-023-04753-9. PMID: 38012642Free PMC Article
Sgouros J, Gkoura S, Spathas N, Tzoudas F, Karampinos K, Miaris N, Visvikis A, Dessypris N, Mauri D, Aravantinos G, Theodoropoulos I, Stamoulis G, Samantas E
Clin Colorectal Cancer 2023 Jun;22(2):238-244. Epub 2023 Mar 4 doi: 10.1016/j.clcc.2023.02.007. PMID: 36967268
Zhao P, Zhen H, Zhao H, Huang Y, Cao B
J Transl Med 2023 Mar 6;21(1):176. doi: 10.1186/s12967-023-04029-2. PMID: 36879254Free PMC Article
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Lin A, Zhang J, Luo P
Front Immunol 2020;11:2039. Epub 2020 Aug 12 doi: 10.3389/fimmu.2020.02039. PMID: 32903444Free PMC Article

Prognosis

Liu Y, Yang Y, Ni F, Tai G, Yu C, Jiang X, Wang D
J Transl Med 2023 Nov 27;21(1):856. doi: 10.1186/s12967-023-04753-9. PMID: 38012642Free PMC Article
Zhao P, Zhen H, Zhao H, Huang Y, Cao B
J Transl Med 2023 Mar 6;21(1):176. doi: 10.1186/s12967-023-04029-2. PMID: 36879254Free PMC Article
Dong Q, Zhang S, Zhang H, Sun J, Lu J, Wang G, Wang X
Int Immunopharmacol 2023 Mar;116:109783. Epub 2023 Feb 9 doi: 10.1016/j.intimp.2023.109783. PMID: 36773567
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Lin A, Zhang J, Luo P
Front Immunol 2020;11:2039. Epub 2020 Aug 12 doi: 10.3389/fimmu.2020.02039. PMID: 32903444Free PMC Article

Clinical prediction guides

Liu Y, Yang Y, Ni F, Tai G, Yu C, Jiang X, Wang D
J Transl Med 2023 Nov 27;21(1):856. doi: 10.1186/s12967-023-04753-9. PMID: 38012642Free PMC Article
Zhao P, Zhen H, Zhao H, Huang Y, Cao B
J Transl Med 2023 Mar 6;21(1):176. doi: 10.1186/s12967-023-04029-2. PMID: 36879254Free PMC Article
Dong Q, Zhang S, Zhang H, Sun J, Lu J, Wang G, Wang X
Int Immunopharmacol 2023 Mar;116:109783. Epub 2023 Feb 9 doi: 10.1016/j.intimp.2023.109783. PMID: 36773567
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Lin A, Zhang J, Luo P
Front Immunol 2020;11:2039. Epub 2020 Aug 12 doi: 10.3389/fimmu.2020.02039. PMID: 32903444Free PMC Article

Recent systematic reviews

Yang FR, Li HJ, Li TT, Zhao YF, Liu ZK, Li XR
Biomed Res Int 2019;2019:2063823. Epub 2019 Apr 2 doi: 10.1155/2019/2063823. PMID: 31061821Free PMC Article

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