- Homage to Howard Temin
- Preface
- Acknowledgments
- Contributors
- Historical Introduction to the General Properties of Retroviruses
- Retroviral Virions and Genomes
- Viral Entry and Receptors
- Reverse Transcriptase and the Generation of Retroviral DNA
- Integration
- Synthesis and Processing of Viral RNA
- Synthesis, Assembly, and Processing of Viral Proteins
- Overview of Retroviral Assembly
- Synthesis of Gag and Gag-Pro-Pol Proteins
- Synthesis and Organization of Env Glycoproteins
- Principles of Particle Assembly
- Viral RNA Packaging
- Incorporation of Env into the Viral Particle
- The Retroviral Protease
- Maturation of Viral Particles
- Accessory Proteins and Assembly
- Summary
- References
- The Interactions of Retroviruses and their Hosts
- Retroviral “Lifestyles”: Simple versus Complex
- Retroviruses and their Interactions with the Host Cell
- Replication, Differentiation, and the Cell Cycle
- Effect of Infection on Cell Division and Differentiation
- Retroviruses and their Interactions with Multicellular Hosts
- Immune Response to Retroviral Infection
- Retroviruses as Agents of Genetic Change
- Conclusion
- Retrotransposons, Endogenous Retroviruses, and the Evolution of Retroelements
- Development and Applications of Retroviral Vectors
- Retroviral Pathogenesis
- Pathogenesis of HIV and SIV
- Etiologic Agents
- Cellular Targets of Infection
- Course of Infection with HIV and SIV
- Immunopathogenic Mechanisms of HIV Infection
- Role of Lymphoid Organs in Immunopathogenesis
- Pathogenesis of Kaposi's Sarcoma and Other Opportunistic Neoplasms
- Tissue-Specific Disease and Organ System Failure
- Immune Responses to HIV and SIV
- Conclusions
- References
- Immunological and Pharmacological Approaches to the Control of Retroviral Infections
- Appendixes