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Select item 39971.

Various bone marrow hematopoietic cell fractions

Analysis of BM hematopoietic cell fractions including CD34-KSL hematopoietic stem cells. HSCs are primitive cells capable of both self-renewal and differentiating into all of the mature blood cell lineages. Results provide insight into molecular mechanisms underlying maintenance of HSC self-renewal.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 12 cell type sets

Platform:: GPL1261
Series:: GSE27787
24 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3997

ID:: 3997

Select item 58132.

Bone morphogenetic protein 4 and forskolin effect on embryonic AGM VE-cadherin+ cells

Analysis of vascular endothelial (VE)-cadherin+ cells isolated from aorta-gonad-mesonephros (AGM) region of E11.5 embryos then treated with bone morphogenetic protein (BMP) 4, adenylyl cyclase activator forskolin, or both. Results provide insight into the role of BMP signaling in AGM hematopoiesis.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 4 agent sets

Platform:: GPL1261
Series:: GSE62517
8 Samples

Download data: CEL

DataSet

Accession:: GDS5813

ID:: 5813

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 58063.

FLT3/ITD-SmoM2 acute myeloid leukemia model: sorted bone marrow cells

Analysis of KSL and GMP cells isolated from bone marrow of Flt3/ITD-SmoM2 transgenics at around 3 months of age when they developed leukemia. Wild-type and FLT3/ITD littermates of the FLT3/ITD-SmoM2 animals were also examined. Results provide insight into the role of SmoM2 in leukemic progression.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 cell type, 3 genotype/variation sets

Platform:: GPL1261
Series:: GSE67134
6 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5806

ID:: 5806

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 56784.

Anti-VEGF and Anti-Notch treatment effect on U87 glioblastoma xenograft tumors [Mouse430_2]

Analysis of U87 human xenograft tumors (in BALB/c SCID mouse host) treated with antiangiogenic agents bevacizumab (anti-VEGF) and dibenzazepine (anti-Notch). The tumors include mouse host stroma. Results, together with those from GDS5672, provide insight into molecular basis of tumor angiogenesis.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array, transformed count, 3 agent sets

Platform:: GPL1261
Series:: GSE39413
14 Samples

Download data: CEL

DataSet

Accession:: GDS5678

ID:: 5678

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 56635.

Pulmonary dendritic cell subsets

Analysis of four dendritic cell (DC) subsets purified from the lungs of C57BL/6 males following inhalation of LPS/OVA. The four subsets represent conventional DCs (cDCs) and monocyte-derived DCs (moDCs). Results provide insight into molecular profiles that would discriminate between cDCs and moDCs.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 4 cell type, 2 other sets

Platform:: GPL1261
Series:: GSE64896
12 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5663

ID:: 5663

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 56606.

Early postnatal skeletal muscle stem cells: time course

Analysis of myogenic stem cells called satellite cells (mSCs) FACS-sorted from the trunk of Pax3GFP/+ mice at postnatal days 1, 12, and 28, a period when most mSCs are in proliferation and quiescence states. Results provide insight into molecular basis of early postnatal skeletal muscle development.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 3 age, 2 tissue sets

Platform:: GPL1261
Series:: GSE65927
11 Samples

Download data: CEL

DataSet

Accession:: GDS5660

ID:: 5660

Select item 56587.

Retinoid X receptor activation effect on stimulated RAW264.7 cells

Analysis of RAW 264.7 macrophages pre-treated with vitamin A derivative 9cis-retinoic acid (9cRA), then stimulated with bacterial LPS or viral mimetic polyI:C. 9cRA is a high affinity ligand for retinoid X receptor (RXR). Results provide insight into the role of RXR in host antiviral response.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 protocol, 3 stress sets

Platform:: GPL1261
Series:: GSE62107
6 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5658

ID:: 5658

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 56568.

Forkhead box O 1,3,4 muscle-specific knockout effect on fasted gastrocnemius muscle

Analysis of gastrocnemius muscle from starved males with muscle-specific deletion of Forkhead Box O transcription factors 1, 3 and 4 (FoxO1,3,4-/-). Results provide insight into the collective roles of FoxOs during muscle atrophy.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation, 2 stress sets

Platform:: GPL1261
Series:: GSE52667
4 Samples

Download data: CEL

DataSet

Accession:: GDS5656

ID:: 5656

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 56449.

Transforming growth factor, beta receptor II knockout effect on embryonic posterior palate

Analysis of posterior portions of the palate from E15.5 embryos with an epithelial cell-specific conditional inactivation of Transforming growth factor, beta receptor II (Tgfbr2). Results, together with those from GDS4921, provide insight into the role of TGFβ signaling in soft palate development.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE46211
12 Samples

Download data: CEL

DataSet

Accession:: GDS5644

ID:: 5644

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 564210.

Tendon development: embryonic limb tendon cells

Analysis of tendon cells isolated by FACS from forelimbs of embryonic day 11.5, E12.5 and E14.5 scleraxis (Scx)-GFP embryos. Basic helix-loop-helix transcription factor Scx is a specific tendon and ligament marker. Results provide insight into molecular pathways involved in tendon development.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 age sets

Platform:: GPL1261
Series:: GSE54207
9 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5642

ID:: 5642

Select item 564011.

Double-knockout p53/PRKDC model of B cell acute lymphoblastic leukemia: leukemic blasts

Analysis of leukemic blasts from p53/Prkdc double-knockout mutants that spontaneously develop early B cell acute lymphoblastic leukemia (B-ALL). Results provide insight into molecular mechanisms underlying high-risk B-ALL.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 cell type, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE56345
9 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5640

ID:: 5640

Select item 563412.

High multiplicity mycobacterial infections of macrophages in vitro

Analysis of macrophage cell line J774A.1 infected with pathogenic mycobacteria BCG and H37Ra and non-pathogenic M. smegmatis under high multiplicity of infection (MOI = 50). Results provide insight into the molecular response of macrophage host cells to pathogenic and non-pathogenic mycobacteria.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 4 infection, 4 species sets

Platform:: GPL1261
Series:: GSE45675
4 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5634

ID:: 5634

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 562413.

Epigenetic modifying reagents effect on a progressive hearing loss model: whole cochlea

Analysis of cochlea from 4 wk old DBA/2J males (a model of progressive hearing loss) injected for 8 wks with a combination of epigenetic modifiers l-methionine and valproic acid. Results provide insight into the effect of epigenetic modifications on the molecular mechanisms underlying hearing loss.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 age, 3 protocol sets

Platform:: GPL1261
Series:: GSE62173
16 Samples

Download data: CEL

DataSet

Accession:: GDS5624

ID:: 5624

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 560914.

Notch ligand delta-like 4 effect on interleukin 10-secreting T helper 1 cells

Analysis of IL-10-secreting and -nonsecreting T helper 1 (Th1) cells stimulated with Notch ligand Delta-like 4. The Notch pathway is a major driver of IL-10 production in Th1 cells. Results provide insight into the molecular basis of Notch-mediated IL-10 induction in Th1 cells.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent, 2 cell type sets

Platform:: GPL1261
Series:: GSE57417
4 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5609

ID:: 5609

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 560815.

NF-κB subunit p65 depletion effect on Ras-induced transformation model: cultured embryonic fibroblasts

Analysis of p65+/+Ras and p65-/-Ras cells generated by infecting NF-κB subunit p65+/+ and p65-/- MEFs with pBabe-HRASG12V. Post-injection of the Ras cells into SCID mice, RasT tumors were removed, reconstituted in culture and examined. Results provide insight into role of NF-κB in tumorigenesis.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 cell line, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE59545
4 Samples

Download data: CEL, DCP, TXT

DataSet

Accession:: GDS5608

ID:: 5608

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 560516.

Listeria monocytogenes infection effect on transcriptional repressor BLIMP1-deficient macrophage

Analysis of B lymphocyte-induced maturation protein 1 (BLIMP1) conditional knockout macrophages infected with Listeria monocytogenes for 2 hr. Results provide insight into BLIMP1-mediated regulatory mechanisms in macrophages in early host defense against intracellular bacteria.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation, 2 infection sets

Platform:: GPL1261
Series:: GSE53145
12 Samples

Download data: CEL

DataSet

Accession:: GDS5605

ID:: 5605

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 560217.

Transcription factor Inhibitor of differentiation 3 knockout effect on invariant natural killer T cells: developmental time course

Analysis of stage 1 (Tet+CD24-CD44-NK1.1-) and stage 2 (Tet+CD24-CD44+NK1.1-) invariant natural killer T (iNKT) cells FACS-sorted from inhibitor of differentiation 3 (Id3) knockout thymus. Results provide insight into the role of transcriptional regulator ID3 during iNKT cell maturation in thymus.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 cell type, 2 development stage, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE50933
10 Samples

Download data: CEL

DataSet

Accession:: GDS5602

ID:: 5602

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 560118.

Nanoemulsion adjuvant W805EC effect on JAWS II dendritic cells: time course

Analysis of JAWS II DCs incubated with nanoemulsion (NE) adjuvant W805EC for up to 24 hrs. W805EC is an oil-in-water emulsion with nanodroplets similar in size to many viruses infecting the nasal mucosa. Results provide insight into the molecular basis of the adjuvant activity of W805EC NE in DCs.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 5 protocol, 2 time sets

Platform:: GPL1261
Series:: GSE51804
10 Samples

Download data: CEL

DataSet

Accession:: GDS5601

ID:: 5601

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 551919.

5-azacytidine effect on mesenchymal progenitor cell line

Analysis of C2C12 mesenchymal progenitor cells treated with 5-azacytidine (5AC). 5AC is a DNA methylation inhibitor and induces genomic demethylation. Results provide insight into the role of DNA demethylation on skeletal myotube maturation.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL1261
Series:: GSE30192
6 Samples

Download data: CEL

DataSet

Accession:: GDS5519

ID:: 5519

Select item 546820.

Interleukin-33 effect on dual-specificity phosphatase 5-deficient bone marrow derived eosinophils

Analysis of BM-derived eosinophils isolated from dual-specificity phosphatase 5-deficient mice and stimulated with IL-33. DUSP5 is a growth factor‐inducible phosphatase preferentially expressed in immune cells. Results provide insight into the role of DUSP5 in IL-33 signaling in eosinophils.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE62999
20 Samples

Download data: CEL

DataSet

Accession:: GDS5468

ID:: 5468

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

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