GEO DataSets

(Submitter supplied) LuxS is an enzyme involved in the activated methyl cycle and the by-product autoinducer 2 (AI-2) was a quorum sensing signal in some species. In our previous study, the functional LuxS in AI-2 production was verified in the porcine respiratory pathogen Actinobacillus pleuropneumoniae. Enhanced biofilm formation and reduced virulence were observed in the luxS mutant. To comprehensively understand the luxS function, in this study, the transcriptional profiles were compared between the A. more...

Organism:

Actinobacillus pleuropneumoniae

Type:

Expression profiling by array

Platform:

GPL9691

16 Samples

Download data: TXT

(Submitter supplied) Cell to cell communication in bacteria to regulate various cellular processes with respect to their population density is termed quorum sensing and is achieved using signaling molecules called autoinducers. LuxS, which is involved in the synthesis of the autoinducer molecule-2 (AI-2), is conserved in several Gram-positive and Gram-negative bacteria including the enteric pathogen Salmonella Typhimurium. more...

Organism:

Salmonella enterica subsp. enterica serovar Typhi str. Ty2; Salmonella enterica subsp. enterica serovar Typhimurium str. LT2; Salmonella enterica subsp. enterica serovar Typhimurium; Salmonella enterica subsp. enterica serovar Typhi str. CT18

Type:

Expression profiling by array

Platforms:

GPL5069 GPL5096

44 Samples

Download data: GPR

(Submitter supplied) The bacterial quorum-sensing autoinducer 2 (AI-2) has received intense interest because the gene for its synthase, luxS, is common among a large number of bacterial species. We have identified luxS-controlled genes in Escherichia coli under two different growth conditions using DNA microarrays. Twenty-three genes were affected by luxS deletion in the presence of glucose, and 63 genes were influenced by luxS deletion in the absence of glucose. more...

Organism:

Escherichia coli; Escherichia coli K-12

Type:

Expression profiling by array

Platform:

GPL199

4 Samples

Download data: CEL, CHP

(Submitter supplied) The bacterial quorum-sensing autoinducer 2 (AI-2) has received intense interest because the gene for its synthase, luxS, is common among a large number of bacterial species. We have identified luxS-controlled genes in Escherichia coli under two different growth conditions using DNA microarrays. Twenty-three genes were affected by luxS deletion in the presence of glucose, and 63 genes were influenced by luxS deletion in the absence of glucose. more...

Organism:

Escherichia coli; Escherichia coli K-12

Type:

Expression profiling by array

Platform:

GPL199

4 Samples

Download data: CEL, CHP

(Submitter supplied) In a transcriptome based trail, we figured out that the deletion of luxS has a massive influence to cell growth and metabolism of Streptococcus sanguinis SK36. The biofilm defective luxS deletion mutant was comlemented by transgenic sahH from Pseudomonas aeruginosa. Thus 209 of 216 influenced genes of the luxS mutant compared to the isogenic wildype were restored in their expression (fold change of n ≥ 3; p ≤ 0.05), including genes involved in cell division processes, stress response and catabolite control. more...

Organism:

Streptococcus sanguinis SK36

Type:

Expression profiling by array

Platform:

GPL15399

12 Samples

Download data: CALLS, PAIR

(Submitter supplied) The autoinducer-2 (AI-2) group of signalling molecules represent a new type of cell-cell communication since they are produced by many phylogenetic groups of bacteria as the by product of a metabolic transformation carried out by the luxS enzyme. To separate the metabolic function of the luxS enzyme from the signalling role of AI-2, we carried out a global transcriptome analysis of a luxS null mutant of Streptococcus mutans UA159, an important cariogenic bacterium and crucial component of the dental plaque biofilm community. more...

Organism:

Streptococcus mutans; Streptococcus mutans UA159

Type:

Expression profiling by array

Platform:

GPL4031

44 Samples

Download data

(Submitter supplied) Autoinducer 2 (AI-2), a widespread by-product of the LuxS-catalyzed S-ribosylhomocysteine cleavage reaction in the activated methyl cycle, has been suggested to serve as an intra- and interspecies signaling molecule, but in many bacteria AI-2 control of gene expression is not completely understood. Particularly, we have a lack of knowledge about AI-2 signaling in the important human pathogens Staphylococcus aureus and S. more...

Organism:

Staphylococcus epidermidis; Chlamydia muridarum; Staphylococcus epidermidis RP62A; Chlamydia caviae GPIC; Staphylococcus haemolyticus JCSC1435; Coxiella burnetii; Rickettsia rickettsii; Chlamydia pneumoniae AR39; Borreliella burgdorferi B31; Coxiella burnetii RSA 493; Chlamydia trachomatis D/UW-3/CX; Staphylococcus epidermidis ATCC 12228; Staphylococcus aureus subsp. aureus MW2; Granulibacter bethesdensis

Type:

Expression profiling by array

Platform:

GPL4692

9 Samples

Download data: CEL, CHP

(Submitter supplied) Autoinducer-2 (AI-2)-mediated quorum sensing has been extensively studied in relation to the regulation of microbial behaviour. There are however two potential roles for the AI-2 synthase (LuxS). The first is in the production of AI-2 and the second is as an enzyme in the activated methyl cycle where it catalyses the conversion of S-ribosylhomocysteine to homocysteine. The by-product of the reaction catalysed by LuxS is (S)-4,5-dihydroxy-2,3-pentanedione (DPD), which spontaneously forms the furanones known collectively as AI-2. more...

Organism:

Limosilactobacillus reuteri subsp. rodentium

Type:

Expression profiling by array

Platform:

GPL10986

8 Samples

Download data: TXT

(Submitter supplied) These E. coli strains were grown with various signaling molecules and the expression profiles were determined. Keywords: addition of quorum and host hormone signals

Organism:

Escherichia coli

Type:

Expression profiling by array

Platform:

GPL3154

5 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 5b str. L20

Type:

Expression profiling by array

Platform:

GPL6658

16 Samples

Download data: MEV

(Submitter supplied) The transcriptome of Actinobacillus pleuropneumoniae dripbiofilm biofilms was compared to the transcriptome of effluent cells

Organism:

Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 5b str. L20

Type:

Expression profiling by array

Platform:

GPL6658

4 Samples

Download data: MEV

(Submitter supplied) The transcriptome of Actinobacillus pleuropneumoniae 4h static biofilms was compared to the transcriptome of 6h static biofilm

Organism:

Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 5b str. L20

Type:

Expression profiling by array

Platform:

GPL6658

4 Samples

Download data: MEV

(Submitter supplied) The transcriptome of Actinobacillus pleuropneumoniae biofilms was compared to the transcriptome of planktonic bacteria

Organism:

Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 5b str. L20

Type:

Expression profiling by array

Platform:

GPL6658

4 Samples

Download data: MEV

(Submitter supplied) The transcriptome of Actinobacillus pleuropneumoniae biofilms was compared to the transcriptome of planktonic bacteria

Organism:

Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 5b str. L20

Type:

Expression profiling by array

Platform:

GPL6658

4 Samples

Download data: MEV

(Submitter supplied) To better understand effects of iron starvation on A. pleuropneumoniae and to identify new potential vaccine targets, we conducted transcript profiling using a DNA microarray containing all 2025 ORFs of the genome of A. pleuropneumoniae serotype 5b strain L20. Upon comparing growth of this pathogen in iron-sufficient versus iron-depleted medium, 210 genes were identified as being differentially expressed. more...

Organism:

Actinobacillus pleuropneumoniae

Type:

Expression profiling by array

Platform:

GPL3648

4 Samples

Download data: MEV

(Submitter supplied) To better understand effects of iron starvation on A. pleuropneumoniae and to identify new potential vaccine targets, we conducted transcript profiling using a DNA microarray containing all 2025 ORFs of the genome of A. pleuropneumoniae serotype 5b strain L20. Upon comparing growth of this pathogen in iron-sufficient versus iron-depleted medium, 210 genes were identified as being differentially expressed. more...

Organism:

Actinobacillus pleuropneumoniae

Type:

Expression profiling by array

Platform:

GPL3648

9 Samples

Download data: TXT

(Submitter supplied) To reveal the transcriptional profiles of Actinobacillus pleuropneumoniae under biofilm and planktonic growth, we established a biofilm-forming culture method and constructed a mutant strain Δpga with defect in biofilm formation. Wild-type and Δpga mutant strains of Actinobacillus pleuropneumoniae strain 4074 were cultured in bottles with shaking for planktonic (WT_PK) and in microplates in static status for biofilm (WT_BF, Δpga), respectively. more...

Organism:

Actinobacillus pleuropneumoniae serovar 1 str. 4074

Type:

Expression profiling by high throughput sequencing

Platform:

GPL32988

9 Samples

Download data: TXT

(Submitter supplied) Quorum signal uptake is an indispensable part of quorum sensing regulations. The coperative regulation of uptake repressor and kinase precisely signale the cells for quorum sensing uptake and terminate the quorum sensing signal production. We use the DNA microarray to detail the E. coli quorum sensing uptake reuglations and related gene regulations. Keywords: specific growth

Organism:

Escherichia coli; Escherichia coli K-12

Type:

Expression profiling by array

Platform:

GPL199

6 Samples

Download data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Yersinia pestis

Type:

Expression profiling by array

Platforms:

GPL10439 GPL10017

54 Samples

Download data: TXT

(Submitter supplied) Temperature is a key environmental factor for facultative pathogens during the host adaptation response. To assess the functional role of temperature in Yersinia pestis, a microarray study was conducted comparing the Δpgm (pigmentation-negative) R88 strain grown at 37°C or 30°C.

Organism:

Yersinia pestis

Type:

Expression profiling by array

Platform:

GPL10439

6 Samples

Download data: TXT