Similar studies for GEO DataSets (Select 200054419) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 2000544191.

Host transcripts detected in exosomes derived from M.tb infected murine RAW264.7 macrophages

(Submitter supplied) Investigation to study mRNA transcripts present in exosomes from M.tb infected cells and how they compare to those derived from uninfected cells. Transcripts were also studied in donor macrophages as controls The gene expression study identified unique transcripts as well as differentially expressed transcripts present in exosomes released from infected macrophages

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10572
12 Samples

Download data: PAIR, TXT

Series

Accession:: GSE54419

ID:: 200054419

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000544442.

Expression analysis for detection of mycobacterial transcripts present in exosomes derived from M.tb infected macrophages

(Submitter supplied) Mycobacterial transcripts were identified in exosomes released from M.tb infected RAW264.7 macrophages that were not present in uninfected exosomes suggesting export of mycobacterial RNA via exosomes Mycobacterial RNA was used as positive control and RNA from exosomes released from uninfected macrophages was used as negative control

Organism:: Mycobacterium tuberculosis; Mycobacterium tuberculosis H37Rv

Type:: Expression profiling by array

Platform:: GPL18228
4 Samples

Download data: PAIR

Series

Accession:: GSE54444

ID:: 200054444

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000297313.

Exosomes isolated from M.tb infected cells modulate macrophage response to IFN-gamma

(Submitter supplied) we studied the role of exosomes isolated from M.tb infected macrophages in modulating the macrophage response to IFN-γ. Nimblegen microarray gene expression studies were used to compare the suppression of IFN-γ inducible genes by exosomes relative to the virulent strain of M.tuberculosis. Overall our study suggest that exosomes, as carriers of M.tb pathogen associated molecular patterns (PAMPs), may provide a mechanistic link by which M.tb may exert its suppression of host immune response beyond the infected cell, and implies a physiological role for exosomes in immune surveillance of TB.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11059
24 Samples

Download data: PAIR

Series

Accession:: GSE29731

ID:: 200029731

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000582834.

Gene expression profiling of mouse bone marrow-derived macrophages (RNA-Seq)

(Submitter supplied) Bone marrow (BM) cells were obtained by flushing the long bones of 8-week old C57BL/6 mice. BM cells were then were plated in macrophage SFM medium (Life Technologies) supplemented with penicillin-streptomycin and CSF-1 (Peprotech, 100 ng/ml) and cultured for one week to allow macrophage differentiation. BMDMs were polarized by adding IL-4 to the medium (40 ng/ml, Peprotech) for 72h or left untreated.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: GTF, TXT

Series

Accession:: GSE58283

ID:: 200058283

PubMed Similar studies SRA Run Selector

Select item 2000658115.

miRNA profile of THP-1 macrophage infected with different MTB strains

(Submitter supplied) We examined the microRNA profiles of THP-1 macrophages upon the MTB infection of (1) Beijing/W and non-Beijing/W clinical strains, and (2) susceptible and multidrug-resistant (MDR-) MTB strains.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL19763
14 Samples

Download data: TXT

Series

Accession:: GSE65811

ID:: 200065811

PubMed Full text in PMC Similar studies

Select item 2000658106.

miRNA profile of macrophage from different TB patients

(Submitter supplied) the microRNA profiles of the host macrophages were studied by microarray in a small cohort with active MTB disease, latent infection (LTBI), and from healthy controls.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL19763
10 Samples

Download data: TXT

Series

Accession:: GSE65810

ID:: 200065810

PubMed Full text in PMC Similar studies

Select item 2000699097.

MicroRNA sequencing of umbilical cord mesenchymal stem cells (uMSCs) and HEK293T cells derived exosomes

(Submitter supplied) Exosomes are cell-derived vesicles that were found in many biological fluids such as blood, urine, and cultured medium. Exosomes are small vesicles (approximately 100nm in diameter) that contain many functional molecules like cytokines, receptors and regulating RNAs. In this study, we found that uMSC-derived exosomes accelerates wound healing and reduce myoblast formation in vivo. In vitro study showed uMSC-exosomes specific microRNAs take major roles in inhibiting myoblast differentiation of fibroblast. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL17303
2 Samples

Download data: TXT

Series

Accession:: GSE69909

ID:: 200069909

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000670208.

Genome-wide analysis of mRNA transcriptomes in dendritic cell and exosome-treated dendritic cell

(Submitter supplied) The present research aimed to demonstrate that pancreatic cancer related miRNAs can be transferred from exosome to dendritic cells and influence mRNA expression, inducing immune tolerance of dendritic cells .Immature dendritic cells were induced from peripheral blood monocytes and stimulated by exosomes collected from PANC-1 cell culture.Genome-wide mRNA chip were performed in iDC and exosome stimulated iDC to detect the change of mRNA expression level.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL19907
2 Samples

Download data: GPR, TXT

Series

Accession:: GSE67020

ID:: 200067020

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000271009.

Integrated miRNA-mRNA-analysis of human monocyte derived macrophages upon Mycobacterium avium subsp. hominissuis infection

(Submitter supplied) The host response to mycobacterial infections was studied after infection of macrophages derived from primary human monocytes. mRNA and miRNA expression studies were performed to identify key regulators of immune defence and their targets.

Organism:: Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Homo sapiens; Mus musculus; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Human alphaherpesvirus 1; human gammaherpesvirus 4; Betapolyomavirus macacae

Type:: Non-coding RNA profiling by array; Expression profiling by array

Platforms:: GPL7722 GPL10128
12 Samples

Download data: GPR

Series

Accession:: GSE27100

ID:: 200027100

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005514410.

MicroRNA expression profiles of bovine milk exosomes in response to Staphylococcus aureus infection

(Submitter supplied) Milk is an essential source of nutrients to all mammalian offspring, and is rich in a wide variety of immunological components. Recently reported miRNAs that are present in breast milk and are selectively packaged into the exosomes, a type of membrane vesicles, secreted by most cell types. These exosomal miRNAs could be actively delivered into recipient cells, and play a key role in the regulation of innate and adaptive immunity. more...

Organism:: Bos taurus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL15749
8 Samples

Download data: TXT

Series

Accession:: GSE55144

ID:: 200055144

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011437111.

AmpliSeq Transcriptome Analysis of Human Alveolar and Monocyte-Derived Macrophages Over Time in Response to Mycobacterium tuberculosis infection

(Submitter supplied) Human alveolar macrophages (HAM) are primary bacterial niche and immune response cells during Mycobacterium tuberculosis (M.tb) infection, and human blood monocyte-derived macrophages (MDM) are a model for investigating M.tb-macrophage interactions. Here, we use a targeted RNA-Seq method to measure transcriptome-wide changes in RNA expression patterns of freshly obtained HAM (used within 6 h) and 6 day cultured MDM upon M.tb infection over time (2, 24 and 72 h), in both uninfected and infected cells from three donors each. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL17303
36 Samples

Download data: TXT

Series

Accession:: GSE114371

ID:: 200114371

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016428712.

RNA sequencing-based analysis of transcriptional reprogramming of primary human monocyte-derived macrophages infected with Mycobacterium tuberculosis

(Submitter supplied) Primary human monocytes were isolated from four healthy human blood donors. Monocytes were isolated from PBMC buffy coats using plastic adherence for 4 hours. Monocytes were allowed to differentiate into macrophages over a period of 1 week. Macrophages from each of the 4 donors were split into two groups - uninfected and infected with Mycobacterium tuberculosis (Mtb). Cells in the infection group were infected with Mtb for 48 hours at a multiplicity of infection (MOI) of 10. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: CSV

Series

Accession:: GSE164287

ID:: 200164287

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20015105013.

Differential production of small RNAs in Mycobacterium tuberculosis infected primary human monocyte-derived macrophages

(Submitter supplied) Primary human monocytes were isolated from four healthy donors. Monocytes were differentiated into macrophages, infected with virulent Mycobacterium tuberculosis (Mtb), strain H37Rv, for 24 or 48 hours, at a multiplicity of infection of 5 or 10. Following infection, infected cells and time-matched uninfected controls were harvested, total RNA including small RNAs was isolated and used for next-generation small RNA sequencing. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18573
24 Samples

Download data: CSV

Series

Accession:: GSE151050

ID:: 200151050

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005081414.

Human exosomal placenta-specific miRNAs modulate expression of target genes in maternal immune cells during pregnancy

(Submitter supplied) We investigated placenta-specific miRNA miR-517a (miR-517a-3p) functions in Jurkat cells. For this purpose, we identified candidate target mRNAs of the placenta-specific miRNAs using DNA microarray analysis. Transfection of Jurkat cells with miR-517a significantly downregulated 123 genes. Among the 123 genes identified, we searched for potential direct targets of miR-517a using the online software MicroCosm Targets. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
2 Samples

Download data: TXT

Series

Accession:: GSE50814

ID:: 200050814

Select item 20006197815.

Expression profiles of microRNA in bovine raw milk exosome and supernatant without exosome

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Bos taurus

Type:: Non-coding RNA profiling by array; Expression profiling by array

Platforms:: GPL11649 GPL19259
4 Samples

Download data: TXT

Series

Accession:: GSE61978

ID:: 200061978

Select item 20006197716.

Expression profiles of microRNA in bovine raw milk exosome and supernatant without exosome [mRNA array]

(Submitter supplied) We have reported that microRNAs are present in human, bovine, and rat milk whey. Milk whey miRNAs were resistant to acidic condition and to RNase. Thus, milk miRNAs were thought to be present packaged into membrane vesicles like exosome. However, body fluid miRNAs have been reported that there are in different forms. To clarify which miRNAs species are exist in exosome and which species are exist in another form, we used bovine raw milk and purified total RNA from exosome fraction and ultracentrifugated supernatant fraction, and analyzed by miRNA microarray.

Organism:: Bos taurus

Type:: Expression profiling by array

Platform:: GPL11649
2 Samples

Download data: TXT

Series

Accession:: GSE61977

ID:: 200061977

Select item 20006197617.

Expression profiles of microRNA in bovine raw milk exosome and supernatant without exosome [miRNA array]

Organism:: Bos taurus

Type:: Non-coding RNA profiling by array

Platform:: GPL19259
2 Samples

Download data: TXT

Series

Accession:: GSE61976

ID:: 200061976

Select item 20007475918.

Small RNA sequencing in cells and exosomes identifies eQTLs and 14q32 as a region of active export

(Submitter supplied) Exosomes are small extracellular vesicles that carry heterogeneous cargo, including RNA, between cells. Increasing evidence suggests that exosomes are important mediators of intercellular communication and biomarkers of disease. Despite this, the variability of exosomal RNA between individuals has not been well quantified. To assess this variability, we sequenced the small RNA of cells and exosomes from a 17-member family. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL11154 GPL15520
68 Samples

Download data: TXT

Series

Accession:: GSE74759

ID:: 200074759

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004567519.

Transcriptome analysis in host defense during high multiplicity mycobacterial infection

(Submitter supplied) This experiment is to compare the transcription patterns of mouse macrophages (J774A.1) infected with BCG, H37Ra and M. smegmatis under high multiplicity of infection (MOI). Through the global transcriptome profiling study, we define a pathogen specific host gene expression pattern and indicate that SRC likely plays a central role in regulating multiple unique signaling pathways activated by MTB infection. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5634
Platform:: GPL1261
4 Samples

Download data: CEL, CHP

Series

Accession:: GSE45675

ID:: 200045675

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 563420.

High multiplicity mycobacterial infections of macrophages in vitro

Analysis of macrophage cell line J774A.1 infected with pathogenic mycobacteria BCG and H37Ra and non-pathogenic M. smegmatis under high multiplicity of infection (MOI = 50). Results provide insight into the molecular response of macrophage host cells to pathogenic and non-pathogenic mycobacteria.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 4 infection, 4 species sets

Platform:: GPL1261
Series:: GSE45675
4 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5634

ID:: 5634

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

GEO DataSets

Functional Genomics Studies

Result Filters

Entry type

Organism

Study type

Author

Attribute name

Publication dates

Custom date range

Additional filters

Send to:

Links from GEO DataSets

Items: 20

Send to:

Supplemental Content

Find related data

Important Links

Recent activity