Similar studies for GEO DataSets (Select 200104795) - GEO DataSets

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Items: 20

Select item 2001047951.

Zinc transporter ZIP8 (SLC39A8) overexpression effect on primary mouse articular chondrocytes

(Submitter supplied) Gene expression profiling of primary mouse articular chondrocyte infected with recombinant adenovirus expressing the zinc transporter ZIP8 (SLC39A8) protein. In this study, we have attempted to explore the effects of ZIP8 overexpression on mouse transcriptome and have identified numerous genes which are involved in osteoarthritis pathogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
8 Samples

Download data: CEL

Series

Accession:: GSE104795

ID:: 200104795

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Select item 2001531792.

Regnase-1 overexpression/knockdown effect on primary mouse articular chondrocytes

(Submitter supplied) Gene expression profiling of primary mouse articular chondrocyte infected with recombinant adenovirus expression mouse Regnase-1 or recombinant adenovirus expressing mouse small hairpin RNA of Regnase-1. In this study, we have attempted to explore the effects of Regnase-1 overexpression or knockdown on mouse transcriptome and have identified numerous genes which are involved in osteoarthritis pathogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
9 Samples

Download data: CEL

Series

Accession:: GSE153179

ID:: 200153179

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Select item 2001105813.

Zfp36l1 overexpression/knockdown effect on primary mouse articular chondrocytes

(Submitter supplied) Gene expression profiling of primary mouse articular chondrocyte infected with recombinant adenovirus expressing mouse ZFP36 Ring Finger Protein Like 1(Zfp36l1) or recombinant adenovirus expressing mouse small hairpin RNA of Zfp36l1. In this study, we have attempted to explore the effects of Zfp36l1 gene overexpression or knockdown on mouse transcriptome and have identified numerous genes which are involved in osteoarthritis pathogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
9 Samples

Download data: CEL

Series

Accession:: GSE110581

ID:: 200110581

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Select item 2001047944.

Hypoxia inducible factor-2 alpha (HIF-2α) overexpression effect on primary mouse articular chondrocytes

(Submitter supplied) Gene expression profiling of primary mouse articular chondrocyte infected with recombinant adenovirus expressing the hypoxia inducible factor-2 alpha (HIF-2α) protein. In this study, we have attempted to explore the effects of HIF-2α overexpression on mouse transcriptome and have identified numerous genes which are involved in osteoarthritis pathogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
8 Samples

Download data: CEL

Series

Accession:: GSE104794

ID:: 200104794

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Select item 2001047935.

Interleukin-1β effect on primary mouse articular chondrocytes

(Submitter supplied) Gene expression profiling of primary mouse articular chondrocyte treated with interleukin-1β. In this study, we have attempted to explore the effects of interleukin-1β on mouse transcriptome and have identified numerous genes which are involved in osteoarthritis pathogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
6 Samples

Download data: CEL

Series

Accession:: GSE104793

ID:: 200104793

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Select item 2000852666.

RNA-Seq analysis of Kdm6bf/f and Col2a1-CreERT2;Kdm6bf/f primary chondrocytes

(Submitter supplied) Purpose: The aims of this study were to identify differentially expressed genes between Kdm6bf/f and Col2a1-CreERT2;Kdm6bf/f primary chondrocytes. Methods: RNA samples of primary chondrocytes were prepared from Kdm6bf/f and Col2a1-CreERT2;Kdm6bf/f mice and were sequenced and analyzed by Shanghai Novel Bioinformatics Co, Ltd. Before read mapping, clean reads were obtained from the raw reads by removing the adaptor sequences, reads with >5% ambiguous bases (noted as N) and low-quality reads containing more than 20 percent of bases with qualities of <13. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18635
3 Samples

Download data: TXT

Series

Accession:: GSE85266

ID:: 200085266

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Select item 2001337757.

Understanding downstream signaling pathways regulated by miR-34a-5p in articular cartilage by RNA sequencing using miR-34a knock-out mice

(Submitter supplied) The goal of this study was to determine the role of miR-34a in regulating chondrocyte transcript profiles. Next Generation Sequencing of total RNA extracted from mouse KO and WT chondrocytes revealed 175 significantly differentially expressed genes (84 up, 91 down) in miR-34a KO chondrocytes compared to WT cells. We are currently validating potential direct targets of miR-34a from our NGS data and performing computational pathway analysis to identify novel pathways regulated by miR-34a.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21626
6 Samples

Download data: TSV

Series

Accession:: GSE133775

ID:: 200133775

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Select item 2002350828.

Effect of Sirt6 depletion on gene expression of primary human chondrocytes

(Submitter supplied) To define the effect of SIRT6-mediated transcriptional regulation, RNA-sequencing was conducted on primary human chondrocytes depleted of SIRT6 and compared to cells nucleofected with a scrambled siRNA control (72 hours).

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: XLS

Series

Accession:: GSE235082

ID:: 200235082

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Select item 2002284699.

Bulk RNA-sequencing of articular cartilage from DMM-treated mice

(Submitter supplied) Identify the therapeutic targets/pathways of Osteoarthritis (OA), the most frequent joint disease. Surgery-induced cartilage degeneration is used as an experimental model for OA in mice. An inducible cartilage-specific c-Fos loss-of-function model is generated by combining c-fos floxed and Col2a1-CreERT mice. Since c-Fos mutant mice have more severe phenotype than c-Fos wild type mice, we focused on c-Fos-related signaling pathway in the articular cartilage.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
11 Samples

Download data: TSV

Series

Accession:: GSE228469

ID:: 200228469

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Select item 20000807710.

Global analyses of gene expression in early experimental knee osteoarthritis

(Submitter supplied) OBJECTIVE: To analyze genome-wide changes in chondrocyte gene expression in a surgically induced model of early osteoarthritis (OA) in rats, to assess the similarity of this model to human OA, and to identify genes and mechanisms leading to OA pathogenesis. METHODS: OA was surgically induced in 5 rats by anterior cruciate ligament transection and partial medial meniscectomy. Sham surgery was performed in 5 additional animals, which were used as controls. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS2809
Platform:: GPL1355
15 Samples

Download data: CEL, CHP

Series

Accession:: GSE8077

ID:: 200008077

Select item 280911.

Knee osteoarthritis model: chondrocytes

Analysis of articular condrocytes from osteoarthritic knees of Sprague-Dawley males. Osteoarthritis (OA) induced by surgery. Results provide insight into the pathogenesis of OA.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 3 protocol sets

Platform:: GPL1355
Series:: GSE8077
15 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS2809

ID:: 2809

Select item 20004579312.

Differential gene expression in cartilage from the mouse DMM osteoarthritis model

(Submitter supplied) Transcriptional profiling of mouse cartilage comparing destabilised medial meniscal operated knee joints to sham operated knee joints in both wild type C57Bl/6 and C57Bl/6 ADAMTS5Dcat mice at 1, 2 and 6 weeks post DMM surgery. The goal was to determine the differential gene expression with the onset of arthritis, both early, mid and late timepoints and to assess the gene expression differences when aggrecan loss is prevented in the ADAMTS5Dcat mouse.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
37 Samples

Download data: TXT

Series

Accession:: GSE45793

ID:: 200045793

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Select item 20005474913.

Inhibition of Hedgehog signaling in human osteoarthritic cartilage

(Submitter supplied) Osteoarthritis (OA) is a common degenerative disease of the joint. Data from our lab indicates that Hedgehog (Hh) signaling is activated in human OA and murine models of OA (Lin et al., 2009, Nature Medicine). To identify Hh target genes, microarray analyses were performed to detect changes in gene expression when the Hh pathway was inhibited in human OA cartilage samples. Identifying Hh target genes in chondrocytes will elucidate key regulatory networks that govern chondrocyte homeostasis and provide novel therapeutic strategies for OA.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE54749

ID:: 200054749

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Select item 20014752914.

Global gene expression of Oscar Knock-out (KO) mice with Wild Type (WT) mice.

(Submitter supplied) Purpose: RNA sequencing (RNA-Seq) analyses of articular cartilage obtained after DMM surgery in Oscar-/- and WT mice. The purpose of this experiment was to demonstrate how the deficiency of Oscar gene affects downstream signal transduction in articular cartilage. Methods: Articular cartilage mRNA profiles of 10-weeks-old wild-type (WT) and Oscar knockout (Oscar−/−) mice were performed for the destabilization of the medial meniscus (DMM) and each cartilage tissue sample was harvested from two time-points (2- and 4-weeks after surgery). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: TXT

Series

Accession:: GSE147529

ID:: 200147529

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Select item 20012684615.

The effect of miR-204 on mRNA expression profiles of primary mouse chondrocytes

(Submitter supplied) mRNA profiles of primary mouse chondrocytes transfected with miR-Ctrl or miR-204 mimics were generated by mRNA sequencing. This study provides insights into the role of miR-204 in chondrocytes.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: TXT

Series

Accession:: GSE126846

ID:: 200126846

PubMed Similar studies SRA Run Selector

Select item 20012666416.

Effect of prolonged exposure to normoxia on miRNA expression of primary mouse chondrocytes

(Submitter supplied) miRNA profiles of primary mouse chondrocytes exposed to prolonged normoxia, which resulted in accumulation of oxidative stress. The sequencing data were generated by miRNA sequencing, in three biological replicates. This study provides insights into the role of chronic oxidative stress in chondrocytes and helps identification of miRNAs related to OA pathogenesis.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TSV

Series

Accession:: GSE126664

ID:: 200126664

PubMed Similar studies SRA Run Selector

Select item 20010696517.

Gene expression of primary chondrocytes obtained from Hif1afl/fl mice transduced with adenovirus expressing GFP or Cre

(Submitter supplied) To identify gene expression profiles when Hif1a is deleted in chondrocytes

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21810
2 Samples

Download data: TXT

Series

Accession:: GSE106965

ID:: 200106965

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Select item 20013618118.

Tet-ZFP36L1 in 6 hours and 24 hours

(Submitter supplied) ZFP36L1 is a tandem zinc-finger RNA-binding protein that recognizes conserved Adenylate-Uridylate-rich Elements (AREs) located in 3' untranslated regions (UTRs) to mediate RNA decay. We hypothesized that ZFP36L1 is a negative regulator of a post-transcriptional hub involved in the RNA half-life regulation of cancer-related transcripts. Forced expression of ZFP36L1 in cancer cells markedly reduced cell proliferation in vitro and in vivo; whereas silencing of ZFP36L1 enhanced tumor cell growth. more...