GEO DataSets

Analysis of males of 3 species (melanogaster, sechellia, simulans) and D. sechellia x D. simulans F1 hybrids during 4 developmental stages. Results within and between pure species and hybrids provide insight into both the evolution of gene regulation in the context of development and speciation.

Organism:

Drosophila melanogaster; Drosophila sechellia; Drosophila simulans; Drosophila sechellia x Drosophila simulans

Type:

Expression profiling by array, log2 ratio, 4 development stage, 4 species sets

Platform:

GPL3598

Series:

GSE17535

48 Samples

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(Submitter supplied) In order to test the hypothesis that adult hybrid misexpression results from the cascading effect of earlier-expressed developmentally important improperly regulated genes, as well as address whether Von Baer’s 3rd law (suggesting that earlier stages of development should be more similar between species than later stages) holds at the level of gene expression, we conducted whole-transcriptome Drosophila melanogaster cDNA microarray-based expression profiling of males of D. more...

Organism:

Drosophila melanogaster; Drosophila sechellia; Drosophila simulans; Drosophila sechellia x Drosophila simulans

Type:

Expression profiling by array

Dataset:

GDS3835

Platform:

GPL3598

48 Samples

Download data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Drosophila melanogaster; Drosophila mauritiana; Drosophila sechellia; Drosophila simulans; Drosophila sechellia x Drosophila simulans; Drosophila simulans x Drosophila mauritiana

Type:

Expression profiling by array

Platforms:

GPL4022 GPL3829

128 Samples

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(Submitter supplied) Species often produce sterile hybrids early in their evolutionary divergence, and some evidence suggests that hybrid sterility may be associated with deviations or disruptions in gene expression. In support of this idea, many studies have shown that a high proportion of male-biased genes are underexpressed compared to non-sex-biased genes in sterile F1 male hybrids of Drosophila species. In this study, we examined and compared patterns of misexpression in 4 day old sterile male F1 hybrids of Drosophila simulans and its sibling species, D. more...

Organism:

Drosophila melanogaster; Drosophila sechellia; Drosophila simulans; Drosophila sechellia x Drosophila simulans

Type:

Expression profiling by array

Platform:

GPL3829

22 Samples

Download data

(Submitter supplied) Species often produce sterile hybrids early in their evolutionary divergence, and some evidence suggests that hybrid sterility may be associated with deviations or disruptions in gene expression. In support of this idea, many studies have shown that a high proportion of male-biased genes are underexpressed compared to non-sex-biased genes in sterile F1 male hybrids of Drosophila species. In this study, we examined and compared patterns of misexpression in 4 day old sterile male F1 hybrids of Drosophila simulans and its sibling species, D. more...

Organism:

Drosophila simulans; Drosophila simulans x Drosophila mauritiana; Drosophila melanogaster; Drosophila mauritiana

Type:

Expression profiling by array

Platform:

GPL3829

22 Samples

Download data

(Submitter supplied) Species often produce sterile hybrids early in their evolutionary divergence, and some evidence suggests that hybrid sterility may be associated with deviations or disruptions in gene expression. In support of this idea, many studies have shown that a high proportion of male-biased genes are underexpressed compared to non-sex-biased genes in sterile F1 male hybrids of Drosophila species. In this study, we examined and compared patterns of misexpression in 4 day old sterile male F1 hybrids of Drosophila simulans and its sibling species, D. more...

Organism:

Drosophila mauritiana; Drosophila sechellia; Drosophila simulans; Drosophila sechellia x Drosophila simulans

Type:

Expression profiling by array

Platform:

GPL4022

22 Samples

Download data

(Submitter supplied) Species often produce sterile hybrids early in their evolutionary divergence, and some evidence suggests that hybrid sterility may be associated with deviations or disruptions in gene expression. In support of this idea, many studies have shown that a high proportion of male-biased genes are underexpressed compared to non-sex-biased genes in sterile F1 male hybrids of Drosophila species. In this study, we examined and compared patterns of misexpression in 4 day old sterile male F1 hybrids of Drosophila simulans and its sibling species, D. more...

Organism:

Drosophila simulans; Drosophila sechellia; Drosophila simulans x Drosophila mauritiana; Drosophila mauritiana

Type:

Expression profiling by array

Platform:

GPL4022

22 Samples

Download data

(Submitter supplied) Species often produce sterile hybrids early in their evolutionary divergence, and some evidence suggests that hybrid sterility may be associated with deviations or disruptions in gene expression. In support of this idea, many studies have shown that a high proportion of male-biased genes are underexpressed compared to non-sex-biased genes in sterile F1 male hybrids of Drosophila species. In this study, we examined and compared patterns of misexpression in F1 hybrid male third instar larvae of Drosophila simulans and its sibling species, D. more...

Organism:

Drosophila mauritiana; Drosophila sechellia; Drosophila simulans; Drosophila sechellia x Drosophila simulans

Type:

Expression profiling by array

Platform:

GPL4022

22 Samples

Download data

(Submitter supplied) Species often produce sterile hybrids early in their evolutionary divergence, and some evidence suggests that hybrid sterility may be associated with deviations or disruptions in gene expression. In support of this idea, many studies have shown that a high proportion of male-biased genes are underexpressed compared to non-sex-biased genes in sterile F1 male hybrids of Drosophila species. In this study, we examined and compared patterns of misexpression in F1 hybrid male third instar larvae of Drosophila simulans and its sibling species, D. more...

Organism:

Drosophila sechellia; Drosophila simulans; Drosophila simulans x Drosophila mauritiana; Drosophila mauritiana

Type:

Expression profiling by array

Platform:

GPL4022

22 Samples

Download data

(Submitter supplied) Hox genes regionalize the animal body axis by modifying complex morphogenetic and differentiation processes during development. The transformation of wings into halteres by the Hox gene Ultrabithorax (Ubx) in Drosophila melanogaster presents an excellent model system to study the transcriptional networks that control such complex developmental programmes. We have employed an inducible misexpression system to switch on Ubx in the wing epithelium at successive larval, prepupal and pupal stages, and have used microarray expression profiling to identify the primary transcriptional responses to Ubx. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

48 Samples

Download data: CEL

(Submitter supplied) Species-specific regulation of gene expression contributes to the development and maintenance of reproductive isolation and to species differences in ecologically important traits. A better understanding of the evolutionary forces which shape regulatory variation and divergence can be developed by comparing expression differences among species and interspecific hybrids. Once expression differences are identified, the underlying genetics of regulatory variation or divergence can be explored. more...

Organism:

Drosophila melanogaster; Drosophila sp. (in: flies); Drosophila simulans

Type:

Expression profiling by genome tiling array

Platform:

GPL5919

24 Samples

Download data: BAR, CEL

(Submitter supplied) The X chromosome has a large effect on hybrid dysfunction, particularly hybrid male sterility. Although the evidence for this so-called large-X effect is clear, its molecular causes are not yet fully understood. One possibility is that, under certain conditions, evolution proceeds faster in X-linked loci than in their autosomal counterparts due to both natural selection and their hemizygosity in males (i.e. more...

Organism:

Drosophila yakuba; Drosophila santomea; Drosophila yakuba x Drosophila santomea

Type:

Expression profiling by array

Platform:

GPL15708

18 Samples

Download data: TXT

(Submitter supplied) Expression profile comparison of females of D. melanogaster, D. simulans and their hybrid. RNA source: whole body. Keywords: other

Organism:

Drosophila melanogaster; Drosophila simulans

Type:

Expression profiling by array

Platform:

GPL356

21 Samples

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(Submitter supplied) These data were generated in a study to analyze the genetic causes of gene regulatory divergence. mRNA-seq libraies were prepared from poly(A)+ RNA prepared from whole F1 hybrids of D. melanogaster and D. sechellia (female 0-3d post eclosion, "D_mel_x_D_sec"). A mixed mRNA- seq library was prepared from D. melanogaster and D. sechellia poly(A) + RNA (mixed before library preparation, "D_mel_+_D_sec). more...

Organism:

Drosophila melanogaster x Drosophila sechellia; Drosophila sechellia; Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

4 related Platforms

4 Samples

Download data: BED

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL6799

88 Samples

Download data: GPR

(Submitter supplied) Drosophila melanogaster undergoes a complete metamorphosis, during which time the larval male and female forms transition into sexually dimorphic, reproductive adult forms. To understand this complex morphogenetic process at a molecular-genetic level, we performed whole genome microarray analyses. Genes were identified that were expressed during metamorphosis in both somatic and germline tissues of males and females. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL6799

60 Samples

Download data: GPR

(Submitter supplied) Drosophila melanogaster undergoes a complete metamorphosis, during which time the larval male and female forms transition into sexually dimorphic, reproductive adult forms. To understand this complex morphogenetic process at a molecular-genetic level, we performed whole genome microarray analyses. In somatic tissues at 48 hour After Puparium Formation (APF), 173 sex-biased transcripts that likely function downstream of the doublesex (dsx) branch of the sex determination hierarchy were identified. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL6799

28 Samples

Download data: GPR

(Submitter supplied) RNA was extracted from adult male and adult female Drosophila simulans carrying small genomic segments introgressed from Drosophila mauritiana

Organism:

Drosophila mauritiana; Drosophila melanogaster; Drosophila simulans

Type:

Expression profiling by array

Platform:

GPL6056

64 Samples

Download data: GPR, TXT

(Submitter supplied) see publication, arrays from 4 sterile genotypes containing homozygous segments with a Hybrid Male Sterility factor and 1 fertile strain in which the region is a Drosophila simulans and D. mauritiana heterozygous

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL6056

10 Samples

Download data: GPR

(Submitter supplied) http://www.nature.com/ng/journal/v33/n2/abs/ng1086.html. Little is known about broad patterns of variation and evolution of gene expression during any developmental process. Here we investigate variation in genome-wide gene expression among Drosophila simulans, Drosophila yakuba and four strains of Drosophila melanogaster during a major developmental transition?the start of metamorphosis. Differences in gene activity between these lineages follow a phylogenetic pattern, and 27% of all of the genes in these genomes differ in their developmental gene expression between at least two strains or species. more...

Organism:

Drosophila melanogaster; Drosophila simulans; Drosophila yakuba

Type:

Expression profiling by array

5 related Platforms

48 Samples

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