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Series GSE112 Query DataSets for GSE112
Status Public on Apr 10, 2003
Title Distinctive gene expression patterns in gastrointestinal stromal tumors identified with cDNA arrays
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Gastrointestinal stromal tumors (GIST) are phenotypically and clinically heterogeneous mesenchymal tumors. Using the cDNA array technique, we analyzed the gene expression profiles of 22 GIST and 7 non-neoplastic gastrointestinal smooth muscle specimens, in order to detect molecular differences between GIST and non-neoplastic tissue, and to detect differences between GIST of various phenotypic and clinical subgroups. As a result, we found 796 differentially expressed genes and ESTs between GIST and smooth muscle tissue, including promising new candidate genes for the pathogenesis of GIST. Furthermore, we identified differences in gene expression between GIST of different site, size, and immunohistochemical expression of CD34 and SMA. Our data show that alterations in gene expression are associated with morphologically and clinically detectable features of GIST and provide new aspects for the understanding of these tumors.
Keywords = Gastrointestinal Stromal Tumor (GIST)
Keywords: other
 
 
Contributor(s) Bergmann F, von Heydebreck A, Huber W, Buness A, Höer J, Langer C, Gunawan B, Füzesi L, Poustka A, Sültmann H
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Submission date Dec 11, 2002
Last update date Jun 17, 2014
Contact name Wolfgang Huber
E-mail(s) w.huber@dkfz.de
Phone +49-6221-424709
Fax +49-6221-423470
URL http://www.dkfz-heidelberg.de/abt0840
Organization name German Cancer Research Center
Department Molecular Genome Analysis
Street address Im Neuenheimer Feld 280
City Heidelberg
ZIP/Postal code 69120
Country Germany
 
Platforms (2)
GPL9 Human Unigene I, part 1
GPL10 Human Unigene I, part 2
Samples (94)
GSM3070 Gastrointestinal Stroma Tumor: patient GIST-1, normal tissue, 1st repetition
GSM3071 Gastrointestinal Stroma Tumor: patient GIST-1, normal tissue, 2nd repetition
GSM3072 Gastrointestinal Stroma Tumor: patient GIST-1, tumor tissue, 1st repetition
Relations
BioProject PRJNA84483

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