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Urinary bladder carcinoma

MedGen UID:
147071
Concept ID:
C0699885
Neoplastic Process
Synonym: Bladder carcinoma
SNOMED CT: Carcinoma of bladder (255108000)
 
HPO: HP:0002862
Monarch Initiative: MONDO:0004986

Definition

Bladder cancer is a disease in which certain cells in the bladder become abnormal and multiply uncontrollably to form a tumor. The bladder is a muscular organ in the lower abdomen that stores urine until it can be removed (excreted) from the body.

Bladder cancer may cause blood in the urine, pain during urination, frequent urination, the feeling of needing to urinate without being able to, or lower back pain. Many of these signs and symptoms are nonspecific, which means they may occur in multiple disorders. People who have one or more of these nonspecific health problems often do not have bladder cancer, but have another condition such as an infection.

Bladder cancer develops when tumors form in the tissue that lines the bladder. There are several types of bladder cancer, categorized by the type of cell in the tissue that becomes cancerous. The most common type is transitional cell carcinoma (also known as urothelial carcinoma); others include squamous cell carcinoma and adenocarcinoma. If the tumor spreads  (metastasizes) beyond the lining of the bladder into nearby tissues or organs, it is known as invasive bladder cancer.  [from MedlinePlus Genetics]

Term Hierarchy

Conditions with this feature

Cutis laxa, X-linked
MedGen UID:
82793
Concept ID:
C0268353
Congenital Abnormality
Occipital horn syndrome (OHS) is a rare connective tissue disorder characterized by hyperelastic and bruisable skin, hernias, bladder diverticula, hyperextensible joints, varicosities, and multiple skeletal abnormalities. The disorder is sometimes accompanied by mild neurologic impairment, and bony abnormalities of the occiput are a common feature, giving rise to the name (summary by Das et al., 1995).
Costello syndrome
MedGen UID:
108454
Concept ID:
C0587248
Disease or Syndrome
While the majority of individuals with Costello syndrome share characteristic findings affecting multiple organ systems, the phenotypic spectrum is wide, ranging from a milder or attenuated phenotype to a severe phenotype with early lethal complications. Costello syndrome is typically characterized by failure to thrive in infancy as a result of severe postnatal feeding difficulties; short stature; developmental delay or intellectual disability; coarse facial features (full lips, large mouth, full nasal tip); curly or sparse, fine hair; loose, soft skin with deep palmar and plantar creases; papillomata of the face and perianal region; diffuse hypotonia and joint laxity with ulnar deviation of the wrists and fingers; tight Achilles tendons; and cardiac involvement including: cardiac hypertrophy (usually typical hypertrophic cardiomyopathy), congenital heart defect (usually valvar pulmonic stenosis), and arrhythmia (usually supraventricular tachycardia, especially chaotic atrial rhythm/multifocal atrial tachycardia or ectopic atrial tachycardia). Relative or absolute macrocephaly is typical, and postnatal cerebellar overgrowth can result in the development of a Chiari I malformation with associated anomalies including hydrocephalus or syringomyelia. Individuals with Costello syndrome have an approximately 15% lifetime risk for malignant tumors including rhabdomyosarcoma and neuroblastoma in young children and transitional cell carcinoma of the bladder in adolescents and young adults.

Professional guidelines

PubMed

Kumar A, Kumar M, Semwal MK, Singh U, Mishra N
J Cancer Res Ther 2023 Apr-Jun;19(3):725-730. doi: 10.4103/jcrt.jcrt_1661_21. PMID: 37470601
Srivastava AK, Singh PK, Singh D, Dalela D, Rath SK, Bhatt ML
Asia Pac J Clin Oncol 2016 Jun;12(2):e215-21. Epub 2014 Feb 27 doi: 10.1111/ajco.12165. PMID: 24576318
Fortin MA, Orlova A, Malmström PU, Tolmachev V
Int J Mol Med 2007 Feb;19(2):285-91. PMID: 17203203

Recent clinical studies

Etiology

Yang G, Shahatiaili A, Bai S, Wang L, Jin D, Cao M, Su P, Liu Q, Tao K, Long Q, Shi Y, Xiao J, Tian F, Zhang L, Chen H, Su X
J Pathol 2024 Mar;262(3):334-346. Epub 2024 Jan 5 doi: 10.1002/path.6239. PMID: 38180342
Matić M, Dmitrović B, Matić S, Kurbel S
Acta Clin Croat 2022 Aug;61(2):239-247. doi: 10.20471/acc.2022.61.02.10. PMID: 36818940Free PMC Article
Al-Sharaky DR, Abdelwahed M, Asaad N, Foda A, Abdou AG
J Immunoassay Immunochem 2021 May 4;42(3):236-251. Epub 2020 Nov 19 doi: 10.1080/15321819.2020.1845726. PMID: 33213275
Wang H, Wu JX, Chen XP, Zhang Q, Wei HB, Wang HJ, Yang X, Zhang DH
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820974017. doi: 10.1177/1533033820974017. PMID: 33191847Free PMC Article
Laderian B, Zhou M, Fojo T
Semin Oncol 2020 Dec;47(6):409-413. Epub 2020 Jun 19 doi: 10.1053/j.seminoncol.2020.05.011. PMID: 32771229

Diagnosis

Zaidi N, Siddiqui Z, Sankhwar SN, Srivastava AN
J Cancer Res Ther 2023 Jul-Sep;19(5):1324-1329. doi: 10.4103/jcrt.jcrt_1014_21. PMID: 37787302
Khabaz MN, Qureshi IA, Al-Maghrabi JA
Libyan J Med 2021 Dec;16(1):1949798. doi: 10.1080/19932820.2021.1949798. PMID: 34229569Free PMC Article
Al-Sharaky DR, Abdelwahed M, Asaad N, Foda A, Abdou AG
J Immunoassay Immunochem 2021 May 4;42(3):236-251. Epub 2020 Nov 19 doi: 10.1080/15321819.2020.1845726. PMID: 33213275
Wang H, Wu JX, Chen XP, Zhang Q, Wei HB, Wang HJ, Yang X, Zhang DH
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820974017. doi: 10.1177/1533033820974017. PMID: 33191847Free PMC Article
Raza SA, Jhaveri KS
Radiol Clin North Am 2012 Nov;50(6):1085-110. doi: 10.1016/j.rcl.2012.08.011. PMID: 23122040

Therapy

Laderian B, Zhou M, Fojo T
Semin Oncol 2020 Dec;47(6):409-413. Epub 2020 Jun 19 doi: 10.1053/j.seminoncol.2020.05.011. PMID: 32771229
Pal DK, Agrawal A, Ghosh S, Ghosh A
Trop Doct 2020 Oct;50(4):325-330. Epub 2020 Jun 9 doi: 10.1177/0049475520930155. PMID: 32515648
Suzuki S, Cohen SM, Arnold LL, Kato H, Fuji S, Pennington KL, Nagayasu Y, Naiki-Ito A, Yamashita Y, Takahashi S
Toxicology 2018 Apr 1;398-399:31-40. Epub 2018 Mar 6 doi: 10.1016/j.tox.2018.02.008. PMID: 29501575
Tinazzi E, Ficarra V, Simeoni S, Artibani W, Lunardi C
Rheumatol Int 2006 Apr;26(6):481-8. Epub 2005 Oct 12 doi: 10.1007/s00296-005-0059-2. PMID: 16220289
Widmark A, Flodgren P, Damber JE, Hellsten S, Cavallin-Ståhl E
Acta Oncol 2003;42(5-6):567-81. doi: 10.1080/02841860310014408. PMID: 14596515

Prognosis

Yang G, Shahatiaili A, Bai S, Wang L, Jin D, Cao M, Su P, Liu Q, Tao K, Long Q, Shi Y, Xiao J, Tian F, Zhang L, Chen H, Su X
J Pathol 2024 Mar;262(3):334-346. Epub 2024 Jan 5 doi: 10.1002/path.6239. PMID: 38180342
Zaidi N, Siddiqui Z, Sankhwar SN, Srivastava AN
J Cancer Res Ther 2023 Jul-Sep;19(5):1324-1329. doi: 10.4103/jcrt.jcrt_1014_21. PMID: 37787302
Khabaz MN, Qureshi IA, Al-Maghrabi JA
Libyan J Med 2021 Dec;16(1):1949798. doi: 10.1080/19932820.2021.1949798. PMID: 34229569Free PMC Article
Al-Sharaky DR, Abdelwahed M, Asaad N, Foda A, Abdou AG
J Immunoassay Immunochem 2021 May 4;42(3):236-251. Epub 2020 Nov 19 doi: 10.1080/15321819.2020.1845726. PMID: 33213275
Damjanov I, Golubović M
Srp Arh Celok Lek 2011 Sep-Oct;139(9-10):693-9. PMID: 22070010

Clinical prediction guides

Yang G, Shahatiaili A, Bai S, Wang L, Jin D, Cao M, Su P, Liu Q, Tao K, Long Q, Shi Y, Xiao J, Tian F, Zhang L, Chen H, Su X
J Pathol 2024 Mar;262(3):334-346. Epub 2024 Jan 5 doi: 10.1002/path.6239. PMID: 38180342
Matić M, Dmitrović B, Matić S, Kurbel S
Acta Clin Croat 2022 Aug;61(2):239-247. doi: 10.20471/acc.2022.61.02.10. PMID: 36818940Free PMC Article
Khabaz MN, Qureshi IA, Al-Maghrabi JA
Libyan J Med 2021 Dec;16(1):1949798. doi: 10.1080/19932820.2021.1949798. PMID: 34229569Free PMC Article
Wang H, Wu JX, Chen XP, Zhang Q, Wei HB, Wang HJ, Yang X, Zhang DH
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820974017. doi: 10.1177/1533033820974017. PMID: 33191847Free PMC Article
Lin C, Yuan H, Wang W, Zhu Z, Lu Y, Wang J, Feng F, Wu J
J Cell Mol Med 2020 Jan;24(2):1504-1515. Epub 2019 Dec 4 doi: 10.1111/jcmm.14835. PMID: 31800162Free PMC Article

Recent systematic reviews

Lu Y, Tao J
Front Endocrinol (Lausanne) 2021;12:699732. Epub 2021 Oct 7 doi: 10.3389/fendo.2021.699732. PMID: 34690923Free PMC Article
Anderson-Otunu O, Akhtar S
Asian Pac J Cancer Prev 2016;17(8):3805-7. PMID: 27644620
Tinazzi E, Ficarra V, Simeoni S, Artibani W, Lunardi C
Rheumatol Int 2006 Apr;26(6):481-8. Epub 2005 Oct 12 doi: 10.1007/s00296-005-0059-2. PMID: 16220289
Widmark A, Flodgren P, Damber JE, Hellsten S, Cavallin-Ståhl E
Acta Oncol 2003;42(5-6):567-81. doi: 10.1080/02841860310014408. PMID: 14596515

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