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Endometrioid tumor

MedGen UID:
105374
•Concept ID:
C0474809
•
Neoplastic Process
Synonyms: Endometrioid Neoplasm; endometrioid neoplasm; endometrioid neoplasm of female reproductive system; endometrioid neoplasm of the female reproductive system; Endometrioid Tumor; endometrioid tumor; endometrioid tumor (morphologic abnormality); endometrioid tumor of female reproductive system; endometrioid tumor of the female reproductive system; endometrioid tumour (morphologic abnormality); endometrioid tumour of female reproductive system; endometrioid tumour of the female reproductive system; female reproductive endometrioid cancer; female reproductive endometrioid neoplasm; female reproductive endometrioid tumor; female reproductive endometrioid tumour
SNOMED CT: Endometrioid tumor (253013001)
 
Monarch Initiative: MONDO:0002480

Definition

A benign, borderline, or malignant epithelial tumor characterized by the presence of glands and/or cysts lined by neoplastic cells that resemble endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Role of diffusion-weighted MRI in the differential diagnosis of endometrioid and non-endometrioid cancer of the uterus.
Bakir VL, Bakir B, Sanli S, Yildiz SO, Iyibozkurt AC, Kartal MG, Yavuz E
Acta Radiol 2017 Jun;58(6):758-767. Epub 2016 Sep 23 doi: 10.1177/0284185116669873. PMID: 27664276
Recommendations of the Fertility Task Force of the European Society of Gynecologic Oncology about the conservative management of ovarian malignant tumors.
Morice P, Denschlag D, Rodolakis A, Reed N, Schneider A, Kesic V, Colombo N; Fertility Task Force of the European Society of Gynecologic Oncology
Int J Gynecol Cancer 2011 Jul;21(5):951-63. doi: 10.1097/IGC.0b013e31821bec6b. PMID: 21697684

Recent clinical studies

Etiology

PAX2, PAX8, and PR are correlated with ovarian seromucinous borderline tumor with endometriosis.
Yun BS, Won S, Kim JH, Lee N, Kim M, Kim MK, Kim ML, Jung YW, Kim JY, Seong SJ, Shin E
J Ovarian Res 2022 Apr 6;15(1):41. doi: 10.1186/s13048-022-00975-5. PMID: 35387670Free PMC Article
Prognostic factors determining survival after extrapelvic recurrence in endometrioid type endometrial cancer.
Kilic F, Unsal M, Cakir C, Yuksel D, Kilic C, Dur R, Kimyon Comert G, Turan T, Turkmen O
Taiwan J Obstet Gynecol 2021 Nov;60(6):1023-1030. doi: 10.1016/j.tjog.2021.09.013. PMID: 34794732
Validation of ultrasound strategies to assess tumor extension and to predict high-risk endometrial cancer in women from the prospective IETA (International Endometrial Tumor Analysis)-4 cohort.
Verbakel JY, Mascilini F, Wynants L, Fischerova D, Testa AC, Franchi D, Frühauf F, Cibula D, Lindqvist PG, Fruscio R, Haak LA, Opolskiene G, Alcazar JL, Mais V, Carlson JW, Sladkevicius P, Timmerman D, Valentin L, Bosch TVD, Epstein E
Ultrasound Obstet Gynecol 2020 Jan;55(1):115-124. Epub 2019 Dec 13 doi: 10.1002/uog.20374. PMID: 31225683
Omental Micrometastasis in Endometrial Cancer.
Bayrak M, Yılmaz A, Yılmaz F, İlhan O, Oz Atalay F, Ozan H
Oncol Res Treat 2019;42(9):466-469. Epub 2019 Jul 24 doi: 10.1159/000501727. PMID: 31340208
Role of diffusion-weighted MRI in the differential diagnosis of endometrioid and non-endometrioid cancer of the uterus.
Bakir VL, Bakir B, Sanli S, Yildiz SO, Iyibozkurt AC, Kartal MG, Yavuz E
Acta Radiol 2017 Jun;58(6):758-767. Epub 2016 Sep 23 doi: 10.1177/0284185116669873. PMID: 27664276

Diagnosis

Assessment of Preoperative Endometrial Histopathological Sampling as a Predictor of Final Surgical Pathology in Endometrial Cancer.
Piotto MASB, Focchi GRA, Marques RM, Teixeira AMS, Gonçalves WJ, Nicolau SM
Rev Bras Ginecol Obstet 2020 Oct;42(10):642-648. Epub 2020 Oct 31 doi: 10.1055/s-0040-1713802. PMID: 33129220
Validation of ultrasound strategies to assess tumor extension and to predict high-risk endometrial cancer in women from the prospective IETA (International Endometrial Tumor Analysis)-4 cohort.
Verbakel JY, Mascilini F, Wynants L, Fischerova D, Testa AC, Franchi D, Frühauf F, Cibula D, Lindqvist PG, Fruscio R, Haak LA, Opolskiene G, Alcazar JL, Mais V, Carlson JW, Sladkevicius P, Timmerman D, Valentin L, Bosch TVD, Epstein E
Ultrasound Obstet Gynecol 2020 Jan;55(1):115-124. Epub 2019 Dec 13 doi: 10.1002/uog.20374. PMID: 31225683
Role of diffusion-weighted MRI in the differential diagnosis of endometrioid and non-endometrioid cancer of the uterus.
Bakir VL, Bakir B, Sanli S, Yildiz SO, Iyibozkurt AC, Kartal MG, Yavuz E
Acta Radiol 2017 Jun;58(6):758-767. Epub 2016 Sep 23 doi: 10.1177/0284185116669873. PMID: 27664276
Elevated serum progesterone levels in postmenopausal women with mucinous ovarian tumors.
Matsuoka A, Tate S, Nishikimi K, Ishikawa H, Shozu M
Menopause 2016 May;23(5):544-9. doi: 10.1097/GME.0000000000000587. PMID: 26926326
Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium.
Mulvany NJ, Allen DG
Int J Gynecol Pathol 2008 Jan;27(1):49-57. doi: 10.1097/pgp.0b013e31806219c5. PMID: 18156975

Therapy

The prognostic importance of p53, bcl-2, and bax in early stage epithelial ovarian carcinoma treated with adjuvant chemotherapy.
Skirnisdóttir I, Seidal T, Gerdin E, Sorbe B
Int J Gynecol Cancer 2002 May-Jun;12(3):265-76. doi: 10.1046/j.1525-1438.2002.01121.x. PMID: 12060448
Androgen-producing, atypically proliferating endometrioid tumor arising in endometriosis.
Powell JL, Connor GP, Henderson GS
South Med J 2001 Apr;94(4):450-3. PMID: 11332919

Prognosis

Prognostic factors determining survival after extrapelvic recurrence in endometrioid type endometrial cancer.
Kilic F, Unsal M, Cakir C, Yuksel D, Kilic C, Dur R, Kimyon Comert G, Turan T, Turkmen O
Taiwan J Obstet Gynecol 2021 Nov;60(6):1023-1030. doi: 10.1016/j.tjog.2021.09.013. PMID: 34794732
Validation of ultrasound strategies to assess tumor extension and to predict high-risk endometrial cancer in women from the prospective IETA (International Endometrial Tumor Analysis)-4 cohort.
Verbakel JY, Mascilini F, Wynants L, Fischerova D, Testa AC, Franchi D, Frühauf F, Cibula D, Lindqvist PG, Fruscio R, Haak LA, Opolskiene G, Alcazar JL, Mais V, Carlson JW, Sladkevicius P, Timmerman D, Valentin L, Bosch TVD, Epstein E
Ultrasound Obstet Gynecol 2020 Jan;55(1):115-124. Epub 2019 Dec 13 doi: 10.1002/uog.20374. PMID: 31225683
Elevated serum progesterone levels in postmenopausal women with mucinous ovarian tumors.
Matsuoka A, Tate S, Nishikimi K, Ishikawa H, Shozu M
Menopause 2016 May;23(5):544-9. doi: 10.1097/GME.0000000000000587. PMID: 26926326
The role of serum CA-125 levels and CA-125 tissue expression positivity in the prediction of the recurrence of stage III and IV epithelial ovarian tumors (CA-125 levels and tissue CA-125 in ovarian tumors).
Gundogdu F, Soylu F, Erkan L, Tatli O, Mavi S, Yavuzcan A
Arch Gynecol Obstet 2011 Jun;283(6):1397-402. Epub 2010 Jul 20 doi: 10.1007/s00404-010-1589-8. PMID: 20645105
Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium.
Mulvany NJ, Allen DG
Int J Gynecol Pathol 2008 Jan;27(1):49-57. doi: 10.1097/pgp.0b013e31806219c5. PMID: 18156975

Clinical prediction guides

Assessment of Preoperative Endometrial Histopathological Sampling as a Predictor of Final Surgical Pathology in Endometrial Cancer.
Piotto MASB, Focchi GRA, Marques RM, Teixeira AMS, Gonçalves WJ, Nicolau SM
Rev Bras Ginecol Obstet 2020 Oct;42(10):642-648. Epub 2020 Oct 31 doi: 10.1055/s-0040-1713802. PMID: 33129220
Validation of ultrasound strategies to assess tumor extension and to predict high-risk endometrial cancer in women from the prospective IETA (International Endometrial Tumor Analysis)-4 cohort.
Verbakel JY, Mascilini F, Wynants L, Fischerova D, Testa AC, Franchi D, Frühauf F, Cibula D, Lindqvist PG, Fruscio R, Haak LA, Opolskiene G, Alcazar JL, Mais V, Carlson JW, Sladkevicius P, Timmerman D, Valentin L, Bosch TVD, Epstein E
Ultrasound Obstet Gynecol 2020 Jan;55(1):115-124. Epub 2019 Dec 13 doi: 10.1002/uog.20374. PMID: 31225683
Elevated serum progesterone levels in postmenopausal women with mucinous ovarian tumors.
Matsuoka A, Tate S, Nishikimi K, Ishikawa H, Shozu M
Menopause 2016 May;23(5):544-9. doi: 10.1097/GME.0000000000000587. PMID: 26926326
Contrast-enhanced MRI in preoperative assessment of myometrial and cervical invasion, and lymph node metastasis: diagnostic value and error analysis in endometrial carcinoma.
Teng F, Zhang YF, Wang YM, Yu J, Lang X, Tian WY, Jiang CX, Xue FX
Acta Obstet Gynecol Scand 2015 Mar;94(3):266-73. Epub 2015 Jan 25 doi: 10.1111/aogs.12570. PMID: 25545203
The role of serum CA-125 levels and CA-125 tissue expression positivity in the prediction of the recurrence of stage III and IV epithelial ovarian tumors (CA-125 levels and tissue CA-125 in ovarian tumors).
Gundogdu F, Soylu F, Erkan L, Tatli O, Mavi S, Yavuzcan A
Arch Gynecol Obstet 2011 Jun;283(6):1397-402. Epub 2010 Jul 20 doi: 10.1007/s00404-010-1589-8. PMID: 20645105

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