U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant tumor of unknown origin

MedGen UID:
10298
Concept ID:
C0027667
Neoplastic Process
Synonym: Metastatic Malignant Neoplasm of Unknown Primary Origin
SNOMED CT: Malignant neoplasm of unknown origin (255052006); Malignant tumor of unknown origin (255052006); Malignant tumor - unknown primary (255052006); UKP - Malignant tumor - unknown primary (255052006); CA - Cancer of unknown origin (255052006); Metastasis - unknown primary (255052006); Cancer - unknown origin (255052006)

Definition

The spread of a malignant neoplasm from an unknown primary to another region remote from the primary site. [from NCI]

Professional guidelines

PubMed

Krämer A, Bochtler T, Pauli C, Baciarello G, Delorme S, Hemminki K, Mileshkin L, Moch H, Oien K, Olivier T, Patrikidou A, Wasan H, Zarkavelis G, Pentheroudakis G, Fizazi K; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Mar;34(3):228-246. Epub 2022 Dec 20 doi: 10.1016/j.annonc.2022.11.013. PMID: 36563965
Soussain C, Malaise D, Cassoux N
Blood 2021 Oct 28;138(17):1519-1534. doi: 10.1182/blood.2020008235. PMID: 34036310
Maghami E, Ismaila N, Alvarez A, Chernock R, Duvvuri U, Geiger J, Gross N, Haughey B, Paul D, Rodriguez C, Sher D, Stambuk HE, Waldron J, Witek M, Caudell J
J Clin Oncol 2020 Aug 1;38(22):2570-2596. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00275. PMID: 32324430

Curated

UK NICE Clinical Guideline (CG104), Metastatic malignant disease of unknown primary origin in adults: diagnosis and management, 2023

Recent clinical studies

Diagnosis

Wang J, Liu Y, Sang L, Wan W
J Ovarian Res 2023 Jul 7;16(1):133. doi: 10.1186/s13048-023-01198-y. PMID: 37420244Free PMC Article
Kishimoto I, Kikuchi M, Shinohara S, Fujiwara K, Kanazawa Y, Tona R, Harada H, Usami Y, Naito Y
Auris Nasus Larynx 2015 Feb;42(1):68-71. Epub 2015 Jan 14 doi: 10.1016/j.anl.2014.08.018. PMID: 25597020

Prognosis

Kishimoto I, Kikuchi M, Shinohara S, Fujiwara K, Kanazawa Y, Tona R, Harada H, Usami Y, Naito Y
Auris Nasus Larynx 2015 Feb;42(1):68-71. Epub 2015 Jan 14 doi: 10.1016/j.anl.2014.08.018. PMID: 25597020

Clinical prediction guides

Hofland J, Steenbergen J, Voorsluijs JM, Verbiest MM, de Krijger RR, Hofland LJ, de Herder WW, Uitterlinden AG, Feelders RA, de Jong FH
PLoS One 2014;9(8):e104944. Epub 2014 Aug 11 doi: 10.1371/journal.pone.0104944. PMID: 25111790Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Clinical Guideline (CG104), Metastatic malignant disease of unknown primary origin in adults: diagnosis and management, 2023

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...