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Malignant tumor of unknown origin

MedGen UID:
10298
•Concept ID:
C0027667
•
Neoplastic Process
Synonym: Metastatic Malignant Neoplasm of Unknown Primary Origin
SNOMED CT: Malignant neoplasm of unknown origin (255052006); Malignant tumor of unknown origin (255052006); Malignant tumor - unknown primary (255052006); UKP - Malignant tumor - unknown primary (255052006); CA - Cancer of unknown origin (255052006); Metastasis - unknown primary (255052006); Cancer - unknown origin (255052006)

Definition

The spread of a malignant neoplasm from an unknown primary to another region remote from the primary site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant tumor of unknown origin

Professional guidelines

PubMed

Cancer of unknown primary: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Krämer A, Bochtler T, Pauli C, Baciarello G, Delorme S, Hemminki K, Mileshkin L, Moch H, Oien K, Olivier T, Patrikidou A, Wasan H, Zarkavelis G, Pentheroudakis G, Fizazi K; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Mar;34(3):228-246. Epub 2022 Dec 20 doi: 10.1016/j.annonc.2022.11.013. PMID: 36563965
Primary vitreoretinal lymphoma: a diagnostic and management challenge.
Soussain C, Malaise D, Cassoux N
Blood 2021 Oct 28;138(17):1519-1534. doi: 10.1182/blood.2020008235. PMID: 34036310
Diagnosis and Management of Squamous Cell Carcinoma of Unknown Primary in the Head and Neck: ASCO Guideline.
Maghami E, Ismaila N, Alvarez A, Chernock R, Duvvuri U, Geiger J, Gross N, Haughey B, Paul D, Rodriguez C, Sher D, Stambuk HE, Waldron J, Witek M, Caudell J
J Clin Oncol 2020 Aug 1;38(22):2570-2596. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00275. PMID: 32324430

Recent clinical studies

Diagnosis

Real-time contrast-enhanced ultrasound-guided percutaneous biopsy in the diagnosis of ovarian metastasis of gallbladder carcinoma: a case report.
Wang J, Liu Y, Sang L, Wan W
J Ovarian Res 2023 Jul 7;16(1):133. doi: 10.1186/s13048-023-01198-y. PMID: 37420244Free PMC Article
A case of angiosarcoma arising from internal jugular vein.
Kishimoto I, Kikuchi M, Shinohara S, Fujiwara K, Kanazawa Y, Tona R, Harada H, Usami Y, Naito Y
Auris Nasus Larynx 2015 Feb;42(1):68-71. Epub 2015 Jan 14 doi: 10.1016/j.anl.2014.08.018. PMID: 25597020

Prognosis

A case of angiosarcoma arising from internal jugular vein.
Kishimoto I, Kikuchi M, Shinohara S, Fujiwara K, Kanazawa Y, Tona R, Harada H, Usami Y, Naito Y
Auris Nasus Larynx 2015 Feb;42(1):68-71. Epub 2015 Jan 14 doi: 10.1016/j.anl.2014.08.018. PMID: 25597020

Clinical prediction guides

Inhibin alpha-subunit (INHA) expression in adrenocortical cancer is linked to genetic and epigenetic INHA promoter variation.
Hofland J, Steenbergen J, Voorsluijs JM, Verbiest MM, de Krijger RR, Hofland LJ, de Herder WW, Uitterlinden AG, Feelders RA, de Jong FH
PLoS One 2014;9(8):e104944. Epub 2014 Aug 11 doi: 10.1371/journal.pone.0104944. PMID: 25111790Free PMC Article

Supplemental Content

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