U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant tumor of unknown origin

MedGen UID:
10298
•Concept ID:
C0027667
•
Neoplastic Process
Synonym: Metastatic Malignant Neoplasm of Unknown Primary Origin
SNOMED CT: Malignant neoplasm of unknown origin (255052006); Malignant tumor of unknown origin (255052006); Malignant tumor - unknown primary (255052006); UKP - Malignant tumor - unknown primary (255052006); CA - Cancer of unknown origin (255052006); Metastasis - unknown primary (255052006); Cancer - unknown origin (255052006)

Definition

The spread of a malignant neoplasm from an unknown primary to another region remote from the primary site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant tumor of unknown origin

Professional guidelines

PubMed

Primary vitreoretinal lymphoma: a diagnostic and management challenge.
Soussain C, Malaise D, Cassoux N
Blood 2021 Oct 28;138(17):1519-1534. doi: 10.1182/blood.2020008235. PMID: 34036310
Management of peritoneal metastasis from neuroendocrine tumors.
Au JT, Levine J, Aytaman A, Weber T, Serafini F
J Surg Oncol 2013 Nov;108(6):385-6. Epub 2013 Sep 20 doi: 10.1002/jso.23399. PMID: 24142576
NCCN Clinical Practice Guidelines Occult primary.
Ettinger DS, Agulnik M, Cates JM, Cristea M, Denlinger CS, Eaton KD, Fidias PM, Gierada D, Gockerman JP, Handorf CR, Iyer R, Lenzi R, Phay J, Rashid A, Saltz L, Shulman LN, Smerage JB, Varadhachary GR, Zager JS, Zhen WK; National Comprehensive Cancer Network
J Natl Compr Canc Netw 2011 Dec;9(12):1358-95. doi: 10.6004/jnccn.2011.0117. PMID: 22157556

Curated

UK NICE Clinical Guideline (CG104), Metastatic malignant disease of unknown primary origin in adults: diagnosis and management, 2023

Recent clinical studies

Diagnosis

Real-time contrast-enhanced ultrasound-guided percutaneous biopsy in the diagnosis of ovarian metastasis of gallbladder carcinoma: a case report.
Wang J, Liu Y, Sang L, Wan W
J Ovarian Res 2023 Jul 7;16(1):133. doi: 10.1186/s13048-023-01198-y. PMID: 37420244Free PMC Article
A case of angiosarcoma arising from internal jugular vein.
Kishimoto I, Kikuchi M, Shinohara S, Fujiwara K, Kanazawa Y, Tona R, Harada H, Usami Y, Naito Y
Auris Nasus Larynx 2015 Feb;42(1):68-71. Epub 2015 Jan 14 doi: 10.1016/j.anl.2014.08.018. PMID: 25597020

Prognosis

A case of angiosarcoma arising from internal jugular vein.
Kishimoto I, Kikuchi M, Shinohara S, Fujiwara K, Kanazawa Y, Tona R, Harada H, Usami Y, Naito Y
Auris Nasus Larynx 2015 Feb;42(1):68-71. Epub 2015 Jan 14 doi: 10.1016/j.anl.2014.08.018. PMID: 25597020

Clinical prediction guides

Inhibin alpha-subunit (INHA) expression in adrenocortical cancer is linked to genetic and epigenetic INHA promoter variation.
Hofland J, Steenbergen J, Voorsluijs JM, Verbiest MM, de Krijger RR, Hofland LJ, de Herder WW, Uitterlinden AG, Feelders RA, de Jong FH
PLoS One 2014;9(8):e104944. Epub 2014 Aug 11 doi: 10.1371/journal.pone.0104944. PMID: 25111790Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Clinical Guideline (CG104), Metastatic malignant disease of unknown primary origin in adults: diagnosis and management, 2023

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...