Similar studies for GEO DataSets (Select 200032119) - GEO DataSets

Select item 2000321191.

Host and pathogen interaction: time course

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Candida albicans; Danio rerio

Type:: Expression profiling by array

Platforms:: GPL14575 GPL6457
54 Samples

Download data: TXT

Series

Accession:: GSE32119

ID:: 200032119

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000321182.

Host and pathogen interaction: time course [zebrafish]

(Submitter supplied) The interaction between fungal pathogen and host during infection is a complex and dynamic process. To resolve this, we chose the zebrafish model organism as the host to study C. albicans infection via systems biology approach. Transcriptome microarray data and histological analysis of surviving fish were sampled at different post-infection time points. The dynamic variations of significant genes expression profiles in C. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL6457
27 Samples

Download data: TXT

Series

Accession:: GSE32118

ID:: 200032118

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000321173.

Host and pathogen interaction: time course [C. albicans]

(Submitter supplied) The interaction between fungal pathogen and host during infection is a complex and dynamic process. To resolve this, we chose the zebrafish model organism as the host to study C. albicans infection via systems biology approach. Transcriptome microarray data and histological analysis of surviving fish were sampled at different post-infection time points. The dynamic variations of significant genes expression profiles in C. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL14575
27 Samples

Download data: TXT

Series

Accession:: GSE32117

ID:: 200032117

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000516034.

Innate and adaptive immunity in zebrafish: time course (zebrafish)

(Submitter supplied) The interaction between fungal pathogen and host innnate and adaptive immunity during infection is a complex and dynamic process. To resolve this, we chose the zebrafish model organism as the host to study C. albicans infection via systems biology approach. Transcriptome microarray data and histological analysis of surviving fish were sampled at different post-infection time points. Time-course microarray data following primary and secondary infection of zebrafish by Candida albicans were obatined. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL6457
30 Samples

Download data: TXT

Series

Accession:: GSE51603

ID:: 200051603

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Select item 2000133455.

Expression profiling of Candida albicans and Candida dubliniensis in reconstituted human oral epithelium 90 min p.i.

(Submitter supplied) Candida albicans and Candida dubliniensis are closely related species displaying differences in virulence and genome content, therefore providing potential opportunities to identify novel C. albicans virulence genes. C. albicans gene arrays were used for comparative analysis of global gene expression in the two species in reconstituted human oral epithelium (RHE). C. albicans (SC5314) showed upregulation of hypha-specific and virulence genes within 30 min postinoculation, coinciding with rapid induction of filamentation and increased RHE damage. more...

Organism:: Candida dubliniensis; Candida albicans

Type:: Expression profiling by array

Platform:: GPL6453
8 Samples

Download data: GPR, TXT

Series

Accession:: GSE13345

ID:: 200013345

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000133186.

Expression profiling of Candida albicans and Candida dubliniensis in reconstituted human oral epithelium 30 min p.i.

(Submitter supplied) Candida albicans and Candida dubliniensis are closely related species displaying differences in virulence and genome content, therefore providing potential opportunities to identify novel C. albicans virulence genes. C. albicans gene arrays were used for comparative analysis of global gene expression in the two species in reconstituted human oral epithelium (RHE). C. albicans (SC5314) showed upregulation of hypha-specific and virulence genes within 30 min postinoculation, coinciding with rapid induction of filamentation and increased RHE damage. more...

Organism:: Candida dubliniensis; Candida albicans

Type:: Expression profiling by array

Platform:: GPL6475
6 Samples

Download data: GPR, TXT

Series

Accession:: GSE13318

ID:: 200013318

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Select item 2000836827.

Combined transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Candida albicans

Type:: Expression profiling by array

Platforms:: GPL6885 GPL22078 GPL6887
80 Samples

Download data: GPR

Series

Accession:: GSE83682

ID:: 200083682

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Select item 2000836818.

Combined transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions [mouse tissues 8 h]

(Submitter supplied) The opportunistic fungal pathogen Candida albicans is a common cause of life-threatening nosocomial bloodstream infections. In the murine model of systemic candidiasis the kidney is the primary target organ while the fungal load declines over time in liver and spleen. To get a better understanding of the organ-specific differences in host-pathogen interaction during systemic murine candidiasis, we performed a time-course gene expression profiling to investigate the differential responses of murine kidney, liver and spleen and determined the fungal transcriptome in liver and kidney. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
9 Samples

Download data: TXT

Series

Accession:: GSE83681

ID:: 200083681

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000836809.

Combined transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions [mouse tissues 12,24,72 h]

(Submitter supplied) The opportunistic fungal pathogen Candida albicans is a common cause of life-threatening nosocomial bloodstream infections. In the murine model of systemic candidiasis the kidney is the primary target organ while the fungal load declines over time in liver and spleen. To get a better understanding of the organ-specific differences in host-pathogen interaction during systemic murine candidiasis, we performed a time-course gene expression profiling to investigate the differential responses of murine kidney, liver and spleen and determined the fungal transcriptome in liver and kidney. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
54 Samples

Download data: TXT

Series

Accession:: GSE83680

ID:: 200083680

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Select item 20008367910.

Combined transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions [C. albicans]

(Submitter supplied) The opportunistic fungal pathogen Candida albicans is a common cause of life-threatening nosocomial bloodstream infections. In the murine model of systemic candidiasis the kidney is the primary target organ while the fungal load declines over time in liver and spleen. To get a better understanding of the organ-specific differences in host-pathogen interaction during systemic murine candidiasis, we performed a time-course gene expression profiling to investigate the differential responses of murine kidney, liver and spleen and determined the fungal transcriptome in liver and kidney. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL22078
17 Samples

Download data: GPR

Series

Accession:: GSE83679

ID:: 200083679

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Select item 20013611611.

Global transcriptomic analyses of the candida albicans response to treatment with a novel inhibitor of filamentation

(Submitter supplied) The opportunistic pathogenic fungus Candida albicans can cause devastating infections in severely compromised patients. Its ability to undergo a morphogenetic transition from yeast to filamentous forms allows it to penetrate tissues and cause damage, and the expression of a number of pathogenetic mechanisms are also coordinately regulated with this yeast-to-hyphae conversion. Therefore, it is widely considered that filamentation represents one of the main virulence factors of C. more...

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15645
6 Samples

Download data: CSV, TXT

Series

Accession:: GSE136116

ID:: 200136116

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013432112.

Filamentation is Associated with Reduced Pathogenicity of Multiple Non-albicans Candida Species

(Submitter supplied) Candidiasis affects a wide variety of immunocompromised individuals, including HIV/AIDS patients and cancer patients on chemotherapy. Candida albicans, a major human fungal pathogen, accounts for about 50% of all cases, while the remainder are caused by the less pathogenic non-albicans Candida species (NACS). These species are believed to be less pathogenic, in part, because they do not filament as readily or robustly as C. more...

Organism:: Candida parapsilosis; Candida tropicalis

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21876 GPL18663
16 Samples

Download data: TXT

Series

Accession:: GSE134321

ID:: 200134321

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005609313.

Characterization of transcriptome dynamics in response to contact with host cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Candida albicans; Homo sapiens

Type:: Expression profiling by high throughput sequencing

5 related Platforms
88 Samples

Download data: TXT

Series

Accession:: GSE56093

ID:: 200056093

PubMed Full text in PMC Similar studies

Select item 20005609214.

Characterization of transcriptome dynamics in response to contact with host cells [Phase II In Vivo]

(Submitter supplied) Candida albicans is the major invasive fungal pathogen of humans, causing diseases ranging from superficial mucosal infections to disseminated, systemic infections which are often life threatening. Hematogenously disseminated candidiasis (HDC) has a 47% mortality rate despite current antifungal therapy. An increase in prevalence, as well as an increasing resistance to most of the clinically important antifungal therapies, provides a strong impetus to understand the molecular mechanisms of pathogenesis and the acquisition of drug resistance. more...

Organism:: Candida albicans; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18449 GPL13112
32 Samples

Download data: TXT

Series

Accession:: GSE56092

ID:: 200056092

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005609115.

Characterization of transcriptome dynamics in response to contact with host cells [Phase I In Vitro]

(Submitter supplied) Candida albicans is the major invasive fungal pathogen of humans, causing diseases ranging from superficial mucosal infections to disseminated, systemic infections which are often life threatening. Hematogenously disseminated candidiasis (HDC) has a 47% mortality rate despite current antifungal therapy. An increase in prevalence, as well as an increasing resistance to most of the clinically important antifungal therapies, provides a strong impetus to understand the molecular mechanisms of pathogenesis and the acquisition of drug resistance. more...

Organism:: Candida albicans; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18448 GPL11154 GPL15645
56 Samples

Download data: TXT

Series

Accession:: GSE56091

ID:: 200056091

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004126616.

Comparative analysis between wild type and hap5-null mutant in response to rapamycin treatment

(Submitter supplied) To identify the potential Hap5-regulated genes, we treated wild type cells and hap5 mutant cells with rapamycin and their corespondent transcriptional profiles were compared. Total 608 significant genes were identified. Among them, 343 genes are upregulated in hap5 mutant in repsonse to rapamycin while 265 genes are downregulated in comparison with the wild type.

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL14575
8 Samples

Download data: TXT

Series

Accession:: GSE41266

ID:: 200041266

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002053717.

Transcriptional response of Candida dubliniensis during hypha formation and environmental change

(Submitter supplied) Transcriptional response of Candida dubliniensis during hypha formation and environmental change (temperature, pH, density and nutrients). Transcript profiling of C. dubliniensis identified a core shared transcriptional response with C. albicans during hypha formation and growth at alkaline pH. However, C. albicans expresses several unique hypha-specific genes, including ALS3, HYR1 and SAP4 and 5. Transcript profiling also revealed a novel role for NRG1 in regulating ferric reductases in C. more...

Organism:: Candida dubliniensis

Type:: Expression profiling by array

Platform:: GPL10110
32 Samples

Download data: GPR

Series

Accession:: GSE20537

ID:: 200020537

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011743318.

Candida albicans Sfl1/Sfl2 regulatory network drives the formation of pathogenic microcolonies.

(Submitter supplied) Candida albicans is an opportunistic fungal pathogen that can infect oral mucosal surfaces despite being under continuous flow from saliva. Previous studies have shown that under specific conditions C. albicans will form microcolonies that more closely resemble the biofilms formed in vivo than standard in vitro biofilm models. However, very little is known about these microcolonies, particularly genomic differences between these specialized biofilm structures and the traditional in vitro biofilms. more...