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Refractory Lymphoma

MedGen UID:
1614250
•Concept ID:
C4525060
•
Neoplastic Process

Definition

A lymphoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Lymphoma

Professional guidelines

PubMed

Critical care management of chimeric antigen receptor T-cell therapy recipients.
Shimabukuro-Vornhagen A, Böll B, Schellongowski P, Valade S, Metaxa V, Azoulay E, von Bergwelt-Baildon M
CA Cancer J Clin 2022 Jan;72(1):78-93. Epub 2021 Oct 6 doi: 10.3322/caac.21702. PMID: 34613616
Assessment and Management of Cardiotoxicity in Hematologic Malignancies.
Bojan A, Torok-Vistai T, Parvu A
Dis Markers 2021;2021:6616265. Epub 2021 Feb 3 doi: 10.1155/2021/6616265. PMID: 33613788Free PMC Article
Romidepsin for the treatment of non-Hodgkin's lymphoma.
Yazbeck VY, Grant S
Expert Opin Investig Drugs 2015;24(7):965-79. Epub 2015 May 4 doi: 10.1517/13543784.2015.1041586. PMID: 25936363

Recent clinical studies

Etiology

Expanding the armory for treating lymphoma: Targeting redox cellular status through thioredoxin reductase inhibition.
Wang S, Di Trapani G, Tonissen KF
Pharmacol Res 2022 Mar;177:106134. Epub 2022 Feb 18 doi: 10.1016/j.phrs.2022.106134. PMID: 35189357
Novel therapies for relapsed/refractory aggressive lymphomas.
Cohen JB
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):75-82. doi: 10.1182/asheducation-2018.1.75. PMID: 30504294Free PMC Article
Research Techniques Made Simple: CAR T-Cell Therapy.
Siddiqi HF, Staser KW, Nambudiri VE
J Invest Dermatol 2018 Dec;138(12):2501-2504.e1. Epub 2018 Sep 19 doi: 10.1016/j.jid.2018.09.002. PMID: 30243656
A Review of Autologous Stem Cell Transplantation in Lymphoma.
Zahid U, Akbar F, Amaraneni A, Husnain M, Chan O, Riaz IB, McBride A, Iftikhar A, Anwer F
Curr Hematol Malig Rep 2017 Jun;12(3):217-226. doi: 10.1007/s11899-017-0382-1. PMID: 28478586Free PMC Article
Haematopoietic SCT for children and adolescents with relapsed and refractory Hodgkin's lymphoma.
Claviez A, Sureda A, Schmitz N
Bone Marrow Transplant 2008 Oct;42 Suppl 2:S16-24. doi: 10.1038/bmt.2008.278. PMID: 18978738

Diagnosis

Cellular Immunotherapy in Lymphoma: Beyond CART Cells.
Gaballa MR, Ramos CA
Curr Treat Options Oncol 2020 Feb 11;21(3):21. doi: 10.1007/s11864-020-0709-3. PMID: 32048071Free PMC Article
Novel therapies for relapsed/refractory aggressive lymphomas.
Cohen JB
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):75-82. doi: 10.1182/asheducation-2018.1.75. PMID: 30504294Free PMC Article
A Review of Autologous Stem Cell Transplantation in Lymphoma.
Zahid U, Akbar F, Amaraneni A, Husnain M, Chan O, Riaz IB, McBride A, Iftikhar A, Anwer F
Curr Hematol Malig Rep 2017 Jun;12(3):217-226. doi: 10.1007/s11899-017-0382-1. PMID: 28478586Free PMC Article
Stem cell transplantation for pediatric lymphoma: past, present and future.
Bradley MB, Cairo MS
Bone Marrow Transplant 2008 Jan;41(2):149-58. Epub 2007 Dec 17 doi: 10.1038/sj.bmt.1705948. PMID: 18084337
Allogeneic transplantation in lymphoma: current status.
Schmitz N, Dreger P, Glass B, Sureda A
Haematologica 2007 Nov;92(11):1533-48. doi: 10.3324/haematol.11185. PMID: 18024402

Therapy

Critical care management of chimeric antigen receptor T-cell therapy recipients.
Shimabukuro-Vornhagen A, Böll B, Schellongowski P, Valade S, Metaxa V, Azoulay E, von Bergwelt-Baildon M
CA Cancer J Clin 2022 Jan;72(1):78-93. Epub 2021 Oct 6 doi: 10.3322/caac.21702. PMID: 34613616
Prophylactic Tocilizumab Prior to Anti-CD19 CAR-T Cell Therapy for Non-Hodgkin Lymphoma.
Caimi PF, Pacheco Sanchez G, Sharma A, Otegbeye F, Ahmed N, Rojas P, Patel S, Kleinsorge Block S, Schiavone J, Zamborsky K, Boughan K, Hillian A, Reese-Koc J, Maschan M, Dropulic B, Sekaly RP, de Lima M
Front Immunol 2021;12:745320. Epub 2021 Oct 12 doi: 10.3389/fimmu.2021.745320. PMID: 34712233Free PMC Article
Interim FDG-PET Imaging in Lymphoma.
Gallamini A, Zwarthoed C
Semin Nucl Med 2018 Jan;48(1):17-27. Epub 2017 Oct 14 doi: 10.1053/j.semnuclmed.2017.09.002. PMID: 29195613
A Review of Autologous Stem Cell Transplantation in Lymphoma.
Zahid U, Akbar F, Amaraneni A, Husnain M, Chan O, Riaz IB, McBride A, Iftikhar A, Anwer F
Curr Hematol Malig Rep 2017 Jun;12(3):217-226. doi: 10.1007/s11899-017-0382-1. PMID: 28478586Free PMC Article
Targeted therapy in lymphoma.
Johnston PB, Yuan R, Cavalli F, Witzig TE
J Hematol Oncol 2010 Nov 23;3:45. doi: 10.1186/1756-8722-3-45. PMID: 21092307Free PMC Article

Prognosis

Clinical experience of CAR T cell therapy in lymphomas.
Oluwole OO
Best Pract Res Clin Haematol 2021 Sep;34(3):101281. Epub 2021 Jun 26 doi: 10.1016/j.beha.2021.101281. PMID: 34625227
Chimeric antigen receptor T-cell lymphoma immunotherapy: the next questions.
Salaroli A, Spilleboudt C, Bron D, Lewalle P
Curr Opin Oncol 2020 Sep;32(5):434-441. doi: 10.1097/CCO.0000000000000671. PMID: 32796231
Interim FDG-PET Imaging in Lymphoma.
Gallamini A, Zwarthoed C
Semin Nucl Med 2018 Jan;48(1):17-27. Epub 2017 Oct 14 doi: 10.1053/j.semnuclmed.2017.09.002. PMID: 29195613
Chimeric antigen receptor T-cell therapies for lymphoma.
Brudno JN, Kochenderfer JN
Nat Rev Clin Oncol 2018 Jan;15(1):31-46. Epub 2017 Aug 31 doi: 10.1038/nrclinonc.2017.128. PMID: 28857075
Non-Hodgkin's lymphoma: the old and the new.
Cabanillas F
Clin Lymphoma Myeloma Leuk 2011 Jun;11 Suppl 1:S87-90. Epub 2011 Apr 28 doi: 10.1016/j.clml.2011.03.029. PMID: 22035756

Clinical prediction guides

Clinical and Radiographic Predictors of Progression and Survival in Relapsed/Refractory Lymphoma Patients Receiving Anti-CD19 CAR T-cell Therapy.
Jodon G, Colton MD, Abbott D, Cai A, Haverkos B, Morgan R, Kamdar M
Clin Lymphoma Myeloma Leuk 2023 Jan;23(1):49-56. Epub 2022 Oct 7 doi: 10.1016/j.clml.2022.09.009. PMID: 36335021
Prediction of Stem Cell Mobilization Failure in Patients with Hodgkin and Non-Hodgkin Lymphoma.
Demiroğlu H, Çiftçiler R, Büyükaşık Y, Göker H
Turk J Haematol 2021 Aug 25;38(3):204-210. Epub 2020 Nov 9 doi: 10.4274/tjh.galenos.2020.2020.0409. PMID: 33161684Free PMC Article
Chimeric antigen receptor T-cell lymphoma immunotherapy: the next questions.
Salaroli A, Spilleboudt C, Bron D, Lewalle P
Curr Opin Oncol 2020 Sep;32(5):434-441. doi: 10.1097/CCO.0000000000000671. PMID: 32796231
Interim FDG-PET Imaging in Lymphoma.
Gallamini A, Zwarthoed C
Semin Nucl Med 2018 Jan;48(1):17-27. Epub 2017 Oct 14 doi: 10.1053/j.semnuclmed.2017.09.002. PMID: 29195613
Outcomes and prognostic factors for relapsed or refractory lymphoma patients in phase I clinical trials.
Michot JM, Benajiba L, Faivre L, Baldini C, Haddag L, Bonnet C, Massard C, Bigot F, Bigenwald C, Verret B, Thomas ZAP, Varga A, Gazzah A, Hollebecque A, Ghez D, Lazarovici J, Balheda R, Jeanson A, Postel-Vinay S, Danu A, Soria JC, Paoletti X, Ribrag V
Invest New Drugs 2018 Feb;36(1):62-74. Epub 2017 Jun 9 doi: 10.1007/s10637-017-0480-x. PMID: 28597151

Recent systematic reviews

Efficiency and safety of autologous chimeric antigen receptor T-cells therapy used for patients with lymphoma: A systematic review and meta-analysis.
Cao G, Lei L, Zhu X
Medicine (Baltimore) 2019 Oct;98(42):e17506. doi: 10.1097/MD.0000000000017506. PMID: 31626107Free PMC Article
Role of Maintenance Therapy after High-Dose Chemotherapy and Autologous Hematopoietic Cell Transplantation in Aggressive Lymphomas: A Systematic Review.
Taverna JA, Yun S, Jonnadula J, Saleh A, Riaz IB, Abraham I, Yeager AM, Persky DO, McBride A, Haldar S, Anwer F
Biol Blood Marrow Transplant 2016 Jul;22(7):1182-1196. Epub 2016 Feb 16 doi: 10.1016/j.bbmt.2016.02.007. PMID: 26899562

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