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Plasma cell neoplasm

MedGen UID:
368758
Concept ID:
C1959632
Neoplastic Process
Synonyms: Neoplasm, Plasma Cell; Neoplasms, Plasma Cell; Plasma Cell Neoplasm; Plasma Cell Neoplasms
SNOMED CT: Plasma cell neoplasm (415111003); Plasma cell neoplasm (127580003); Plasma cell neoplasm (morphology) (127580003)
 
Monarch Initiative: MONDO:0004959
Orphanet: ORPHA98282

Definition

A clonal proliferation of immunoglobulin-secreting plasma cells. This category includes multiple myeloma, plasma cell leukemia, plasmacytoma, and plasma cell post-transplant lymphoproliferative disorder. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlasma cell neoplasm

Professional guidelines

PubMed

Dispenzieri A
Am J Hematol 2023 Dec;98(12):1934-1950. Epub 2023 Sep 21 doi: 10.1002/ajh.27081. PMID: 37732822
Dispenzieri A
Am J Hematol 2021 Jul 1;96(7):872-888. Epub 2021 May 31 doi: 10.1002/ajh.26240. PMID: 34000085
Dispenzieri A
Am J Hematol 2019 Jul;94(7):812-827. Epub 2019 May 23 doi: 10.1002/ajh.25495. PMID: 31012139

Recent clinical studies

Etiology

Dispenzieri A
Am J Hematol 2023 Dec;98(12):1934-1950. Epub 2023 Sep 21 doi: 10.1002/ajh.27081. PMID: 37732822
Dispenzieri A
Am J Hematol 2021 Jul 1;96(7):872-888. Epub 2021 May 31 doi: 10.1002/ajh.26240. PMID: 34000085
Liu MC, Oxnard GR, Klein EA, Swanton C, Seiden MV; CCGA Consortium
Ann Oncol 2020 Jun;31(6):745-759. Epub 2020 Mar 30 doi: 10.1016/j.annonc.2020.02.011. PMID: 33506766Free PMC Article
Castaneda O, Baz R
Acta Med Acad 2019 Apr;48(1):57-67. doi: 10.5644/ama2006-124.242. PMID: 31264433
Dispenzieri A
Am J Hematol 2019 Jul;94(7):812-827. Epub 2019 May 23 doi: 10.1002/ajh.25495. PMID: 31012139

Diagnosis

Shah UA, Parikh R, Castro F, Bellone M, Lesokhin AM
Leukemia 2023 May;37(5):964-980. Epub 2023 Mar 30 doi: 10.1038/s41375-023-01874-4. PMID: 36997677Free PMC Article
Dispenzieri A
Am J Hematol 2021 Jul 1;96(7):872-888. Epub 2021 May 31 doi: 10.1002/ajh.26240. PMID: 34000085
Liu MC, Oxnard GR, Klein EA, Swanton C, Seiden MV; CCGA Consortium
Ann Oncol 2020 Jun;31(6):745-759. Epub 2020 Mar 30 doi: 10.1016/j.annonc.2020.02.011. PMID: 33506766Free PMC Article
Castaneda O, Baz R
Acta Med Acad 2019 Apr;48(1):57-67. doi: 10.5644/ama2006-124.242. PMID: 31264433
Dispenzieri A
Am J Hematol 2019 Jul;94(7):812-827. Epub 2019 May 23 doi: 10.1002/ajh.25495. PMID: 31012139

Therapy

Frigault MJ, Bishop MR, Rosenblatt J, O'Donnell EK, Raje N, Cook D, Yee AJ, Logan E, Avigan DE, Jakubowiak A, Shaw K, Daley H, Nikiforow S, Griffin F, Cornwell C, Shen A, Heery C, Maus MV
Blood Adv 2023 Mar 14;7(5):768-777. doi: 10.1182/bloodadvances.2022007210. PMID: 35468618Free PMC Article
Bębnowska D, Hrynkiewicz R, Grywalska E, Pasiarski M, Sosnowska-Pasiarska B, Smarz-Widelska I, Góźdź S, Roliński J, Niedźwiedzka-Rystwej P
Int J Mol Sci 2021 Mar 30;22(7) doi: 10.3390/ijms22073587. PMID: 33808304Free PMC Article
Dispenzieri A
Am J Hematol 2019 Jul;94(7):812-827. Epub 2019 May 23 doi: 10.1002/ajh.25495. PMID: 31012139
Cowan AJ, Allen C, Barac A, Basaleem H, Bensenor I, Curado MP, Foreman K, Gupta R, Harvey J, Hosgood HD, Jakovljevic M, Khader Y, Linn S, Lad D, Mantovani L, Nong VM, Mokdad A, Naghavi M, Postma M, Roshandel G, Shackelford K, Sisay M, Nguyen CT, Tran TT, Xuan BT, Ukwaja KN, Vollset SE, Weiderpass E, Libby EN, Fitzmaurice C
JAMA Oncol 2018 Sep 1;4(9):1221-1227. doi: 10.1001/jamaoncol.2018.2128. PMID: 29800065Free PMC Article
Diamond E, Lahoud OB, Landau H
Leuk Lymphoma 2018 Jun;59(6):1300-1311. Epub 2017 Aug 28 doi: 10.1080/10428194.2017.1365859. PMID: 28847191Free PMC Article

Prognosis

Clarke SE, Fuller KA, Erber WN
Blood Rev 2024 Mar;64:101168. Epub 2024 Jan 4 doi: 10.1016/j.blre.2024.101168. PMID: 38212176
Alejo E, Puertas B, Mateos MV
Med Clin (Barc) 2023 Sep 8;161(5):217-224. Epub 2023 Jun 15 doi: 10.1016/j.medcli.2023.05.006. PMID: 37330390
Liu MC, Oxnard GR, Klein EA, Swanton C, Seiden MV; CCGA Consortium
Ann Oncol 2020 Jun;31(6):745-759. Epub 2020 Mar 30 doi: 10.1016/j.annonc.2020.02.011. PMID: 33506766Free PMC Article
Castaneda O, Baz R
Acta Med Acad 2019 Apr;48(1):57-67. doi: 10.5644/ama2006-124.242. PMID: 31264433
Cowan AJ, Allen C, Barac A, Basaleem H, Bensenor I, Curado MP, Foreman K, Gupta R, Harvey J, Hosgood HD, Jakovljevic M, Khader Y, Linn S, Lad D, Mantovani L, Nong VM, Mokdad A, Naghavi M, Postma M, Roshandel G, Shackelford K, Sisay M, Nguyen CT, Tran TT, Xuan BT, Ukwaja KN, Vollset SE, Weiderpass E, Libby EN, Fitzmaurice C
JAMA Oncol 2018 Sep 1;4(9):1221-1227. doi: 10.1001/jamaoncol.2018.2128. PMID: 29800065Free PMC Article

Clinical prediction guides

Li L, Yu Z, Ren J, Niu T
Cancer Med 2023 Nov;12(22):20964-20975. Epub 2023 Nov 1 doi: 10.1002/cam4.6649. PMID: 37908181Free PMC Article
Frigault MJ, Bishop MR, Rosenblatt J, O'Donnell EK, Raje N, Cook D, Yee AJ, Logan E, Avigan DE, Jakubowiak A, Shaw K, Daley H, Nikiforow S, Griffin F, Cornwell C, Shen A, Heery C, Maus MV
Blood Adv 2023 Mar 14;7(5):768-777. doi: 10.1182/bloodadvances.2022007210. PMID: 35468618Free PMC Article
Liu MC, Oxnard GR, Klein EA, Swanton C, Seiden MV; CCGA Consortium
Ann Oncol 2020 Jun;31(6):745-759. Epub 2020 Mar 30 doi: 10.1016/j.annonc.2020.02.011. PMID: 33506766Free PMC Article
Castaneda O, Baz R
Acta Med Acad 2019 Apr;48(1):57-67. doi: 10.5644/ama2006-124.242. PMID: 31264433
Altindag SD, Cakir E, Ekinci N, Avci A, Dilek FH
Ann Diagn Pathol 2019 Jun;40:66-71. Epub 2019 Apr 3 doi: 10.1016/j.anndiagpath.2019.04.003. PMID: 31031217

Recent systematic reviews

Venkatesulu B, Mallick S, Giridhar P, Upadhyay AD, Rath GK
Eur Arch Otorhinolaryngol 2018 Feb;275(2):595-606. Epub 2017 Dec 9 doi: 10.1007/s00405-017-4817-z. PMID: 29224044

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